PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJC4_LEIBR

TriTrypDb:

LbrM.31.1640 , LBRM2903_310025600

Length:

1148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1128	1132	PF00656	0.627
CLV_C14_Caspase3-7	213	217	PF00656	0.644
CLV_C14_Caspase3-7	606	610	PF00656	0.514
CLV_C14_Caspase3-7	697	701	PF00656	0.734
CLV_C14_Caspase3-7	888	892	PF00656	0.575
CLV_NRD_NRD_1	111	113	PF00675	0.654
CLV_NRD_NRD_1	19	21	PF00675	0.651
CLV_NRD_NRD_1	30	32	PF00675	0.541
CLV_NRD_NRD_1	321	323	PF00675	0.742
CLV_NRD_NRD_1	363	365	PF00675	0.614
CLV_NRD_NRD_1	370	372	PF00675	0.535
CLV_NRD_NRD_1	755	757	PF00675	0.593
CLV_NRD_NRD_1	841	843	PF00675	0.667
CLV_NRD_NRD_1	978	980	PF00675	0.707
CLV_PCSK_FUR_1	839	843	PF00082	0.694
CLV_PCSK_KEX2_1	29	31	PF00082	0.693
CLV_PCSK_KEX2_1	321	323	PF00082	0.742
CLV_PCSK_KEX2_1	363	365	PF00082	0.614
CLV_PCSK_KEX2_1	370	372	PF00082	0.535
CLV_PCSK_KEX2_1	755	757	PF00082	0.592
CLV_PCSK_KEX2_1	841	843	PF00082	0.667
CLV_PCSK_KEX2_1	956	958	PF00082	0.733
CLV_PCSK_KEX2_1	978	980	PF00082	0.707
CLV_PCSK_PC1ET2_1	956	958	PF00082	0.733
CLV_PCSK_SKI1_1	1082	1086	PF00082	0.732
CLV_PCSK_SKI1_1	307	311	PF00082	0.607
CLV_PCSK_SKI1_1	355	359	PF00082	0.454
CLV_PCSK_SKI1_1	842	846	PF00082	0.689
DEG_SPOP_SBC_1	641	645	PF00917	0.527
DEG_SPOP_SBC_1	914	918	PF00917	0.523
DOC_AGCK_PIF_2	716	721	PF00069	0.650
DOC_CDC14_PxL_1	340	348	PF14671	0.580
DOC_MAPK_FxFP_2	200	203	PF00069	0.644
DOC_MAPK_gen_1	29	39	PF00069	0.652
DOC_MAPK_gen_1	363	374	PF00069	0.598
DOC_MAPK_gen_1	839	847	PF00069	0.677
DOC_MAPK_MEF2A_6	239	246	PF00069	0.461
DOC_MAPK_MEF2A_6	839	847	PF00069	0.697
DOC_MAPK_MEF2A_6	991	1000	PF00069	0.565
DOC_PP1_RVXF_1	1135	1141	PF00149	0.653
DOC_PP1_RVXF_1	356	362	PF00149	0.456
DOC_PP1_RVXF_1	399	405	PF00149	0.632
DOC_PP2B_LxvP_1	265	268	PF13499	0.827
DOC_PP2B_LxvP_1	681	684	PF13499	0.559
DOC_PP4_FxxP_1	200	203	PF00568	0.644
DOC_PP4_FxxP_1	264	267	PF00568	0.707
DOC_USP7_MATH_1	137	141	PF00917	0.588
DOC_USP7_MATH_1	168	172	PF00917	0.764
DOC_USP7_MATH_1	229	233	PF00917	0.713
DOC_USP7_MATH_1	237	241	PF00917	0.560
DOC_USP7_MATH_1	268	272	PF00917	0.666
DOC_USP7_MATH_1	294	298	PF00917	0.459
DOC_USP7_MATH_1	3	7	PF00917	0.561
DOC_USP7_MATH_1	330	334	PF00917	0.622
DOC_USP7_MATH_1	386	390	PF00917	0.499
DOC_USP7_MATH_1	434	438	PF00917	0.713
DOC_USP7_MATH_1	483	487	PF00917	0.651
DOC_USP7_MATH_1	585	589	PF00917	0.705
DOC_USP7_MATH_1	641	645	PF00917	0.649
DOC_USP7_MATH_1	770	774	PF00917	0.785
DOC_USP7_MATH_1	858	862	PF00917	0.729
DOC_USP7_MATH_1	864	868	PF00917	0.646
DOC_USP7_MATH_1	878	882	PF00917	0.578
DOC_USP7_MATH_1	892	896	PF00917	0.623
DOC_USP7_MATH_1	899	903	PF00917	0.572
DOC_USP7_MATH_1	914	918	PF00917	0.643
DOC_USP7_MATH_1	929	933	PF00917	0.516
DOC_WW_Pin1_4	1002	1007	PF00397	0.554
DOC_WW_Pin1_4	191	196	PF00397	0.634
DOC_WW_Pin1_4	404	409	PF00397	0.647
DOC_WW_Pin1_4	488	493	PF00397	0.594
DOC_WW_Pin1_4	626	631	PF00397	0.646
DOC_WW_Pin1_4	648	653	PF00397	0.644
DOC_WW_Pin1_4	701	706	PF00397	0.655
DOC_WW_Pin1_4	945	950	PF00397	0.604
DOC_WW_Pin1_4	958	963	PF00397	0.720
LIG_14-3-3_CanoR_1	1053	1061	PF00244	0.587
LIG_14-3-3_CanoR_1	258	265	PF00244	0.555
LIG_14-3-3_CanoR_1	335	343	PF00244	0.610
LIG_14-3-3_CanoR_1	574	583	PF00244	0.615
LIG_14-3-3_CanoR_1	670	676	PF00244	0.642
LIG_14-3-3_CanoR_1	72	78	PF00244	0.540
LIG_14-3-3_CanoR_1	755	760	PF00244	0.549
LIG_14-3-3_CanoR_1	835	839	PF00244	0.664
LIG_14-3-3_CanoR_1	842	848	PF00244	0.649
LIG_14-3-3_CanoR_1	868	876	PF00244	0.533
LIG_Actin_WH2_2	1107	1123	PF00022	0.550
LIG_Actin_WH2_2	336	352	PF00022	0.585
LIG_APCC_ABBA_1	573	578	PF00400	0.525
LIG_BIR_III_2	702	706	PF00653	0.572
LIG_BIR_III_2	86	90	PF00653	0.647
LIG_BIR_III_4	1131	1135	PF00653	0.635
LIG_BIR_III_4	891	895	PF00653	0.567
LIG_BRCT_BRCA1_1	231	235	PF00533	0.665
LIG_BRCT_BRCA1_1	332	336	PF00533	0.612
LIG_BRCT_BRCA1_1	344	348	PF00533	0.437
LIG_BRCT_BRCA1_1	644	648	PF00533	0.540
LIG_BRCT_BRCA1_1	866	870	PF00533	0.535
LIG_BRCT_BRCA1_1	899	903	PF00533	0.678
LIG_BRCT_BRCA1_1	90	94	PF00533	0.632
LIG_BRCT_BRCA1_1	919	923	PF00533	0.485
LIG_BRCT_BRCA1_1	932	936	PF00533	0.643
LIG_CaM_IQ_9	356	372	PF13499	0.604
LIG_eIF4E_1	157	163	PF01652	0.480
LIG_FHA_1	1056	1062	PF00498	0.609
LIG_FHA_1	202	208	PF00498	0.681
LIG_FHA_1	360	366	PF00498	0.606
LIG_FHA_1	499	505	PF00498	0.653
LIG_FHA_1	508	514	PF00498	0.474
LIG_FHA_1	527	533	PF00498	0.471
LIG_FHA_1	627	633	PF00498	0.552
LIG_FHA_1	666	672	PF00498	0.635
LIG_FHA_1	713	719	PF00498	0.566
LIG_FHA_1	727	733	PF00498	0.710
LIG_FHA_1	778	784	PF00498	0.691
LIG_FHA_1	78	84	PF00498	0.521
LIG_FHA_2	147	153	PF00498	0.649
LIG_FHA_2	281	287	PF00498	0.707
LIG_FHA_2	522	528	PF00498	0.660
LIG_FHA_2	554	560	PF00498	0.554
LIG_FHA_2	959	965	PF00498	0.716
LIG_GBD_Chelix_1	387	395	PF00786	0.567
LIG_LIR_Apic_2	1141	1145	PF02991	0.518
LIG_LIR_Apic_2	262	267	PF02991	0.700
LIG_LIR_Gen_1	1109	1119	PF02991	0.550
LIG_LIR_Gen_1	240	249	PF02991	0.607
LIG_LIR_Gen_1	289	296	PF02991	0.601
LIG_LIR_Gen_1	333	344	PF02991	0.604
LIG_LIR_Gen_1	757	767	PF02991	0.547
LIG_LIR_Gen_1	920	930	PF02991	0.527
LIG_LIR_Nem_3	1033	1037	PF02991	0.696
LIG_LIR_Nem_3	115	119	PF02991	0.657
LIG_LIR_Nem_3	125	131	PF02991	0.592
LIG_LIR_Nem_3	240	244	PF02991	0.615
LIG_LIR_Nem_3	289	293	PF02991	0.602
LIG_LIR_Nem_3	333	339	PF02991	0.726
LIG_LIR_Nem_3	757	762	PF02991	0.550
LIG_LIR_Nem_3	900	906	PF02991	0.526
LIG_LIR_Nem_3	920	926	PF02991	0.485
LIG_LIR_Nem_3	967	973	PF02991	0.555
LIG_LYPXL_yS_3	128	131	PF13949	0.602
LIG_MYND_1	189	193	PF01753	0.511
LIG_NRP_CendR_1	1147	1148	PF00754	0.576
LIG_Pex14_1	612	616	PF04695	0.683
LIG_Pex14_2	310	314	PF04695	0.578
LIG_PTB_Apo_2	957	964	PF02174	0.721
LIG_PTB_Phospho_1	957	963	PF10480	0.722
LIG_SH2_GRB2like	1027	1030	PF00017	0.521
LIG_SH2_GRB2like	853	856	PF00017	0.697
LIG_SH2_GRB2like	958	961	PF00017	0.729
LIG_SH2_NCK_1	290	294	PF00017	0.591
LIG_SH2_SRC	963	966	PF00017	0.713
LIG_SH2_STAP1	135	139	PF00017	0.644
LIG_SH2_STAP1	142	146	PF00017	0.591
LIG_SH2_STAP1	290	294	PF00017	0.591
LIG_SH2_STAP1	569	573	PF00017	0.690
LIG_SH2_STAP1	853	857	PF00017	0.602
LIG_SH2_STAT3	157	160	PF00017	0.638
LIG_SH2_STAT3	316	319	PF00017	0.562
LIG_SH2_STAT3	621	624	PF00017	0.533
LIG_SH2_STAT5	1034	1037	PF00017	0.620
LIG_SH2_STAT5	110	113	PF00017	0.652
LIG_SH2_STAT5	13	16	PF00017	0.653
LIG_SH2_STAT5	316	319	PF00017	0.640
LIG_SH2_STAT5	599	602	PF00017	0.673
LIG_SH2_STAT5	621	624	PF00017	0.691
LIG_SH2_STAT5	717	720	PF00017	0.720
LIG_SH2_STAT5	728	731	PF00017	0.634
LIG_SH2_STAT5	78	81	PF00017	0.682
LIG_SH3_1	625	631	PF00018	0.539
LIG_SH3_2	652	657	PF14604	0.713
LIG_SH3_3	1064	1070	PF00018	0.679
LIG_SH3_3	1112	1118	PF00018	0.768
LIG_SH3_3	179	185	PF00018	0.578
LIG_SH3_3	231	237	PF00018	0.680
LIG_SH3_3	323	329	PF00018	0.632
LIG_SH3_3	49	55	PF00018	0.534
LIG_SH3_3	515	521	PF00018	0.657
LIG_SH3_3	625	631	PF00018	0.656
LIG_SH3_3	649	655	PF00018	0.636
LIG_SH3_3	908	914	PF00018	0.527
LIG_SH3_3	943	949	PF00018	0.704
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.668
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.500
LIG_SUMO_SIM_par_1	843	849	PF11976	0.702
LIG_TRAF2_1	1073	1076	PF00917	0.575
LIG_TRAF2_1	787	790	PF00917	0.564
LIG_TYR_ITIM	126	131	PF00017	0.619
LIG_UBA3_1	36	42	PF00899	0.678
LIG_WRC_WIRS_1	131	136	PF05994	0.590
LIG_WW_2	329	332	PF00397	0.625
MOD_CK1_1	1040	1046	PF00069	0.621
MOD_CK1_1	1106	1112	PF00069	0.560
MOD_CK1_1	115	121	PF00069	0.766
MOD_CK1_1	260	266	PF00069	0.692
MOD_CK1_1	389	395	PF00069	0.414
MOD_CK1_1	494	500	PF00069	0.621
MOD_CK1_1	57	63	PF00069	0.686
MOD_CK1_1	581	587	PF00069	0.552
MOD_CK1_1	643	649	PF00069	0.669
MOD_CK1_1	65	71	PF00069	0.698
MOD_CK1_1	669	675	PF00069	0.684
MOD_CK1_1	682	688	PF00069	0.588
MOD_CK1_1	757	763	PF00069	0.548
MOD_CK1_1	793	799	PF00069	0.734
MOD_CK1_1	806	812	PF00069	0.599
MOD_CK1_1	821	827	PF00069	0.567
MOD_CK1_1	846	852	PF00069	0.752
MOD_CK1_1	869	875	PF00069	0.717
MOD_CK1_1	917	923	PF00069	0.586
MOD_CK2_1	137	143	PF00069	0.664
MOD_CK2_1	207	213	PF00069	0.535
MOD_CK2_1	280	286	PF00069	0.672
MOD_CK2_1	296	302	PF00069	0.612
MOD_CK2_1	521	527	PF00069	0.661
MOD_CK2_1	546	552	PF00069	0.679
MOD_CK2_1	558	564	PF00069	0.555
MOD_CK2_1	757	763	PF00069	0.706
MOD_CK2_1	784	790	PF00069	0.561
MOD_CK2_1	925	931	PF00069	0.654
MOD_CK2_1	945	951	PF00069	0.511
MOD_CK2_1	958	964	PF00069	0.688
MOD_Cter_Amidation	27	30	PF01082	0.541
MOD_GlcNHglycan	1006	1009	PF01048	0.559
MOD_GlcNHglycan	1038	1042	PF01048	0.603
MOD_GlcNHglycan	1049	1052	PF01048	0.667
MOD_GlcNHglycan	1108	1111	PF01048	0.661
MOD_GlcNHglycan	170	173	PF01048	0.625
MOD_GlcNHglycan	175	178	PF01048	0.545
MOD_GlcNHglycan	218	221	PF01048	0.764
MOD_GlcNHglycan	25	28	PF01048	0.538
MOD_GlcNHglycan	259	262	PF01048	0.684
MOD_GlcNHglycan	270	273	PF01048	0.587
MOD_GlcNHglycan	298	301	PF01048	0.617
MOD_GlcNHglycan	390	394	PF01048	0.414
MOD_GlcNHglycan	423	426	PF01048	0.760
MOD_GlcNHglycan	436	439	PF01048	0.738
MOD_GlcNHglycan	447	450	PF01048	0.677
MOD_GlcNHglycan	472	475	PF01048	0.685
MOD_GlcNHglycan	480	483	PF01048	0.690
MOD_GlcNHglycan	485	488	PF01048	0.674
MOD_GlcNHglycan	493	496	PF01048	0.615
MOD_GlcNHglycan	547	551	PF01048	0.727
MOD_GlcNHglycan	578	581	PF01048	0.513
MOD_GlcNHglycan	62	65	PF01048	0.736
MOD_GlcNHglycan	681	684	PF01048	0.559
MOD_GlcNHglycan	707	710	PF01048	0.668
MOD_GlcNHglycan	772	775	PF01048	0.749
MOD_GlcNHglycan	792	795	PF01048	0.613
MOD_GlcNHglycan	811	814	PF01048	0.538
MOD_GlcNHglycan	872	875	PF01048	0.692
MOD_GlcNHglycan	885	890	PF01048	0.646
MOD_GlcNHglycan	894	897	PF01048	0.688
MOD_GlcNHglycan	917	920	PF01048	0.678
MOD_GlcNHglycan	927	930	PF01048	0.564
MOD_GlcNHglycan	931	935	PF01048	0.524
MOD_GlcNHglycan	941	944	PF01048	0.587
MOD_GlcNHglycan	980	983	PF01048	0.555
MOD_GSK3_1	1106	1113	PF00069	0.551
MOD_GSK3_1	137	144	PF00069	0.567
MOD_GSK3_1	203	210	PF00069	0.508
MOD_GSK3_1	330	337	PF00069	0.618
MOD_GSK3_1	490	497	PF00069	0.739
MOD_GSK3_1	50	57	PF00069	0.695
MOD_GSK3_1	507	514	PF00069	0.688
MOD_GSK3_1	546	553	PF00069	0.525
MOD_GSK3_1	574	581	PF00069	0.687
MOD_GSK3_1	58	65	PF00069	0.650
MOD_GSK3_1	607	614	PF00069	0.536
MOD_GSK3_1	642	649	PF00069	0.641
MOD_GSK3_1	661	668	PF00069	0.589
MOD_GSK3_1	67	74	PF00069	0.792
MOD_GSK3_1	701	708	PF00069	0.589
MOD_GSK3_1	750	757	PF00069	0.572
MOD_GSK3_1	789	796	PF00069	0.709
MOD_GSK3_1	799	806	PF00069	0.608
MOD_GSK3_1	812	819	PF00069	0.597
MOD_GSK3_1	858	865	PF00069	0.587
MOD_GSK3_1	866	873	PF00069	0.548
MOD_GSK3_1	913	920	PF00069	0.587
MOD_GSK3_1	925	932	PF00069	0.647
MOD_GSK3_1	978	985	PF00069	0.791
MOD_N-GLC_1	68	73	PF02516	0.571
MOD_N-GLC_2	224	226	PF02516	0.805
MOD_NEK2_1	1057	1062	PF00069	0.565
MOD_NEK2_1	1103	1108	PF00069	0.654
MOD_NEK2_1	359	364	PF00069	0.684
MOD_NEK2_1	456	461	PF00069	0.649
MOD_NEK2_1	526	531	PF00069	0.506
MOD_NEK2_1	576	581	PF00069	0.522
MOD_NEK2_1	592	597	PF00069	0.738
MOD_NEK2_1	642	647	PF00069	0.560
MOD_NEK2_1	671	676	PF00069	0.675
MOD_NEK2_1	679	684	PF00069	0.630
MOD_NEK2_1	843	848	PF00069	0.700
MOD_NEK2_1	870	875	PF00069	0.533
MOD_NEK2_2	137	142	PF00069	0.596
MOD_NEK2_2	498	503	PF00069	0.664
MOD_NEK2_2	712	717	PF00069	0.512
MOD_NEK2_2	834	839	PF00069	0.602
MOD_NEK2_2	878	883	PF00069	0.620
MOD_NMyristoyl	1	7	PF02799	0.815
MOD_PIKK_1	104	110	PF00454	0.691
MOD_PIKK_1	183	189	PF00454	0.638
MOD_PIKK_1	50	56	PF00454	0.538
MOD_PIKK_1	655	661	PF00454	0.725
MOD_PIKK_1	71	77	PF00454	0.590
MOD_PIKK_1	793	799	PF00454	0.734
MOD_PK_1	567	573	PF00069	0.690
MOD_PKA_1	112	118	PF00069	0.654
MOD_PKA_1	183	189	PF00069	0.656
MOD_PKA_1	755	761	PF00069	0.552
MOD_PKA_1	978	984	PF00069	0.712
MOD_PKA_2	1052	1058	PF00069	0.574
MOD_PKA_2	257	263	PF00069	0.546
MOD_PKA_2	334	340	PF00069	0.645
MOD_PKA_2	65	71	PF00069	0.686
MOD_PKA_2	666	672	PF00069	0.550
MOD_PKA_2	754	760	PF00069	0.547
MOD_PKA_2	807	813	PF00069	0.731
MOD_PKA_2	816	822	PF00069	0.638
MOD_PKA_2	834	840	PF00069	0.643
MOD_PKA_2	978	984	PF00069	0.712
MOD_Plk_1	32	38	PF00069	0.671
MOD_Plk_1	389	395	PF00069	0.414
MOD_Plk_1	526	532	PF00069	0.506
MOD_Plk_1	567	573	PF00069	0.799
MOD_Plk_1	885	891	PF00069	0.639
MOD_Plk_4	130	136	PF00069	0.667
MOD_Plk_4	229	235	PF00069	0.749
MOD_Plk_4	260	266	PF00069	0.813
MOD_Plk_4	32	38	PF00069	0.671
MOD_Plk_4	521	527	PF00069	0.661
MOD_Plk_4	643	649	PF00069	0.539
MOD_Plk_4	858	864	PF00069	0.571
MOD_ProDKin_1	1002	1008	PF00069	0.553
MOD_ProDKin_1	191	197	PF00069	0.633
MOD_ProDKin_1	404	410	PF00069	0.649
MOD_ProDKin_1	488	494	PF00069	0.592
MOD_ProDKin_1	626	632	PF00069	0.650
MOD_ProDKin_1	648	654	PF00069	0.644
MOD_ProDKin_1	701	707	PF00069	0.653
MOD_ProDKin_1	945	951	PF00069	0.606
MOD_ProDKin_1	958	964	PF00069	0.718
MOD_SUMO_for_1	990	993	PF00179	0.546
TRG_DiLeu_BaEn_1	452	457	PF01217	0.652
TRG_DiLeu_BaEn_2	290	296	PF01217	0.597
TRG_DiLeu_BaEn_2	389	395	PF01217	0.571
TRG_ENDOCYTIC_2	128	131	PF00928	0.680
TRG_ENDOCYTIC_2	290	293	PF00928	0.600
TRG_ER_diArg_1	29	31	PF00400	0.693
TRG_ER_diArg_1	352	355	PF00400	0.590
TRG_ER_diArg_1	363	365	PF00400	0.501
TRG_ER_diArg_1	369	371	PF00400	0.419
TRG_ER_diArg_1	838	841	PF00400	0.688
TRG_ER_diArg_1	978	980	PF00400	0.707
TRG_NLS_MonoExtN_4	18	25	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4F1	Leishmania donovani	74%	99%
A4I6R9	Leishmania infantum	74%	99%
E9B1U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q6C0	Leishmania major	72%	100%