Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJC2_LEIBR

TriTrypDb:

LbrM.31.1620 , LBRM2903_310025000

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.559
CLV_NRD_NRD_1	69	71	PF00675	0.490
CLV_NRD_NRD_1	98	100	PF00675	0.493
CLV_PCSK_KEX2_1	239	241	PF00082	0.559
CLV_PCSK_KEX2_1	353	355	PF00082	0.433
CLV_PCSK_KEX2_1	69	71	PF00082	0.490
CLV_PCSK_KEX2_1	98	100	PF00082	0.500
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.433
CLV_PCSK_PC7_1	349	355	PF00082	0.434
CLV_PCSK_SKI1_1	215	219	PF00082	0.411
CLV_PCSK_SKI1_1	533	537	PF00082	0.450
CLV_PCSK_SKI1_1	671	675	PF00082	0.520
CLV_PCSK_SKI1_1	697	701	PF00082	0.331
DEG_APCC_DBOX_1	532	540	PF00400	0.632
DEG_APCC_DBOX_1	670	678	PF00400	0.714
DEG_APCC_DBOX_1	696	704	PF00400	0.660
DEG_SPOP_SBC_1	232	236	PF00917	0.696
DOC_CKS1_1	387	392	PF01111	0.672
DOC_CKS1_1	625	630	PF01111	0.625
DOC_CYCLIN_RxL_1	705	713	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	712	718	PF00134	0.525
DOC_MAPK_DCC_7	533	541	PF00069	0.632
DOC_MAPK_FxFP_2	196	199	PF00069	0.626
DOC_MAPK_gen_1	69	76	PF00069	0.661
DOC_MAPK_JIP1_4	487	493	PF00069	0.626
DOC_MAPK_MEF2A_6	271	279	PF00069	0.647
DOC_MAPK_MEF2A_6	533	541	PF00069	0.632
DOC_MAPK_MEF2A_6	552	559	PF00069	0.640
DOC_MAPK_MEF2A_6	81	88	PF00069	0.647
DOC_MAPK_RevD_3	84	99	PF00069	0.645
DOC_PP2B_LxvP_1	457	460	PF13499	0.794
DOC_PP2B_LxvP_1	656	659	PF13499	0.691
DOC_PP2B_LxvP_1	712	715	PF13499	0.526
DOC_PP2B_LxvP_1	84	87	PF13499	0.645
DOC_PP4_FxxP_1	196	199	PF00568	0.626
DOC_SPAK_OSR1_1	720	724	PF12202	0.240
DOC_USP7_MATH_1	162	166	PF00917	0.727
DOC_USP7_MATH_1	223	227	PF00917	0.734
DOC_USP7_MATH_1	257	261	PF00917	0.700
DOC_USP7_MATH_1	265	269	PF00917	0.712
DOC_USP7_MATH_1	284	288	PF00917	0.667
DOC_USP7_MATH_1	327	331	PF00917	0.706
DOC_USP7_MATH_1	361	365	PF00917	0.697
DOC_USP7_MATH_1	366	370	PF00917	0.726
DOC_USP7_MATH_1	385	389	PF00917	0.741
DOC_USP7_MATH_1	587	591	PF00917	0.740
DOC_USP7_MATH_1	659	663	PF00917	0.702
DOC_USP7_MATH_1	678	682	PF00917	0.613
DOC_USP7_MATH_1	690	694	PF00917	0.573
DOC_USP7_UBL2_3	379	383	PF12436	0.715
DOC_WW_Pin1_4	239	244	PF00397	0.752
DOC_WW_Pin1_4	305	310	PF00397	0.690
DOC_WW_Pin1_4	322	327	PF00397	0.759
DOC_WW_Pin1_4	368	373	PF00397	0.727
DOC_WW_Pin1_4	378	383	PF00397	0.735
DOC_WW_Pin1_4	386	391	PF00397	0.673
DOC_WW_Pin1_4	397	402	PF00397	0.797
DOC_WW_Pin1_4	43	48	PF00397	0.653
DOC_WW_Pin1_4	432	437	PF00397	0.712
DOC_WW_Pin1_4	463	468	PF00397	0.662
DOC_WW_Pin1_4	472	477	PF00397	0.641
DOC_WW_Pin1_4	526	531	PF00397	0.728
DOC_WW_Pin1_4	540	545	PF00397	0.619
DOC_WW_Pin1_4	551	556	PF00397	0.653
DOC_WW_Pin1_4	583	588	PF00397	0.646
DOC_WW_Pin1_4	624	629	PF00397	0.658
DOC_WW_Pin1_4	74	79	PF00397	0.808
LIG_14-3-3_CanoR_1	183	192	PF00244	0.648
LIG_14-3-3_CanoR_1	246	252	PF00244	0.749
LIG_14-3-3_CanoR_1	354	362	PF00244	0.654
LIG_14-3-3_CanoR_1	506	512	PF00244	0.677
LIG_14-3-3_CanoR_1	581	587	PF00244	0.720
LIG_14-3-3_CanoR_1	631	639	PF00244	0.672
LIG_14-3-3_CanoR_1	697	703	PF00244	0.660
LIG_14-3-3_CanoR_1	720	724	PF00244	0.240
LIG_14-3-3_CanoR_1	81	87	PF00244	0.728
LIG_BIR_III_2	189	193	PF00653	0.644
LIG_BIR_III_2	591	595	PF00653	0.745
LIG_BRCT_BRCA1_1	212	216	PF00533	0.608
LIG_BRCT_BRCA1_1	291	295	PF00533	0.634
LIG_BRCT_BRCA1_1	479	483	PF00533	0.643
LIG_Clathr_ClatBox_1	729	733	PF01394	0.415
LIG_deltaCOP1_diTrp_1	733	739	PF00928	0.463
LIG_eIF4E_1	669	675	PF01652	0.719
LIG_FHA_1	336	342	PF00498	0.645
LIG_FHA_1	631	637	PF00498	0.662
LIG_FHA_1	646	652	PF00498	0.613
LIG_FHA_1	720	726	PF00498	0.288
LIG_FHA_1	752	758	PF00498	0.488
LIG_FHA_2	510	516	PF00498	0.675
LIG_FHA_2	70	76	PF00498	0.684
LIG_Integrin_isoDGR_2	137	139	PF01839	0.446
LIG_IRF3_LxIS_1	535	542	PF10401	0.629
LIG_IRF3_LxIS_1	598	605	PF10401	0.720
LIG_LIR_Apic_2	667	672	PF02991	0.716
LIG_LIR_Apic_2	701	707	PF02991	0.537
LIG_LIR_Gen_1	713	724	PF02991	0.428
LIG_LIR_Nem_3	7	12	PF02991	0.650
LIG_LIR_Nem_3	713	719	PF02991	0.428
LIG_PCNA_yPIPBox_3	603	617	PF02747	0.583
LIG_Pex14_2	499	503	PF04695	0.574
LIG_RPA_C_Fungi	338	350	PF08784	0.536
LIG_SH2_CRK	669	673	PF00017	0.647
LIG_SH2_CRK	704	708	PF00017	0.394
LIG_SH2_GRB2like	110	113	PF00017	0.542
LIG_SH2_NCK_1	253	257	PF00017	0.528
LIG_SH2_NCK_1	612	616	PF00017	0.510
LIG_SH2_SRC	106	109	PF00017	0.727
LIG_SH2_SRC	142	145	PF00017	0.536
LIG_SH2_SRC	253	256	PF00017	0.677
LIG_SH2_SRC	416	419	PF00017	0.571
LIG_SH2_STAP1	106	110	PF00017	0.552
LIG_SH2_STAP1	114	118	PF00017	0.525
LIG_SH2_STAP1	12	16	PF00017	0.542
LIG_SH2_STAP1	745	749	PF00017	0.627
LIG_SH2_STAT5	12	15	PF00017	0.720
LIG_SH2_STAT5	30	33	PF00017	0.518
LIG_SH2_STAT5	41	44	PF00017	0.559
LIG_SH2_STAT5	669	672	PF00017	0.674
LIG_SH2_STAT5	704	707	PF00017	0.388
LIG_SH2_STAT5	745	748	PF00017	0.597
LIG_SH3_1	323	329	PF00018	0.564
LIG_SH3_1	379	385	PF00018	0.582
LIG_SH3_1	622	628	PF00018	0.505
LIG_SH3_2	401	406	PF14604	0.746
LIG_SH3_2	460	465	PF14604	0.559
LIG_SH3_3	323	329	PF00018	0.624
LIG_SH3_3	379	385	PF00018	0.582
LIG_SH3_3	398	404	PF00018	0.750
LIG_SH3_3	457	463	PF00018	0.723
LIG_SH3_3	470	476	PF00018	0.580
LIG_SH3_3	531	537	PF00018	0.527
LIG_SH3_3	592	598	PF00018	0.648
LIG_SH3_3	622	628	PF00018	0.505
LIG_SH3_3	652	658	PF00018	0.620
LIG_SH3_3	672	678	PF00018	0.640
LIG_SH3_3	73	79	PF00018	0.731
LIG_SUMO_SIM_anti_2	722	727	PF11976	0.241
LIG_SUMO_SIM_par_1	275	281	PF11976	0.541
LIG_SUMO_SIM_par_1	756	762	PF11976	0.443
LIG_WW_1	593	596	PF00397	0.506
LIG_WW_3	78	82	PF00397	0.722
MOD_CDC14_SPxK_1	403	406	PF00782	0.744
MOD_CDC14_SPxK_1	586	589	PF00782	0.540
MOD_CDK_SPK_2	378	383	PF00069	0.685
MOD_CDK_SPxK_1	322	328	PF00069	0.568
MOD_CDK_SPxK_1	400	406	PF00069	0.748
MOD_CDK_SPxK_1	583	589	PF00069	0.544
MOD_CDK_SPxxK_3	239	246	PF00069	0.691
MOD_CDK_SPxxK_3	386	393	PF00069	0.584
MOD_CDK_SPxxK_3	526	533	PF00069	0.526
MOD_CDK_SPxxK_3	624	631	PF00069	0.520
MOD_CDK_SPxxK_3	74	81	PF00069	0.729
MOD_CK1_1	15	21	PF00069	0.673
MOD_CK1_1	150	156	PF00069	0.638
MOD_CK1_1	278	284	PF00069	0.534
MOD_CK1_1	33	39	PF00069	0.531
MOD_CK1_1	337	343	PF00069	0.543
MOD_CK1_1	355	361	PF00069	0.566
MOD_CK1_1	396	402	PF00069	0.793
MOD_CK1_1	426	432	PF00069	0.552
MOD_CK1_1	46	52	PF00069	0.608
MOD_CK1_1	494	500	PF00069	0.481
MOD_CK1_1	59	65	PF00069	0.535
MOD_CK1_1	605	611	PF00069	0.485
MOD_CK1_1	660	666	PF00069	0.463
MOD_CK1_1	743	749	PF00069	0.596
MOD_CK2_1	263	269	PF00069	0.660
MOD_CK2_1	378	384	PF00069	0.749
MOD_CK2_1	507	513	PF00069	0.531
MOD_CK2_1	516	522	PF00069	0.593
MOD_CK2_1	610	616	PF00069	0.679
MOD_CK2_1	756	762	PF00069	0.644
MOD_CMANNOS	736	739	PF00535	0.588
MOD_DYRK1A_RPxSP_1	43	47	PF00069	0.547
MOD_GlcNHglycan	14	17	PF01048	0.525
MOD_GlcNHglycan	156	159	PF01048	0.645
MOD_GlcNHglycan	164	167	PF01048	0.629
MOD_GlcNHglycan	225	228	PF01048	0.712
MOD_GlcNHglycan	24	27	PF01048	0.534
MOD_GlcNHglycan	265	268	PF01048	0.583
MOD_GlcNHglycan	329	332	PF01048	0.693
MOD_GlcNHglycan	359	362	PF01048	0.544
MOD_GlcNHglycan	368	371	PF01048	0.668
MOD_GlcNHglycan	428	431	PF01048	0.667
MOD_GlcNHglycan	479	482	PF01048	0.704
MOD_GlcNHglycan	484	487	PF01048	0.641
MOD_GlcNHglycan	493	496	PF01048	0.494
MOD_GlcNHglycan	50	53	PF01048	0.697
MOD_GlcNHglycan	518	521	PF01048	0.505
MOD_GlcNHglycan	6	9	PF01048	0.552
MOD_GlcNHglycan	641	644	PF01048	0.549
MOD_GlcNHglycan	659	662	PF01048	0.655
MOD_GlcNHglycan	692	695	PF01048	0.615
MOD_GSK3_1	150	157	PF00069	0.611
MOD_GSK3_1	162	169	PF00069	0.547
MOD_GSK3_1	284	291	PF00069	0.577
MOD_GSK3_1	305	312	PF00069	0.679
MOD_GSK3_1	31	38	PF00069	0.739
MOD_GSK3_1	333	340	PF00069	0.615
MOD_GSK3_1	341	348	PF00069	0.658
MOD_GSK3_1	357	364	PF00069	0.666
MOD_GSK3_1	39	46	PF00069	0.570
MOD_GSK3_1	393	400	PF00069	0.616
MOD_GSK3_1	422	429	PF00069	0.611
MOD_GSK3_1	509	516	PF00069	0.578
MOD_GSK3_1	583	590	PF00069	0.730
MOD_GSK3_1	630	637	PF00069	0.650
MOD_GSK3_1	660	667	PF00069	0.517
MOD_GSK3_1	706	713	PF00069	0.395
MOD_LATS_1	67	73	PF00433	0.562
MOD_N-GLC_1	602	607	PF02516	0.574
MOD_N-GLC_1	610	615	PF02516	0.660
MOD_N-GLC_1	740	745	PF02516	0.485
MOD_N-GLC_1	751	756	PF02516	0.543
MOD_NEK2_1	179	184	PF00069	0.553
MOD_NEK2_1	22	27	PF00069	0.707
MOD_NEK2_1	288	293	PF00069	0.537
MOD_NEK2_1	477	482	PF00069	0.552
MOD_NEK2_1	491	496	PF00069	0.488
MOD_NEK2_1	539	544	PF00069	0.681
MOD_NEK2_1	56	61	PF00069	0.526
MOD_NEK2_1	602	607	PF00069	0.621
MOD_NEK2_1	710	715	PF00069	0.535
MOD_NEK2_1	756	761	PF00069	0.619
MOD_NEK2_1	764	769	PF00069	0.524
MOD_NEK2_2	740	745	PF00069	0.585
MOD_PIKK_1	166	172	PF00454	0.638
MOD_PIKK_1	2	8	PF00454	0.688
MOD_PIKK_1	302	308	PF00454	0.572
MOD_PIKK_1	31	37	PF00454	0.715
MOD_PIKK_1	41	47	PF00454	0.544
MOD_PIKK_1	630	636	PF00454	0.571
MOD_PK_1	635	641	PF00069	0.562
MOD_PKA_1	69	75	PF00069	0.565
MOD_PKA_2	119	125	PF00069	0.570
MOD_PKA_2	405	411	PF00069	0.742
MOD_PKA_2	491	497	PF00069	0.630
MOD_PKA_2	630	636	PF00069	0.673
MOD_PKA_2	69	75	PF00069	0.589
MOD_PKA_2	719	725	PF00069	0.240
MOD_Plk_1	106	112	PF00069	0.604
MOD_Plk_1	288	294	PF00069	0.529
MOD_Plk_1	309	315	PF00069	0.591
MOD_Plk_1	602	608	PF00069	0.469
MOD_Plk_1	740	746	PF00069	0.486
MOD_Plk_1	751	757	PF00069	0.541
MOD_Plk_2-3	119	125	PF00069	0.628
MOD_Plk_4	479	485	PF00069	0.538
MOD_Plk_4	605	611	PF00069	0.463
MOD_Plk_4	664	670	PF00069	0.705
MOD_Plk_4	698	704	PF00069	0.474
MOD_Plk_4	740	746	PF00069	0.598
MOD_Plk_4	751	757	PF00069	0.527
MOD_ProDKin_1	239	245	PF00069	0.691
MOD_ProDKin_1	305	311	PF00069	0.607
MOD_ProDKin_1	322	328	PF00069	0.705
MOD_ProDKin_1	368	374	PF00069	0.657
MOD_ProDKin_1	378	384	PF00069	0.670
MOD_ProDKin_1	386	392	PF00069	0.582
MOD_ProDKin_1	397	403	PF00069	0.754
MOD_ProDKin_1	43	49	PF00069	0.554
MOD_ProDKin_1	432	438	PF00069	0.638
MOD_ProDKin_1	463	469	PF00069	0.570
MOD_ProDKin_1	472	478	PF00069	0.538
MOD_ProDKin_1	526	532	PF00069	0.660
MOD_ProDKin_1	540	546	PF00069	0.508
MOD_ProDKin_1	551	557	PF00069	0.556
MOD_ProDKin_1	583	589	PF00069	0.544
MOD_ProDKin_1	624	630	PF00069	0.563
MOD_ProDKin_1	74	80	PF00069	0.771
MOD_SUMO_rev_2	371	381	PF00179	0.569
TRG_DiLeu_BaEn_1	616	621	PF01217	0.467
TRG_DiLeu_BaLyEn_6	545	550	PF01217	0.524
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.649
TRG_ER_diArg_1	238	240	PF00400	0.707
TRG_ER_diArg_1	559	562	PF00400	0.603
TRG_ER_diArg_1	97	99	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	671	676	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG54	Leishmania donovani	49%	100%
A4I6R5	Leishmania infantum	49%	100%
E9B1T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4Q6C4	Leishmania major	49%	98%