Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJB9_LEIBR

TriTrypDb:

LbrM.31.1590 , LBRM2903_310024700

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.766
CLV_C14_Caspase3-7	294	298	PF00656	0.426
CLV_C14_Caspase3-7	8	12	PF00656	0.382
CLV_NRD_NRD_1	118	120	PF00675	0.532
CLV_NRD_NRD_1	168	170	PF00675	0.379
CLV_NRD_NRD_1	253	255	PF00675	0.517
CLV_NRD_NRD_1	284	286	PF00675	0.331
CLV_NRD_NRD_1	64	66	PF00675	0.532
CLV_PCSK_KEX2_1	105	107	PF00082	0.383
CLV_PCSK_KEX2_1	118	120	PF00082	0.557
CLV_PCSK_KEX2_1	168	170	PF00082	0.436
CLV_PCSK_KEX2_1	252	254	PF00082	0.526
CLV_PCSK_KEX2_1	283	285	PF00082	0.486
CLV_PCSK_KEX2_1	32	34	PF00082	0.469
CLV_PCSK_KEX2_1	327	329	PF00082	0.396
CLV_PCSK_KEX2_1	64	66	PF00082	0.532
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.370
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.428
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.349
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.396
CLV_PCSK_PC7_1	279	285	PF00082	0.430
CLV_PCSK_SKI1_1	284	288	PF00082	0.410
CLV_PCSK_SKI1_1	65	69	PF00082	0.531
DEG_APCC_DBOX_1	145	153	PF00400	0.508
DEG_APCC_DBOX_1	271	279	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DOC_CYCLIN_RxL_1	279	292	PF00134	0.319
DOC_MAPK_gen_1	102	112	PF00069	0.341
DOC_MAPK_gen_1	272	280	PF00069	0.469
DOC_MAPK_gen_1	283	289	PF00069	0.438
DOC_MAPK_gen_1	32	40	PF00069	0.336
DOC_MAPK_MEF2A_6	105	114	PF00069	0.390
DOC_MAPK_MEF2A_6	274	282	PF00069	0.526
DOC_PP2B_LxvP_1	96	99	PF13499	0.358
DOC_PP4_FxxP_1	135	138	PF00568	0.520
DOC_USP7_MATH_1	12	16	PF00917	0.570
DOC_USP7_MATH_1	138	142	PF00917	0.441
DOC_USP7_MATH_1	213	217	PF00917	0.731
DOC_USP7_MATH_1	23	27	PF00917	0.430
DOC_USP7_MATH_1	260	264	PF00917	0.460
LIG_14-3-3_CanoR_1	328	334	PF00244	0.446
LIG_14-3-3_CanoR_1	33	39	PF00244	0.455
LIG_Actin_WH2_2	109	126	PF00022	0.426
LIG_Actin_WH2_2	89	104	PF00022	0.362
LIG_APCC_ABBA_1	238	243	PF00400	0.423
LIG_BIR_III_4	313	317	PF00653	0.414
LIG_FHA_1	102	108	PF00498	0.570
LIG_FHA_1	264	270	PF00498	0.385
LIG_FHA_1	35	41	PF00498	0.477
LIG_FHA_1	43	49	PF00498	0.448
LIG_FHA_2	156	162	PF00498	0.369
LIG_FHA_2	186	192	PF00498	0.596
LIG_FHA_2	240	246	PF00498	0.500
LIG_FHA_2	271	277	PF00498	0.371
LIG_FHA_2	6	12	PF00498	0.484
LIG_LIR_Nem_3	332	337	PF02991	0.586
LIG_Pex14_2	131	135	PF04695	0.509
LIG_SUMO_SIM_par_1	42	49	PF11976	0.488
LIG_TRAF2_1	230	233	PF00917	0.479
LIG_WRC_WIRS_1	13	18	PF05994	0.629
MOD_CK1_1	263	269	PF00069	0.385
MOD_CK1_1	42	48	PF00069	0.502
MOD_CK1_1	58	64	PF00069	0.376
MOD_CK2_1	155	161	PF00069	0.523
MOD_CK2_1	205	211	PF00069	0.774
MOD_CK2_1	239	245	PF00069	0.415
MOD_CK2_1	270	276	PF00069	0.377
MOD_GlcNHglycan	207	210	PF01048	0.741
MOD_GlcNHglycan	254	257	PF01048	0.388
MOD_GlcNHglycan	262	265	PF01048	0.366
MOD_GlcNHglycan	34	37	PF01048	0.451
MOD_GlcNHglycan	58	61	PF01048	0.593
MOD_GSK3_1	1	8	PF00069	0.495
MOD_GSK3_1	185	192	PF00069	0.601
MOD_GSK3_1	213	220	PF00069	0.701
MOD_GSK3_1	248	255	PF00069	0.463
MOD_N-GLC_1	194	199	PF02516	0.566
MOD_NEK2_1	101	106	PF00069	0.439
MOD_NEK2_1	34	39	PF00069	0.474
MOD_NEK2_1	5	10	PF00069	0.449
MOD_NEK2_1	76	81	PF00069	0.591
MOD_NEK2_2	12	17	PF00069	0.518
MOD_OFUCOSY	326	331	PF10250	0.404
MOD_PIKK_1	155	161	PF00454	0.523
MOD_PIKK_1	263	269	PF00454	0.482
MOD_PKA_1	252	258	PF00069	0.545
MOD_PKA_1	32	38	PF00069	0.338
MOD_PKA_1	327	333	PF00069	0.380
MOD_PKA_2	252	258	PF00069	0.451
MOD_PKA_2	32	38	PF00069	0.574
MOD_PKA_2	327	333	PF00069	0.404
MOD_Plk_1	270	276	PF00069	0.408
MOD_Plk_1	42	48	PF00069	0.426
MOD_SUMO_for_1	51	54	PF00179	0.386
MOD_SUMO_rev_2	108	117	PF00179	0.468
MOD_SUMO_rev_2	171	175	PF00179	0.486
MOD_SUMO_rev_2	26	34	PF00179	0.349
MOD_SUMO_rev_2	297	306	PF00179	0.524
TRG_DiLeu_BaEn_4	270	276	PF01217	0.377
TRG_ER_diArg_1	117	119	PF00400	0.580
TRG_ER_diArg_1	168	170	PF00400	0.370
TRG_ER_diArg_1	252	254	PF00400	0.649
TRG_ER_diArg_1	272	275	PF00400	0.413
TRG_ER_diArg_1	284	286	PF00400	0.340
TRG_NES_CRM1_1	276	292	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL4	Leptomonas seymouri	38%	100%
A0A3S7X4F2	Leishmania donovani	73%	100%
A4I6R2	Leishmania infantum	74%	100%
C9ZWT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q6C7	Leishmania major	73%	100%