RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJB8_LEIBR

TriTrypDb:

LbrM.31.1580 , LBRM2903_310024600

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.688
CLV_MEL_PAP_1	186	192	PF00089	0.532
CLV_NRD_NRD_1	265	267	PF00675	0.675
CLV_NRD_NRD_1	401	403	PF00675	0.552
CLV_PCSK_FUR_1	283	287	PF00082	0.416
CLV_PCSK_KEX2_1	285	287	PF00082	0.459
CLV_PCSK_KEX2_1	467	469	PF00082	0.504
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.459
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.439
CLV_PCSK_SKI1_1	254	258	PF00082	0.712
CLV_PCSK_SKI1_1	330	334	PF00082	0.570
CLV_PCSK_SKI1_1	483	487	PF00082	0.457
DEG_APCC_KENBOX_2	45	49	PF00400	0.545
DOC_MAPK_HePTP_8	464	479	PF00069	0.514
DOC_PP1_RVXF_1	418	424	PF00149	0.423
DOC_PP2B_LxvP_1	222	225	PF13499	0.677
DOC_PP2B_LxvP_1	449	452	PF13499	0.591
DOC_USP7_MATH_1	122	126	PF00917	0.587
DOC_USP7_MATH_1	166	170	PF00917	0.584
DOC_USP7_MATH_1	181	185	PF00917	0.599
DOC_USP7_MATH_1	21	25	PF00917	0.572
DOC_USP7_MATH_1	213	217	PF00917	0.635
DOC_USP7_MATH_1	236	240	PF00917	0.587
DOC_USP7_MATH_1	304	308	PF00917	0.366
DOC_USP7_MATH_1	39	43	PF00917	0.621
DOC_USP7_MATH_1	492	496	PF00917	0.674
DOC_USP7_MATH_1	503	507	PF00917	0.533
DOC_USP7_MATH_1	7	11	PF00917	0.639
DOC_WW_Pin1_4	126	131	PF00397	0.535
DOC_WW_Pin1_4	201	206	PF00397	0.559
DOC_WW_Pin1_4	215	220	PF00397	0.573
DOC_WW_Pin1_4	259	264	PF00397	0.703
DOC_WW_Pin1_4	26	31	PF00397	0.642
DOC_WW_Pin1_4	3	8	PF00397	0.583
DOC_WW_Pin1_4	41	46	PF00397	0.555
DOC_WW_Pin1_4	99	104	PF00397	0.603
LIG_14-3-3_CanoR_1	196	205	PF00244	0.544
LIG_14-3-3_CanoR_1	382	388	PF00244	0.469
LIG_Actin_WH2_2	422	437	PF00022	0.392
LIG_BRCT_BRCA1_1	174	178	PF00533	0.663
LIG_BRCT_BRCA1_1	238	242	PF00533	0.572
LIG_CtBP_PxDLS_1	219	223	PF00389	0.537
LIG_FHA_1	180	186	PF00498	0.630
LIG_FHA_1	204	210	PF00498	0.613
LIG_FHA_1	260	266	PF00498	0.700
LIG_FHA_1	297	303	PF00498	0.421
LIG_FHA_1	30	36	PF00498	0.572
LIG_FHA_2	165	171	PF00498	0.676
LIG_FHA_2	332	338	PF00498	0.585
LIG_FHA_2	342	348	PF00498	0.680
LIG_FHA_2	51	57	PF00498	0.547
LIG_LIR_Gen_1	138	148	PF02991	0.519
LIG_LIR_Gen_1	56	63	PF02991	0.534
LIG_LIR_Nem_3	138	143	PF02991	0.522
LIG_LIR_Nem_3	174	179	PF02991	0.547
LIG_LIR_Nem_3	389	394	PF02991	0.392
LIG_LIR_Nem_3	56	60	PF02991	0.567
LIG_SH2_CRK	228	232	PF00017	0.729
LIG_SH2_CRK	293	297	PF00017	0.387
LIG_SH2_CRK	394	398	PF00017	0.458
LIG_SH2_SRC	119	122	PF00017	0.545
LIG_SH2_STAP1	228	232	PF00017	0.684
LIG_SH2_STAT3	96	99	PF00017	0.679
LIG_SH2_STAT5	119	122	PF00017	0.610
LIG_SH2_STAT5	374	377	PF00017	0.473
LIG_SH2_STAT5	380	383	PF00017	0.364
LIG_SH2_STAT5	96	99	PF00017	0.599
LIG_SH3_3	476	482	PF00018	0.423
LIG_SH3_3	69	75	PF00018	0.534
LIG_SH3_3	87	93	PF00018	0.682
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.499
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.536
LIG_SUMO_SIM_par_1	349	354	PF11976	0.579
LIG_TRAF2_1	53	56	PF00917	0.549
LIG_TYR_ITIM	392	397	PF00017	0.423
LIG_WW_1	116	119	PF00397	0.512
LIG_WW_1	225	228	PF00397	0.691
MOD_CDK_SPK_2	41	46	PF00069	0.549
MOD_CDK_SPxxK_3	259	266	PF00069	0.686
MOD_CK1_1	102	108	PF00069	0.649
MOD_CK1_1	125	131	PF00069	0.652
MOD_CK1_1	154	160	PF00069	0.683
MOD_CK1_1	162	168	PF00069	0.667
MOD_CK1_1	169	175	PF00069	0.609
MOD_CK1_1	180	186	PF00069	0.615
MOD_CK1_1	192	198	PF00069	0.572
MOD_CK1_1	259	265	PF00069	0.731
MOD_CK1_1	26	32	PF00069	0.666
MOD_CK1_1	331	337	PF00069	0.605
MOD_CK1_1	506	512	PF00069	0.603
MOD_CK1_1	79	85	PF00069	0.574
MOD_CK2_1	164	170	PF00069	0.656
MOD_CK2_1	243	249	PF00069	0.528
MOD_CK2_1	315	321	PF00069	0.619
MOD_CK2_1	41	47	PF00069	0.549
MOD_CK2_1	50	56	PF00069	0.516
MOD_GlcNHglycan	112	115	PF01048	0.725
MOD_GlcNHglycan	122	125	PF01048	0.663
MOD_GlcNHglycan	137	140	PF01048	0.784
MOD_GlcNHglycan	156	159	PF01048	0.515
MOD_GlcNHglycan	164	167	PF01048	0.598
MOD_GlcNHglycan	179	182	PF01048	0.542
MOD_GlcNHglycan	191	194	PF01048	0.772
MOD_GlcNHglycan	206	209	PF01048	0.633
MOD_GlcNHglycan	213	216	PF01048	0.680
MOD_GlcNHglycan	234	237	PF01048	0.608
MOD_GlcNHglycan	249	253	PF01048	0.619
MOD_GlcNHglycan	25	28	PF01048	0.574
MOD_GlcNHglycan	296	299	PF01048	0.389
MOD_GlcNHglycan	353	356	PF01048	0.609
MOD_GlcNHglycan	367	370	PF01048	0.415
MOD_GlcNHglycan	39	42	PF01048	0.676
MOD_GlcNHglycan	460	463	PF01048	0.472
MOD_GlcNHglycan	494	497	PF01048	0.691
MOD_GlcNHglycan	508	511	PF01048	0.517
MOD_GlcNHglycan	87	90	PF01048	0.530
MOD_GlcNHglycan	9	12	PF01048	0.692
MOD_GSK3_1	120	127	PF00069	0.671
MOD_GSK3_1	131	138	PF00069	0.577
MOD_GSK3_1	162	169	PF00069	0.631
MOD_GSK3_1	177	184	PF00069	0.668
MOD_GSK3_1	188	195	PF00069	0.574
MOD_GSK3_1	197	204	PF00069	0.623
MOD_GSK3_1	211	218	PF00069	0.564
MOD_GSK3_1	227	234	PF00069	0.575
MOD_GSK3_1	29	36	PF00069	0.687
MOD_GSK3_1	3	10	PF00069	0.651
MOD_GSK3_1	317	324	PF00069	0.563
MOD_GSK3_1	328	335	PF00069	0.606
MOD_GSK3_1	37	44	PF00069	0.657
MOD_GSK3_1	46	53	PF00069	0.760
MOD_GSK3_1	79	86	PF00069	0.672
MOD_N-GLC_1	220	225	PF02516	0.533
MOD_N-GLC_1	232	237	PF02516	0.473
MOD_N-GLC_1	7	12	PF02516	0.550
MOD_NEK2_1	110	115	PF00069	0.650
MOD_NEK2_1	135	140	PF00069	0.630
MOD_NEK2_1	179	184	PF00069	0.678
MOD_NEK2_1	33	38	PF00069	0.685
MOD_NEK2_1	445	450	PF00069	0.468
MOD_NEK2_1	50	55	PF00069	0.525
MOD_NEK2_1	85	90	PF00069	0.545
MOD_NEK2_2	304	309	PF00069	0.374
MOD_PIKK_1	485	491	PF00454	0.482
MOD_PIKK_1	9	15	PF00454	0.645
MOD_PKA_2	188	194	PF00069	0.540
MOD_PKA_2	195	201	PF00069	0.527
MOD_Plk_1	169	175	PF00069	0.687
MOD_Plk_1	346	352	PF00069	0.598
MOD_Plk_1	46	52	PF00069	0.628
MOD_Plk_1	503	509	PF00069	0.550
MOD_Plk_4	181	187	PF00069	0.519
MOD_Plk_4	227	233	PF00069	0.755
MOD_Plk_4	236	242	PF00069	0.566
MOD_Plk_4	346	352	PF00069	0.566
MOD_Plk_4	46	52	PF00069	0.683
MOD_Plk_4	68	74	PF00069	0.658
MOD_ProDKin_1	126	132	PF00069	0.535
MOD_ProDKin_1	201	207	PF00069	0.560
MOD_ProDKin_1	215	221	PF00069	0.572
MOD_ProDKin_1	259	265	PF00069	0.695
MOD_ProDKin_1	26	32	PF00069	0.641
MOD_ProDKin_1	3	9	PF00069	0.586
MOD_ProDKin_1	41	47	PF00069	0.554
MOD_ProDKin_1	99	105	PF00069	0.605
MOD_SUMO_for_1	423	426	PF00179	0.393
MOD_SUMO_rev_2	324	332	PF00179	0.592
MOD_SUMO_rev_2	432	442	PF00179	0.481
TRG_DiLeu_BaEn_2	311	317	PF01217	0.480
TRG_ENDOCYTIC_2	228	231	PF00928	0.688
TRG_ENDOCYTIC_2	293	296	PF00928	0.403
TRG_ENDOCYTIC_2	394	397	PF00928	0.445
TRG_ENDOCYTIC_2	472	475	PF00928	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J5	Leptomonas seymouri	39%	89%
A0A3Q8ICJ1	Leishmania donovani	58%	100%
A4HJX4	Leishmania braziliensis	96%	95%
A4I6R1	Leishmania infantum	59%	100%
E9B1T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	97%
Q4Q6C8	Leishmania major	59%	100%