CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

'Cold-shock' DNA-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJB7_LEIBR

TriTrypDb:

LbrM.31.1570 , LBRM2903_310024500

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJB7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.520
CLV_NRD_NRD_1	390	392	PF00675	0.389
CLV_PCSK_KEX2_1	337	339	PF00082	0.405
CLV_PCSK_KEX2_1	389	391	PF00082	0.413
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.402
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DEG_SPOP_SBC_1	162	166	PF00917	0.695
DEG_SPOP_SBC_1	247	251	PF00917	0.600
DEG_SPOP_SBC_1	452	456	PF00917	0.491
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	371	377	PF00134	0.539
DOC_MAPK_gen_1	389	396	PF00069	0.483
DOC_PP1_RVXF_1	417	423	PF00149	0.479
DOC_PP2B_LxvP_1	262	265	PF13499	0.519
DOC_PP2B_LxvP_1	280	283	PF13499	0.664
DOC_PP2B_LxvP_1	306	309	PF13499	0.568
DOC_PP2B_LxvP_1	371	374	PF13499	0.542
DOC_SPAK_OSR1_1	421	425	PF12202	0.479
DOC_USP7_MATH_1	100	104	PF00917	0.739
DOC_USP7_MATH_1	105	109	PF00917	0.532
DOC_USP7_MATH_1	210	214	PF00917	0.569
DOC_USP7_MATH_1	265	269	PF00917	0.612
DOC_USP7_MATH_1	486	490	PF00917	0.575
DOC_USP7_MATH_1	80	84	PF00917	0.578
DOC_WW_Pin1_4	109	114	PF00397	0.780
DOC_WW_Pin1_4	137	142	PF00397	0.684
DOC_WW_Pin1_4	24	29	PF00397	0.415
DOC_WW_Pin1_4	301	306	PF00397	0.612
DOC_WW_Pin1_4	310	315	PF00397	0.518
DOC_WW_Pin1_4	363	368	PF00397	0.679
DOC_WW_Pin1_4	389	394	PF00397	0.518
DOC_WW_Pin1_4	453	458	PF00397	0.510
DOC_WW_Pin1_4	5	10	PF00397	0.458
DOC_WW_Pin1_4	60	65	PF00397	0.553
LIG_14-3-3_CanoR_1	148	156	PF00244	0.517
LIG_14-3-3_CanoR_1	206	214	PF00244	0.528
LIG_14-3-3_CanoR_1	488	496	PF00244	0.496
LIG_14-3-3_CanoR_1	76	80	PF00244	0.583
LIG_14-3-3_CanoR_1	93	97	PF00244	0.520
LIG_BRCT_BRCA1_1	296	300	PF00533	0.581
LIG_BRCT_BRCA1_1	94	98	PF00533	0.518
LIG_EVH1_1	311	315	PF00568	0.592
LIG_FHA_1	145	151	PF00498	0.605
LIG_FHA_1	162	168	PF00498	0.514
LIG_FHA_1	349	355	PF00498	0.403
LIG_FHA_1	453	459	PF00498	0.509
LIG_FHA_1	461	467	PF00498	0.516
LIG_FHA_1	468	474	PF00498	0.516
LIG_FHA_2	241	247	PF00498	0.612
LIG_FHA_2	502	508	PF00498	0.501
LIG_LIR_Apic_2	51	57	PF02991	0.521
LIG_LIR_Gen_1	15	23	PF02991	0.503
LIG_LIR_Gen_1	518	525	PF02991	0.550
LIG_LIR_Nem_3	330	335	PF02991	0.411
LIG_LIR_Nem_3	409	414	PF02991	0.564
LIG_LIR_Nem_3	514	520	PF02991	0.533
LIG_PDZ_Class_2	520	525	PF00595	0.468
LIG_Pex14_2	296	300	PF04695	0.497
LIG_SH2_CRK	55	59	PF00017	0.534
LIG_SH2_SRC	55	58	PF00017	0.366
LIG_SH2_STAT3	256	259	PF00017	0.541
LIG_SH2_STAT5	279	282	PF00017	0.673
LIG_SH2_STAT5	3	6	PF00017	0.445
LIG_SH2_STAT5	503	506	PF00017	0.506
LIG_SH2_STAT5	69	72	PF00017	0.651
LIG_SH3_2	28	33	PF14604	0.445
LIG_SH3_2	314	319	PF14604	0.644
LIG_SH3_3	201	207	PF00018	0.598
LIG_SH3_3	215	221	PF00018	0.543
LIG_SH3_3	22	28	PF00018	0.574
LIG_SH3_3	280	286	PF00018	0.590
LIG_SH3_3	306	312	PF00018	0.619
LIG_SH3_3	476	482	PF00018	0.628
LIG_SUMO_SIM_anti_2	437	442	PF11976	0.544
LIG_SUMO_SIM_par_1	112	118	PF11976	0.524
LIG_WRC_WIRS_1	122	127	PF05994	0.509
LIG_WRC_WIRS_1	2	7	PF05994	0.447
LIG_WRC_WIRS_1	285	290	PF05994	0.608
LIG_WRC_WIRS_1	520	525	PF05994	0.468
MOD_CK1_1	109	115	PF00069	0.705
MOD_CK1_1	134	140	PF00069	0.583
MOD_CK1_1	144	150	PF00069	0.676
MOD_CK1_1	163	169	PF00069	0.552
MOD_CK1_1	174	180	PF00069	0.511
MOD_CK1_1	181	187	PF00069	0.517
MOD_CK1_1	209	215	PF00069	0.659
MOD_CK1_1	252	258	PF00069	0.635
MOD_CK1_1	263	269	PF00069	0.771
MOD_CK1_1	272	278	PF00069	0.571
MOD_CK1_1	294	300	PF00069	0.689
MOD_CK1_1	453	459	PF00069	0.618
MOD_CK1_1	489	495	PF00069	0.526
MOD_CK1_1	502	508	PF00069	0.466
MOD_CK1_1	78	84	PF00069	0.739
MOD_CK2_1	149	155	PF00069	0.683
MOD_CK2_1	501	507	PF00069	0.507
MOD_CK2_1	518	524	PF00069	0.473
MOD_GlcNHglycan	102	105	PF01048	0.660
MOD_GlcNHglycan	173	176	PF01048	0.793
MOD_GlcNHglycan	19	22	PF01048	0.601
MOD_GlcNHglycan	194	197	PF01048	0.633
MOD_GlcNHglycan	208	211	PF01048	0.686
MOD_GlcNHglycan	267	270	PF01048	0.700
MOD_GlcNHglycan	271	274	PF01048	0.759
MOD_GlcNHglycan	356	359	PF01048	0.503
MOD_GlcNHglycan	361	364	PF01048	0.616
MOD_GlcNHglycan	371	374	PF01048	0.551
MOD_GlcNHglycan	474	477	PF01048	0.723
MOD_GlcNHglycan	488	491	PF01048	0.466
MOD_GlcNHglycan	80	83	PF01048	0.647
MOD_GSK3_1	1	8	PF00069	0.567
MOD_GSK3_1	105	112	PF00069	0.664
MOD_GSK3_1	137	144	PF00069	0.652
MOD_GSK3_1	150	157	PF00069	0.541
MOD_GSK3_1	161	168	PF00069	0.584
MOD_GSK3_1	174	181	PF00069	0.617
MOD_GSK3_1	205	212	PF00069	0.710
MOD_GSK3_1	228	235	PF00069	0.632
MOD_GSK3_1	242	249	PF00069	0.635
MOD_GSK3_1	263	270	PF00069	0.680
MOD_GSK3_1	284	291	PF00069	0.501
MOD_GSK3_1	296	303	PF00069	0.605
MOD_GSK3_1	348	355	PF00069	0.555
MOD_GSK3_1	359	366	PF00069	0.591
MOD_GSK3_1	369	376	PF00069	0.594
MOD_GSK3_1	467	474	PF00069	0.517
MOD_GSK3_1	499	506	PF00069	0.507
MOD_GSK3_1	83	90	PF00069	0.574
MOD_N-GLC_1	105	110	PF02516	0.578
MOD_N-GLC_1	17	22	PF02516	0.506
MOD_N-GLC_1	184	189	PF02516	0.643
MOD_N-GLC_1	227	232	PF02516	0.469
MOD_N-GLC_1	294	299	PF02516	0.491
MOD_NEK2_1	1	6	PF00069	0.445
MOD_NEK2_1	115	120	PF00069	0.606
MOD_NEK2_1	160	165	PF00069	0.694
MOD_NEK2_1	191	196	PF00069	0.661
MOD_NEK2_1	200	205	PF00069	0.564
MOD_NEK2_1	288	293	PF00069	0.539
MOD_NEK2_1	296	301	PF00069	0.608
MOD_NEK2_1	348	353	PF00069	0.393
MOD_NEK2_1	451	456	PF00069	0.608
MOD_NEK2_1	469	474	PF00069	0.537
MOD_NEK2_1	484	489	PF00069	0.506
MOD_NEK2_1	501	506	PF00069	0.510
MOD_PIKK_1	134	140	PF00454	0.524
MOD_PIKK_1	263	269	PF00454	0.688
MOD_PIKK_1	83	89	PF00454	0.509
MOD_PKA_2	144	150	PF00069	0.670
MOD_PKA_2	205	211	PF00069	0.524
MOD_PKA_2	75	81	PF00069	0.645
MOD_PKA_2	92	98	PF00069	0.531
MOD_Plk_1	240	246	PF00069	0.585
MOD_Plk_2-3	240	246	PF00069	0.699
MOD_Plk_4	115	121	PF00069	0.522
MOD_Plk_4	232	238	PF00069	0.414
MOD_Plk_4	48	54	PF00069	0.349
MOD_Plk_4	65	71	PF00069	0.706
MOD_ProDKin_1	109	115	PF00069	0.781
MOD_ProDKin_1	137	143	PF00069	0.684
MOD_ProDKin_1	24	30	PF00069	0.417
MOD_ProDKin_1	301	307	PF00069	0.614
MOD_ProDKin_1	310	316	PF00069	0.519
MOD_ProDKin_1	363	369	PF00069	0.682
MOD_ProDKin_1	389	395	PF00069	0.521
MOD_ProDKin_1	453	459	PF00069	0.511
MOD_ProDKin_1	5	11	PF00069	0.460
MOD_ProDKin_1	60	66	PF00069	0.557
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.545
TRG_ENDOCYTIC_2	325	328	PF00928	0.450
TRG_ENDOCYTIC_2	332	335	PF00928	0.407
TRG_ENDOCYTIC_2	520	523	PF00928	0.512
TRG_ENDOCYTIC_2	55	58	PF00928	0.366
TRG_ENDOCYTIC_2	69	72	PF00928	0.459
TRG_ER_diArg_1	32	35	PF00400	0.493
TRG_ER_diArg_1	419	422	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P654	Leptomonas seymouri	40%	95%
A0A3S7X4H1	Leishmania donovani	61%	98%
A4I6R0	Leishmania infantum	61%	98%
E9B1T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
Q4Q6C9	Leishmania major	62%	100%