MT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding stalk of dynein motor, putative

Species:

Leishmania braziliensis

UniProt:

A4HJA9_LEIBR

TriTrypDb:

LbrM.31.1490 , LBRM2903_310023100

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	10
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:1902494	catalytic complex	2	10
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HJA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJA9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0007018	microtubule-based movement	3	10
GO:0009987	cellular process	1	10
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035721	intraciliary retrograde transport	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	10
GO:0003777	microtubule motor activity	2	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008569	minus-end-directed microtubule motor activity	3	10
GO:0045505	dynein intermediate chain binding	3	10
GO:0051959	dynein light intermediate chain binding	3	10
GO:0140657	ATP-dependent activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.475
CLV_C14_Caspase3-7	458	462	PF00656	0.624
CLV_NRD_NRD_1	10	12	PF00675	0.756
CLV_NRD_NRD_1	229	231	PF00675	0.526
CLV_NRD_NRD_1	297	299	PF00675	0.613
CLV_NRD_NRD_1	525	527	PF00675	0.476
CLV_PCSK_FUR_1	295	299	PF00082	0.585
CLV_PCSK_FUR_1	310	314	PF00082	0.601
CLV_PCSK_KEX2_1	105	107	PF00082	0.546
CLV_PCSK_KEX2_1	213	215	PF00082	0.495
CLV_PCSK_KEX2_1	228	230	PF00082	0.465
CLV_PCSK_KEX2_1	297	299	PF00082	0.612
CLV_PCSK_KEX2_1	312	314	PF00082	0.411
CLV_PCSK_KEX2_1	326	328	PF00082	0.667
CLV_PCSK_KEX2_1	525	527	PF00082	0.516
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.615
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.522
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.659
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.667
CLV_PCSK_PC7_1	209	215	PF00082	0.523
CLV_PCSK_SKI1_1	126	130	PF00082	0.588
CLV_PCSK_SKI1_1	182	186	PF00082	0.517
CLV_PCSK_SKI1_1	209	213	PF00082	0.569
CLV_PCSK_SKI1_1	388	392	PF00082	0.557
CLV_PCSK_SKI1_1	418	422	PF00082	0.550
CLV_PCSK_SKI1_1	424	428	PF00082	0.564
CLV_PCSK_SKI1_1	449	453	PF00082	0.589
CLV_PCSK_SKI1_1	545	549	PF00082	0.656
DEG_APCC_DBOX_1	208	216	PF00400	0.565
DEG_ODPH_VHL_1	7	19	PF01847	0.550
DOC_ANK_TNKS_1	297	304	PF00023	0.357
DOC_MAPK_gen_1	11	19	PF00069	0.694
DOC_MAPK_gen_1	580	587	PF00069	0.422
DOC_MAPK_MEF2A_6	74	82	PF00069	0.340
DOC_PP1_RVXF_1	193	200	PF00149	0.467
DOC_PP1_RVXF_1	422	429	PF00149	0.398
DOC_USP7_UBL2_3	105	109	PF12436	0.366
DOC_USP7_UBL2_3	285	289	PF12436	0.617
DOC_USP7_UBL2_3	530	534	PF12436	0.744
DOC_WW_Pin1_4	12	17	PF00397	0.667
DOC_WW_Pin1_4	315	320	PF00397	0.670
DOC_WW_Pin1_4	343	348	PF00397	0.823
DOC_WW_Pin1_4	357	362	PF00397	0.573
DOC_WW_Pin1_4	407	412	PF00397	0.583
DOC_WW_Pin1_4	85	90	PF00397	0.601
LIG_14-3-3_CanoR_1	207	212	PF00244	0.506
LIG_14-3-3_CanoR_1	240	247	PF00244	0.511
LIG_14-3-3_CanoR_1	424	429	PF00244	0.617
LIG_Actin_WH2_2	402	420	PF00022	0.616
LIG_Actin_WH2_2	434	451	PF00022	0.383
LIG_Clathr_ClatBox_1	47	51	PF01394	0.496
LIG_FHA_1	497	503	PF00498	0.726
LIG_FHA_2	189	195	PF00498	0.500
LIG_FHA_2	20	26	PF00498	0.514
LIG_FHA_2	240	246	PF00498	0.454
LIG_FHA_2	537	543	PF00498	0.554
LIG_FHA_2	86	92	PF00498	0.524
LIG_LIR_Apic_2	173	177	PF02991	0.516
LIG_LIR_Gen_1	198	206	PF02991	0.421
LIG_LIR_Gen_1	25	34	PF02991	0.477
LIG_LIR_Gen_1	275	283	PF02991	0.541
LIG_LIR_Nem_3	129	135	PF02991	0.327
LIG_LIR_Nem_3	165	171	PF02991	0.478
LIG_LIR_Nem_3	198	202	PF02991	0.391
LIG_LIR_Nem_3	25	31	PF02991	0.562
LIG_PDZ_Class_3	615	620	PF00595	0.576
LIG_PTB_Apo_2	235	242	PF02174	0.464
LIG_SH2_CRK	28	32	PF00017	0.468
LIG_SH2_CRK	399	403	PF00017	0.506
LIG_SH2_NCK_1	399	403	PF00017	0.536
LIG_SH2_PTP2	174	177	PF00017	0.552
LIG_SH2_STAP1	142	146	PF00017	0.508
LIG_SH2_STAP1	276	280	PF00017	0.329
LIG_SH2_STAP1	324	328	PF00017	0.649
LIG_SH2_STAT5	174	177	PF00017	0.552
LIG_SH2_STAT5	201	204	PF00017	0.464
LIG_SH2_STAT5	235	238	PF00017	0.480
LIG_SH2_STAT5	52	55	PF00017	0.513
LIG_SH3_1	362	368	PF00018	0.798
LIG_SH3_2	13	18	PF14604	0.743
LIG_SH3_3	172	178	PF00018	0.505
LIG_SH3_3	362	368	PF00018	0.798
LIG_SH3_3	7	13	PF00018	0.750
LIG_SUMO_SIM_par_1	188	194	PF11976	0.409
LIG_SUMO_SIM_par_1	404	410	PF11976	0.628
LIG_TRAF2_1	117	120	PF00917	0.580
LIG_TRAF2_1	156	159	PF00917	0.599
LIG_TRAF2_1	503	506	PF00917	0.470
LIG_TRAF2_1	89	92	PF00917	0.643
LIG_UBA3_1	577	583	PF00899	0.680
LIG_WW_3	8	12	PF00397	0.548
MOD_CDC14_SPxK_1	15	18	PF00782	0.749
MOD_CDC14_SPxK_1	318	321	PF00782	0.542
MOD_CDK_SPK_2	343	348	PF00069	0.800
MOD_CDK_SPK_2	357	362	PF00069	0.573
MOD_CDK_SPxK_1	12	18	PF00069	0.748
MOD_CDK_SPxK_1	315	321	PF00069	0.516
MOD_CDK_SPxxK_3	357	364	PF00069	0.818
MOD_CK1_1	23	29	PF00069	0.716
MOD_CK1_1	384	390	PF00069	0.389
MOD_CK1_1	493	499	PF00069	0.505
MOD_CK1_1	528	534	PF00069	0.586
MOD_CK1_1	93	99	PF00069	0.522
MOD_CK2_1	188	194	PF00069	0.484
MOD_CK2_1	416	422	PF00069	0.377
MOD_CK2_1	85	91	PF00069	0.658
MOD_GlcNHglycan	351	354	PF01048	0.666
MOD_GlcNHglycan	418	421	PF01048	0.421
MOD_GlcNHglycan	492	495	PF01048	0.520
MOD_GlcNHglycan	553	556	PF01048	0.558
MOD_GlcNHglycan	591	594	PF01048	0.475
MOD_GlcNHglycan	595	598	PF01048	0.464
MOD_GSK3_1	19	26	PF00069	0.683
MOD_GSK3_1	239	246	PF00069	0.601
MOD_GSK3_1	29	36	PF00069	0.543
MOD_GSK3_1	338	345	PF00069	0.654
MOD_GSK3_1	377	384	PF00069	0.625
MOD_GSK3_1	401	408	PF00069	0.599
MOD_GSK3_1	524	531	PF00069	0.530
MOD_GSK3_1	549	556	PF00069	0.586
MOD_GSK3_1	589	596	PF00069	0.604
MOD_N-GLC_1	124	129	PF02516	0.502
MOD_N-GLC_1	342	347	PF02516	0.832
MOD_N-GLC_1	496	501	PF02516	0.643
MOD_N-GLC_1	535	540	PF02516	0.653
MOD_N-GLC_2	607	609	PF02516	0.421
MOD_NEK2_1	124	129	PF00069	0.531
MOD_NEK2_1	188	193	PF00069	0.460
MOD_NEK2_1	247	252	PF00069	0.449
MOD_NEK2_1	290	295	PF00069	0.539
MOD_NEK2_1	322	327	PF00069	0.528
MOD_NEK2_1	391	396	PF00069	0.480
MOD_PIKK_1	217	223	PF00454	0.545
MOD_PIKK_1	536	542	PF00454	0.551
MOD_PIKK_1	549	555	PF00454	0.507
MOD_PK_1	33	39	PF00069	0.599
MOD_PKA_1	525	531	PF00069	0.578
MOD_PKA_2	239	245	PF00069	0.524
MOD_PKA_2	524	530	PF00069	0.487
MOD_PKA_2	602	608	PF00069	0.656
MOD_Plk_1	124	130	PF00069	0.505
MOD_Plk_1	26	32	PF00069	0.473
MOD_Plk_1	290	296	PF00069	0.590
MOD_Plk_4	26	32	PF00069	0.691
MOD_Plk_4	377	383	PF00069	0.669
MOD_Plk_4	391	397	PF00069	0.506
MOD_Plk_4	402	408	PF00069	0.594
MOD_ProDKin_1	12	18	PF00069	0.668
MOD_ProDKin_1	315	321	PF00069	0.678
MOD_ProDKin_1	343	349	PF00069	0.823
MOD_ProDKin_1	357	363	PF00069	0.570
MOD_ProDKin_1	407	413	PF00069	0.577
MOD_ProDKin_1	85	91	PF00069	0.604
MOD_SUMO_for_1	581	584	PF00179	0.575
MOD_SUMO_rev_2	155	163	PF00179	0.561
MOD_SUMO_rev_2	267	271	PF00179	0.458
MOD_SUMO_rev_2	277	287	PF00179	0.522
MOD_SUMO_rev_2	384	390	PF00179	0.605
MOD_SUMO_rev_2	458	465	PF00179	0.646
MOD_SUMO_rev_2	477	486	PF00179	0.538
MOD_SUMO_rev_2	538	547	PF00179	0.557
TRG_DiLeu_BaEn_4	119	125	PF01217	0.594
TRG_DiLeu_BaEn_4	306	312	PF01217	0.369
TRG_ENDOCYTIC_2	135	138	PF00928	0.425
TRG_ENDOCYTIC_2	276	279	PF00928	0.336
TRG_ENDOCYTIC_2	28	31	PF00928	0.639
TRG_ER_diArg_1	206	209	PF00400	0.524
TRG_ER_diArg_1	228	230	PF00400	0.574
TRG_ER_diArg_1	294	297	PF00400	0.597
TRG_ER_diArg_1	361	364	PF00400	0.814
TRG_NES_CRM1_1	119	131	PF08389	0.344
TRG_NES_CRM1_1	179	194	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	586	591	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ0	Leptomonas seymouri	52%	100%
A0A1X0NQ11	Trypanosomatidae	37%	73%
A0A3S7X4D8	Leishmania donovani	72%	99%
A0A422NZ91	Trypanosoma rangeli	36%	76%
A4I6Q2	Leishmania infantum	72%	99%
E9B1S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q6D7	Leishmania major	72%	100%
V5DGE3	Trypanosoma cruzi	36%	77%