Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJA8_LEIBR

TriTrypDb:

LbrM.31.1480 , LBRM2903_310023000

Length:

1069

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.524
CLV_C14_Caspase3-7	570	574	PF00656	0.520
CLV_C14_Caspase3-7	607	611	PF00656	0.507
CLV_C14_Caspase3-7	871	875	PF00656	0.600
CLV_NRD_NRD_1	1011	1013	PF00675	0.587
CLV_NRD_NRD_1	1015	1017	PF00675	0.553
CLV_NRD_NRD_1	1065	1067	PF00675	0.610
CLV_NRD_NRD_1	188	190	PF00675	0.596
CLV_NRD_NRD_1	227	229	PF00675	0.524
CLV_NRD_NRD_1	371	373	PF00675	0.517
CLV_NRD_NRD_1	374	376	PF00675	0.478
CLV_NRD_NRD_1	534	536	PF00675	0.448
CLV_NRD_NRD_1	778	780	PF00675	0.667
CLV_PCSK_FUR_1	1012	1016	PF00082	0.593
CLV_PCSK_KEX2_1	1013	1015	PF00082	0.626
CLV_PCSK_KEX2_1	1065	1067	PF00082	0.602
CLV_PCSK_KEX2_1	226	228	PF00082	0.547
CLV_PCSK_KEX2_1	267	269	PF00082	0.516
CLV_PCSK_KEX2_1	536	538	PF00082	0.433
CLV_PCSK_KEX2_1	575	577	PF00082	0.552
CLV_PCSK_PC1ET2_1	1013	1015	PF00082	0.626
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.516
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.433
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.534
CLV_PCSK_SKI1_1	101	105	PF00082	0.558
CLV_PCSK_SKI1_1	128	132	PF00082	0.392
CLV_PCSK_SKI1_1	134	138	PF00082	0.362
CLV_PCSK_SKI1_1	204	208	PF00082	0.519
CLV_PCSK_SKI1_1	214	218	PF00082	0.416
CLV_PCSK_SKI1_1	287	291	PF00082	0.511
CLV_PCSK_SKI1_1	680	684	PF00082	0.680
CLV_PCSK_SKI1_1	818	822	PF00082	0.573
CLV_Separin_Metazoa	153	157	PF03568	0.413
DEG_APCC_DBOX_1	209	217	PF00400	0.493
DEG_APCC_DBOX_1	575	583	PF00400	0.519
DEG_SCF_FBW7_1	37	44	PF00400	0.566
DEG_SCF_FBW7_1	629	635	PF00400	0.533
DEG_SCF_FBW7_1	833	839	PF00400	0.643
DEG_SPOP_SBC_1	401	405	PF00917	0.467
DEG_SPOP_SBC_1	712	716	PF00917	0.565
DEG_SPOP_SBC_1	836	840	PF00917	0.552
DOC_ANK_TNKS_1	605	612	PF00023	0.664
DOC_CDC14_PxL_1	1044	1052	PF14671	0.558
DOC_CKS1_1	629	634	PF01111	0.532
DOC_CKS1_1	833	838	PF01111	0.642
DOC_MAPK_DCC_7	418	426	PF00069	0.656
DOC_MAPK_gen_1	1019	1027	PF00069	0.407
DOC_MAPK_gen_1	214	224	PF00069	0.353
DOC_MAPK_JIP1_4	470	476	PF00069	0.532
DOC_MAPK_MEF2A_6	1022	1029	PF00069	0.400
DOC_MAPK_MEF2A_6	418	426	PF00069	0.656
DOC_MAPK_MEF2A_6	654	662	PF00069	0.429
DOC_MAPK_RevD_3	479	494	PF00069	0.551
DOC_MAPK_RevD_3	563	576	PF00069	0.531
DOC_PP1_RVXF_1	17	24	PF00149	0.629
DOC_PP1_RVXF_1	215	222	PF00149	0.355
DOC_PP1_RVXF_1	282	289	PF00149	0.496
DOC_PP1_RVXF_1	451	458	PF00149	0.602
DOC_PP2B_LxvP_1	175	178	PF13499	0.659
DOC_PP2B_LxvP_1	424	427	PF13499	0.646
DOC_PP2B_LxvP_1	474	477	PF13499	0.538
DOC_PP2B_LxvP_1	61	64	PF13499	0.713
DOC_PP2B_PxIxI_1	57	63	PF00149	0.526
DOC_PP4_MxPP_1	1	4	PF00568	0.556
DOC_USP7_MATH_1	109	113	PF00917	0.607
DOC_USP7_MATH_1	188	192	PF00917	0.383
DOC_USP7_MATH_1	27	31	PF00917	0.617
DOC_USP7_MATH_1	343	347	PF00917	0.722
DOC_USP7_MATH_1	350	354	PF00917	0.621
DOC_USP7_MATH_1	604	608	PF00917	0.612
DOC_USP7_MATH_1	836	840	PF00917	0.596
DOC_USP7_MATH_1	855	859	PF00917	0.536
DOC_USP7_MATH_1	900	904	PF00917	0.593
DOC_USP7_MATH_1	907	911	PF00917	0.601
DOC_USP7_MATH_1	948	952	PF00917	0.771
DOC_USP7_MATH_1	962	966	PF00917	0.532
DOC_USP7_MATH_2	967	973	PF00917	0.597
DOC_USP7_UBL2_3	1009	1013	PF12436	0.591
DOC_USP7_UBL2_3	12	16	PF12436	0.643
DOC_WW_Pin1_4	336	341	PF00397	0.645
DOC_WW_Pin1_4	37	42	PF00397	0.741
DOC_WW_Pin1_4	410	415	PF00397	0.669
DOC_WW_Pin1_4	506	511	PF00397	0.731
DOC_WW_Pin1_4	628	633	PF00397	0.699
DOC_WW_Pin1_4	699	704	PF00397	0.842
DOC_WW_Pin1_4	715	720	PF00397	0.521
DOC_WW_Pin1_4	727	732	PF00397	0.678
DOC_WW_Pin1_4	738	743	PF00397	0.544
DOC_WW_Pin1_4	832	837	PF00397	0.620
DOC_WW_Pin1_4	858	863	PF00397	0.572
DOC_WW_Pin1_4	909	914	PF00397	0.712
DOC_WW_Pin1_4	951	956	PF00397	0.542
DOC_WW_Pin1_4	96	101	PF00397	0.693
LIG_14-3-3_CanoR_1	189	193	PF00244	0.603
LIG_14-3-3_CanoR_1	226	231	PF00244	0.415
LIG_14-3-3_CanoR_1	250	256	PF00244	0.633
LIG_14-3-3_CanoR_1	351	355	PF00244	0.671
LIG_14-3-3_CanoR_1	511	517	PF00244	0.604
LIG_14-3-3_CanoR_1	581	589	PF00244	0.528
LIG_14-3-3_CanoR_1	654	662	PF00244	0.586
LIG_14-3-3_CanoR_1	694	700	PF00244	0.598
LIG_14-3-3_CanoR_1	818	828	PF00244	0.605
LIG_14-3-3_CanoR_1	924	928	PF00244	0.593
LIG_Actin_WH2_2	911	926	PF00022	0.531
LIG_Actin_WH2_2	980	998	PF00022	0.563
LIG_BRCT_BRCA1_1	453	457	PF00533	0.496
LIG_BRCT_BRCA1_1	924	928	PF00533	0.573
LIG_FHA_1	1039	1045	PF00498	0.604
LIG_FHA_1	38	44	PF00498	0.603
LIG_FHA_1	47	53	PF00498	0.642
LIG_FHA_1	543	549	PF00498	0.567
LIG_FHA_1	76	82	PF00498	0.563
LIG_FHA_1	764	770	PF00498	0.554
LIG_FHA_1	92	98	PF00498	0.573
LIG_FHA_2	1001	1007	PF00498	0.580
LIG_FHA_2	276	282	PF00498	0.514
LIG_FHA_2	42	48	PF00498	0.582
LIG_FHA_2	516	522	PF00498	0.558
LIG_FHA_2	629	635	PF00498	0.691
LIG_FHA_2	944	950	PF00498	0.541
LIG_GBD_Chelix_1	640	648	PF00786	0.592
LIG_LIR_Gen_1	254	263	PF02991	0.364
LIG_LIR_Gen_1	380	389	PF02991	0.499
LIG_LIR_Gen_1	743	752	PF02991	0.545
LIG_LIR_Gen_1	795	806	PF02991	0.571
LIG_LIR_Nem_3	254	258	PF02991	0.358
LIG_LIR_Nem_3	377	381	PF02991	0.366
LIG_LIR_Nem_3	743	748	PF02991	0.556
LIG_LIR_Nem_3	795	801	PF02991	0.564
LIG_LIR_Nem_3	925	931	PF02991	0.726
LIG_NRP_CendR_1	1066	1069	PF00754	0.481
LIG_PCNA_yPIPBox_3	1028	1037	PF02747	0.545
LIG_PCNA_yPIPBox_3	791	800	PF02747	0.406
LIG_Pex14_2	288	292	PF04695	0.510
LIG_PTB_Apo_2	842	849	PF02174	0.560
LIG_RPA_C_Fungi	184	196	PF08784	0.529
LIG_SH2_STAP1	600	604	PF00017	0.460
LIG_SH2_STAP1	919	923	PF00017	0.527
LIG_SH2_STAT5	378	381	PF00017	0.475
LIG_SH2_STAT5	826	829	PF00017	0.494
LIG_SH3_3	465	471	PF00018	0.515
LIG_SH3_3	623	629	PF00018	0.569
LIG_SH3_3	725	731	PF00018	0.630
LIG_SH3_3	732	738	PF00018	0.557
LIG_SH3_3	825	831	PF00018	0.541
LIG_SH3_3	949	955	PF00018	0.540
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.606
LIG_SUMO_SIM_par_1	1047	1052	PF11976	0.402
LIG_SUMO_SIM_par_1	235	242	PF11976	0.471
LIG_SUMO_SIM_par_1	656	666	PF11976	0.451
LIG_TRAF2_1	123	126	PF00917	0.565
LIG_TRAF2_1	436	439	PF00917	0.509
LIG_WRC_WIRS_1	928	933	PF05994	0.688
MOD_CDC14_SPxK_1	730	733	PF00782	0.688
MOD_CDK_SPK_2	506	511	PF00069	0.705
MOD_CDK_SPK_2	628	633	PF00069	0.699
MOD_CDK_SPK_2	720	725	PF00069	0.688
MOD_CDK_SPK_2	96	101	PF00069	0.669
MOD_CDK_SPxK_1	727	733	PF00069	0.686
MOD_CDK_SPxxK_3	715	722	PF00069	0.666
MOD_CDK_SPxxK_3	951	958	PF00069	0.543
MOD_CK1_1	108	114	PF00069	0.656
MOD_CK1_1	164	170	PF00069	0.732
MOD_CK1_1	229	235	PF00069	0.605
MOD_CK1_1	39	45	PF00069	0.745
MOD_CK1_1	459	465	PF00069	0.723
MOD_CK1_1	46	52	PF00069	0.438
MOD_CK1_1	466	472	PF00069	0.562
MOD_CK1_1	488	494	PF00069	0.679
MOD_CK1_1	506	512	PF00069	0.623
MOD_CK1_1	695	701	PF00069	0.781
MOD_CK1_1	736	742	PF00069	0.489
MOD_CK1_1	838	844	PF00069	0.636
MOD_CK1_1	858	864	PF00069	0.636
MOD_CK1_1	903	909	PF00069	0.756
MOD_CK1_1	912	918	PF00069	0.735
MOD_CK1_1	922	928	PF00069	0.613
MOD_CK1_1	951	957	PF00069	0.699
MOD_CK2_1	1000	1006	PF00069	0.575
MOD_CK2_1	1037	1043	PF00069	0.548
MOD_CK2_1	235	241	PF00069	0.556
MOD_CK2_1	362	368	PF00069	0.590
MOD_CK2_1	477	483	PF00069	0.659
MOD_CK2_1	486	492	PF00069	0.590
MOD_CK2_1	515	521	PF00069	0.562
MOD_CK2_1	636	642	PF00069	0.636
MOD_CK2_1	969	975	PF00069	0.587
MOD_GlcNHglycan	107	110	PF01048	0.567
MOD_GlcNHglycan	164	167	PF01048	0.662
MOD_GlcNHglycan	169	172	PF01048	0.658
MOD_GlcNHglycan	25	28	PF01048	0.606
MOD_GlcNHglycan	325	328	PF01048	0.397
MOD_GlcNHglycan	459	462	PF01048	0.682
MOD_GlcNHglycan	552	555	PF01048	0.632
MOD_GlcNHglycan	619	622	PF01048	0.819
MOD_GlcNHglycan	683	686	PF01048	0.547
MOD_GlcNHglycan	688	691	PF01048	0.574
MOD_GlcNHglycan	703	706	PF01048	0.634
MOD_GlcNHglycan	709	712	PF01048	0.720
MOD_GlcNHglycan	715	718	PF01048	0.783
MOD_GlcNHglycan	755	758	PF01048	0.373
MOD_GlcNHglycan	787	790	PF01048	0.404
MOD_GlcNHglycan	82	85	PF01048	0.568
MOD_GlcNHglycan	857	860	PF01048	0.581
MOD_GlcNHglycan	902	905	PF01048	0.752
MOD_GlcNHglycan	909	912	PF01048	0.775
MOD_GlcNHglycan	934	937	PF01048	0.664
MOD_GlcNHglycan	960	963	PF01048	0.725
MOD_GlcNHglycan	991	994	PF01048	0.563
MOD_GSK3_1	104	111	PF00069	0.555
MOD_GSK3_1	226	233	PF00069	0.614
MOD_GSK3_1	23	30	PF00069	0.640
MOD_GSK3_1	235	242	PF00069	0.460
MOD_GSK3_1	275	282	PF00069	0.566
MOD_GSK3_1	332	339	PF00069	0.653
MOD_GSK3_1	350	357	PF00069	0.580
MOD_GSK3_1	37	44	PF00069	0.718
MOD_GSK3_1	451	458	PF00069	0.677
MOD_GSK3_1	459	466	PF00069	0.603
MOD_GSK3_1	488	495	PF00069	0.719
MOD_GSK3_1	505	512	PF00069	0.550
MOD_GSK3_1	595	602	PF00069	0.577
MOD_GSK3_1	615	622	PF00069	0.551
MOD_GSK3_1	628	635	PF00069	0.546
MOD_GSK3_1	681	688	PF00069	0.588
MOD_GSK3_1	695	702	PF00069	0.742
MOD_GSK3_1	707	714	PF00069	0.659
MOD_GSK3_1	720	727	PF00069	0.597
MOD_GSK3_1	832	839	PF00069	0.629
MOD_GSK3_1	874	881	PF00069	0.608
MOD_GSK3_1	896	903	PF00069	0.744
MOD_GSK3_1	91	98	PF00069	0.661
MOD_GSK3_1	919	926	PF00069	0.566
MOD_GSK3_1	954	961	PF00069	0.692
MOD_LATS_1	102	108	PF00433	0.557
MOD_N-GLC_1	105	110	PF02516	0.711
MOD_N-GLC_1	503	508	PF02516	0.639
MOD_N-GLC_1	846	851	PF02516	0.603
MOD_N-GLC_1	877	882	PF02516	0.596
MOD_NEK2_1	1061	1066	PF00069	0.506
MOD_NEK2_1	141	146	PF00069	0.404
MOD_NEK2_1	23	28	PF00069	0.467
MOD_NEK2_1	235	240	PF00069	0.450
MOD_NEK2_1	251	256	PF00069	0.463
MOD_NEK2_1	332	337	PF00069	0.534
MOD_NEK2_1	36	41	PF00069	0.498
MOD_NEK2_1	402	407	PF00069	0.636
MOD_NEK2_1	457	462	PF00069	0.720
MOD_NEK2_1	463	468	PF00069	0.665
MOD_NEK2_1	819	824	PF00069	0.694
MOD_NEK2_1	837	842	PF00069	0.750
MOD_NEK2_1	843	848	PF00069	0.665
MOD_NEK2_1	868	873	PF00069	0.552
MOD_NEK2_1	92	97	PF00069	0.620
MOD_NEK2_1	923	928	PF00069	0.647
MOD_NEK2_2	212	217	PF00069	0.498
MOD_NEK2_2	663	668	PF00069	0.501
MOD_NEK2_2	919	924	PF00069	0.530
MOD_PIKK_1	156	162	PF00454	0.546
MOD_PIKK_1	230	236	PF00454	0.615
MOD_PIKK_1	279	285	PF00454	0.506
MOD_PIKK_1	334	340	PF00454	0.535
MOD_PIKK_1	354	360	PF00454	0.489
MOD_PIKK_1	41	47	PF00454	0.575
MOD_PIKK_1	615	621	PF00454	0.706
MOD_PIKK_1	812	818	PF00454	0.570
MOD_PIKK_1	819	825	PF00454	0.519
MOD_PIKK_1	826	832	PF00454	0.518
MOD_PIKK_1	846	852	PF00454	0.723
MOD_PIKK_1	888	894	PF00454	0.709
MOD_PK_1	226	232	PF00069	0.381
MOD_PK_1	273	279	PF00069	0.535
MOD_PK_1	362	368	PF00069	0.590
MOD_PK_1	486	492	PF00069	0.552
MOD_PKA_1	226	232	PF00069	0.538
MOD_PKA_2	1038	1044	PF00069	0.391
MOD_PKA_2	188	194	PF00069	0.634
MOD_PKA_2	226	232	PF00069	0.538
MOD_PKA_2	343	349	PF00069	0.665
MOD_PKA_2	350	356	PF00069	0.656
MOD_PKA_2	498	504	PF00069	0.671
MOD_PKA_2	550	556	PF00069	0.596
MOD_PKA_2	580	586	PF00069	0.540
MOD_PKA_2	595	601	PF00069	0.423
MOD_PKA_2	632	638	PF00069	0.632
MOD_PKA_2	653	659	PF00069	0.576
MOD_PKA_2	724	730	PF00069	0.660
MOD_PKA_2	923	929	PF00069	0.591
MOD_PKB_1	226	234	PF00069	0.365
MOD_Plk_1	477	483	PF00069	0.650
MOD_Plk_1	486	492	PF00069	0.571
MOD_Plk_1	542	548	PF00069	0.567
MOD_Plk_1	636	642	PF00069	0.636
MOD_Plk_1	692	698	PF00069	0.579
MOD_Plk_1	877	883	PF00069	0.598
MOD_Plk_2-3	1000	1006	PF00069	0.611
MOD_Plk_2-3	969	975	PF00069	0.539
MOD_Plk_4	117	123	PF00069	0.628
MOD_Plk_4	235	241	PF00069	0.511
MOD_Plk_4	416	422	PF00069	0.699
MOD_Plk_4	426	432	PF00069	0.527
MOD_Plk_4	459	465	PF00069	0.784
MOD_Plk_4	724	730	PF00069	0.556
MOD_Plk_4	923	929	PF00069	0.566
MOD_Plk_4	969	975	PF00069	0.430
MOD_ProDKin_1	336	342	PF00069	0.650
MOD_ProDKin_1	37	43	PF00069	0.740
MOD_ProDKin_1	410	416	PF00069	0.667
MOD_ProDKin_1	506	512	PF00069	0.730
MOD_ProDKin_1	628	634	PF00069	0.697
MOD_ProDKin_1	699	705	PF00069	0.842
MOD_ProDKin_1	715	721	PF00069	0.521
MOD_ProDKin_1	727	733	PF00069	0.680
MOD_ProDKin_1	738	744	PF00069	0.537
MOD_ProDKin_1	832	838	PF00069	0.620
MOD_ProDKin_1	858	864	PF00069	0.567
MOD_ProDKin_1	909	915	PF00069	0.712
MOD_ProDKin_1	951	957	PF00069	0.541
MOD_ProDKin_1	96	102	PF00069	0.694
MOD_SUMO_rev_2	299	305	PF00179	0.342
MOD_SUMO_rev_2	487	495	PF00179	0.555
MOD_SUMO_rev_2	539	545	PF00179	0.686
MOD_SUMO_rev_2	570	577	PF00179	0.525
TRG_DiLeu_BaEn_1	1057	1062	PF01217	0.553
TRG_DiLeu_BaEn_1	203	208	PF01217	0.519
TRG_DiLeu_BaEn_1	521	526	PF01217	0.525
TRG_DiLeu_BaEn_1	543	548	PF01217	0.564
TRG_DiLeu_BaEn_1	585	590	PF01217	0.540
TRG_DiLeu_BaEn_1	809	814	PF01217	0.579
TRG_DiLeu_BaEn_3	125	131	PF01217	0.400
TRG_DiLeu_BaEn_4	809	815	PF01217	0.576
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.646
TRG_DiLeu_LyEn_5	438	443	PF01217	0.490
TRG_DiLeu_LyEn_5	543	548	PF01217	0.564
TRG_DiLeu_LyEn_5	585	590	PF01217	0.540
TRG_ENDOCYTIC_2	309	312	PF00928	0.465
TRG_ENDOCYTIC_2	381	384	PF00928	0.508
TRG_ENDOCYTIC_2	745	748	PF00928	0.535
TRG_ER_diArg_1	1012	1015	PF00400	0.596
TRG_ER_diArg_1	1065	1067	PF00400	0.602
TRG_ER_diArg_1	226	228	PF00400	0.378
TRG_NES_CRM1_1	249	261	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E7	Leishmania donovani	70%	98%
A4I6Q1	Leishmania infantum	70%	98%
E9B1S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4Q6D8	Leishmania major	69%	100%