Dynein heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein heavy chain

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJA6_LEIBR

TriTrypDb:

LbrM.31.1460 , LBRM2903_310022600

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HJA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.475
CLV_C14_Caspase3-7	773	777	PF00656	0.532
CLV_MEL_PAP_1	575	581	PF00089	0.301
CLV_NRD_NRD_1	185	187	PF00675	0.571
CLV_NRD_NRD_1	482	484	PF00675	0.329
CLV_NRD_NRD_1	731	733	PF00675	0.595
CLV_NRD_NRD_1	882	884	PF00675	0.355
CLV_PCSK_FUR_1	451	455	PF00082	0.516
CLV_PCSK_KEX2_1	185	187	PF00082	0.571
CLV_PCSK_KEX2_1	453	455	PF00082	0.516
CLV_PCSK_KEX2_1	478	480	PF00082	0.310
CLV_PCSK_KEX2_1	482	484	PF00082	0.320
CLV_PCSK_KEX2_1	633	635	PF00082	0.371
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.516
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.310
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.371
CLV_PCSK_SKI1_1	159	163	PF00082	0.477
CLV_PCSK_SKI1_1	210	214	PF00082	0.470
CLV_PCSK_SKI1_1	239	243	PF00082	0.419
CLV_PCSK_SKI1_1	28	32	PF00082	0.666
CLV_PCSK_SKI1_1	291	295	PF00082	0.354
CLV_PCSK_SKI1_1	531	535	PF00082	0.550
CLV_PCSK_SKI1_1	63	67	PF00082	0.394
CLV_PCSK_SKI1_1	796	800	PF00082	0.368
DEG_APCC_DBOX_1	288	296	PF00400	0.350
DEG_APCC_DBOX_1	603	611	PF00400	0.497
DEG_APCC_DBOX_1	795	803	PF00400	0.410
DEG_COP1_1	313	321	PF00400	0.510
DEG_MDM2_SWIB_1	48	56	PF02201	0.444
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DOC_CKS1_1	235	240	PF01111	0.545
DOC_CKS1_1	38	43	PF01111	0.548
DOC_CYCLIN_RxL_1	288	299	PF00134	0.342
DOC_CYCLIN_RxL_1	478	490	PF00134	0.335
DOC_CYCLIN_RxL_1	542	552	PF00134	0.329
DOC_CYCLIN_RxL_1	855	865	PF00134	0.299
DOC_MAPK_gen_1	451	459	PF00069	0.509
DOC_MAPK_gen_1	478	486	PF00069	0.462
DOC_MAPK_gen_1	793	801	PF00069	0.290
DOC_MAPK_JIP1_4	451	457	PF00069	0.511
DOC_MAPK_MEF2A_6	451	459	PF00069	0.509
DOC_MAPK_MEF2A_6	793	801	PF00069	0.290
DOC_MAPK_MEF2A_6	837	844	PF00069	0.295
DOC_MAPK_RevD_3	621	634	PF00069	0.327
DOC_PP1_RVXF_1	183	190	PF00149	0.478
DOC_PP1_RVXF_1	43	49	PF00149	0.377
DOC_PP1_RVXF_1	557	563	PF00149	0.289
DOC_PP4_FxxP_1	235	238	PF00568	0.487
DOC_PP4_FxxP_1	72	75	PF00568	0.467
DOC_USP7_MATH_1	113	117	PF00917	0.448
DOC_USP7_MATH_1	192	196	PF00917	0.338
DOC_USP7_MATH_1	278	282	PF00917	0.478
DOC_USP7_MATH_1	285	289	PF00917	0.374
DOC_USP7_MATH_1	358	362	PF00917	0.507
DOC_USP7_MATH_1	364	368	PF00917	0.524
DOC_USP7_MATH_1	553	557	PF00917	0.540
DOC_USP7_MATH_1	698	702	PF00917	0.723
DOC_USP7_MATH_1	739	743	PF00917	0.470
DOC_WW_Pin1_4	234	239	PF00397	0.533
DOC_WW_Pin1_4	32	37	PF00397	0.599
DOC_WW_Pin1_4	439	444	PF00397	0.725
DOC_WW_Pin1_4	501	506	PF00397	0.419
DOC_WW_Pin1_4	692	697	PF00397	0.584
DOC_WW_Pin1_4	875	880	PF00397	0.322
LIG_14-3-3_CanoR_1	109	117	PF00244	0.652
LIG_14-3-3_CanoR_1	239	246	PF00244	0.387
LIG_14-3-3_CanoR_1	366	371	PF00244	0.660
LIG_14-3-3_CanoR_1	45	49	PF00244	0.522
LIG_14-3-3_CanoR_1	454	458	PF00244	0.563
LIG_14-3-3_CanoR_1	548	557	PF00244	0.327
LIG_14-3-3_CanoR_1	732	736	PF00244	0.601
LIG_14-3-3_CanoR_1	77	82	PF00244	0.598
LIG_14-3-3_CanoR_1	8	12	PF00244	0.576
LIG_Actin_WH2_2	52	69	PF00022	0.526
LIG_Actin_WH2_2	535	550	PF00022	0.393
LIG_Actin_WH2_2	565	580	PF00022	0.302
LIG_Actin_WH2_2	781	798	PF00022	0.315
LIG_APCC_ABBAyCdc20_2	837	843	PF00400	0.300
LIG_BRCT_BRCA1_1	166	170	PF00533	0.460
LIG_BRCT_BRCA1_1	522	526	PF00533	0.318
LIG_Clathr_ClatBox_1	307	311	PF01394	0.389
LIG_Clathr_ClatBox_1	533	537	PF01394	0.422
LIG_Clathr_ClatBox_1	839	843	PF01394	0.367
LIG_EH_1	119	123	PF12763	0.533
LIG_eIF4E_1	804	810	PF01652	0.445
LIG_FHA_1	229	235	PF00498	0.569
LIG_FHA_1	249	255	PF00498	0.376
LIG_FHA_1	267	273	PF00498	0.335
LIG_FHA_1	299	305	PF00498	0.399
LIG_FHA_1	371	377	PF00498	0.476
LIG_FHA_1	440	446	PF00498	0.794
LIG_FHA_1	563	569	PF00498	0.512
LIG_FHA_1	653	659	PF00498	0.475
LIG_FHA_1	710	716	PF00498	0.528
LIG_FHA_1	780	786	PF00498	0.517
LIG_FHA_1	83	89	PF00498	0.568
LIG_FHA_1	867	873	PF00498	0.368
LIG_FHA_1	90	96	PF00498	0.561
LIG_FHA_2	219	225	PF00498	0.418
LIG_FHA_2	240	246	PF00498	0.489
LIG_FHA_2	376	382	PF00498	0.538
LIG_FHA_2	38	44	PF00498	0.529
LIG_FHA_2	863	869	PF00498	0.306
LIG_GBD_Chelix_1	246	254	PF00786	0.438
LIG_LIR_Apic_2	69	75	PF02991	0.578
LIG_LIR_Gen_1	160	170	PF02991	0.377
LIG_LIR_Gen_1	172	181	PF02991	0.405
LIG_LIR_Gen_1	294	304	PF02991	0.312
LIG_LIR_Gen_1	326	333	PF02991	0.507
LIG_LIR_Gen_1	384	393	PF02991	0.618
LIG_LIR_Gen_1	47	56	PF02991	0.472
LIG_LIR_Gen_1	537	547	PF02991	0.522
LIG_LIR_Gen_1	586	593	PF02991	0.383
LIG_LIR_Gen_1	594	605	PF02991	0.403
LIG_LIR_Gen_1	778	788	PF02991	0.534
LIG_LIR_Gen_1	843	854	PF02991	0.366
LIG_LIR_Nem_3	160	165	PF02991	0.387
LIG_LIR_Nem_3	167	173	PF02991	0.405
LIG_LIR_Nem_3	182	187	PF02991	0.476
LIG_LIR_Nem_3	294	300	PF02991	0.324
LIG_LIR_Nem_3	326	330	PF02991	0.525
LIG_LIR_Nem_3	384	389	PF02991	0.626
LIG_LIR_Nem_3	47	51	PF02991	0.477
LIG_LIR_Nem_3	503	509	PF02991	0.394
LIG_LIR_Nem_3	537	542	PF02991	0.552
LIG_LIR_Nem_3	555	560	PF02991	0.257
LIG_LIR_Nem_3	594	600	PF02991	0.442
LIG_LIR_Nem_3	712	717	PF02991	0.493
LIG_LIR_Nem_3	778	783	PF02991	0.467
LIG_LIR_Nem_3	786	792	PF02991	0.436
LIG_LIR_Nem_3	843	849	PF02991	0.384
LIG_LYPXL_yS_3	506	509	PF13949	0.402
LIG_MLH1_MIPbox_1	166	170	PF16413	0.460
LIG_Pex14_2	169	173	PF04695	0.389
LIG_Pex14_2	48	52	PF04695	0.442
LIG_PTB_Apo_2	117	124	PF02174	0.460
LIG_PTB_Apo_2	684	691	PF02174	0.550
LIG_Rb_LxCxE_1	859	878	PF01857	0.447
LIG_SH2_CRK	184	188	PF00017	0.413
LIG_SH2_CRK	297	301	PF00017	0.305
LIG_SH2_CRK	557	561	PF00017	0.285
LIG_SH2_NCK_1	297	301	PF00017	0.305
LIG_SH2_NCK_1	502	506	PF00017	0.327
LIG_SH2_PTP2	789	792	PF00017	0.470
LIG_SH2_STAP1	166	170	PF00017	0.460
LIG_SH2_STAP1	196	200	PF00017	0.478
LIG_SH2_STAT5	249	252	PF00017	0.529
LIG_SH2_STAT5	303	306	PF00017	0.388
LIG_SH2_STAT5	510	513	PF00017	0.506
LIG_SH2_STAT5	789	792	PF00017	0.448
LIG_SH3_2	573	578	PF14604	0.382
LIG_SH3_3	132	138	PF00018	0.564
LIG_SH3_3	30	36	PF00018	0.649
LIG_SH3_3	318	324	PF00018	0.533
LIG_SH3_3	570	576	PF00018	0.438
LIG_SH3_3	671	677	PF00018	0.517
LIG_SUMO_SIM_anti_2	532	538	PF11976	0.362
LIG_SUMO_SIM_anti_2	627	633	PF11976	0.303
LIG_SUMO_SIM_par_1	305	311	PF11976	0.378
LIG_SUMO_SIM_par_1	345	353	PF11976	0.632
LIG_SUMO_SIM_par_1	371	378	PF11976	0.479
LIG_SUMO_SIM_par_1	532	538	PF11976	0.509
LIG_SUMO_SIM_par_1	781	786	PF11976	0.365
LIG_SUMO_SIM_par_1	807	813	PF11976	0.382
LIG_SUMO_SIM_par_1	859	865	PF11976	0.298
LIG_SUMO_SIM_par_1	868	875	PF11976	0.286
LIG_TRAF2_1	143	146	PF00917	0.489
LIG_TRAF2_1	348	351	PF00917	0.533
LIG_TYR_ITIM	295	300	PF00017	0.318
LIG_UBA3_1	392	401	PF00899	0.469
LIG_UBA3_1	629	633	PF00899	0.299
LIG_UBA3_1	724	733	PF00899	0.443
LIG_WRC_WIRS_1	11	16	PF05994	0.594
LIG_WRC_WIRS_1	170	175	PF05994	0.397
MOD_CDK_SPK_2	234	239	PF00069	0.352
MOD_CDK_SPxxK_3	692	699	PF00069	0.500
MOD_CK1_1	222	228	PF00069	0.536
MOD_CK1_1	298	304	PF00069	0.373
MOD_CK1_1	692	698	PF00069	0.554
MOD_CK1_1	701	707	PF00069	0.598
MOD_CK1_1	731	737	PF00069	0.662
MOD_CK1_1	744	750	PF00069	0.486
MOD_CK1_1	764	770	PF00069	0.328
MOD_CK1_1	779	785	PF00069	0.354
MOD_CK2_1	140	146	PF00069	0.442
MOD_CK2_1	169	175	PF00069	0.311
MOD_CK2_1	239	245	PF00069	0.508
MOD_CK2_1	317	323	PF00069	0.559
MOD_CK2_1	375	381	PF00069	0.616
MOD_CK2_1	667	673	PF00069	0.536
MOD_CK2_1	731	737	PF00069	0.661
MOD_CK2_1	862	868	PF00069	0.460
MOD_GlcNHglycan	166	169	PF01048	0.401
MOD_GlcNHglycan	263	266	PF01048	0.381
MOD_GlcNHglycan	579	582	PF01048	0.304
MOD_GlcNHglycan	700	703	PF01048	0.559
MOD_GSK3_1	10	17	PF00069	0.498
MOD_GSK3_1	109	116	PF00069	0.468
MOD_GSK3_1	157	164	PF00069	0.512
MOD_GSK3_1	206	213	PF00069	0.399
MOD_GSK3_1	215	222	PF00069	0.407
MOD_GSK3_1	233	240	PF00069	0.419
MOD_GSK3_1	249	256	PF00069	0.463
MOD_GSK3_1	28	35	PF00069	0.557
MOD_GSK3_1	291	298	PF00069	0.466
MOD_GSK3_1	319	326	PF00069	0.602
MOD_GSK3_1	366	373	PF00069	0.476
MOD_GSK3_1	423	430	PF00069	0.550
MOD_GSK3_1	435	442	PF00069	0.819
MOD_GSK3_1	548	555	PF00069	0.498
MOD_GSK3_1	611	618	PF00069	0.451
MOD_GSK3_1	657	664	PF00069	0.629
MOD_GSK3_1	715	722	PF00069	0.637
MOD_GSK3_1	741	748	PF00069	0.486
MOD_GSK3_1	779	786	PF00069	0.431
MOD_GSK3_1	818	825	PF00069	0.375
MOD_GSK3_1	862	869	PF00069	0.378
MOD_LATS_1	26	32	PF00433	0.517
MOD_N-GLC_1	201	206	PF02516	0.331
MOD_N-GLC_1	228	233	PF02516	0.565
MOD_N-GLC_1	267	272	PF02516	0.351
MOD_N-GLC_1	764	769	PF02516	0.401
MOD_NEK2_1	14	19	PF00069	0.539
MOD_NEK2_1	161	166	PF00069	0.447
MOD_NEK2_1	169	174	PF00069	0.418
MOD_NEK2_1	180	185	PF00069	0.471
MOD_NEK2_1	250	255	PF00069	0.396
MOD_NEK2_1	295	300	PF00069	0.462
MOD_NEK2_1	374	379	PF00069	0.629
MOD_NEK2_1	577	582	PF00069	0.299
MOD_NEK2_1	583	588	PF00069	0.393
MOD_NEK2_1	66	71	PF00069	0.493
MOD_NEK2_1	690	695	PF00069	0.655
MOD_NEK2_1	7	12	PF00069	0.580
MOD_NEK2_1	728	733	PF00069	0.601
MOD_NEK2_1	745	750	PF00069	0.336
MOD_NEK2_1	783	788	PF00069	0.403
MOD_NEK2_1	827	832	PF00069	0.391
MOD_NEK2_1	842	847	PF00069	0.361
MOD_NEK2_1	860	865	PF00069	0.443
MOD_NEK2_2	157	162	PF00069	0.427
MOD_NEK2_2	446	451	PF00069	0.534
MOD_PIKK_1	128	134	PF00454	0.406
MOD_PIKK_1	423	429	PF00454	0.656
MOD_PIKK_1	489	495	PF00454	0.449
MOD_PIKK_1	652	658	PF00454	0.583
MOD_PIKK_1	82	88	PF00454	0.463
MOD_PK_1	317	323	PF00069	0.521
MOD_PK_1	366	372	PF00069	0.602
MOD_PK_1	453	459	PF00069	0.507
MOD_PK_1	720	726	PF00069	0.494
MOD_PKA_1	453	459	PF00069	0.507
MOD_PKA_2	427	433	PF00069	0.732
MOD_PKA_2	44	50	PF00069	0.525
MOD_PKA_2	453	459	PF00069	0.556
MOD_PKA_2	520	526	PF00069	0.443
MOD_PKA_2	577	583	PF00069	0.300
MOD_PKA_2	66	72	PF00069	0.491
MOD_PKA_2	698	704	PF00069	0.519
MOD_PKA_2	7	13	PF00069	0.569
MOD_PKA_2	719	725	PF00069	0.513
MOD_PKA_2	731	737	PF00069	0.585
MOD_Plk_1	228	234	PF00069	0.561
MOD_Plk_1	267	273	PF00069	0.356
MOD_Plk_1	349	355	PF00069	0.527
MOD_Plk_1	370	376	PF00069	0.473
MOD_Plk_1	399	405	PF00069	0.495
MOD_Plk_1	537	543	PF00069	0.392
MOD_Plk_1	562	568	PF00069	0.440
MOD_Plk_1	715	721	PF00069	0.482
MOD_Plk_1	764	770	PF00069	0.407
MOD_Plk_1	842	848	PF00069	0.363
MOD_Plk_2-3	710	716	PF00069	0.500
MOD_Plk_4	161	167	PF00069	0.380
MOD_Plk_4	2	8	PF00069	0.706
MOD_Plk_4	267	273	PF00069	0.508
MOD_Plk_4	278	284	PF00069	0.322
MOD_Plk_4	291	297	PF00069	0.422
MOD_Plk_4	370	376	PF00069	0.512
MOD_Plk_4	427	433	PF00069	0.604
MOD_Plk_4	453	459	PF00069	0.518
MOD_Plk_4	470	476	PF00069	0.536
MOD_Plk_4	583	589	PF00069	0.355
MOD_Plk_4	66	72	PF00069	0.484
MOD_Plk_4	680	686	PF00069	0.488
MOD_Plk_4	701	707	PF00069	0.511
MOD_Plk_4	710	716	PF00069	0.497
MOD_Plk_4	720	726	PF00069	0.580
MOD_Plk_4	764	770	PF00069	0.497
MOD_Plk_4	776	782	PF00069	0.358
MOD_Plk_4	872	878	PF00069	0.429
MOD_ProDKin_1	234	240	PF00069	0.540
MOD_ProDKin_1	32	38	PF00069	0.589
MOD_ProDKin_1	439	445	PF00069	0.727
MOD_ProDKin_1	501	507	PF00069	0.422
MOD_ProDKin_1	692	698	PF00069	0.586
MOD_ProDKin_1	875	881	PF00069	0.319
MOD_SUMO_for_1	707	710	PF00179	0.513
MOD_SUMO_rev_2	204	212	PF00179	0.449
MOD_SUMO_rev_2	887	894	PF00179	0.347
TRG_AP2beta_CARGO_1	594	604	PF09066	0.468
TRG_DiLeu_BaEn_1	529	534	PF01217	0.307
TRG_DiLeu_BaEn_2	709	715	PF01217	0.502
TRG_DiLeu_BaEn_4	413	419	PF01217	0.509
TRG_ENDOCYTIC_2	166	169	PF00928	0.465
TRG_ENDOCYTIC_2	184	187	PF00928	0.424
TRG_ENDOCYTIC_2	297	300	PF00928	0.310
TRG_ENDOCYTIC_2	506	509	PF00928	0.402
TRG_ENDOCYTIC_2	557	560	PF00928	0.284
TRG_ENDOCYTIC_2	588	591	PF00928	0.443
TRG_ENDOCYTIC_2	789	792	PF00928	0.470
TRG_ENDOCYTIC_2	846	849	PF00928	0.492
TRG_ER_diArg_1	108	111	PF00400	0.443
TRG_ER_diArg_1	184	186	PF00400	0.559
TRG_ER_diArg_1	482	484	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	883	887	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A0	Leptomonas seymouri	34%	95%
A0A3S7X4D3	Leishmania donovani	64%	100%
A4I6P9	Leishmania infantum	63%	100%
E9B1S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q6E0	Leishmania major	63%	100%