Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJA2_LEIBR

TriTrypDb:

LbrM.31.1420 , LBRM2903_310022100

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HJA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJA2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.344
CLV_PCSK_KEX2_1	39	41	PF00082	0.344
CLV_PCSK_SKI1_1	46	50	PF00082	0.338
CLV_PCSK_SKI1_1	54	58	PF00082	0.263
CLV_PCSK_SKI1_1	71	75	PF00082	0.311
DEG_APCC_DBOX_1	31	39	PF00400	0.238
DEG_APCC_DBOX_1	70	78	PF00400	0.344
DOC_CYCLIN_RxL_1	65	78	PF00134	0.344
DOC_MAPK_gen_1	29	37	PF00069	0.410
DOC_MAPK_gen_1	67	76	PF00069	0.344
DOC_MAPK_MEF2A_6	29	37	PF00069	0.308
DOC_MAPK_MEF2A_6	40	49	PF00069	0.242
DOC_PIKK_1	78	86	PF02985	0.519
DOC_PP2B_LxvP_1	47	50	PF13499	0.297
DOC_USP7_MATH_1	18	22	PF00917	0.363
DOC_USP7_MATH_1	63	67	PF00917	0.333
LIG_14-3-3_CanoR_1	32	38	PF00244	0.314
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_FHA_1	28	34	PF00498	0.297
LIG_FHA_2	11	17	PF00498	0.576
LIG_LIR_Apic_2	30	34	PF02991	0.332
LIG_LIR_Nem_3	21	26	PF02991	0.310
LIG_PCNA_PIPBox_1	70	79	PF02747	0.477
LIG_SH2_CRK	31	35	PF00017	0.327
LIG_SH2_GRB2like	51	54	PF00017	0.324
LIG_SH2_NCK_1	60	64	PF00017	0.275
LIG_SH3_1	39	45	PF00018	0.254
LIG_SH3_3	39	45	PF00018	0.254
MOD_CK1_1	3	9	PF00069	0.565
MOD_GSK3_1	3	10	PF00069	0.545
MOD_NEK2_1	77	82	PF00069	0.455
MOD_PIKK_1	54	60	PF00454	0.433
MOD_PKA_2	10	16	PF00069	0.514
MOD_Plk_1	77	83	PF00069	0.523
MOD_Plk_2-3	79	85	PF00069	0.530
MOD_Plk_4	18	24	PF00069	0.395
MOD_Plk_4	33	39	PF00069	0.268
TRG_DiLeu_BaEn_1	84	89	PF01217	0.527
TRG_ER_diArg_1	38	40	PF00400	0.344
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	60%	79%
A0A3Q8IGB7	Leishmania donovani	82%	85%
A0A3S7X4C9	Leishmania donovani	37%	92%
A4HJA0	Leishmania braziliensis	89%	100%
A4I6P2	Leishmania infantum	37%	92%
A4I6P5	Leishmania infantum	84%	85%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	92%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	85%
Q4Q6E4	Leishmania major	83%	100%