Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJA1_LEIBR

TriTrypDb:

LbrM.31.1430 , LBRM2903_310022200

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A4HJA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJA1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.418
CLV_NRD_NRD_1	126	128	PF00675	0.665
CLV_NRD_NRD_1	81	83	PF00675	0.505
CLV_NRD_NRD_1	93	95	PF00675	0.393
CLV_PCSK_KEX2_1	100	102	PF00082	0.467
CLV_PCSK_KEX2_1	126	128	PF00082	0.586
CLV_PCSK_KEX2_1	130	132	PF00082	0.608
CLV_PCSK_KEX2_1	93	95	PF00082	0.477
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.571
CLV_PCSK_PC7_1	126	132	PF00082	0.524
CLV_PCSK_SKI1_1	105	109	PF00082	0.216
CLV_PCSK_SKI1_1	127	131	PF00082	0.549
CLV_PCSK_SKI1_1	82	86	PF00082	0.415
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.547
DOC_MAPK_MEF2A_6	13	21	PF00069	0.586
DOC_PP2B_LxvP_1	17	20	PF13499	0.682
LIG_14-3-3_CanoR_1	126	130	PF00244	0.347
LIG_14-3-3_CanoR_1	93	102	PF00244	0.698
LIG_Actin_WH2_2	111	128	PF00022	0.261
LIG_Actin_WH2_2	59	74	PF00022	0.555
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_eIF4E_1	12	18	PF01652	0.532
LIG_FHA_1	104	110	PF00498	0.462
LIG_FHA_2	60	66	PF00498	0.623
LIG_LIR_Gen_1	5	15	PF02991	0.590
LIG_LIR_Gen_1	62	71	PF02991	0.759
LIG_LIR_Nem_3	5	10	PF02991	0.625
LIG_LIR_Nem_3	62	66	PF02991	0.742
LIG_SH2_GRB2like	38	41	PF00017	0.481
LIG_SH2_PTP2	7	10	PF00017	0.590
LIG_SH2_STAT3	34	37	PF00017	0.486
LIG_SH2_STAT3	38	41	PF00017	0.486
LIG_SH2_STAT5	123	126	PF00017	0.495
LIG_SH2_STAT5	34	37	PF00017	0.491
LIG_SH2_STAT5	7	10	PF00017	0.621
LIG_TRAF2_1	89	92	PF00917	0.653
LIG_WRC_WIRS_1	60	65	PF05994	0.618
MOD_CK2_1	42	48	PF00069	0.480
MOD_CK2_1	59	65	PF00069	0.473
MOD_CK2_1	86	92	PF00069	0.613
MOD_GlcNHglycan	44	47	PF01048	0.242
MOD_GSK3_1	103	110	PF00069	0.511
MOD_GSK3_1	125	132	PF00069	0.327
MOD_N-GLC_1	50	55	PF02516	0.285
MOD_NEK2_1	125	130	PF00069	0.396
MOD_NEK2_1	59	64	PF00069	0.510
MOD_PKA_1	93	99	PF00069	0.644
MOD_PKA_2	125	131	PF00069	0.318
MOD_PKA_2	93	99	PF00069	0.728
MOD_PKB_1	101	109	PF00069	0.656
MOD_Plk_4	13	19	PF00069	0.575
MOD_Plk_4	3	9	PF00069	0.685
MOD_SUMO_rev_2	65	74	PF00179	0.584
TRG_ENDOCYTIC_2	7	10	PF00928	0.614
TRG_ER_diArg_1	102	105	PF00400	0.644
TRG_ER_diArg_1	125	127	PF00400	0.364
TRG_ER_diArg_1	99	101	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	38%	94%
A0A0N1I3U0	Leptomonas seymouri	59%	99%
A0A0N1IH82	Leptomonas seymouri	38%	100%
A0A3Q8ICI2	Leishmania donovani	36%	100%
A0A3Q8IG43	Leishmania donovani	81%	99%
A0A3Q8ILC3	Leishmania donovani	28%	100%
A0A3S7WPP2	Leishmania donovani	29%	100%
A4HJ98	Leishmania braziliensis	31%	100%
A4I6P3	Leishmania infantum	36%	100%
A4I6P6	Leishmania infantum	82%	99%
E9AGY1	Leishmania infantum	28%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4Q6E3	Leishmania major	82%	100%
Q4Q6E4	Leishmania major	35%	100%
Q4Q6E5	Leishmania major	30%	81%