Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJ99_LEIBR

TriTrypDb:

LbrM.31.1390 , LBRM2903_310022000

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HJ99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.467
CLV_NRD_NRD_1	116	118	PF00675	0.488
CLV_PCSK_SKI1_1	40	44	PF00082	0.316
CLV_PCSK_SKI1_1	8	12	PF00082	0.437
DOC_USP7_MATH_1	101	105	PF00917	0.708
DOC_USP7_MATH_1	111	115	PF00917	0.771
DOC_USP7_MATH_1	49	53	PF00917	0.488
DOC_WW_Pin1_4	118	123	PF00397	0.681
DOC_WW_Pin1_4	77	82	PF00397	0.785
DOC_WW_Pin1_4	93	98	PF00397	0.628
LIG_14-3-3_CanoR_1	117	122	PF00244	0.655
LIG_14-3-3_CanoR_1	123	128	PF00244	0.652
LIG_FHA_2	52	58	PF00498	0.445
LIG_LIR_Apic_2	15	19	PF02991	0.544
LIG_NRP_CendR_1	160	161	PF00754	0.749
LIG_REV1ctd_RIR_1	7	16	PF16727	0.633
LIG_SH2_CRK	155	159	PF00017	0.387
LIG_SH2_SRC	16	19	PF00017	0.633
LIG_SH2_SRC	22	25	PF00017	0.535
LIG_SH2_SRC	67	70	PF00017	0.585
LIG_SH2_STAT5	16	19	PF00017	0.642
LIG_SH2_STAT5	22	25	PF00017	0.535
LIG_SH2_STAT5	37	40	PF00017	0.448
LIG_SH3_3	66	72	PF00018	0.683
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.343
LIG_TRAF2_1	82	85	PF00917	0.800
LIG_TYR_ITIM	153	158	PF00017	0.642
LIG_UBA3_1	34	40	PF00899	0.445
MOD_CDK_SPK_2	118	123	PF00069	0.698
MOD_CK1_1	126	132	PF00069	0.769
MOD_CK1_1	137	143	PF00069	0.307
MOD_CK1_1	70	76	PF00069	0.662
MOD_CK1_1	79	85	PF00069	0.730
MOD_CK2_1	121	127	PF00069	0.802
MOD_CK2_1	51	57	PF00069	0.494
MOD_CK2_1	79	85	PF00069	0.727
MOD_CK2_1	88	94	PF00069	0.651
MOD_GlcNHglycan	103	106	PF01048	0.401
MOD_GlcNHglycan	123	126	PF01048	0.424
MOD_GlcNHglycan	75	78	PF01048	0.509
MOD_GlcNHglycan	90	93	PF01048	0.419
MOD_GSK3_1	112	119	PF00069	0.769
MOD_GSK3_1	126	133	PF00069	0.658
MOD_GSK3_1	73	80	PF00069	0.776
MOD_NEK2_1	147	152	PF00069	0.470
MOD_PKA_1	117	123	PF00069	0.654
MOD_PKA_2	116	122	PF00069	0.650
MOD_Plk_1	49	55	PF00069	0.593
MOD_Plk_4	12	18	PF00069	0.574
MOD_Plk_4	130	136	PF00069	0.453
MOD_ProDKin_1	118	124	PF00069	0.679
MOD_ProDKin_1	77	83	PF00069	0.787
MOD_ProDKin_1	93	99	PF00069	0.629
MOD_SUMO_rev_2	114	120	PF00179	0.661
MOD_SUMO_rev_2	79	89	PF00179	0.684
TRG_ENDOCYTIC_2	155	158	PF00928	0.538
TRG_ENDOCYTIC_2	7	10	PF00928	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E5	Leishmania donovani	68%	99%
A4H4U1	Leishmania braziliensis	31%	100%
A4I6P4	Leishmania infantum	68%	99%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q6E5	Leishmania major	69%	100%