Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ98_LEIBR

TriTrypDb:

LbrM.31.1380 , LBRM2903_310021900

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HJ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ98

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.566
CLV_PCSK_KEX2_1	109	111	PF00082	0.486
CLV_PCSK_KEX2_1	76	78	PF00082	0.421
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.329
CLV_PCSK_SKI1_1	31	35	PF00082	0.276
CLV_PCSK_SKI1_1	40	44	PF00082	0.248
DOC_MAPK_gen_1	89	97	PF00069	0.453
DOC_USP7_MATH_1	49	53	PF00917	0.500
DOC_USP7_MATH_1	64	68	PF00917	0.606
LIG_14-3-3_CanoR_1	89	99	PF00244	0.461
LIG_14-3-3_CterR_2	109	112	PF00244	0.375
LIG_Actin_WH2_2	95	111	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	5	9	PF00533	0.485
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.553
LIG_FHA_1	67	73	PF00498	0.481
LIG_SH2_NCK_1	16	20	PF00017	0.379
LIG_UBA3_1	33	40	PF00899	0.430
MOD_CK1_1	2	8	PF00069	0.638
MOD_CK2_1	14	20	PF00069	0.379
MOD_CK2_1	64	70	PF00069	0.536
MOD_N-GLC_1	14	19	PF02516	0.179
MOD_PK_1	14	20	PF00069	0.379
MOD_PKA_2	90	96	PF00069	0.458
MOD_Plk_1	14	20	PF00069	0.382
TRG_ER_diArg_1	108	110	PF00400	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	35%	79%
A0A0N1I3U0	Leptomonas seymouri	32%	84%
A0A0N1IH82	Leptomonas seymouri	71%	100%
A0A3Q8ICI2	Leishmania donovani	86%	100%
A0A3Q8IG43	Leishmania donovani	32%	84%
A0A3Q8IGB7	Leishmania donovani	36%	86%
A0A3Q8ILC3	Leishmania donovani	33%	91%
A0A3S7WPP2	Leishmania donovani	37%	91%
A0A3S7X4C9	Leishmania donovani	30%	93%
A4H4U1	Leishmania braziliensis	38%	100%
A4HJ97	Leishmania braziliensis	33%	93%
A4HJA0	Leishmania braziliensis	37%	86%
A4HJA1	Leishmania braziliensis	31%	85%
A4HT20	Leishmania infantum	36%	91%
A4I6P2	Leishmania infantum	30%	93%
A4I6P3	Leishmania infantum	86%	100%
A4I6P5	Leishmania infantum	35%	86%
A4I6P6	Leishmania infantum	32%	84%
E9AGY1	Leishmania infantum	33%	91%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	91%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	91%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	93%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	71%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	86%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
O48845	Arabidopsis thaliana	28%	84%
P49096	Musca domestica	31%	84%
Q4Q6E3	Leishmania major	29%	84%
Q4Q6E4	Leishmania major	36%	86%
Q4Q6E6	Leishmania major	83%	100%
Q4QIU6	Leishmania major	38%	100%
Q874I5	Candida tropicalis	33%	87%
Q9HFV1	Rhizopus stolonifer	34%	85%