Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HJ97_LEIBR

TriTrypDb:

LbrM.31.1370 , LBRM2903_310021800

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A4HJ97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ97

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	34	38	PF00082	0.395
DEG_APCC_DBOX_1	33	41	PF00400	0.487
DOC_MAPK_MEF2A_6	52	60	PF00069	0.486
DOC_PP2B_LxvP_1	35	38	PF13499	0.529
DOC_USP7_MATH_1	109	113	PF00917	0.260
DOC_USP7_MATH_1	51	55	PF00917	0.631
DOC_USP7_MATH_1	70	74	PF00917	0.602
DOC_USP7_MATH_1	83	87	PF00917	0.613
LIG_14-3-3_CanoR_1	10	14	PF00244	0.513
LIG_Clathr_ClatBox_1	19	23	PF01394	0.482
LIG_DCNL_PONY_1	1	4	PF03556	0.572
LIG_FHA_1	112	118	PF00498	0.273
LIG_LIR_Apic_2	16	21	PF02991	0.524
LIG_LIR_Gen_1	93	104	PF02991	0.598
LIG_LIR_Nem_3	93	99	PF02991	0.682
LIG_NRP_CendR_1	120	121	PF00754	0.580
LIG_SH2_CRK	96	100	PF00017	0.550
LIG_SH2_GRB2like	39	42	PF00017	0.525
LIG_SH2_STAP1	96	100	PF00017	0.595
LIG_SH2_STAT3	39	42	PF00017	0.503
LIG_SH2_STAT5	18	21	PF00017	0.512
LIG_SH2_STAT5	39	42	PF00017	0.526
MOD_CK1_1	73	79	PF00069	0.543
MOD_GlcNHglycan	79	82	PF01048	0.607
MOD_GSK3_1	70	77	PF00069	0.596
MOD_GSK3_1	9	16	PF00069	0.329
MOD_NEK2_1	9	14	PF00069	0.274
MOD_PIKK_1	42	48	PF00454	0.402
MOD_PKA_2	73	79	PF00069	0.495
MOD_PKA_2	9	15	PF00069	0.324
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.327
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.301
TRG_ENDOCYTIC_2	96	99	PF00928	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	36%	91%
A0A3Q8ICI2	Leishmania donovani	31%	100%
A0A3Q8IGB7	Leishmania donovani	39%	93%
A0A3Q8ILC3	Leishmania donovani	33%	98%
A0A3S7WPP2	Leishmania donovani	32%	98%
A0A3S7X4C9	Leishmania donovani	78%	100%
A4H4U1	Leishmania braziliensis	33%	100%
A4HJ98	Leishmania braziliensis	33%	100%
A4HT20	Leishmania infantum	32%	98%
A4I6P2	Leishmania infantum	78%	100%
A4I6P3	Leishmania infantum	31%	100%
E9ACS1	Leishmania major	35%	100%
E9AGY1	Leishmania infantum	33%	98%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9B1R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	77%
Q4Q6E4	Leishmania major	39%	100%
Q4Q6E6	Leishmania major	30%	100%
Q4QIU6	Leishmania major	32%	100%