Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJ96_LEIBR

TriTrypDb:

LbrM.31.1360 , LBRM2903_310021700

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HJ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ96

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	498	502	PF00656	0.470
CLV_NRD_NRD_1	309	311	PF00675	0.440
CLV_NRD_NRD_1	357	359	PF00675	0.462
CLV_NRD_NRD_1	92	94	PF00675	0.667
CLV_PCSK_KEX2_1	147	149	PF00082	0.769
CLV_PCSK_KEX2_1	266	268	PF00082	0.491
CLV_PCSK_KEX2_1	309	311	PF00082	0.440
CLV_PCSK_KEX2_1	357	359	PF00082	0.465
CLV_PCSK_KEX2_1	40	42	PF00082	0.702
CLV_PCSK_KEX2_1	92	94	PF00082	0.701
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.688
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.407
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.505
CLV_PCSK_SKI1_1	131	135	PF00082	0.673
CLV_PCSK_SKI1_1	179	183	PF00082	0.468
CLV_PCSK_SKI1_1	251	255	PF00082	0.455
CLV_PCSK_SKI1_1	309	313	PF00082	0.521
CLV_PCSK_SKI1_1	320	324	PF00082	0.374
CLV_PCSK_SKI1_1	430	434	PF00082	0.539
CLV_PCSK_SKI1_1	475	479	PF00082	0.442
CLV_PCSK_SKI1_1	48	52	PF00082	0.509
CLV_PCSK_SKI1_1	84	88	PF00082	0.500
CLV_Separin_Metazoa	493	497	PF03568	0.298
CLV_Separin_Metazoa	626	630	PF03568	0.469
DEG_APCC_DBOX_1	429	437	PF00400	0.488
DEG_APCC_DBOX_1	628	636	PF00400	0.533
DOC_CDC14_PxL_1	282	290	PF14671	0.274
DOC_CDC14_PxL_1	328	336	PF14671	0.439
DOC_CDC14_PxL_1	431	439	PF14671	0.481
DOC_CKS1_1	56	61	PF01111	0.669
DOC_MAPK_gen_1	309	316	PF00069	0.259
DOC_MAPK_gen_1	317	325	PF00069	0.266
DOC_MAPK_gen_1	538	547	PF00069	0.479
DOC_MAPK_gen_1	92	98	PF00069	0.615
DOC_PP1_RVXF_1	121	128	PF00149	0.588
DOC_PP1_RVXF_1	46	52	PF00149	0.490
DOC_PP2B_LxvP_1	234	237	PF13499	0.553
DOC_USP7_MATH_1	235	239	PF00917	0.466
DOC_USP7_MATH_1	29	33	PF00917	0.626
DOC_USP7_MATH_1	35	39	PF00917	0.627
DOC_USP7_MATH_1	425	429	PF00917	0.519
DOC_USP7_MATH_1	86	90	PF00917	0.765
DOC_WW_Pin1_4	166	171	PF00397	0.605
DOC_WW_Pin1_4	486	491	PF00397	0.398
DOC_WW_Pin1_4	55	60	PF00397	0.672
LIG_14-3-3_CanoR_1	148	154	PF00244	0.565
LIG_14-3-3_CanoR_1	179	184	PF00244	0.469
LIG_14-3-3_CanoR_1	248	254	PF00244	0.475
LIG_14-3-3_CanoR_1	26	36	PF00244	0.770
LIG_14-3-3_CanoR_1	267	271	PF00244	0.285
LIG_14-3-3_CanoR_1	272	277	PF00244	0.415
LIG_14-3-3_CanoR_1	309	315	PF00244	0.333
LIG_14-3-3_CanoR_1	352	359	PF00244	0.300
LIG_14-3-3_CanoR_1	362	368	PF00244	0.290
LIG_14-3-3_CanoR_1	386	396	PF00244	0.502
LIG_14-3-3_CanoR_1	440	450	PF00244	0.576
LIG_14-3-3_CanoR_1	475	480	PF00244	0.446
LIG_14-3-3_CanoR_1	496	501	PF00244	0.275
LIG_14-3-3_CanoR_1	529	536	PF00244	0.523
LIG_14-3-3_CanoR_1	538	543	PF00244	0.391
LIG_14-3-3_CanoR_1	575	583	PF00244	0.662
LIG_14-3-3_CanoR_1	92	100	PF00244	0.680
LIG_Actin_WH2_2	235	250	PF00022	0.297
LIG_Actin_WH2_2	261	279	PF00022	0.327
LIG_Actin_WH2_2	481	498	PF00022	0.448
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	392	396	PF00533	0.601
LIG_FHA_1	413	419	PF00498	0.486
LIG_FHA_1	56	62	PF00498	0.661
LIG_FHA_2	102	108	PF00498	0.726
LIG_FHA_2	209	215	PF00498	0.470
LIG_FHA_2	218	224	PF00498	0.387
LIG_FHA_2	252	258	PF00498	0.446
LIG_FHA_2	476	482	PF00498	0.510
LIG_FHA_2	496	502	PF00498	0.468
LIG_Integrin_RGD_1	302	304	PF01839	0.302
LIG_LIR_Gen_1	105	115	PF02991	0.617
LIG_LIR_Gen_1	226	236	PF02991	0.557
LIG_LIR_Gen_1	518	528	PF02991	0.416
LIG_LIR_Nem_3	105	111	PF02991	0.664
LIG_LIR_Nem_3	226	231	PF02991	0.572
LIG_LIR_Nem_3	338	344	PF02991	0.454
LIG_LIR_Nem_3	501	507	PF02991	0.542
LIG_LIR_Nem_3	518	524	PF02991	0.471
LIG_LYPXL_S_1	433	437	PF13949	0.605
LIG_LYPXL_yS_3	434	437	PF13949	0.601
LIG_Rb_LxCxE_1	198	220	PF01857	0.325
LIG_SH2_CRK	108	112	PF00017	0.630
LIG_SH2_CRK	341	345	PF00017	0.531
LIG_SH2_GRB2like	10	13	PF00017	0.509
LIG_SH2_GRB2like	521	524	PF00017	0.456
LIG_SH2_PTP2	521	524	PF00017	0.429
LIG_SH2_STAP1	75	79	PF00017	0.644
LIG_SH2_STAT3	10	13	PF00017	0.509
LIG_SH2_STAT5	10	13	PF00017	0.618
LIG_SH2_STAT5	521	524	PF00017	0.382
LIG_SH2_STAT5	57	60	PF00017	0.630
LIG_SH2_STAT5	97	100	PF00017	0.569
LIG_SH3_3	255	261	PF00018	0.410
LIG_SH3_3	429	435	PF00018	0.577
LIG_SH3_3	56	62	PF00018	0.627
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.377
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.457
LIG_SUMO_SIM_anti_2	447	453	PF11976	0.295
LIG_SUMO_SIM_par_1	458	465	PF11976	0.449
LIG_TRAF2_2	185	190	PF00917	0.575
LIG_TYR_ITIM	432	437	PF00017	0.617
LIG_TYR_ITIM	519	524	PF00017	0.431
LIG_UBA3_1	215	224	PF00899	0.474
LIG_UBA3_1	259	266	PF00899	0.297
LIG_WRC_WIRS_1	225	230	PF05994	0.465
MOD_CDK_SPxK_1	166	172	PF00069	0.481
MOD_CK1_1	152	158	PF00069	0.532
MOD_CK1_1	160	166	PF00069	0.709
MOD_CK1_1	238	244	PF00069	0.475
MOD_CK1_1	275	281	PF00069	0.475
MOD_CK1_1	39	45	PF00069	0.691
MOD_CK1_1	444	450	PF00069	0.563
MOD_CK1_1	465	471	PF00069	0.507
MOD_CK2_1	101	107	PF00069	0.723
MOD_CK2_1	109	115	PF00069	0.546
MOD_CK2_1	208	214	PF00069	0.468
MOD_CK2_1	217	223	PF00069	0.388
MOD_CK2_1	251	257	PF00069	0.493
MOD_CK2_1	363	369	PF00069	0.590
MOD_CK2_1	446	452	PF00069	0.485
MOD_CK2_1	475	481	PF00069	0.552
MOD_CK2_1	538	544	PF00069	0.486
MOD_CK2_1	575	581	PF00069	0.515
MOD_GlcNHglycan	111	114	PF01048	0.676
MOD_GlcNHglycan	160	163	PF01048	0.742
MOD_GlcNHglycan	165	168	PF01048	0.679
MOD_GlcNHglycan	22	25	PF01048	0.626
MOD_GlcNHglycan	262	265	PF01048	0.452
MOD_GlcNHglycan	31	34	PF01048	0.660
MOD_GlcNHglycan	341	344	PF01048	0.427
MOD_GlcNHglycan	392	395	PF01048	0.553
MOD_GlcNHglycan	41	44	PF01048	0.556
MOD_GlcNHglycan	412	415	PF01048	0.628
MOD_GlcNHglycan	427	430	PF01048	0.483
MOD_GlcNHglycan	443	446	PF01048	0.528
MOD_GlcNHglycan	464	467	PF01048	0.433
MOD_GlcNHglycan	504	507	PF01048	0.391
MOD_GlcNHglycan	547	550	PF01048	0.484
MOD_GlcNHglycan	568	571	PF01048	0.689
MOD_GlcNHglycan	590	593	PF01048	0.793
MOD_GlcNHglycan	88	91	PF01048	0.681
MOD_GSK3_1	107	114	PF00069	0.532
MOD_GSK3_1	127	134	PF00069	0.621
MOD_GSK3_1	148	155	PF00069	0.725
MOD_GSK3_1	191	198	PF00069	0.518
MOD_GSK3_1	35	42	PF00069	0.607
MOD_GSK3_1	390	397	PF00069	0.463
MOD_GSK3_1	417	424	PF00069	0.651
MOD_GSK3_1	436	443	PF00069	0.707
MOD_GSK3_1	456	463	PF00069	0.326
MOD_GSK3_1	496	503	PF00069	0.429
MOD_GSK3_1	511	518	PF00069	0.362
MOD_GSK3_1	584	591	PF00069	0.601
MOD_N-GLC_1	20	25	PF02516	0.532
MOD_N-GLC_1	203	208	PF02516	0.363
MOD_N-GLC_1	597	602	PF02516	0.508
MOD_N-GLC_2	525	527	PF02516	0.337
MOD_NEK2_1	1	6	PF00069	0.491
MOD_NEK2_1	337	342	PF00069	0.443
MOD_NEK2_1	36	41	PF00069	0.506
MOD_NEK2_1	412	417	PF00069	0.604
MOD_NEK2_1	495	500	PF00069	0.576
MOD_NEK2_1	513	518	PF00069	0.293
MOD_NEK2_1	588	593	PF00069	0.783
MOD_NEK2_2	363	368	PF00069	0.423
MOD_OFUCOSY	99	106	PF10250	0.439
MOD_PIKK_1	179	185	PF00454	0.538
MOD_PIKK_1	226	232	PF00454	0.474
MOD_PIKK_1	280	286	PF00454	0.437
MOD_PIKK_1	351	357	PF00454	0.361
MOD_PIKK_1	465	471	PF00454	0.294
MOD_PIKK_1	575	581	PF00454	0.525
MOD_PK_1	310	316	PF00069	0.447
MOD_PK_1	496	502	PF00069	0.430
MOD_PKA_1	266	272	PF00069	0.409
MOD_PKA_1	309	315	PF00069	0.418
MOD_PKA_2	266	272	PF00069	0.489
MOD_PKA_2	309	315	PF00069	0.319
MOD_PKA_2	351	357	PF00069	0.306
MOD_PKA_2	495	501	PF00069	0.284
MOD_PKA_2	588	594	PF00069	0.581
MOD_PKA_2	91	97	PF00069	0.445
MOD_PKB_1	573	581	PF00069	0.541
MOD_Plk_1	303	309	PF00069	0.287
MOD_Plk_1	337	343	PF00069	0.529
MOD_Plk_1	500	506	PF00069	0.430
MOD_Plk_1	597	603	PF00069	0.510
MOD_Plk_4	173	179	PF00069	0.487
MOD_Plk_4	240	246	PF00069	0.457
MOD_Plk_4	446	452	PF00069	0.378
MOD_ProDKin_1	166	172	PF00069	0.602
MOD_ProDKin_1	486	492	PF00069	0.398
MOD_ProDKin_1	55	61	PF00069	0.671
TRG_DiLeu_BaEn_1	623	628	PF01217	0.591
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.280
TRG_ENDOCYTIC_2	108	111	PF00928	0.684
TRG_ENDOCYTIC_2	341	344	PF00928	0.435
TRG_ENDOCYTIC_2	434	437	PF00928	0.613
TRG_ENDOCYTIC_2	521	524	PF00928	0.454
TRG_ER_diArg_1	245	248	PF00400	0.294
TRG_ER_diArg_1	309	311	PF00400	0.440
TRG_ER_diArg_1	356	358	PF00400	0.427
TRG_NES_CRM1_1	284	295	PF08389	0.433
TRG_NES_CRM1_1	508	520	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	23%	97%
A0A0N1I0W0	Leptomonas seymouri	24%	100%
A0A3Q8ISJ9	Leishmania donovani	72%	100%
A4I6P1	Leishmania infantum	73%	100%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	94%
E9B1R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q6E7	Leishmania major	71%	100%