Putative monoglyceride lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monoglyceride lipase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ94_LEIBR

TriTrypDb:

LbrM.31.1340 , LBRM2903_310021500

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ94

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0047372	acylglycerol lipase activity	5	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	179	183	PF00082	0.226
CLV_PCSK_SKI1_1	266	270	PF00082	0.314
DOC_MAPK_MEF2A_6	187	194	PF00069	0.279
DOC_MAPK_MEF2A_6	244	252	PF00069	0.180
DOC_MAPK_MEF2A_6	73	81	PF00069	0.312
DOC_PP1_RVXF_1	56	63	PF00149	0.274
DOC_PP2B_LxvP_1	168	171	PF13499	0.269
DOC_PP4_FxxP_1	62	65	PF00568	0.312
DOC_USP7_UBL2_3	187	191	PF12436	0.279
DOC_USP7_UBL2_3	266	270	PF12436	0.290
DOC_WW_Pin1_4	16	21	PF00397	0.493
DOC_WW_Pin1_4	49	54	PF00397	0.496
LIG_14-3-3_CanoR_1	176	182	PF00244	0.258
LIG_AP2alpha_2	215	217	PF02296	0.367
LIG_APCC_ABBA_1	250	255	PF00400	0.312
LIG_BRCT_BRCA1_1	245	249	PF00533	0.174
LIG_BRCT_BRCA1_1	264	268	PF00533	0.274
LIG_BRCT_BRCA1_2	264	270	PF00533	0.290
LIG_EH1_1	139	147	PF00400	0.250
LIG_FHA_1	108	114	PF00498	0.401
LIG_FHA_1	133	139	PF00498	0.322
LIG_FHA_1	180	186	PF00498	0.174
LIG_FHA_1	55	61	PF00498	0.397
LIG_KLC1_Yacidic_2	102	107	PF13176	0.312
LIG_LIR_Apic_2	203	207	PF02991	0.312
LIG_LIR_Gen_1	107	116	PF02991	0.275
LIG_LIR_Gen_1	215	225	PF02991	0.336
LIG_LIR_Gen_1	246	256	PF02991	0.200
LIG_LIR_Gen_1	71	81	PF02991	0.307
LIG_LIR_Gen_1	84	91	PF02991	0.193
LIG_LIR_Nem_3	107	112	PF02991	0.251
LIG_LIR_Nem_3	215	221	PF02991	0.376
LIG_LIR_Nem_3	245	250	PF02991	0.283
LIG_LIR_Nem_3	71	77	PF02991	0.264
LIG_LIR_Nem_3	84	89	PF02991	0.222
LIG_MYND_1	23	27	PF01753	0.424
LIG_NRP_CendR_1	309	311	PF00754	0.389
LIG_PCNA_yPIPBox_3	205	213	PF02747	0.331
LIG_Pex14_2	184	188	PF04695	0.312
LIG_Pex14_2	40	44	PF04695	0.504
LIG_REV1ctd_RIR_1	266	272	PF16727	0.290
LIG_SH2_CRK	127	131	PF00017	0.306
LIG_SH2_CRK	13	17	PF00017	0.531
LIG_SH2_CRK	204	208	PF00017	0.460
LIG_SH2_CRK	218	222	PF00017	0.230
LIG_SH2_CRK	74	78	PF00017	0.250
LIG_SH2_GRB2like	218	221	PF00017	0.312
LIG_SH2_NCK_1	13	17	PF00017	0.528
LIG_SH2_NCK_1	218	222	PF00017	0.335
LIG_SH2_NCK_1	74	78	PF00017	0.367
LIG_SH2_SRC	105	108	PF00017	0.174
LIG_SH2_SRC	13	16	PF00017	0.403
LIG_SH2_STAP1	74	78	PF00017	0.309
LIG_SH2_STAT5	105	108	PF00017	0.250
LIG_SH2_STAT5	86	89	PF00017	0.307
LIG_SH3_1	187	193	PF00018	0.195
LIG_SH3_2	53	58	PF14604	0.441
LIG_SH3_3	17	23	PF00018	0.446
LIG_SH3_3	187	193	PF00018	0.465
LIG_SH3_3	277	283	PF00018	0.247
LIG_SH3_3	50	56	PF00018	0.470
LIG_SH3_CIN85_PxpxPR_1	171	176	PF14604	0.174
MOD_CK1_1	219	225	PF00069	0.446
MOD_CK1_1	243	249	PF00069	0.275
MOD_CK2_1	96	102	PF00069	0.352
MOD_GlcNHglycan	163	166	PF01048	0.220
MOD_GlcNHglycan	5	8	PF01048	0.547
MOD_GSK3_1	128	135	PF00069	0.204
MOD_GSK3_1	179	186	PF00069	0.181
MOD_GSK3_1	239	246	PF00069	0.186
MOD_GSK3_1	258	265	PF00069	0.383
MOD_N-GLC_1	219	224	PF02516	0.290
MOD_NEK2_1	138	143	PF00069	0.205
MOD_NEK2_1	145	150	PF00069	0.274
MOD_NEK2_1	177	182	PF00069	0.407
MOD_NEK2_1	262	267	PF00069	0.342
MOD_PK_1	73	79	PF00069	0.367
MOD_Plk_1	219	225	PF00069	0.290
MOD_Plk_2-3	258	264	PF00069	0.195
MOD_Plk_4	132	138	PF00069	0.426
MOD_Plk_4	145	151	PF00069	0.375
MOD_ProDKin_1	16	22	PF00069	0.487
MOD_ProDKin_1	49	55	PF00069	0.487
TRG_ENDOCYTIC_2	127	130	PF00928	0.288
TRG_ENDOCYTIC_2	218	221	PF00928	0.376
TRG_ENDOCYTIC_2	74	77	PF00928	0.250
TRG_ENDOCYTIC_2	86	89	PF00928	0.250
TRG_ER_diArg_1	223	226	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.174

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ITL6	Bodo saltans	47%	96%
A0A3R7L576	Trypanosoma rangeli	50%	100%
A0A3S7X4B8	Leishmania donovani	85%	100%
A0QNZ7	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	33%	100%
A4I6N9	Leishmania infantum	85%	100%
C9ZM73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZWV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9B1R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O07427	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
O34705	Bacillus subtilis (strain 168)	29%	100%
O35678	Mus musculus	34%	100%
O94305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	82%
P28321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q4Q6E9	Leishmania major	84%	100%
Q8R431	Rattus norvegicus	33%	100%
Q99685	Homo sapiens	34%	100%
Q9C942	Arabidopsis thaliana	25%	94%