Related to other eukaryotic COPII adaptors. Likely involved in ER to Golgi transport.. A Leishmaniid-specific subgroup of these proteins is missing the SigP (unclear topology and function). Localization: ER (by homology) / Golgi (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 16 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 12, no: 9 |
| NetGPI | no | yes: 0, no: 21 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 22 |
| GO:0110165 | cellular anatomical entity | 1 | 22 |
| GO:0005783 | endoplasmic reticulum | 5 | 3 |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | 5 | 3 |
| GO:0005794 | Golgi apparatus | 5 | 3 |
| GO:0030134 | COPII-coated ER to Golgi transport vesicle | 8 | 3 |
| GO:0030135 | coated vesicle | 7 | 3 |
| GO:0031410 | cytoplasmic vesicle | 6 | 3 |
| GO:0031982 | vesicle | 4 | 3 |
| GO:0043226 | organelle | 2 | 3 |
| GO:0043227 | membrane-bounded organelle | 3 | 3 |
| GO:0043229 | intracellular organelle | 3 | 3 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 3 |
| GO:0097708 | intracellular vesicle | 5 | 3 |
Related structures:
AlphaFold database: A4HJ92
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006810 | transport | 3 | 3 |
| GO:0006886 | intracellular protein transport | 4 | 3 |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 4 | 3 |
| GO:0006996 | organelle organization | 4 | 3 |
| GO:0007030 | Golgi organization | 5 | 3 |
| GO:0008104 | protein localization | 4 | 3 |
| GO:0009987 | cellular process | 1 | 3 |
| GO:0015031 | protein transport | 4 | 3 |
| GO:0016043 | cellular component organization | 3 | 3 |
| GO:0016192 | vesicle-mediated transport | 4 | 3 |
| GO:0033036 | macromolecule localization | 2 | 3 |
| GO:0045184 | establishment of protein localization | 3 | 3 |
| GO:0046907 | intracellular transport | 3 | 3 |
| GO:0048193 | Golgi vesicle transport | 5 | 3 |
| GO:0051179 | localization | 1 | 3 |
| GO:0051234 | establishment of localization | 2 | 3 |
| GO:0051641 | cellular localization | 2 | 3 |
| GO:0051649 | establishment of localization in cell | 3 | 3 |
| GO:0070727 | cellular macromolecule localization | 3 | 3 |
| GO:0071702 | organic substance transport | 4 | 3 |
| GO:0071705 | nitrogen compound transport | 4 | 3 |
| GO:0071840 | cellular component organization or biogenesis | 2 | 3 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 153 | 155 | PF00675 | 0.440 |
| CLV_PCSK_KEX2_1 | 152 | 154 | PF00082 | 0.448 |
| CLV_PCSK_KEX2_1 | 44 | 46 | PF00082 | 0.476 |
| CLV_PCSK_PC1ET2_1 | 152 | 154 | PF00082 | 0.437 |
| CLV_PCSK_PC1ET2_1 | 44 | 46 | PF00082 | 0.476 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.324 |
| DOC_CYCLIN_RxL_1 | 42 | 52 | PF00134 | 0.367 |
| DOC_MAPK_FxFP_2 | 10 | 13 | PF00069 | 0.321 |
| DOC_MAPK_gen_1 | 43 | 49 | PF00069 | 0.341 |
| DOC_PP1_RVXF_1 | 121 | 128 | PF00149 | 0.308 |
| DOC_PP1_RVXF_1 | 43 | 50 | PF00149 | 0.346 |
| DOC_PP4_FxxP_1 | 10 | 13 | PF00568 | 0.321 |
| DOC_PP4_FxxP_1 | 36 | 39 | PF00568 | 0.379 |
| DOC_USP7_MATH_1 | 138 | 142 | PF00917 | 0.212 |
| DOC_USP7_MATH_1 | 84 | 88 | PF00917 | 0.256 |
| LIG_14-3-3_CanoR_1 | 114 | 118 | PF00244 | 0.252 |
| LIG_14-3-3_CanoR_1 | 15 | 25 | PF00244 | 0.367 |
| LIG_14-3-3_CterR_2 | 153 | 156 | PF00244 | 0.607 |
| LIG_BIR_III_4 | 31 | 35 | PF00653 | 0.205 |
| LIG_FHA_1 | 19 | 25 | PF00498 | 0.408 |
| LIG_FHA_1 | 9 | 15 | PF00498 | 0.352 |
| LIG_FHA_2 | 113 | 119 | PF00498 | 0.248 |
| LIG_LIR_Apic_2 | 7 | 13 | PF02991 | 0.469 |
| LIG_LIR_Nem_3 | 7 | 12 | PF02991 | 0.354 |
| LIG_NRBOX | 145 | 151 | PF00104 | 0.344 |
| LIG_SH2_STAP1 | 75 | 79 | PF00017 | 0.311 |
| LIG_SH2_STAT3 | 75 | 78 | PF00017 | 0.205 |
| LIG_SH2_STAT5 | 9 | 12 | PF00017 | 0.418 |
| LIG_UBA3_1 | 145 | 152 | PF00899 | 0.392 |
| LIG_UBA3_1 | 35 | 43 | PF00899 | 0.205 |
| LIG_WRC_WIRS_1 | 1 | 6 | PF05994 | 0.283 |
| MOD_CK1_1 | 54 | 60 | PF00069 | 0.327 |
| MOD_CK2_1 | 112 | 118 | PF00069 | 0.306 |
| MOD_CK2_1 | 145 | 151 | PF00069 | 0.259 |
| MOD_GSK3_1 | 113 | 120 | PF00069 | 0.262 |
| MOD_GSK3_1 | 67 | 74 | PF00069 | 0.409 |
| MOD_NEK2_1 | 125 | 130 | PF00069 | 0.332 |
| MOD_NEK2_1 | 145 | 150 | PF00069 | 0.298 |
| MOD_NEK2_1 | 51 | 56 | PF00069 | 0.343 |
| MOD_PIKK_1 | 138 | 144 | PF00454 | 0.212 |
| MOD_PIKK_1 | 51 | 57 | PF00454 | 0.267 |
| MOD_PKA_2 | 113 | 119 | PF00069 | 0.301 |
| MOD_Plk_4 | 145 | 151 | PF00069 | 0.348 |
| MOD_SUMO_rev_2 | 80 | 89 | PF00179 | 0.335 |
| TRG_ENDOCYTIC_2 | 9 | 12 | PF00928 | 0.371 |
| TRG_ENDOCYTIC_2 | 93 | 96 | PF00928 | 0.205 |
| TRG_Pf-PMV_PEXEL_1 | 15 | 20 | PF00026 | 0.558 |
| TRG_Pf-PMV_PEXEL_1 | 45 | 50 | PF00026 | 0.584 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I2E2 | Leptomonas seymouri | 39% | 73% |
| A0A0N1II77 | Leptomonas seymouri | 44% | 76% |
| A0A0N1PA81 | Leptomonas seymouri | 43% | 77% |
| A0A0S4JG68 | Bodo saltans | 27% | 71% |
| A0A0S4JHA6 | Bodo saltans | 27% | 77% |
| A0A0S4JYK0 | Bodo saltans | 36% | 77% |
| A0A1X0NKZ3 | Trypanosomatidae | 33% | 71% |
| A0A1X0NVX2 | Trypanosomatidae | 30% | 69% |
| A0A3Q8ITC4 | Leishmania donovani | 32% | 98% |
| A0A3R7KJS3 | Trypanosoma rangeli | 32% | 72% |
| A0A3S7X4G7 | Leishmania donovani | 44% | 73% |
| A0A422NB76 | Trypanosoma rangeli | 29% | 71% |
| A4HJ91 | Leishmania braziliensis | 42% | 73% |
| A4I6N5 | Leishmania infantum | 44% | 73% |
| A4I6N6 | Leishmania infantum | 58% | 75% |
| A4I824 | Leishmania infantum | 32% | 98% |
| A7SXK3 | Nematostella vectensis | 27% | 77% |
| B3MTS8 | Drosophila ananassae | 23% | 72% |
| B3NZM5 | Drosophila erecta | 23% | 72% |
| B4GMC3 | Drosophila persimilis | 23% | 72% |
| B4HJV5 | Drosophila sechellia | 23% | 72% |
| B4JG34 | Drosophila grimshawi | 24% | 72% |
| B4KB41 | Drosophila mojavensis | 23% | 72% |
| B4LYB8 | Drosophila virilis | 23% | 72% |
| B4NKL0 | Drosophila willistoni | 23% | 72% |
| B4PVC6 | Drosophila yakuba | 23% | 72% |
| B4QWH9 | Drosophila simulans | 24% | 72% |
| C9ZM72 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 26% | 77% |
| C9ZWV3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 25% | 76% |
| E9B1Q8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 43% | 73% |
| E9B1Q9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 60% | 75% |
| E9B2Y2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 98% |
| Q295B2 | Drosophila pseudoobscura pseudoobscura | 23% | 72% |
| Q4Q574 | Leishmania major | 32% | 98% |
| Q4Q6F1 | Leishmania major | 58% | 100% |
| Q4Q6F2 | Leishmania major | 43% | 73% |
| Q54BN0 | Dictyostelium discoideum | 29% | 75% |
| Q769F9 | Dictyostelium discoideum | 28% | 76% |
| Q9I7K5 | Drosophila melanogaster | 24% | 72% |
| Q9LIL4 | Arabidopsis thaliana | 27% | 73% |
| V5BG96 | Trypanosoma cruzi | 27% | 71% |
| V5BK13 | Trypanosoma cruzi | 32% | 71% |