Cilia- and flagella-associated protein 300

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4498), putative

Species:

Leishmania braziliensis

UniProt:

A4HJ90_LEIBR

TriTrypDb:

LbrM.31.1300 , LBRM2903_310021100

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HJ90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.553
CLV_C14_Caspase3-7	206	210	PF00656	0.471
CLV_PCSK_KEX2_1	68	70	PF00082	0.588
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.628
CLV_PCSK_SKI1_1	137	141	PF00082	0.428
CLV_PCSK_SKI1_1	20	24	PF00082	0.557
CLV_PCSK_SKI1_1	43	47	PF00082	0.661
CLV_PCSK_SKI1_1	85	89	PF00082	0.507
CLV_Separin_Metazoa	30	34	PF03568	0.539
DOC_CYCLIN_yClb1_LxF_4	14	19	PF00134	0.427
DOC_PP1_RVXF_1	14	20	PF00149	0.446
DOC_PP2B_LxvP_1	205	208	PF13499	0.373
DOC_USP7_MATH_1	57	61	PF00917	0.440
LIG_14-3-3_CanoR_1	20	29	PF00244	0.560
LIG_APCC_ABBA_1	73	78	PF00400	0.669
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_FHA_1	257	263	PF00498	0.511
LIG_FHA_2	25	31	PF00498	0.430
LIG_LIR_Apic_2	60	65	PF02991	0.594
LIG_LIR_Gen_1	147	158	PF02991	0.461
LIG_LIR_Gen_1	23	32	PF02991	0.433
LIG_LIR_Nem_3	147	153	PF02991	0.482
LIG_LIR_Nem_3	179	184	PF02991	0.555
LIG_LIR_Nem_3	23	29	PF02991	0.413
LIG_SH2_CRK	181	185	PF00017	0.449
LIG_SH2_CRK	215	219	PF00017	0.493
LIG_SH2_CRK	248	252	PF00017	0.438
LIG_SH2_PTP2	250	253	PF00017	0.438
LIG_SH2_SRC	173	176	PF00017	0.462
LIG_SH2_STAP1	224	228	PF00017	0.373
LIG_SH2_STAT5	173	176	PF00017	0.449
LIG_SH2_STAT5	248	251	PF00017	0.438
LIG_SH2_STAT5	62	65	PF00017	0.631
LIG_SH3_3	249	255	PF00018	0.407
LIG_SUMO_SIM_par_1	189	195	PF11976	0.373
LIG_TRAF2_1	144	147	PF00917	0.493
LIG_TRAF2_1	194	197	PF00917	0.493
LIG_TYR_ITIM	246	251	PF00017	0.449
MOD_CK1_1	141	147	PF00069	0.569
MOD_CK1_1	256	262	PF00069	0.545
MOD_CK2_1	141	147	PF00069	0.534
MOD_CK2_1	219	225	PF00069	0.480
MOD_CK2_1	24	30	PF00069	0.431
MOD_GlcNHglycan	126	129	PF01048	0.535
MOD_GlcNHglycan	159	162	PF01048	0.355
MOD_GlcNHglycan	48	52	PF01048	0.449
MOD_GSK3_1	20	27	PF00069	0.534
MOD_N-GLC_1	57	62	PF02516	0.476
MOD_N-GLC_2	247	249	PF02516	0.265
MOD_NEK2_1	149	154	PF00069	0.555
MOD_NEK2_1	184	189	PF00069	0.538
MOD_NEK2_1	46	51	PF00069	0.443
MOD_NEK2_2	230	235	PF00069	0.540
MOD_NEK2_2	57	62	PF00069	0.442
MOD_PKA_2	24	30	PF00069	0.558
MOD_Plk_1	119	125	PF00069	0.431
MOD_Plk_1	208	214	PF00069	0.500
MOD_Plk_1	219	225	PF00069	0.527
MOD_Plk_1	57	63	PF00069	0.443
MOD_Plk_2-3	105	111	PF00069	0.698
MOD_Plk_2-3	78	84	PF00069	0.573
MOD_Plk_4	149	155	PF00069	0.410
MOD_Plk_4	219	225	PF00069	0.473
MOD_Plk_4	230	236	PF00069	0.446
MOD_Plk_4	258	264	PF00069	0.493
MOD_Plk_4	57	63	PF00069	0.739
TRG_ENDOCYTIC_2	150	153	PF00928	0.460
TRG_ENDOCYTIC_2	181	184	PF00928	0.453
TRG_ENDOCYTIC_2	215	218	PF00928	0.540
TRG_ENDOCYTIC_2	248	251	PF00928	0.438
TRG_NES_CRM1_1	179	192	PF08389	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P369	Leptomonas seymouri	61%	70%
A0A0S4JGK6	Bodo saltans	32%	90%
A0A1X0NJZ3	Trypanosomatidae	31%	68%
A0A3S7X4F5	Leishmania donovani	79%	70%
A0A422NQV4	Trypanosoma rangeli	42%	76%
A4I6N4	Leishmania infantum	79%	70%
C9ZM71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	73%
E9B1Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	70%
Q4Q6F3	Leishmania major	79%	100%
V5DGC7	Trypanosoma cruzi	40%	68%