SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ86_LEIBR

TriTrypDb:

LbrM.31.1260 , LBRM2903_310020700

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HJ86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ86

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.530
CLV_C14_Caspase3-7	574	578	PF00656	0.595
CLV_NRD_NRD_1	134	136	PF00675	0.756
CLV_NRD_NRD_1	143	145	PF00675	0.579
CLV_NRD_NRD_1	164	166	PF00675	0.526
CLV_NRD_NRD_1	307	309	PF00675	0.197
CLV_NRD_NRD_1	365	367	PF00675	0.235
CLV_NRD_NRD_1	50	52	PF00675	0.725
CLV_NRD_NRD_1	714	716	PF00675	0.504
CLV_NRD_NRD_1	755	757	PF00675	0.593
CLV_PCSK_FUR_1	140	144	PF00082	0.554
CLV_PCSK_KEX2_1	134	136	PF00082	0.782
CLV_PCSK_KEX2_1	142	144	PF00082	0.600
CLV_PCSK_KEX2_1	164	166	PF00082	0.526
CLV_PCSK_KEX2_1	193	195	PF00082	0.526
CLV_PCSK_KEX2_1	303	305	PF00082	0.395
CLV_PCSK_KEX2_1	307	309	PF00082	0.343
CLV_PCSK_KEX2_1	365	367	PF00082	0.236
CLV_PCSK_KEX2_1	438	440	PF00082	0.294
CLV_PCSK_KEX2_1	50	52	PF00082	0.690
CLV_PCSK_KEX2_1	714	716	PF00082	0.507
CLV_PCSK_KEX2_1	755	757	PF00082	0.599
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.526
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.273
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.294
CLV_PCSK_SKI1_1	12	16	PF00082	0.380
CLV_PCSK_SKI1_1	25	29	PF00082	0.421
CLV_PCSK_SKI1_1	254	258	PF00082	0.579
CLV_PCSK_SKI1_1	303	307	PF00082	0.301
CLV_PCSK_SKI1_1	544	548	PF00082	0.257
CLV_PCSK_SKI1_1	560	564	PF00082	0.291
CLV_PCSK_SKI1_1	587	591	PF00082	0.275
CLV_PCSK_SKI1_1	85	89	PF00082	0.696
DOC_CYCLIN_RxL_1	415	426	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.388
DOC_MAPK_DCC_7	476	485	PF00069	0.388
DOC_MAPK_DCC_7	549	558	PF00069	0.494
DOC_MAPK_gen_1	164	175	PF00069	0.525
DOC_MAPK_gen_1	303	313	PF00069	0.533
DOC_MAPK_gen_1	549	558	PF00069	0.494
DOC_MAPK_gen_1	755	763	PF00069	0.408
DOC_MAPK_HePTP_8	546	558	PF00069	0.494
DOC_MAPK_MEF2A_6	12	21	PF00069	0.367
DOC_MAPK_MEF2A_6	307	315	PF00069	0.499
DOC_MAPK_MEF2A_6	476	485	PF00069	0.388
DOC_MAPK_MEF2A_6	549	558	PF00069	0.494
DOC_MAPK_RevD_3	180	194	PF00069	0.601
DOC_MAPK_RevD_3	290	304	PF00069	0.409
DOC_PP2B_LxvP_1	313	316	PF13499	0.472
DOC_USP7_MATH_1	138	142	PF00917	0.831
DOC_USP7_MATH_1	160	164	PF00917	0.659
DOC_USP7_MATH_1	167	171	PF00917	0.616
DOC_USP7_MATH_1	275	279	PF00917	0.537
DOC_USP7_MATH_1	320	324	PF00917	0.590
DOC_USP7_MATH_1	364	368	PF00917	0.584
DOC_USP7_MATH_1	454	458	PF00917	0.514
DOC_USP7_MATH_1	475	479	PF00917	0.494
DOC_USP7_MATH_1	53	57	PF00917	0.540
DOC_USP7_MATH_1	670	674	PF00917	0.494
DOC_USP7_MATH_1	737	741	PF00917	0.684
DOC_USP7_UBL2_3	193	197	PF12436	0.577
DOC_USP7_UBL2_3	581	585	PF12436	0.537
DOC_WW_Pin1_4	218	223	PF00397	0.564
DOC_WW_Pin1_4	232	237	PF00397	0.550
DOC_WW_Pin1_4	394	399	PF00397	0.441
DOC_WW_Pin1_4	653	658	PF00397	0.545
DOC_WW_Pin1_4	668	673	PF00397	0.500
DOC_WW_Pin1_4	738	743	PF00397	0.742
LIG_14-3-3_CanoR_1	134	138	PF00244	0.657
LIG_14-3-3_CanoR_1	142	150	PF00244	0.549
LIG_14-3-3_CanoR_1	267	276	PF00244	0.398
LIG_14-3-3_CanoR_1	293	301	PF00244	0.435
LIG_14-3-3_CanoR_1	32	39	PF00244	0.487
LIG_14-3-3_CanoR_1	341	350	PF00244	0.401
LIG_14-3-3_CanoR_1	365	370	PF00244	0.441
LIG_14-3-3_CanoR_1	404	412	PF00244	0.388
LIG_14-3-3_CanoR_1	476	481	PF00244	0.501
LIG_14-3-3_CanoR_1	755	763	PF00244	0.408
LIG_Actin_WH2_2	277	295	PF00022	0.435
LIG_BIR_III_4	252	256	PF00653	0.531
LIG_BIR_III_4	577	581	PF00653	0.494
LIG_BRCT_BRCA1_1	208	212	PF00533	0.566
LIG_BRCT_BRCA1_1	396	400	PF00533	0.442
LIG_BRCT_BRCA1_1	523	527	PF00533	0.388
LIG_BRCT_BRCA1_1	670	674	PF00533	0.388
LIG_EVH1_1	182	186	PF00568	0.504
LIG_FAT_LD_1	536	544	PF03623	0.388
LIG_FHA_1	312	318	PF00498	0.522
LIG_FHA_1	381	387	PF00498	0.507
LIG_FHA_1	491	497	PF00498	0.394
LIG_FHA_1	632	638	PF00498	0.485
LIG_FHA_1	648	654	PF00498	0.534
LIG_FHA_1	679	685	PF00498	0.535
LIG_FHA_2	149	155	PF00498	0.648
LIG_FHA_2	427	433	PF00498	0.436
LIG_Integrin_RGD_1	308	310	PF01839	0.265
LIG_LIR_Gen_1	10	21	PF02991	0.369
LIG_LIR_Gen_1	354	362	PF02991	0.441
LIG_LIR_Gen_1	671	680	PF02991	0.540
LIG_LIR_Nem_3	10	16	PF02991	0.379
LIG_LIR_Nem_3	354	358	PF02991	0.441
LIG_LIR_Nem_3	367	372	PF02991	0.441
LIG_LIR_Nem_3	397	403	PF02991	0.491
LIG_LIR_Nem_3	428	433	PF02991	0.388
LIG_LIR_Nem_3	500	506	PF02991	0.388
LIG_LIR_Nem_3	671	677	PF02991	0.540
LIG_LIR_Nem_3	699	705	PF02991	0.331
LIG_PDZ_Class_2	758	763	PF00595	0.409
LIG_Pex14_1	451	455	PF04695	0.454
LIG_Pex14_2	118	122	PF04695	0.515
LIG_PTB_Apo_2	629	636	PF02174	0.535
LIG_PTB_Phospho_1	629	635	PF10480	0.508
LIG_SH2_CRK	23	27	PF00017	0.356
LIG_SH2_CRK	355	359	PF00017	0.535
LIG_SH2_CRK	503	507	PF00017	0.388
LIG_SH2_CRK	707	711	PF00017	0.434
LIG_SH2_NCK_1	342	346	PF00017	0.520
LIG_SH2_NCK_1	455	459	PF00017	0.535
LIG_SH2_NCK_1	698	702	PF00017	0.470
LIG_SH2_SRC	591	594	PF00017	0.494
LIG_SH2_STAP1	301	305	PF00017	0.535
LIG_SH2_STAP1	342	346	PF00017	0.535
LIG_SH2_STAP1	455	459	PF00017	0.419
LIG_SH2_STAP1	698	702	PF00017	0.351
LIG_SH2_STAT5	23	26	PF00017	0.356
LIG_SH2_STAT5	402	405	PF00017	0.441
LIG_SH2_STAT5	555	558	PF00017	0.485
LIG_SH2_STAT5	635	638	PF00017	0.472
LIG_SH2_STAT5	694	697	PF00017	0.414
LIG_SH2_STAT5	702	705	PF00017	0.292
LIG_SH3_2	183	188	PF14604	0.509
LIG_SH3_3	172	178	PF00018	0.576
LIG_SH3_3	180	186	PF00018	0.583
LIG_SH3_3	198	204	PF00018	0.503
LIG_SH3_3	221	227	PF00018	0.485
LIG_SH3_3	258	264	PF00018	0.321
LIG_SH3_3	3	9	PF00018	0.426
LIG_SH3_3	347	353	PF00018	0.554
LIG_SH3_3	395	401	PF00018	0.456
LIG_SH3_3	421	427	PF00018	0.441
LIG_SH3_3	739	745	PF00018	0.602
LIG_SUMO_SIM_par_1	649	656	PF11976	0.548
LIG_TYR_ITIM	21	26	PF00017	0.350
LIG_TYR_ITIM	553	558	PF00017	0.388
LIG_UBA3_1	17	25	PF00899	0.354
LIG_UBA3_1	482	487	PF00899	0.388
MOD_CDK_SPK_2	218	223	PF00069	0.526
MOD_CDK_SPxxK_3	218	225	PF00069	0.494
MOD_CK1_1	145	151	PF00069	0.547
MOD_CK1_1	199	205	PF00069	0.443
MOD_CK1_1	231	237	PF00069	0.520
MOD_CK1_1	247	253	PF00069	0.538
MOD_CK1_1	354	360	PF00069	0.454
MOD_CK1_1	507	513	PF00069	0.490
MOD_CK1_1	56	62	PF00069	0.606
MOD_CK1_1	664	670	PF00069	0.456
MOD_CK1_1	738	744	PF00069	0.646
MOD_CK1_1	746	752	PF00069	0.435
MOD_CK1_1	81	87	PF00069	0.766
MOD_CK1_1	96	102	PF00069	0.517
MOD_CK2_1	148	154	PF00069	0.537
MOD_CK2_1	404	410	PF00069	0.420
MOD_CK2_1	426	432	PF00069	0.424
MOD_CK2_1	454	460	PF00069	0.476
MOD_CK2_1	646	652	PF00069	0.572
MOD_CK2_1	710	716	PF00069	0.584
MOD_GlcNHglycan	156	159	PF01048	0.703
MOD_GlcNHglycan	277	280	PF01048	0.490
MOD_GlcNHglycan	362	365	PF01048	0.213
MOD_GlcNHglycan	407	410	PF01048	0.335
MOD_GlcNHglycan	456	459	PF01048	0.335
MOD_GlcNHglycan	523	526	PF01048	0.289
MOD_GlcNHglycan	668	671	PF01048	0.267
MOD_GlcNHglycan	737	740	PF01048	0.730
MOD_GlcNHglycan	751	754	PF01048	0.385
MOD_GlcNHglycan	90	93	PF01048	0.624
MOD_GlcNHglycan	95	98	PF01048	0.547
MOD_GSK3_1	138	145	PF00069	0.597
MOD_GSK3_1	202	209	PF00069	0.582
MOD_GSK3_1	228	235	PF00069	0.526
MOD_GSK3_1	320	327	PF00069	0.533
MOD_GSK3_1	360	367	PF00069	0.533
MOD_GSK3_1	471	478	PF00069	0.432
MOD_GSK3_1	608	615	PF00069	0.535
MOD_GSK3_1	64	71	PF00069	0.705
MOD_GSK3_1	640	647	PF00069	0.494
MOD_GSK3_1	664	671	PF00069	0.533
MOD_GSK3_1	696	703	PF00069	0.361
MOD_GSK3_1	737	744	PF00069	0.749
MOD_GSK3_1	77	84	PF00069	0.618
MOD_N-GLC_1	218	223	PF02516	0.535
MOD_N-GLC_1	259	264	PF02516	0.426
MOD_N-GLC_1	631	636	PF02516	0.297
MOD_N-GLC_1	653	658	PF02516	0.268
MOD_N-GLC_1	88	93	PF02516	0.779
MOD_NEK2_1	228	233	PF00069	0.526
MOD_NEK2_1	269	274	PF00069	0.475
MOD_NEK2_1	292	297	PF00069	0.261
MOD_NEK2_1	39	44	PF00069	0.524
MOD_NEK2_1	690	695	PF00069	0.518
MOD_PIKK_1	133	139	PF00454	0.555
MOD_PIKK_1	202	208	PF00454	0.574
MOD_PIKK_1	32	38	PF00454	0.601
MOD_PIKK_1	53	59	PF00454	0.623
MOD_PK_1	476	482	PF00069	0.388
MOD_PK_1	696	702	PF00069	0.424
MOD_PKA_1	142	148	PF00069	0.553
MOD_PKA_1	365	371	PF00069	0.426
MOD_PKA_2	133	139	PF00069	0.728
MOD_PKA_2	142	148	PF00069	0.602
MOD_PKA_2	154	160	PF00069	0.778
MOD_PKA_2	167	173	PF00069	0.509
MOD_PKA_2	206	212	PF00069	0.586
MOD_PKA_2	292	298	PF00069	0.465
MOD_PKA_2	340	346	PF00069	0.412
MOD_PKA_2	364	370	PF00069	0.441
MOD_PKA_2	475	481	PF00069	0.501
MOD_PKA_2	678	684	PF00069	0.496
MOD_PKB_1	140	148	PF00069	0.553
MOD_Plk_1	244	250	PF00069	0.603
MOD_Plk_1	631	637	PF00069	0.500
MOD_Plk_1	664	670	PF00069	0.436
MOD_Plk_1	688	694	PF00069	0.471
MOD_Plk_2-3	426	432	PF00069	0.408
MOD_Plk_4	244	250	PF00069	0.550
MOD_Plk_4	269	275	PF00069	0.453
MOD_Plk_4	426	432	PF00069	0.388
MOD_Plk_4	523	529	PF00069	0.397
MOD_Plk_4	612	618	PF00069	0.452
MOD_Plk_4	690	696	PF00069	0.474
MOD_Plk_4	700	706	PF00069	0.288
MOD_Plk_4	746	752	PF00069	0.477
MOD_Plk_4	757	763	PF00069	0.627
MOD_ProDKin_1	218	224	PF00069	0.563
MOD_ProDKin_1	232	238	PF00069	0.542
MOD_ProDKin_1	394	400	PF00069	0.441
MOD_ProDKin_1	653	659	PF00069	0.545
MOD_ProDKin_1	668	674	PF00069	0.500
MOD_ProDKin_1	738	744	PF00069	0.739
MOD_SUMO_rev_2	510	519	PF00179	0.466
TRG_DiLeu_BaEn_1	285	290	PF01217	0.427
TRG_DiLeu_BaEn_4	685	691	PF01217	0.472
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.497
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.497
TRG_ENDOCYTIC_2	23	26	PF00928	0.356
TRG_ENDOCYTIC_2	355	358	PF00928	0.454
TRG_ENDOCYTIC_2	402	405	PF00928	0.469
TRG_ENDOCYTIC_2	503	506	PF00928	0.494
TRG_ENDOCYTIC_2	555	558	PF00928	0.388
TRG_ENDOCYTIC_2	707	710	PF00928	0.443
TRG_ER_diArg_1	140	143	PF00400	0.579
TRG_ER_diArg_1	306	308	PF00400	0.388
TRG_ER_diArg_1	49	51	PF00400	0.700
TRG_ER_diArg_1	754	756	PF00400	0.617
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM8	Leptomonas seymouri	50%	100%
A0A0S4IKB7	Bodo saltans	34%	100%
A0A1X0NJ79	Trypanosomatidae	41%	100%
A0A3S7X4A8	Leishmania donovani	77%	100%
A4I6N0	Leishmania infantum	77%	100%
C9ZM67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q6F7	Leishmania major	77%	100%
V5BPH7	Trypanosoma cruzi	41%	100%