RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ83_LEIBR

TriTrypDb:

LbrM.31.1230 , LBRM2903_310020200

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ83

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.642
CLV_C14_Caspase3-7	27	31	PF00656	0.641
CLV_C14_Caspase3-7	310	314	PF00656	0.371
CLV_C14_Caspase3-7	554	558	PF00656	0.538
CLV_NRD_NRD_1	164	166	PF00675	0.546
CLV_NRD_NRD_1	257	259	PF00675	0.463
CLV_NRD_NRD_1	774	776	PF00675	0.398
CLV_PCSK_KEX2_1	257	259	PF00082	0.463
CLV_PCSK_KEX2_1	308	310	PF00082	0.421
CLV_PCSK_KEX2_1	644	646	PF00082	0.391
CLV_PCSK_KEX2_1	774	776	PF00082	0.398
CLV_PCSK_KEX2_1	856	858	PF00082	0.424
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.399
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.388
CLV_PCSK_PC1ET2_1	856	858	PF00082	0.424
CLV_PCSK_SKI1_1	14	18	PF00082	0.510
CLV_PCSK_SKI1_1	566	570	PF00082	0.541
CLV_PCSK_SKI1_1	59	63	PF00082	0.569
CLV_PCSK_SKI1_1	781	785	PF00082	0.343
CLV_PCSK_SKI1_1	814	818	PF00082	0.406
CLV_PCSK_SKI1_1	857	861	PF00082	0.384
CLV_PCSK_SKI1_1	864	868	PF00082	0.372
CLV_Separin_Metazoa	876	880	PF03568	0.320
DEG_APCC_DBOX_1	697	705	PF00400	0.511
DEG_APCC_DBOX_1	780	788	PF00400	0.342
DEG_SCF_FBW7_1	332	339	PF00400	0.509
DEG_SCF_FBW7_1	496	502	PF00400	0.492
DEG_SPOP_SBC_1	23	27	PF00917	0.495
DEG_SPOP_SBC_1	336	340	PF00917	0.562
DEG_SPOP_SBC_1	762	766	PF00917	0.516
DOC_CKS1_1	442	447	PF01111	0.546
DOC_CKS1_1	496	501	PF01111	0.490
DOC_CYCLIN_RxL_1	198	208	PF00134	0.370
DOC_CYCLIN_yClb5_NLxxxL_5	642	651	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	522	525	PF00134	0.586
DOC_MAPK_gen_1	257	263	PF00069	0.447
DOC_MAPK_MEF2A_6	781	790	PF00069	0.341
DOC_PP1_RVXF_1	855	862	PF00149	0.405
DOC_PP2B_LxvP_1	126	129	PF13499	0.593
DOC_PP2B_LxvP_1	522	525	PF13499	0.590
DOC_PP4_FxxP_1	521	524	PF00568	0.665
DOC_PP4_FxxP_1	62	65	PF00568	0.528
DOC_PP4_FxxP_1	723	726	PF00568	0.565
DOC_USP7_MATH_1	15	19	PF00917	0.549
DOC_USP7_MATH_1	190	194	PF00917	0.465
DOC_USP7_MATH_1	24	28	PF00917	0.512
DOC_USP7_MATH_1	314	318	PF00917	0.458
DOC_USP7_MATH_1	438	442	PF00917	0.599
DOC_USP7_MATH_1	463	467	PF00917	0.643
DOC_USP7_MATH_1	477	481	PF00917	0.539
DOC_USP7_MATH_1	507	511	PF00917	0.511
DOC_USP7_MATH_1	65	69	PF00917	0.616
DOC_USP7_MATH_1	751	755	PF00917	0.700
DOC_USP7_MATH_1	762	766	PF00917	0.514
DOC_USP7_UBL2_3	175	179	PF12436	0.481
DOC_WW_Pin1_4	103	108	PF00397	0.602
DOC_WW_Pin1_4	120	125	PF00397	0.473
DOC_WW_Pin1_4	294	299	PF00397	0.402
DOC_WW_Pin1_4	332	337	PF00397	0.621
DOC_WW_Pin1_4	339	344	PF00397	0.601
DOC_WW_Pin1_4	354	359	PF00397	0.528
DOC_WW_Pin1_4	365	370	PF00397	0.586
DOC_WW_Pin1_4	383	388	PF00397	0.515
DOC_WW_Pin1_4	396	401	PF00397	0.640
DOC_WW_Pin1_4	436	441	PF00397	0.622
DOC_WW_Pin1_4	495	500	PF00397	0.532
DOC_WW_Pin1_4	54	59	PF00397	0.650
DOC_WW_Pin1_4	829	834	PF00397	0.377
LIG_14-3-3_CanoR_1	487	496	PF00244	0.494
LIG_14-3-3_CanoR_1	513	518	PF00244	0.508
LIG_14-3-3_CanoR_1	625	632	PF00244	0.367
LIG_14-3-3_CanoR_1	645	654	PF00244	0.376
LIG_14-3-3_CanoR_1	694	701	PF00244	0.570
LIG_14-3-3_CanoR_1	803	807	PF00244	0.312
LIG_14-3-3_CanoR_1	864	873	PF00244	0.368
LIG_BIR_III_2	290	294	PF00653	0.446
LIG_BIR_III_2	649	653	PF00653	0.375
LIG_BIR_III_4	588	592	PF00653	0.352
LIG_BRCT_BRCA1_1	30	34	PF00533	0.510
LIG_BRCT_BRCA1_1	4	8	PF00533	0.511
LIG_eIF4E_1	56	62	PF01652	0.527
LIG_eIF4E_1	782	788	PF01652	0.339
LIG_EVH1_1	126	130	PF00568	0.594
LIG_FHA_1	190	196	PF00498	0.448
LIG_FHA_1	197	203	PF00498	0.375
LIG_FHA_1	24	30	PF00498	0.686
LIG_FHA_1	295	301	PF00498	0.337
LIG_FHA_1	336	342	PF00498	0.586
LIG_FHA_1	419	425	PF00498	0.661
LIG_FHA_1	500	506	PF00498	0.670
LIG_FHA_1	617	623	PF00498	0.432
LIG_FHA_1	803	809	PF00498	0.311
LIG_FHA_2	142	148	PF00498	0.578
LIG_FHA_2	308	314	PF00498	0.460
LIG_FHA_2	496	502	PF00498	0.576
LIG_FHA_2	531	537	PF00498	0.618
LIG_FHA_2	554	560	PF00498	0.460
LIG_FHA_2	866	872	PF00498	0.440
LIG_IBAR_NPY_1	151	153	PF08397	0.557
LIG_LIR_Apic_2	154	158	PF02991	0.572
LIG_LIR_Apic_2	520	524	PF02991	0.669
LIG_LIR_Gen_1	113	119	PF02991	0.592
LIG_LIR_Gen_1	223	229	PF02991	0.370
LIG_LIR_Gen_1	31	42	PF02991	0.645
LIG_LIR_Gen_1	884	892	PF02991	0.377
LIG_LIR_Nem_3	113	117	PF02991	0.593
LIG_LIR_Nem_3	173	177	PF02991	0.478
LIG_LIR_Nem_3	223	227	PF02991	0.372
LIG_LIR_Nem_3	31	37	PF02991	0.591
LIG_LIR_Nem_3	316	321	PF02991	0.437
LIG_LIR_Nem_3	717	723	PF02991	0.569
LIG_LIR_Nem_3	77	83	PF02991	0.746
LIG_LIR_Nem_3	776	782	PF02991	0.360
LIG_LIR_Nem_3	839	845	PF02991	0.460
LIG_LIR_Nem_3	860	865	PF02991	0.401
LIG_LIR_Nem_3	884	890	PF02991	0.383
LIG_MYND_1	124	128	PF01753	0.599
LIG_NRBOX	595	601	PF00104	0.361
LIG_PAM2_1	354	366	PF00658	0.605
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.528
LIG_PCNA_yPIPBox_3	275	288	PF02747	0.444
LIG_Pex14_1	239	243	PF04695	0.378
LIG_Pex14_2	862	866	PF04695	0.403
LIG_PROFILIN_1	127	133	PF00235	0.498
LIG_SH2_CRK	114	118	PF00017	0.662
LIG_SH2_CRK	155	159	PF00017	0.571
LIG_SH2_CRK	842	846	PF00017	0.437
LIG_SH2_GRB2like	318	321	PF00017	0.438
LIG_SH2_NCK_1	806	810	PF00017	0.376
LIG_SH2_SRC	653	656	PF00017	0.288
LIG_SH2_STAP1	4	8	PF00017	0.511
LIG_SH2_STAP1	711	715	PF00017	0.492
LIG_SH2_STAP1	806	810	PF00017	0.376
LIG_SH2_STAT5	153	156	PF00017	0.584
LIG_SH2_STAT5	162	165	PF00017	0.548
LIG_SH2_STAT5	224	227	PF00017	0.362
LIG_SH2_STAT5	41	44	PF00017	0.663
LIG_SH2_STAT5	431	434	PF00017	0.534
LIG_SH2_STAT5	653	656	PF00017	0.325
LIG_SH2_STAT5	782	785	PF00017	0.340
LIG_SH3_1	52	58	PF00018	0.601
LIG_SH3_3	121	127	PF00018	0.634
LIG_SH3_3	264	270	PF00018	0.463
LIG_SH3_3	471	477	PF00018	0.681
LIG_SH3_3	493	499	PF00018	0.483
LIG_SH3_3	52	58	PF00018	0.601
LIG_SH3_5	158	162	PF00018	0.559
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.361
LIG_SUMO_SIM_par_1	595	601	PF11976	0.375
LIG_TRAF2_1	178	181	PF00917	0.485
LIG_TRAF2_1	793	796	PF00917	0.357
LIG_TRFH_1	521	525	PF08558	0.664
LIG_UBA3_1	300	308	PF00899	0.409
LIG_UBA3_1	635	644	PF00899	0.334
LIG_WW_2	124	127	PF00397	0.602
LIG_WW_3	444	448	PF00397	0.545
MOD_CDK_SPK_2	54	59	PF00069	0.599
MOD_CDK_SPxK_1	441	447	PF00069	0.545
MOD_CDK_SPxxK_3	354	361	PF00069	0.607
MOD_CDK_SPxxK_3	383	390	PF00069	0.542
MOD_CK1_1	106	112	PF00069	0.700
MOD_CK1_1	3	9	PF00069	0.582
MOD_CK1_1	416	422	PF00069	0.788
MOD_CK1_1	425	431	PF00069	0.770
MOD_CK1_1	441	447	PF00069	0.546
MOD_CK1_1	508	514	PF00069	0.765
MOD_CK1_1	763	769	PF00069	0.483
MOD_CK1_1	851	857	PF00069	0.506
MOD_CK2_1	256	262	PF00069	0.456
MOD_CK2_1	495	501	PF00069	0.572
MOD_CK2_1	592	598	PF00069	0.397
MOD_CK2_1	657	663	PF00069	0.353
MOD_CK2_1	725	731	PF00069	0.688
MOD_CK2_1	733	739	PF00069	0.630
MOD_CK2_1	762	768	PF00069	0.500
MOD_CK2_1	790	796	PF00069	0.355
MOD_CK2_1	865	871	PF00069	0.381
MOD_GlcNHglycan	19	22	PF01048	0.594
MOD_GlcNHglycan	258	261	PF01048	0.479
MOD_GlcNHglycan	26	29	PF01048	0.634
MOD_GlcNHglycan	277	280	PF01048	0.422
MOD_GlcNHglycan	391	394	PF01048	0.572
MOD_GlcNHglycan	418	421	PF01048	0.650
MOD_GlcNHglycan	432	435	PF01048	0.559
MOD_GlcNHglycan	465	468	PF01048	0.692
MOD_GlcNHglycan	481	484	PF01048	0.503
MOD_GlcNHglycan	489	492	PF01048	0.698
MOD_GlcNHglycan	553	556	PF01048	0.674
MOD_GlcNHglycan	608	611	PF01048	0.448
MOD_GlcNHglycan	749	752	PF01048	0.758
MOD_GlcNHglycan	820	823	PF01048	0.512
MOD_GlcNHglycan	89	92	PF01048	0.623
MOD_GSK3_1	106	113	PF00069	0.554
MOD_GSK3_1	205	212	PF00069	0.365
MOD_GSK3_1	24	31	PF00069	0.561
MOD_GSK3_1	331	338	PF00069	0.711
MOD_GSK3_1	409	416	PF00069	0.771
MOD_GSK3_1	418	425	PF00069	0.669
MOD_GSK3_1	432	439	PF00069	0.548
MOD_GSK3_1	454	461	PF00069	0.599
MOD_GSK3_1	495	502	PF00069	0.552
MOD_GSK3_1	508	515	PF00069	0.479
MOD_GSK3_1	549	556	PF00069	0.501
MOD_GSK3_1	606	613	PF00069	0.403
MOD_GSK3_1	745	752	PF00069	0.645
MOD_GSK3_1	758	765	PF00069	0.544
MOD_GSK3_1	83	90	PF00069	0.705
MOD_GSK3_1	845	852	PF00069	0.531
MOD_N-GLC_1	120	125	PF02516	0.678
MOD_N-GLC_1	231	236	PF02516	0.459
MOD_N-GLC_1	645	650	PF02516	0.376
MOD_N-GLC_1	65	70	PF02516	0.536
MOD_N-GLC_1	848	853	PF02516	0.482
MOD_N-GLC_2	120	122	PF02516	0.528
MOD_NEK2_1	141	146	PF00069	0.674
MOD_NEK2_1	196	201	PF00069	0.378
MOD_NEK2_1	246	251	PF00069	0.423
MOD_NEK2_1	256	261	PF00069	0.488
MOD_NEK2_1	337	342	PF00069	0.637
MOD_NEK2_1	549	554	PF00069	0.662
MOD_NEK2_1	579	584	PF00069	0.386
MOD_NEK2_1	669	674	PF00069	0.459
MOD_NEK2_1	828	833	PF00069	0.527
MOD_NEK2_1	83	88	PF00069	0.542
MOD_NEK2_2	589	594	PF00069	0.348
MOD_PIKK_1	432	438	PF00454	0.584
MOD_PIKK_1	579	585	PF00454	0.415
MOD_PIKK_1	624	630	PF00454	0.363
MOD_PIKK_1	669	675	PF00454	0.464
MOD_PIKK_1	680	686	PF00454	0.575
MOD_PIKK_1	93	99	PF00454	0.690
MOD_PK_1	513	519	PF00069	0.535
MOD_PKA_2	256	262	PF00069	0.476
MOD_PKA_2	389	395	PF00069	0.534
MOD_PKA_2	46	52	PF00069	0.553
MOD_PKA_2	512	518	PF00069	0.509
MOD_PKA_2	624	630	PF00069	0.393
MOD_PKA_2	693	699	PF00069	0.571
MOD_PKA_2	802	808	PF00069	0.312
MOD_PKB_1	564	572	PF00069	0.452
MOD_Plk_1	540	546	PF00069	0.496
MOD_Plk_1	566	572	PF00069	0.450
MOD_Plk_1	857	863	PF00069	0.373
MOD_Plk_2-3	110	116	PF00069	0.659
MOD_Plk_2-3	30	36	PF00069	0.658
MOD_Plk_4	205	211	PF00069	0.363
MOD_Plk_4	314	320	PF00069	0.415
MOD_Plk_4	513	519	PF00069	0.575
MOD_Plk_4	725	731	PF00069	0.500
MOD_ProDKin_1	103	109	PF00069	0.598
MOD_ProDKin_1	120	126	PF00069	0.472
MOD_ProDKin_1	294	300	PF00069	0.401
MOD_ProDKin_1	332	338	PF00069	0.622
MOD_ProDKin_1	339	345	PF00069	0.603
MOD_ProDKin_1	354	360	PF00069	0.527
MOD_ProDKin_1	365	371	PF00069	0.588
MOD_ProDKin_1	383	389	PF00069	0.517
MOD_ProDKin_1	396	402	PF00069	0.632
MOD_ProDKin_1	436	442	PF00069	0.626
MOD_ProDKin_1	495	501	PF00069	0.536
MOD_ProDKin_1	54	60	PF00069	0.647
MOD_ProDKin_1	829	835	PF00069	0.370
MOD_SUMO_for_1	178	181	PF00179	0.485
MOD_SUMO_for_1	408	411	PF00179	0.518
TRG_DiLeu_BaEn_1	181	186	PF01217	0.482
TRG_DiLeu_BaEn_1	768	773	PF01217	0.458
TRG_DiLeu_BaEn_4	78	84	PF01217	0.543
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.602
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.347
TRG_ENDOCYTIC_2	114	117	PF00928	0.589
TRG_ENDOCYTIC_2	224	227	PF00928	0.362
TRG_ENDOCYTIC_2	241	244	PF00928	0.374
TRG_ENDOCYTIC_2	318	321	PF00928	0.438
TRG_ENDOCYTIC_2	587	590	PF00928	0.396
TRG_ENDOCYTIC_2	720	723	PF00928	0.584
TRG_ENDOCYTIC_2	842	845	PF00928	0.538
TRG_ER_diArg_1	182	185	PF00400	0.481
TRG_ER_diArg_1	225	228	PF00400	0.402
TRG_ER_diArg_1	256	258	PF00400	0.453
TRG_ER_diArg_1	773	775	PF00400	0.411
TRG_NES_CRM1_1	588	601	PF08389	0.452
TRG_NES_CRM1_1	649	663	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P425	Leptomonas seymouri	58%	98%
A0A3S7X4F6	Leishmania donovani	80%	100%
A4I6M7	Leishmania infantum	80%	100%
E9B1Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q6G0	Leishmania major	79%	99%