Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ82_LEIBR

TriTrypDb:

LbrM.31.1220 , LBRM2903_310020000 , LBRM2903_310020100

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.537
CLV_C14_Caspase3-7	405	409	PF00656	0.516
CLV_C14_Caspase3-7	637	641	PF00656	0.529
CLV_NRD_NRD_1	213	215	PF00675	0.583
CLV_NRD_NRD_1	266	268	PF00675	0.726
CLV_NRD_NRD_1	281	283	PF00675	0.453
CLV_NRD_NRD_1	489	491	PF00675	0.455
CLV_NRD_NRD_1	771	773	PF00675	0.520
CLV_PCSK_KEX2_1	213	215	PF00082	0.583
CLV_PCSK_KEX2_1	266	268	PF00082	0.686
CLV_PCSK_KEX2_1	281	283	PF00082	0.466
CLV_PCSK_KEX2_1	290	292	PF00082	0.519
CLV_PCSK_KEX2_1	489	491	PF00082	0.455
CLV_PCSK_KEX2_1	59	61	PF00082	0.702
CLV_PCSK_KEX2_1	67	69	PF00082	0.594
CLV_PCSK_KEX2_1	699	701	PF00082	0.435
CLV_PCSK_KEX2_1	771	773	PF00082	0.520
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.550
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.657
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.660
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.379
CLV_PCSK_SKI1_1	385	389	PF00082	0.707
CLV_PCSK_SKI1_1	45	49	PF00082	0.827
CLV_PCSK_SKI1_1	483	487	PF00082	0.471
CLV_PCSK_SKI1_1	540	544	PF00082	0.466
CLV_PCSK_SKI1_1	565	569	PF00082	0.582
CLV_PCSK_SKI1_1	603	607	PF00082	0.420
CLV_PCSK_SKI1_1	705	709	PF00082	0.487
CLV_PCSK_SKI1_1	772	776	PF00082	0.515
CLV_PCSK_SKI1_1	777	781	PF00082	0.545
CLV_PCSK_SKI1_1	847	851	PF00082	0.624
DEG_SCF_FBW7_1	47	54	PF00400	0.543
DEG_SCF_TRCP1_1	241	246	PF00400	0.539
DEG_SIAH_1	877	885	PF03145	0.521
DEG_SPOP_SBC_1	139	143	PF00917	0.501
DEG_SPOP_SBC_1	713	717	PF00917	0.681
DOC_ANK_TNKS_1	785	792	PF00023	0.521
DOC_CDC14_PxL_1	520	528	PF14671	0.396
DOC_CKS1_1	48	53	PF01111	0.615
DOC_CKS1_1	686	691	PF01111	0.401
DOC_CYCLIN_RxL_1	536	547	PF00134	0.452
DOC_CYCLIN_RxL_1	597	608	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	707	710	PF00134	0.480
DOC_MAPK_gen_1	505	514	PF00069	0.307
DOC_MAPK_gen_1	771	778	PF00069	0.439
DOC_MAPK_MEF2A_6	771	778	PF00069	0.429
DOC_MAPK_NFAT4_5	771	779	PF00069	0.431
DOC_PP1_RVXF_1	481	487	PF00149	0.528
DOC_PP2B_LxvP_1	369	372	PF13499	0.475
DOC_PP2B_LxvP_1	707	710	PF13499	0.480
DOC_PP4_FxxP_1	598	601	PF00568	0.304
DOC_USP7_MATH_1	239	243	PF00917	0.671
DOC_USP7_MATH_1	254	258	PF00917	0.665
DOC_USP7_MATH_1	308	312	PF00917	0.612
DOC_USP7_MATH_1	327	331	PF00917	0.585
DOC_USP7_MATH_1	354	358	PF00917	0.586
DOC_USP7_MATH_1	474	478	PF00917	0.465
DOC_USP7_MATH_1	621	625	PF00917	0.511
DOC_USP7_MATH_1	735	739	PF00917	0.527
DOC_USP7_MATH_1	831	835	PF00917	0.640
DOC_USP7_MATH_2	51	57	PF00917	0.534
DOC_USP7_UBL2_3	272	276	PF12436	0.479
DOC_USP7_UBL2_3	286	290	PF12436	0.539
DOC_WW_Pin1_4	148	153	PF00397	0.697
DOC_WW_Pin1_4	187	192	PF00397	0.535
DOC_WW_Pin1_4	222	227	PF00397	0.765
DOC_WW_Pin1_4	267	272	PF00397	0.508
DOC_WW_Pin1_4	28	33	PF00397	0.552
DOC_WW_Pin1_4	447	452	PF00397	0.595
DOC_WW_Pin1_4	465	470	PF00397	0.485
DOC_WW_Pin1_4	47	52	PF00397	0.598
DOC_WW_Pin1_4	685	690	PF00397	0.405
DOC_WW_Pin1_4	798	803	PF00397	0.541
LIG_14-3-3_CanoR_1	216	226	PF00244	0.607
LIG_14-3-3_CanoR_1	233	239	PF00244	0.530
LIG_14-3-3_CanoR_1	404	412	PF00244	0.510
LIG_14-3-3_CanoR_1	455	460	PF00244	0.585
LIG_14-3-3_CanoR_1	71	77	PF00244	0.669
LIG_14-3-3_CanoR_1	718	724	PF00244	0.555
LIG_14-3-3_CanoR_1	732	741	PF00244	0.502
LIG_14-3-3_CanoR_1	757	767	PF00244	0.435
LIG_14-3-3_CanoR_1	82	86	PF00244	0.559
LIG_14-3-3_CanoR_1	890	898	PF00244	0.548
LIG_Actin_WH2_2	343	361	PF00022	0.667
LIG_Actin_WH2_2	863	879	PF00022	0.581
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	4	8	PF00533	0.486
LIG_Clathr_ClatBox_1	108	112	PF01394	0.548
LIG_Clathr_ClatBox_1	418	422	PF01394	0.492
LIG_deltaCOP1_diTrp_1	493	497	PF00928	0.343
LIG_deltaCOP1_diTrp_1	599	606	PF00928	0.403
LIG_deltaCOP1_diTrp_1	677	682	PF00928	0.382
LIG_eIF4E_1	480	486	PF01652	0.531
LIG_EVH1_1	708	712	PF00568	0.589
LIG_FHA_1	104	110	PF00498	0.750
LIG_FHA_1	195	201	PF00498	0.603
LIG_FHA_1	28	34	PF00498	0.630
LIG_FHA_1	336	342	PF00498	0.755
LIG_FHA_1	345	351	PF00498	0.528
LIG_FHA_1	360	366	PF00498	0.668
LIG_FHA_1	686	692	PF00498	0.370
LIG_FHA_1	893	899	PF00498	0.564
LIG_FHA_2	248	254	PF00498	0.548
LIG_FHA_2	312	318	PF00498	0.649
LIG_FHA_2	48	54	PF00498	0.543
LIG_FHA_2	529	535	PF00498	0.499
LIG_FHA_2	626	632	PF00498	0.536
LIG_FHA_2	802	808	PF00498	0.682
LIG_FHA_2	904	910	PF00498	0.706
LIG_LIR_Apic_2	560	566	PF02991	0.405
LIG_LIR_Apic_2	595	601	PF02991	0.330
LIG_LIR_Gen_1	2	8	PF02991	0.484
LIG_LIR_Gen_1	297	306	PF02991	0.494
LIG_LIR_Gen_1	493	500	PF02991	0.342
LIG_LIR_Gen_1	590	598	PF02991	0.617
LIG_LIR_Gen_1	604	613	PF02991	0.402
LIG_LIR_Gen_1	84	93	PF02991	0.500
LIG_LIR_Gen_1	929	935	PF02991	0.537
LIG_LIR_Nem_3	2	7	PF02991	0.483
LIG_LIR_Nem_3	297	302	PF02991	0.483
LIG_LIR_Nem_3	493	497	PF02991	0.343
LIG_LIR_Nem_3	590	594	PF02991	0.508
LIG_LIR_Nem_3	599	605	PF02991	0.429
LIG_LIR_Nem_3	681	687	PF02991	0.302
LIG_LIR_Nem_3	747	753	PF02991	0.643
LIG_LIR_Nem_3	84	89	PF02991	0.481
LIG_LIR_Nem_3	929	934	PF02991	0.532
LIG_NRBOX	495	501	PF00104	0.338
LIG_PCNA_yPIPBox_3	203	216	PF02747	0.496
LIG_Pex14_1	602	606	PF04695	0.406
LIG_Pex14_1	679	683	PF04695	0.367
LIG_Pex14_2	234	238	PF04695	0.528
LIG_Pex14_2	4	8	PF04695	0.486
LIG_Pex14_2	598	602	PF04695	0.394
LIG_Pex14_2	926	930	PF04695	0.535
LIG_SH2_CRK	367	371	PF00017	0.667
LIG_SH2_CRK	380	384	PF00017	0.696
LIG_SH2_CRK	429	433	PF00017	0.750
LIG_SH2_CRK	563	567	PF00017	0.440
LIG_SH2_NCK_1	380	384	PF00017	0.653
LIG_SH2_PTP2	521	524	PF00017	0.388
LIG_SH2_SRC	380	383	PF00017	0.508
LIG_SH2_SRC	521	524	PF00017	0.461
LIG_SH2_SRC	96	99	PF00017	0.663
LIG_SH2_STAT5	480	483	PF00017	0.410
LIG_SH2_STAT5	521	524	PF00017	0.426
LIG_SH2_STAT5	583	586	PF00017	0.528
LIG_SH2_STAT5	612	615	PF00017	0.598
LIG_SH2_STAT5	686	689	PF00017	0.401
LIG_SH2_STAT5	750	753	PF00017	0.567
LIG_SH3_3	17	23	PF00018	0.540
LIG_SH3_3	185	191	PF00018	0.531
LIG_SH3_3	330	336	PF00018	0.567
LIG_SH3_3	706	712	PF00018	0.522
LIG_SH3_3	784	790	PF00018	0.510
LIG_SH3_3	796	802	PF00018	0.519
LIG_SH3_3	92	98	PF00018	0.602
LIG_SUMO_SIM_par_1	106	112	PF11976	0.707
LIG_TRAF2_1	191	194	PF00917	0.539
LIG_TRAF2_1	391	394	PF00917	0.539
LIG_TYR_ITIM	427	432	PF00017	0.746
LIG_TYR_ITIM	517	522	PF00017	0.582
LIG_TYR_ITIM	589	594	PF00017	0.353
MOD_CDK_SPK_2	267	272	PF00069	0.449
MOD_CDK_SPK_2	685	690	PF00069	0.311
MOD_CDK_SPxxK_3	465	472	PF00069	0.469
MOD_CK1_1	138	144	PF00069	0.503
MOD_CK1_1	172	178	PF00069	0.536
MOD_CK1_1	192	198	PF00069	0.540
MOD_CK1_1	2	8	PF00069	0.601
MOD_CK1_1	224	230	PF00069	0.596
MOD_CK1_1	24	30	PF00069	0.541
MOD_CK1_1	246	252	PF00069	0.599
MOD_CK1_1	257	263	PF00069	0.622
MOD_CK1_1	311	317	PF00069	0.565
MOD_CK1_1	344	350	PF00069	0.600
MOD_CK1_1	400	406	PF00069	0.669
MOD_CK1_1	465	471	PF00069	0.517
MOD_CK1_1	622	628	PF00069	0.508
MOD_CK1_1	693	699	PF00069	0.370
MOD_CK1_1	801	807	PF00069	0.611
MOD_CK1_1	822	828	PF00069	0.577
MOD_CK1_1	84	90	PF00069	0.547
MOD_CK1_1	889	895	PF00069	0.584
MOD_CK1_1	903	909	PF00069	0.678
MOD_CK1_1	929	935	PF00069	0.610
MOD_CK2_1	139	145	PF00069	0.590
MOD_CK2_1	187	193	PF00069	0.680
MOD_CK2_1	267	273	PF00069	0.613
MOD_CK2_1	311	317	PF00069	0.786
MOD_CK2_1	354	360	PF00069	0.662
MOD_CK2_1	47	53	PF00069	0.544
MOD_CK2_1	625	631	PF00069	0.617
MOD_CK2_1	717	723	PF00069	0.554
MOD_CK2_1	801	807	PF00069	0.704
MOD_CK2_1	849	855	PF00069	0.509
MOD_CK2_1	903	909	PF00069	0.544
MOD_CK2_1	929	935	PF00069	0.523
MOD_CMANNOS	679	682	PF00535	0.371
MOD_GlcNHglycan	127	130	PF01048	0.513
MOD_GlcNHglycan	142	145	PF01048	0.651
MOD_GlcNHglycan	169	172	PF01048	0.508
MOD_GlcNHglycan	174	177	PF01048	0.492
MOD_GlcNHglycan	227	230	PF01048	0.750
MOD_GlcNHglycan	23	26	PF01048	0.562
MOD_GlcNHglycan	241	244	PF01048	0.592
MOD_GlcNHglycan	262	265	PF01048	0.554
MOD_GlcNHglycan	304	307	PF01048	0.634
MOD_GlcNHglycan	310	313	PF01048	0.544
MOD_GlcNHglycan	325	328	PF01048	0.725
MOD_GlcNHglycan	329	332	PF01048	0.807
MOD_GlcNHglycan	437	440	PF01048	0.759
MOD_GlcNHglycan	546	549	PF01048	0.423
MOD_GlcNHglycan	55	58	PF01048	0.594
MOD_GlcNHglycan	570	573	PF01048	0.638
MOD_GlcNHglycan	636	639	PF01048	0.661
MOD_GlcNHglycan	670	673	PF01048	0.380
MOD_GlcNHglycan	692	695	PF01048	0.471
MOD_GlcNHglycan	72	75	PF01048	0.523
MOD_GlcNHglycan	826	829	PF01048	0.518
MOD_GlcNHglycan	834	837	PF01048	0.479
MOD_GlcNHglycan	851	854	PF01048	0.636
MOD_GlcNHglycan	878	881	PF01048	0.575
MOD_GlcNHglycan	921	924	PF01048	0.469
MOD_GSK3_1	125	132	PF00069	0.594
MOD_GSK3_1	135	142	PF00069	0.704
MOD_GSK3_1	217	224	PF00069	0.619
MOD_GSK3_1	239	246	PF00069	0.691
MOD_GSK3_1	24	31	PF00069	0.556
MOD_GSK3_1	249	256	PF00069	0.701
MOD_GSK3_1	319	326	PF00069	0.623
MOD_GSK3_1	327	334	PF00069	0.588
MOD_GSK3_1	340	347	PF00069	0.670
MOD_GSK3_1	354	361	PF00069	0.622
MOD_GSK3_1	400	407	PF00069	0.639
MOD_GSK3_1	447	454	PF00069	0.516
MOD_GSK3_1	47	54	PF00069	0.543
MOD_GSK3_1	557	564	PF00069	0.568
MOD_GSK3_1	621	628	PF00069	0.601
MOD_GSK3_1	642	649	PF00069	0.592
MOD_GSK3_1	652	659	PF00069	0.367
MOD_GSK3_1	713	720	PF00069	0.667
MOD_GSK3_1	801	808	PF00069	0.696
MOD_GSK3_1	811	818	PF00069	0.585
MOD_GSK3_1	849	856	PF00069	0.617
MOD_N-GLC_1	161	166	PF02516	0.572
MOD_N-GLC_1	239	244	PF02516	0.649
MOD_N-GLC_1	27	32	PF02516	0.669
MOD_NEK2_1	232	237	PF00069	0.692
MOD_NEK2_1	302	307	PF00069	0.591
MOD_NEK2_1	341	346	PF00069	0.537
MOD_NEK2_1	358	363	PF00069	0.532
MOD_NEK2_1	462	467	PF00069	0.542
MOD_NEK2_1	538	543	PF00069	0.384
MOD_NEK2_1	544	549	PF00069	0.416
MOD_NEK2_1	552	557	PF00069	0.410
MOD_NEK2_1	568	573	PF00069	0.540
MOD_NEK2_1	812	817	PF00069	0.544
MOD_NEK2_1	849	854	PF00069	0.674
MOD_NEK2_1	926	931	PF00069	0.532
MOD_NEK2_2	354	359	PF00069	0.661
MOD_PIKK_1	113	119	PF00454	0.577
MOD_PIKK_1	12	18	PF00454	0.713
MOD_PIKK_1	359	365	PF00454	0.669
MOD_PIKK_1	407	413	PF00454	0.667
MOD_PIKK_1	462	468	PF00454	0.660
MOD_PIKK_1	717	723	PF00454	0.615
MOD_PK_1	135	141	PF00069	0.643
MOD_PKA_2	139	145	PF00069	0.625
MOD_PKA_2	217	223	PF00069	0.539
MOD_PKA_2	232	238	PF00069	0.496
MOD_PKA_2	257	263	PF00069	0.759
MOD_PKA_2	358	364	PF00069	0.508
MOD_PKA_2	403	409	PF00069	0.605
MOD_PKA_2	435	441	PF00069	0.606
MOD_PKA_2	454	460	PF00069	0.621
MOD_PKA_2	462	468	PF00069	0.516
MOD_PKA_2	666	672	PF00069	0.426
MOD_PKA_2	70	76	PF00069	0.690
MOD_PKA_2	717	723	PF00069	0.554
MOD_PKA_2	733	739	PF00069	0.500
MOD_PKA_2	81	87	PF00069	0.493
MOD_PKA_2	822	828	PF00069	0.520
MOD_PKA_2	889	895	PF00069	0.543
MOD_PKB_1	216	224	PF00069	0.589
MOD_Plk_1	407	413	PF00069	0.561
MOD_Plk_1	538	544	PF00069	0.465
MOD_Plk_1	574	580	PF00069	0.446
MOD_Plk_2-3	900	906	PF00069	0.673
MOD_Plk_4	169	175	PF00069	0.734
MOD_Plk_4	218	224	PF00069	0.703
MOD_Plk_4	257	263	PF00069	0.528
MOD_Plk_4	652	658	PF00069	0.499
MOD_Plk_4	678	684	PF00069	0.291
MOD_Plk_4	751	757	PF00069	0.469
MOD_Plk_4	81	87	PF00069	0.536
MOD_Plk_4	926	932	PF00069	0.607
MOD_ProDKin_1	148	154	PF00069	0.690
MOD_ProDKin_1	187	193	PF00069	0.537
MOD_ProDKin_1	222	228	PF00069	0.766
MOD_ProDKin_1	267	273	PF00069	0.504
MOD_ProDKin_1	28	34	PF00069	0.553
MOD_ProDKin_1	447	453	PF00069	0.596
MOD_ProDKin_1	465	471	PF00069	0.477
MOD_ProDKin_1	47	53	PF00069	0.597
MOD_ProDKin_1	685	691	PF00069	0.402
MOD_ProDKin_1	798	804	PF00069	0.543
MOD_SUMO_rev_2	440	450	PF00179	0.527
MOD_SUMO_rev_2	5	15	PF00179	0.560
MOD_SUMO_rev_2	604	611	PF00179	0.468
MOD_SUMO_rev_2	731	741	PF00179	0.529
MOD_SUMO_rev_2	864	873	PF00179	0.501
TRG_DiLeu_BaEn_1	539	544	PF01217	0.306
TRG_DiLeu_BaEn_1	845	850	PF01217	0.676
TRG_DiLeu_BaEn_1	857	862	PF01217	0.495
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.646
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.591
TRG_ENDOCYTIC_2	429	432	PF00928	0.747
TRG_ENDOCYTIC_2	519	522	PF00928	0.439
TRG_ENDOCYTIC_2	583	586	PF00928	0.600
TRG_ENDOCYTIC_2	591	594	PF00928	0.417
TRG_ENDOCYTIC_2	612	615	PF00928	0.572
TRG_ENDOCYTIC_2	684	687	PF00928	0.598
TRG_ENDOCYTIC_2	750	753	PF00928	0.567
TRG_ER_diArg_1	213	216	PF00400	0.578
TRG_ER_diArg_1	266	268	PF00400	0.651
TRG_ER_diArg_1	433	436	PF00400	0.684
TRG_ER_diArg_1	770	772	PF00400	0.526
TRG_NES_CRM1_1	604	619	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	603	608	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC02	Leptomonas seymouri	43%	95%
A0A3S7X4E6	Leishmania donovani	62%	98%
A4I6M6	Leishmania infantum	62%	98%
E9B1P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	98%
Q4Q6G1	Leishmania major	60%	100%