Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ81_LEIBR

TriTrypDb:

LbrM.31.1210 , LBRM2903_310019900

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.432
CLV_NRD_NRD_1	226	228	PF00675	0.549
CLV_NRD_NRD_1	233	235	PF00675	0.576
CLV_NRD_NRD_1	270	272	PF00675	0.610
CLV_NRD_NRD_1	286	288	PF00675	0.656
CLV_NRD_NRD_1	494	496	PF00675	0.590
CLV_NRD_NRD_1	546	548	PF00675	0.520
CLV_NRD_NRD_1	553	555	PF00675	0.487
CLV_NRD_NRD_1	567	569	PF00675	0.374
CLV_NRD_NRD_1	621	623	PF00675	0.500
CLV_NRD_NRD_1	728	730	PF00675	0.358
CLV_PCSK_FUR_1	22	26	PF00082	0.436
CLV_PCSK_KEX2_1	141	143	PF00082	0.432
CLV_PCSK_KEX2_1	150	152	PF00082	0.366
CLV_PCSK_KEX2_1	224	226	PF00082	0.587
CLV_PCSK_KEX2_1	233	235	PF00082	0.530
CLV_PCSK_KEX2_1	24	26	PF00082	0.480
CLV_PCSK_KEX2_1	270	272	PF00082	0.610
CLV_PCSK_KEX2_1	286	288	PF00082	0.640
CLV_PCSK_KEX2_1	494	496	PF00082	0.570
CLV_PCSK_KEX2_1	546	548	PF00082	0.514
CLV_PCSK_KEX2_1	555	557	PF00082	0.464
CLV_PCSK_KEX2_1	621	623	PF00082	0.509
CLV_PCSK_KEX2_1	728	730	PF00082	0.366
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.371
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.477
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.379
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.490
CLV_PCSK_SKI1_1	147	151	PF00082	0.511
CLV_PCSK_SKI1_1	24	28	PF00082	0.384
CLV_PCSK_SKI1_1	650	654	PF00082	0.382
CLV_PCSK_SKI1_1	7	11	PF00082	0.361
DEG_APCC_DBOX_1	178	186	PF00400	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DEG_SCF_FBW7_1	246	252	PF00400	0.391
DEG_SPOP_SBC_1	163	167	PF00917	0.503
DEG_SPOP_SBC_1	304	308	PF00917	0.379
DOC_ANK_TNKS_1	100	107	PF00023	0.731
DOC_ANK_TNKS_1	150	157	PF00023	0.528
DOC_CDC14_PxL_1	695	703	PF14671	0.581
DOC_CKS1_1	246	251	PF01111	0.431
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.436
DOC_MAPK_DCC_7	555	565	PF00069	0.609
DOC_MAPK_gen_1	22	32	PF00069	0.642
DOC_MAPK_gen_1	459	469	PF00069	0.370
DOC_MAPK_gen_1	477	486	PF00069	0.280
DOC_MAPK_gen_1	494	500	PF00069	0.378
DOC_MAPK_gen_1	554	563	PF00069	0.610
DOC_MAPK_gen_1	621	627	PF00069	0.539
DOC_MAPK_gen_1	80	88	PF00069	0.524
DOC_MAPK_MEF2A_6	179	186	PF00069	0.566
DOC_MAPK_MEF2A_6	339	348	PF00069	0.364
DOC_MAPK_MEF2A_6	462	469	PF00069	0.381
DOC_MAPK_MEF2A_6	556	565	PF00069	0.608
DOC_MAPK_RevD_3	126	142	PF00069	0.558
DOC_MAPK_RevD_3	482	495	PF00069	0.374
DOC_PP1_RVXF_1	44	51	PF00149	0.559
DOC_PP1_RVXF_1	622	628	PF00149	0.643
DOC_PP2B_LxvP_1	92	95	PF13499	0.588
DOC_PP2B_PxIxI_1	328	334	PF00149	0.313
DOC_USP7_MATH_1	104	108	PF00917	0.732
DOC_USP7_MATH_1	208	212	PF00917	0.741
DOC_USP7_MATH_1	304	308	PF00917	0.477
DOC_USP7_MATH_1	365	369	PF00917	0.458
DOC_USP7_MATH_1	632	636	PF00917	0.597
DOC_USP7_UBL2_3	646	650	PF12436	0.594
DOC_USP7_UBL2_3	683	687	PF12436	0.477
DOC_WW_Pin1_4	245	250	PF00397	0.566
DOC_WW_Pin1_4	379	384	PF00397	0.339
DOC_WW_Pin1_4	517	522	PF00397	0.312
DOC_WW_Pin1_4	533	538	PF00397	0.603
DOC_WW_Pin1_4	556	561	PF00397	0.699
DOC_WW_Pin1_4	59	64	PF00397	0.607
LIG_14-3-3_CanoR_1	141	149	PF00244	0.571
LIG_14-3-3_CanoR_1	179	185	PF00244	0.588
LIG_14-3-3_CanoR_1	214	223	PF00244	0.683
LIG_14-3-3_CanoR_1	25	33	PF00244	0.573
LIG_14-3-3_CanoR_1	270	278	PF00244	0.394
LIG_14-3-3_CanoR_1	381	387	PF00244	0.369
LIG_14-3-3_CanoR_1	44	49	PF00244	0.531
LIG_14-3-3_CanoR_1	464	470	PF00244	0.261
LIG_14-3-3_CanoR_1	477	486	PF00244	0.235
LIG_14-3-3_CanoR_1	554	560	PF00244	0.772
LIG_14-3-3_CanoR_1	668	675	PF00244	0.593
LIG_14-3-3_CanoR_1	7	13	PF00244	0.709
LIG_14-3-3_CanoR_1	72	79	PF00244	0.525
LIG_Actin_WH2_2	691	708	PF00022	0.482
LIG_APCC_ABBA_1	65	70	PF00400	0.460
LIG_BRCT_BRCA1_1	261	265	PF00533	0.205
LIG_BRCT_BRCA1_1	46	50	PF00533	0.559
LIG_CtBP_PxDLS_1	562	566	PF00389	0.605
LIG_eIF4E_1	180	186	PF01652	0.564
LIG_eIF4E_1	596	602	PF01652	0.527
LIG_FHA_1	1	7	PF00498	0.646
LIG_FHA_1	111	117	PF00498	0.561
LIG_FHA_1	128	134	PF00498	0.538
LIG_FHA_1	181	187	PF00498	0.586
LIG_FHA_1	218	224	PF00498	0.600
LIG_FHA_1	246	252	PF00498	0.494
LIG_FHA_1	25	31	PF00498	0.557
LIG_FHA_1	290	296	PF00498	0.409
LIG_FHA_1	479	485	PF00498	0.364
LIG_FHA_1	556	562	PF00498	0.662
LIG_FHA_1	595	601	PF00498	0.617
LIG_FHA_1	76	82	PF00498	0.581
LIG_FHA_2	150	156	PF00498	0.681
LIG_FHA_2	163	169	PF00498	0.513
LIG_FHA_2	310	316	PF00498	0.314
LIG_FHA_2	456	462	PF00498	0.407
LIG_FHA_2	50	56	PF00498	0.680
LIG_FHA_2	537	543	PF00498	0.592
LIG_FHA_2	573	579	PF00498	0.723
LIG_FHA_2	580	586	PF00498	0.678
LIG_LIR_Gen_1	155	163	PF02991	0.590
LIG_LIR_Gen_1	262	273	PF02991	0.285
LIG_LIR_Gen_1	319	330	PF02991	0.303
LIG_LIR_Gen_1	424	434	PF02991	0.327
LIG_LIR_Gen_1	439	447	PF02991	0.341
LIG_LIR_Gen_1	452	460	PF02991	0.377
LIG_LIR_Gen_1	47	58	PF02991	0.553
LIG_LIR_Gen_1	593	603	PF02991	0.466
LIG_LIR_Gen_1	635	645	PF02991	0.582
LIG_LIR_Gen_1	692	703	PF02991	0.541
LIG_LIR_Nem_3	155	161	PF02991	0.596
LIG_LIR_Nem_3	192	198	PF02991	0.501
LIG_LIR_Nem_3	262	268	PF02991	0.333
LIG_LIR_Nem_3	272	278	PF02991	0.318
LIG_LIR_Nem_3	319	325	PF02991	0.295
LIG_LIR_Nem_3	424	430	PF02991	0.316
LIG_LIR_Nem_3	439	443	PF02991	0.335
LIG_LIR_Nem_3	47	53	PF02991	0.550
LIG_LIR_Nem_3	497	502	PF02991	0.320
LIG_LIR_Nem_3	593	599	PF02991	0.487
LIG_LIR_Nem_3	626	630	PF02991	0.593
LIG_LIR_Nem_3	635	641	PF02991	0.633
LIG_LIR_Nem_3	692	698	PF02991	0.523
LIG_NRBOX	181	187	PF00104	0.564
LIG_NRBOX	399	405	PF00104	0.326
LIG_NRBOX	429	435	PF00104	0.311
LIG_Pex14_2	397	401	PF04695	0.353
LIG_PTB_Apo_2	654	661	PF02174	0.508
LIG_PTB_Phospho_1	654	660	PF10480	0.504
LIG_Rb_pABgroove_1	421	429	PF01858	0.324
LIG_RPA_C_Fungi	222	234	PF08784	0.510
LIG_RPA_C_Plants	718	729	PF08784	0.531
LIG_SH2_CRK	427	431	PF00017	0.361
LIG_SH2_CRK	502	506	PF00017	0.426
LIG_SH2_CRK	638	642	PF00017	0.336
LIG_SH2_CRK	670	674	PF00017	0.410
LIG_SH2_GRB2like	453	456	PF00017	0.571
LIG_SH2_NCK_1	388	392	PF00017	0.339
LIG_SH2_NCK_1	502	506	PF00017	0.449
LIG_SH2_NCK_1	670	674	PF00017	0.434
LIG_SH2_PTP2	440	443	PF00017	0.442
LIG_SH2_SRC	68	71	PF00017	0.473
LIG_SH2_STAP1	427	431	PF00017	0.405
LIG_SH2_STAP1	511	515	PF00017	0.245
LIG_SH2_STAP1	596	600	PF00017	0.502
LIG_SH2_STAT5	12	15	PF00017	0.525
LIG_SH2_STAT5	440	443	PF00017	0.453
LIG_SH2_STAT5	453	456	PF00017	0.635
LIG_SH2_STAT5	596	599	PF00017	0.585
LIG_SH2_STAT5	68	71	PF00017	0.455
LIG_SH3_3	193	199	PF00018	0.439
LIG_SH3_3	243	249	PF00018	0.699
LIG_SH3_3	515	521	PF00018	0.312
LIG_SH3_3	54	60	PF00018	0.655
LIG_SH3_5	712	716	PF00018	0.616
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.485
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.553
LIG_SUMO_SIM_anti_2	597	603	PF11976	0.447
LIG_SUMO_SIM_par_1	111	117	PF11976	0.499
LIG_SUMO_SIM_par_1	129	134	PF11976	0.527
LIG_SUMO_SIM_par_1	182	188	PF11976	0.394
LIG_SUMO_SIM_par_1	255	262	PF11976	0.351
LIG_SUMO_SIM_par_1	561	566	PF11976	0.507
LIG_SxIP_EBH_1	554	567	PF03271	0.511
LIG_TRAF2_1	743	746	PF00917	0.546
LIG_TRFH_1	502	506	PF08558	0.302
LIG_TYR_ITIM	500	505	PF00017	0.379
LIG_TYR_ITIM	594	599	PF00017	0.490
LIG_UBA3_1	295	303	PF00899	0.572
LIG_UBA3_1	400	405	PF00899	0.451
LIG_UBA3_1	700	706	PF00899	0.574
MOD_CK1_1	109	115	PF00069	0.517
MOD_CK1_1	215	221	PF00069	0.675
MOD_CK1_1	306	312	PF00069	0.558
MOD_CK1_1	366	372	PF00069	0.614
MOD_CK1_1	382	388	PF00069	0.299
MOD_CK1_1	75	81	PF00069	0.565
MOD_CK1_1	97	103	PF00069	0.559
MOD_CK2_1	131	137	PF00069	0.469
MOD_CK2_1	149	155	PF00069	0.614
MOD_CK2_1	162	168	PF00069	0.487
MOD_CK2_1	309	315	PF00069	0.396
MOD_CK2_1	468	474	PF00069	0.540
MOD_CK2_1	49	55	PF00069	0.520
MOD_CK2_1	536	542	PF00069	0.645
MOD_CK2_1	579	585	PF00069	0.660
MOD_DYRK1A_RPxSP_1	556	560	PF00069	0.624
MOD_GlcNHglycan	108	111	PF01048	0.604
MOD_GlcNHglycan	133	136	PF01048	0.457
MOD_GlcNHglycan	187	190	PF01048	0.547
MOD_GlcNHglycan	214	217	PF01048	0.730
MOD_GlcNHglycan	261	264	PF01048	0.319
MOD_GlcNHglycan	271	274	PF01048	0.362
MOD_GlcNHglycan	359	362	PF01048	0.695
MOD_GlcNHglycan	374	377	PF01048	0.643
MOD_GlcNHglycan	634	637	PF01048	0.582
MOD_GlcNHglycan	74	77	PF01048	0.464
MOD_GSK3_1	106	113	PF00069	0.580
MOD_GSK3_1	127	134	PF00069	0.476
MOD_GSK3_1	185	192	PF00069	0.497
MOD_GSK3_1	208	215	PF00069	0.723
MOD_GSK3_1	225	232	PF00069	0.756
MOD_GSK3_1	241	248	PF00069	0.583
MOD_GSK3_1	287	294	PF00069	0.505
MOD_GSK3_1	295	302	PF00069	0.524
MOD_GSK3_1	303	310	PF00069	0.647
MOD_GSK3_1	365	372	PF00069	0.570
MOD_GSK3_1	44	51	PF00069	0.536
MOD_GSK3_1	451	458	PF00069	0.501
MOD_GSK3_1	465	472	PF00069	0.426
MOD_GSK3_1	532	539	PF00069	0.637
MOD_GSK3_1	572	579	PF00069	0.650
MOD_GSK3_1	71	78	PF00069	0.625
MOD_N-GLC_1	509	514	PF02516	0.359
MOD_N-GLC_1	594	599	PF02516	0.465
MOD_N-GLC_2	191	193	PF02516	0.503
MOD_NEK2_1	114	119	PF00069	0.540
MOD_NEK2_1	131	136	PF00069	0.305
MOD_NEK2_1	162	167	PF00069	0.474
MOD_NEK2_1	277	282	PF00069	0.426
MOD_NEK2_1	295	300	PF00069	0.318
MOD_NEK2_1	316	321	PF00069	0.480
MOD_NEK2_1	509	514	PF00069	0.333
MOD_NEK2_1	705	710	PF00069	0.585
MOD_NEK2_1	81	86	PF00069	0.529
MOD_NEK2_2	189	194	PF00069	0.393
MOD_NEK2_2	663	668	PF00069	0.482
MOD_PIKK_1	225	231	PF00454	0.507
MOD_PIKK_1	509	515	PF00454	0.355
MOD_PIKK_1	81	87	PF00454	0.483
MOD_PK_1	44	50	PF00069	0.446
MOD_PK_1	494	500	PF00069	0.457
MOD_PKA_1	225	231	PF00069	0.670
MOD_PKA_1	24	30	PF00069	0.620
MOD_PKA_1	494	500	PF00069	0.457
MOD_PKA_1	546	552	PF00069	0.647
MOD_PKA_1	554	560	PF00069	0.619
MOD_PKA_2	140	146	PF00069	0.478
MOD_PKA_2	225	231	PF00069	0.617
MOD_PKA_2	24	30	PF00069	0.595
MOD_PKA_2	269	275	PF00069	0.483
MOD_PKA_2	494	500	PF00069	0.412
MOD_PKA_2	546	552	PF00069	0.685
MOD_PKA_2	555	561	PF00069	0.642
MOD_PKA_2	71	77	PF00069	0.465
MOD_PKB_1	225	233	PF00069	0.520
MOD_PKB_1	552	560	PF00069	0.716
MOD_Plk_1	110	116	PF00069	0.420
MOD_Plk_1	241	247	PF00069	0.604
MOD_Plk_1	469	475	PF00069	0.521
MOD_Plk_1	48	54	PF00069	0.632
MOD_Plk_1	509	515	PF00069	0.355
MOD_Plk_1	579	585	PF00069	0.610
MOD_Plk_1	594	600	PF00069	0.427
MOD_Plk_2-3	49	55	PF00069	0.429
MOD_Plk_2-3	580	586	PF00069	0.532
MOD_Plk_4	180	186	PF00069	0.485
MOD_Plk_4	291	297	PF00069	0.540
MOD_Plk_4	421	427	PF00069	0.380
MOD_Plk_4	429	435	PF00069	0.373
MOD_Plk_4	436	442	PF00069	0.339
MOD_Plk_4	494	500	PF00069	0.359
MOD_Plk_4	53	59	PF00069	0.523
MOD_Plk_4	61	67	PF00069	0.449
MOD_Plk_4	8	14	PF00069	0.459
MOD_ProDKin_1	245	251	PF00069	0.450
MOD_ProDKin_1	379	385	PF00069	0.400
MOD_ProDKin_1	517	523	PF00069	0.312
MOD_ProDKin_1	533	539	PF00069	0.502
MOD_ProDKin_1	556	562	PF00069	0.636
MOD_ProDKin_1	59	65	PF00069	0.498
MOD_SUMO_for_1	240	243	PF00179	0.601
MOD_SUMO_rev_2	144	149	PF00179	0.449
MOD_SUMO_rev_2	580	589	PF00179	0.759
MOD_SUMO_rev_2	677	684	PF00179	0.474
TRG_DiLeu_BaEn_2	420	426	PF01217	0.326
TRG_DiLeu_BaEn_4	177	183	PF01217	0.399
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.526
TRG_ENDOCYTIC_2	195	198	PF00928	0.480
TRG_ENDOCYTIC_2	427	430	PF00928	0.349
TRG_ENDOCYTIC_2	431	434	PF00928	0.387
TRG_ENDOCYTIC_2	440	443	PF00928	0.409
TRG_ENDOCYTIC_2	453	456	PF00928	0.484
TRG_ENDOCYTIC_2	502	505	PF00928	0.336
TRG_ENDOCYTIC_2	511	514	PF00928	0.351
TRG_ENDOCYTIC_2	596	599	PF00928	0.394
TRG_ENDOCYTIC_2	638	641	PF00928	0.521
TRG_ENDOCYTIC_2	670	673	PF00928	0.401
TRG_ENDOCYTIC_2	731	734	PF00928	0.549
TRG_ER_diArg_1	225	227	PF00400	0.506
TRG_ER_diArg_1	285	287	PF00400	0.562
TRG_ER_diArg_1	351	354	PF00400	0.457
TRG_ER_diArg_1	462	465	PF00400	0.457
TRG_ER_diArg_1	493	495	PF00400	0.477
TRG_ER_diArg_1	545	547	PF00400	0.656
TRG_ER_diArg_1	621	623	PF00400	0.663
TRG_NES_CRM1_1	123	137	PF08389	0.410
TRG_NLS_Bipartite_1	554	572	PF00514	0.511
TRG_NLS_MonoCore_2	223	228	PF00514	0.501
TRG_NLS_MonoExtN_4	552	558	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P427	Leptomonas seymouri	56%	100%
A0A3R7LDE0	Trypanosoma rangeli	35%	100%
A0A3S7X4C5	Leishmania donovani	77%	100%
A4I6M5	Leishmania infantum	77%	100%
D0A0I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B1P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q9BHG4	Leishmania major	77%	100%
V5BX02	Trypanosoma cruzi	34%	100%