Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ80_LEIBR

TriTrypDb:

LbrM.31.1200 , LBRM2903_310019800

Length:

1150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1010	1014	PF00656	0.590
CLV_C14_Caspase3-7	340	344	PF00656	0.390
CLV_C14_Caspase3-7	578	582	PF00656	0.740
CLV_C14_Caspase3-7	617	621	PF00656	0.661
CLV_C14_Caspase3-7	694	698	PF00656	0.617
CLV_NRD_NRD_1	1148	1150	PF00675	0.723
CLV_NRD_NRD_1	197	199	PF00675	0.519
CLV_NRD_NRD_1	240	242	PF00675	0.741
CLV_NRD_NRD_1	284	286	PF00675	0.665
CLV_NRD_NRD_1	437	439	PF00675	0.573
CLV_NRD_NRD_1	65	67	PF00675	0.670
CLV_NRD_NRD_1	755	757	PF00675	0.603
CLV_PCSK_KEX2_1	13	15	PF00082	0.728
CLV_PCSK_KEX2_1	199	201	PF00082	0.680
CLV_PCSK_KEX2_1	240	242	PF00082	0.741
CLV_PCSK_KEX2_1	284	286	PF00082	0.665
CLV_PCSK_KEX2_1	437	439	PF00082	0.676
CLV_PCSK_KEX2_1	65	67	PF00082	0.670
CLV_PCSK_KEX2_1	973	975	PF00082	0.609
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.580
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.680
CLV_PCSK_PC1ET2_1	973	975	PF00082	0.609
CLV_PCSK_PC7_1	9	15	PF00082	0.555
CLV_PCSK_SKI1_1	1039	1043	PF00082	0.394
CLV_PCSK_SKI1_1	105	109	PF00082	0.592
CLV_PCSK_SKI1_1	1071	1075	PF00082	0.656
CLV_PCSK_SKI1_1	1090	1094	PF00082	0.361
CLV_PCSK_SKI1_1	132	136	PF00082	0.620
CLV_PCSK_SKI1_1	284	288	PF00082	0.637
CLV_PCSK_SKI1_1	355	359	PF00082	0.596
CLV_PCSK_SKI1_1	447	451	PF00082	0.557
CLV_PCSK_SKI1_1	465	469	PF00082	0.296
CLV_PCSK_SKI1_1	484	488	PF00082	0.431
CLV_PCSK_SKI1_1	507	511	PF00082	0.630
CLV_PCSK_SKI1_1	518	522	PF00082	0.432
CLV_PCSK_SKI1_1	700	704	PF00082	0.609
CLV_PCSK_SKI1_1	75	79	PF00082	0.388
CLV_PCSK_SKI1_1	797	801	PF00082	0.832
DEG_APCC_DBOX_1	1028	1036	PF00400	0.695
DEG_APCC_DBOX_1	354	362	PF00400	0.357
DEG_APCC_DBOX_1	446	454	PF00400	0.631
DEG_APCC_DBOX_1	513	521	PF00400	0.624
DEG_SCF_FBW7_1	313	319	PF00400	0.567
DOC_CKS1_1	313	318	PF01111	0.630
DOC_CKS1_1	92	97	PF01111	0.617
DOC_CYCLIN_RxL_1	1036	1046	PF00134	0.410
DOC_CYCLIN_RxL_1	426	436	PF00134	0.637
DOC_CYCLIN_RxL_1	501	512	PF00134	0.633
DOC_CYCLIN_RxL_1	99	112	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.617
DOC_MAPK_gen_1	272	280	PF00069	0.573
DOC_MAPK_gen_1	396	404	PF00069	0.454
DOC_MAPK_gen_1	437	445	PF00069	0.670
DOC_MAPK_gen_1	484	492	PF00069	0.406
DOC_MAPK_gen_1	514	522	PF00069	0.624
DOC_MAPK_MEF2A_6	1065	1074	PF00069	0.661
DOC_MAPK_MEF2A_6	1136	1145	PF00069	0.371
DOC_PP1_RVXF_1	1037	1044	PF00149	0.406
DOC_PP1_RVXF_1	1069	1075	PF00149	0.653
DOC_PP1_RVXF_1	270	277	PF00149	0.561
DOC_PP1_RVXF_1	445	452	PF00149	0.627
DOC_PP1_RVXF_1	505	512	PF00149	0.631
DOC_PP2B_LxvP_1	142	145	PF13499	0.372
DOC_PP2B_LxvP_1	443	446	PF13499	0.639
DOC_PP4_FxxP_1	53	56	PF00568	0.341
DOC_USP7_MATH_1	1011	1015	PF00917	0.592
DOC_USP7_MATH_1	1028	1032	PF00917	0.395
DOC_USP7_MATH_1	228	232	PF00917	0.604
DOC_USP7_MATH_1	25	29	PF00917	0.752
DOC_USP7_MATH_1	314	318	PF00917	0.713
DOC_USP7_MATH_1	473	477	PF00917	0.589
DOC_USP7_MATH_1	590	594	PF00917	0.770
DOC_USP7_MATH_1	652	656	PF00917	0.781
DOC_USP7_MATH_1	782	786	PF00917	0.717
DOC_USP7_MATH_1	799	803	PF00917	0.514
DOC_USP7_MATH_1	858	862	PF00917	0.866
DOC_USP7_MATH_1	911	915	PF00917	0.800
DOC_USP7_MATH_1	936	940	PF00917	0.717
DOC_USP7_UBL2_3	1136	1140	PF12436	0.647
DOC_USP7_UBL2_3	650	654	PF12436	0.620
DOC_USP7_UBL2_3	800	804	PF12436	0.723
DOC_USP7_UBL2_3	817	821	PF12436	0.661
DOC_WW_Pin1_4	100	105	PF00397	0.482
DOC_WW_Pin1_4	252	257	PF00397	0.676
DOC_WW_Pin1_4	304	309	PF00397	0.779
DOC_WW_Pin1_4	312	317	PF00397	0.653
DOC_WW_Pin1_4	91	96	PF00397	0.608
LIG_14-3-3_CanoR_1	1029	1033	PF00244	0.700
LIG_14-3-3_CanoR_1	1061	1068	PF00244	0.667
LIG_14-3-3_CanoR_1	198	203	PF00244	0.451
LIG_14-3-3_CanoR_1	241	247	PF00244	0.778
LIG_14-3-3_CanoR_1	318	324	PF00244	0.506
LIG_14-3-3_CanoR_1	336	340	PF00244	0.299
LIG_14-3-3_CanoR_1	366	375	PF00244	0.641
LIG_14-3-3_CanoR_1	39	47	PF00244	0.427
LIG_14-3-3_CanoR_1	421	431	PF00244	0.649
LIG_14-3-3_CanoR_1	472	481	PF00244	0.503
LIG_14-3-3_CanoR_1	501	510	PF00244	0.380
LIG_14-3-3_CanoR_1	75	84	PF00244	0.416
LIG_14-3-3_CanoR_1	9	15	PF00244	0.571
LIG_14-3-3_CanoR_1	917	923	PF00244	0.605
LIG_AP2alpha_2	331	333	PF02296	0.382
LIG_AP2alpha_2	669	671	PF02296	0.575
LIG_APCC_ABBAyCdc20_2	700	706	PF00400	0.608
LIG_BIR_III_4	1002	1006	PF00653	0.615
LIG_Clathr_ClatBox_1	358	362	PF01394	0.596
LIG_Clathr_ClatBox_1	467	471	PF01394	0.595
LIG_EH1_1	81	89	PF00400	0.602
LIG_eIF4E_1	102	108	PF01652	0.603
LIG_FHA_1	1127	1133	PF00498	0.647
LIG_FHA_1	176	182	PF00498	0.599
LIG_FHA_1	304	310	PF00498	0.667
LIG_FHA_1	332	338	PF00498	0.428
LIG_FHA_1	35	41	PF00498	0.629
LIG_FHA_1	426	432	PF00498	0.651
LIG_FHA_1	566	572	PF00498	0.694
LIG_FHA_1	678	684	PF00498	0.867
LIG_FHA_1	76	82	PF00498	0.369
LIG_FHA_1	869	875	PF00498	0.620
LIG_FHA_2	1008	1014	PF00498	0.583
LIG_FHA_2	101	107	PF00498	0.616
LIG_FHA_2	170	176	PF00498	0.601
LIG_FHA_2	246	252	PF00498	0.771
LIG_FHA_2	295	301	PF00498	0.773
LIG_FHA_2	599	605	PF00498	0.604
LIG_FHA_2	756	762	PF00498	0.647
LIG_FHA_2	773	779	PF00498	0.675
LIG_FHA_2	864	870	PF00498	0.628
LIG_FHA_2	932	938	PF00498	0.661
LIG_FHA_2	956	962	PF00498	0.679
LIG_FHA_2	970	976	PF00498	0.626
LIG_FHA_2	980	986	PF00498	0.717
LIG_HP1_1	1028	1032	PF01393	0.465
LIG_Integrin_RGD_1	999	1001	PF01839	0.611
LIG_LIR_Apic_2	51	56	PF02991	0.594
LIG_LIR_Apic_2	673	679	PF02991	0.698
LIG_LIR_Gen_1	178	188	PF02991	0.602
LIG_LIR_Gen_1	227	235	PF02991	0.370
LIG_LIR_Gen_1	669	679	PF02991	0.743
LIG_LIR_Nem_3	178	183	PF02991	0.399
LIG_LIR_Nem_3	227	232	PF02991	0.602
LIG_LIR_Nem_3	267	273	PF02991	0.565
LIG_LIR_Nem_3	329	333	PF02991	0.625
LIG_LIR_Nem_3	373	379	PF02991	0.647
LIG_LIR_Nem_3	54	60	PF02991	0.614
LIG_LIR_Nem_3	669	674	PF02991	0.737
LIG_MYND_3	144	148	PF01753	0.624
LIG_NRBOX	1031	1037	PF00104	0.685
LIG_PCNA_PIPBox_1	144	153	PF02747	0.622
LIG_Pex14_2	53	57	PF04695	0.353
LIG_PTB_Apo_2	67	74	PF02174	0.650
LIG_PTB_Phospho_1	67	73	PF10480	0.651
LIG_SH2_CRK	271	275	PF00017	0.562
LIG_SH2_CRK	376	380	PF00017	0.636
LIG_SH2_NCK_1	376	380	PF00017	0.636
LIG_SH2_STAP1	60	64	PF00017	0.654
LIG_SH2_STAP1	73	77	PF00017	0.429
LIG_SH2_STAT3	60	63	PF00017	0.657
LIG_SH2_STAT5	102	105	PF00017	0.615
LIG_SH2_STAT5	133	136	PF00017	0.368
LIG_SH2_STAT5	485	488	PF00017	0.691
LIG_SH3_1	1083	1089	PF00018	0.538
LIG_SH3_3	1083	1089	PF00018	0.538
LIG_SH3_3	19	25	PF00018	0.682
LIG_SH3_3	310	316	PF00018	0.636
LIG_SH3_3	559	565	PF00018	0.700
LIG_SH3_3	568	574	PF00018	0.702
LIG_SH3_3	65	71	PF00018	0.451
LIG_Sin3_3	158	165	PF02671	0.325
LIG_SUMO_SIM_anti_2	1119	1124	PF11976	0.660
LIG_SUMO_SIM_anti_2	1138	1145	PF11976	0.292
LIG_SUMO_SIM_anti_2	488	495	PF11976	0.383
LIG_SUMO_SIM_par_1	276	281	PF11976	0.585
LIG_SUMO_SIM_par_1	428	434	PF11976	0.585
LIG_TRAF2_1	298	301	PF00917	0.551
LIG_TRAF2_1	405	408	PF00917	0.599
LIG_TRAF2_1	575	578	PF00917	0.854
LIG_TRAF2_1	642	645	PF00917	0.638
LIG_TRAF2_1	659	662	PF00917	0.733
LIG_TRAF2_1	670	673	PF00917	0.604
LIG_TRAF2_1	764	767	PF00917	0.657
LIG_TRAF2_1	927	930	PF00917	0.682
LIG_TYR_ITSM	225	232	PF00017	0.601
LIG_WRC_WIRS_1	147	152	PF05994	0.617
LIG_WRC_WIRS_1	177	182	PF05994	0.600
MOD_CDK_SPK_2	100	105	PF00069	0.631
MOD_CDK_SPxK_1	312	318	PF00069	0.571
MOD_CK1_1	1121	1127	PF00069	0.676
MOD_CK1_1	169	175	PF00069	0.597
MOD_CK1_1	231	237	PF00069	0.639
MOD_CK1_1	245	251	PF00069	0.553
MOD_CK1_1	317	323	PF00069	0.529
MOD_CK1_1	5	11	PF00069	0.556
MOD_CK1_1	537	543	PF00069	0.616
MOD_CK1_1	752	758	PF00069	0.596
MOD_CK1_1	785	791	PF00069	0.612
MOD_CK1_1	918	924	PF00069	0.604
MOD_CK2_1	100	106	PF00069	0.631
MOD_CK2_1	1052	1058	PF00069	0.644
MOD_CK2_1	198	204	PF00069	0.692
MOD_CK2_1	294	300	PF00069	0.765
MOD_CK2_1	402	408	PF00069	0.597
MOD_CK2_1	528	534	PF00069	0.677
MOD_CK2_1	572	578	PF00069	0.784
MOD_CK2_1	598	604	PF00069	0.630
MOD_CK2_1	639	645	PF00069	0.596
MOD_CK2_1	761	767	PF00069	0.618
MOD_CK2_1	863	869	PF00069	0.703
MOD_CK2_1	931	937	PF00069	0.616
MOD_CK2_1	955	961	PF00069	0.684
MOD_CK2_1	969	975	PF00069	0.622
MOD_CK2_1	979	985	PF00069	0.718
MOD_Cter_Amidation	805	808	PF01082	0.665
MOD_GlcNHglycan	204	208	PF01048	0.605
MOD_GlcNHglycan	261	264	PF01048	0.357
MOD_GlcNHglycan	319	322	PF01048	0.537
MOD_GlcNHglycan	382	385	PF01048	0.591
MOD_GlcNHglycan	411	414	PF01048	0.626
MOD_GlcNHglycan	498	501	PF01048	0.439
MOD_GlcNHglycan	503	506	PF01048	0.368
MOD_GlcNHglycan	530	533	PF01048	0.551
MOD_GlcNHglycan	539	542	PF01048	0.517
MOD_GlcNHglycan	574	577	PF01048	0.693
MOD_GlcNHglycan	641	644	PF01048	0.603
MOD_GlcNHglycan	750	754	PF01048	0.623
MOD_GlcNHglycan	801	804	PF01048	0.561
MOD_GlcNHglycan	808	811	PF01048	0.578
MOD_GlcNHglycan	913	916	PF01048	0.694
MOD_GlcNHglycan	920	923	PF01048	0.573
MOD_GlcNHglycan	937	941	PF01048	0.761
MOD_GlcNHglycan	944	947	PF01048	0.768
MOD_GlcNHglycan	977	980	PF01048	0.864
MOD_GSK3_1	1	8	PF00069	0.555
MOD_GSK3_1	1007	1014	PF00069	0.593
MOD_GSK3_1	1135	1142	PF00069	0.627
MOD_GSK3_1	166	173	PF00069	0.589
MOD_GSK3_1	224	231	PF00069	0.599
MOD_GSK3_1	299	306	PF00069	0.706
MOD_GSK3_1	30	37	PF00069	0.738
MOD_GSK3_1	312	319	PF00069	0.602
MOD_GSK3_1	331	338	PF00069	0.547
MOD_GSK3_1	39	46	PF00069	0.517
MOD_GSK3_1	425	432	PF00069	0.619
MOD_GSK3_1	471	478	PF00069	0.624
MOD_GSK3_1	496	503	PF00069	0.400
MOD_GSK3_1	530	537	PF00069	0.545
MOD_GSK3_1	539	546	PF00069	0.563
MOD_GSK3_1	83	90	PF00069	0.604
MOD_GSK3_1	895	902	PF00069	0.606
MOD_GSK3_1	911	918	PF00069	0.539
MOD_GSK3_1	936	943	PF00069	0.717
MOD_GSK3_1	975	982	PF00069	0.610
MOD_N-GLC_1	1126	1131	PF02516	0.611
MOD_N-GLC_1	366	371	PF02516	0.636
MOD_N-GLC_1	863	868	PF02516	0.613
MOD_N-GLC_1	911	916	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	1052	1057	PF00069	0.647
MOD_NEK2_1	1059	1064	PF00069	0.535
MOD_NEK2_1	1096	1101	PF00069	0.642
MOD_NEK2_1	1123	1128	PF00069	0.619
MOD_NEK2_1	208	213	PF00069	0.618
MOD_NEK2_1	351	356	PF00069	0.368
MOD_NEK2_1	420	425	PF00069	0.534
MOD_NEK2_1	486	491	PF00069	0.577
MOD_NEK2_1	543	548	PF00069	0.594
MOD_NEK2_1	629	634	PF00069	0.694
MOD_NEK2_1	704	709	PF00069	0.580
MOD_PIKK_1	1030	1036	PF00454	0.430
MOD_PIKK_1	233	239	PF00454	0.668
MOD_PIKK_1	565	571	PF00454	0.814
MOD_PIKK_1	8	14	PF00454	0.556
MOD_PK_1	198	204	PF00069	0.445
MOD_PK_1	83	89	PF00069	0.599
MOD_PKA_1	13	19	PF00069	0.734
MOD_PKA_1	198	204	PF00069	0.445
MOD_PKA_2	1028	1034	PF00069	0.707
MOD_PKA_2	1060	1066	PF00069	0.670
MOD_PKA_2	13	19	PF00069	0.709
MOD_PKA_2	317	323	PF00069	0.529
MOD_PKA_2	335	341	PF00069	0.292
MOD_PKA_2	365	371	PF00069	0.631
MOD_PKA_2	420	426	PF00069	0.538
MOD_PKA_2	471	477	PF00069	0.514
MOD_PKA_2	5	11	PF00069	0.816
MOD_PKA_2	500	506	PF00069	0.421
MOD_PKA_2	755	761	PF00069	0.648
MOD_PKA_2	969	975	PF00069	0.593
MOD_Plk_1	1118	1124	PF00069	0.660
MOD_Plk_1	126	132	PF00069	0.582
MOD_Plk_1	203	209	PF00069	0.414
MOD_Plk_1	266	272	PF00069	0.318
MOD_Plk_1	299	305	PF00069	0.556
MOD_Plk_1	441	447	PF00069	0.655
MOD_Plk_1	73	79	PF00069	0.390
MOD_Plk_1	858	864	PF00069	0.793
MOD_Plk_1	880	886	PF00069	0.751
MOD_Plk_2-3	598	604	PF00069	0.602
MOD_Plk_4	1118	1124	PF00069	0.660
MOD_Plk_4	1139	1145	PF00069	0.602
MOD_Plk_4	146	152	PF00069	0.617
MOD_Plk_4	176	182	PF00069	0.364
MOD_Plk_4	266	272	PF00069	0.318
MOD_Plk_4	534	540	PF00069	0.511
MOD_Plk_4	83	89	PF00069	0.599
MOD_ProDKin_1	100	106	PF00069	0.482
MOD_ProDKin_1	252	258	PF00069	0.663
MOD_ProDKin_1	304	310	PF00069	0.779
MOD_ProDKin_1	312	318	PF00069	0.650
MOD_ProDKin_1	91	97	PF00069	0.615
MOD_SUMO_for_1	737	740	PF00179	0.804
MOD_SUMO_rev_2	191	201	PF00179	0.677
MOD_SUMO_rev_2	531	538	PF00179	0.548
MOD_SUMO_rev_2	642	652	PF00179	0.616
MOD_SUMO_rev_2	843	849	PF00179	0.686
MOD_SUMO_rev_2	887	895	PF00179	0.633
TRG_DiLeu_BaEn_1	139	144	PF01217	0.361
TRG_DiLeu_BaEn_1	204	209	PF01217	0.653
TRG_DiLeu_BaEn_1	534	539	PF01217	0.631
TRG_DiLeu_BaEn_1	741	746	PF01217	0.598
TRG_DiLeu_BaEn_4	869	875	PF01217	0.764
TRG_DiLeu_BaLyEn_6	948	953	PF01217	0.595
TRG_ENDOCYTIC_2	229	232	PF00928	0.609
TRG_ENDOCYTIC_2	271	274	PF00928	0.560
TRG_ENDOCYTIC_2	330	333	PF00928	0.371
TRG_ENDOCYTIC_2	376	379	PF00928	0.637
TRG_ER_diArg_1	396	399	PF00400	0.483
TRG_ER_diArg_1	513	516	PF00400	0.640
TRG_ER_diArg_1	65	67	PF00400	0.670
TRG_NES_CRM1_1	512	526	PF08389	0.630
TRG_NES_CRM1_1	954	965	PF08389	0.569
TRG_NLS_MonoExtC_3	803	808	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	847	851	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E0	Leishmania donovani	66%	100%
A4I6M4	Leishmania infantum	66%	100%
E9B1P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q6G3	Leishmania major	66%	96%