Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJ79_LEIBR

TriTrypDb:

LbrM.31.1190 , LBRM2903_310019700

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ79

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.373
CLV_C14_Caspase3-7	233	237	PF00656	0.614
CLV_NRD_NRD_1	165	167	PF00675	0.650
CLV_NRD_NRD_1	193	195	PF00675	0.715
CLV_NRD_NRD_1	279	281	PF00675	0.661
CLV_NRD_NRD_1	331	333	PF00675	0.716
CLV_NRD_NRD_1	334	336	PF00675	0.717
CLV_NRD_NRD_1	379	381	PF00675	0.778
CLV_NRD_NRD_1	383	385	PF00675	0.710
CLV_PCSK_FUR_1	163	167	PF00082	0.556
CLV_PCSK_FUR_1	277	281	PF00082	0.654
CLV_PCSK_FUR_1	332	336	PF00082	0.803
CLV_PCSK_KEX2_1	165	167	PF00082	0.658
CLV_PCSK_KEX2_1	192	194	PF00082	0.722
CLV_PCSK_KEX2_1	211	213	PF00082	0.677
CLV_PCSK_KEX2_1	279	281	PF00082	0.651
CLV_PCSK_KEX2_1	291	293	PF00082	0.687
CLV_PCSK_KEX2_1	333	335	PF00082	0.724
CLV_PCSK_KEX2_1	357	359	PF00082	0.726
CLV_PCSK_KEX2_1	378	380	PF00082	0.603
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.722
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.677
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.786
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.588
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.726
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.595
CLV_PCSK_PC7_1	275	281	PF00082	0.806
CLV_PCSK_SKI1_1	115	119	PF00082	0.596
CLV_PCSK_SKI1_1	165	169	PF00082	0.620
CLV_PCSK_SKI1_1	172	176	PF00082	0.629
CLV_PCSK_SKI1_1	84	88	PF00082	0.651
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DOC_ANK_TNKS_1	218	225	PF00023	0.538
DOC_CYCLIN_RxL_1	111	120	PF00134	0.601
DOC_MAPK_gen_1	161	169	PF00069	0.698
DOC_MAPK_MEF2A_6	163	171	PF00069	0.690
DOC_MAPK_RevD_3	365	380	PF00069	0.554
DOC_USP7_MATH_1	199	203	PF00917	0.698
DOC_USP7_MATH_1	206	210	PF00917	0.753
DOC_USP7_MATH_1	249	253	PF00917	0.564
DOC_USP7_UBL2_3	168	172	PF12436	0.745
DOC_USP7_UBL2_3	184	188	PF12436	0.613
DOC_USP7_UBL2_3	207	211	PF12436	0.539
DOC_WW_Pin1_4	183	188	PF00397	0.723
DOC_WW_Pin1_4	335	340	PF00397	0.684
LIG_14-3-3_CanoR_1	277	287	PF00244	0.783
LIG_14-3-3_CanoR_1	362	370	PF00244	0.801
LIG_14-3-3_CanoR_1	99	106	PF00244	0.496
LIG_Actin_WH2_2	69	86	PF00022	0.588
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.550
LIG_BRCT_BRCA1_1	20	24	PF00533	0.498
LIG_BRCT_BRCA1_1	201	205	PF00533	0.538
LIG_BRCT_BRCA1_1	47	51	PF00533	0.621
LIG_BRCT_BRCA1_2	201	207	PF00533	0.539
LIG_Clathr_ClatBox_1	367	371	PF01394	0.586
LIG_FHA_1	362	368	PF00498	0.570
LIG_FHA_1	37	43	PF00498	0.501
LIG_FHA_1	393	399	PF00498	0.558
LIG_FHA_2	224	230	PF00498	0.784
LIG_FHA_2	262	268	PF00498	0.521
LIG_FHA_2	293	299	PF00498	0.723
LIG_LIR_Gen_1	323	330	PF02991	0.560
LIG_LIR_Gen_1	413	420	PF02991	0.524
LIG_LIR_Nem_3	202	208	PF02991	0.539
LIG_LIR_Nem_3	323	329	PF02991	0.561
LIG_LIR_Nem_3	413	418	PF02991	0.522
LIG_LIR_Nem_3	54	60	PF02991	0.614
LIG_PDZ_Class_2	415	420	PF00595	0.776
LIG_SH2_CRK	326	330	PF00017	0.558
LIG_SH2_GRB2like	94	97	PF00017	0.429
LIG_SH2_NCK_1	326	330	PF00017	0.558
LIG_SH2_PTP2	415	418	PF00017	0.520
LIG_SH2_SRC	94	97	PF00017	0.429
LIG_SH2_STAP1	9	13	PF00017	0.469
LIG_SH2_STAT5	415	418	PF00017	0.520
LIG_SH3_2	270	275	PF14604	0.808
LIG_SH3_3	242	248	PF00018	0.537
LIG_SH3_3	267	273	PF00018	0.797
LIG_TRAF2_1	389	392	PF00917	0.564
LIG_UBA3_1	367	375	PF00899	0.549
LIG_WRPW_2	57	60	PF00400	0.371
MOD_CDK_SPK_2	183	188	PF00069	0.560
MOD_CDK_SPK_2	335	340	PF00069	0.684
MOD_CK1_1	186	192	PF00069	0.573
MOD_CK1_1	294	300	PF00069	0.649
MOD_CK1_1	34	40	PF00069	0.485
MOD_CK2_1	14	20	PF00069	0.526
MOD_CK2_1	217	223	PF00069	0.618
MOD_CK2_1	261	267	PF00069	0.514
MOD_CK2_1	292	298	PF00069	0.724
MOD_CK2_1	386	392	PF00069	0.598
MOD_CK2_1	400	406	PF00069	0.729
MOD_Cter_Amidation	277	280	PF01082	0.765
MOD_GlcNHglycan	119	122	PF01048	0.599
MOD_GlcNHglycan	130	133	PF01048	0.504
MOD_GlcNHglycan	14	17	PF01048	0.556
MOD_GlcNHglycan	215	218	PF01048	0.787
MOD_GlcNHglycan	236	240	PF01048	0.687
MOD_GlcNHglycan	24	27	PF01048	0.733
MOD_GlcNHglycan	251	254	PF01048	0.559
MOD_GlcNHglycan	284	287	PF01048	0.553
MOD_GlcNHglycan	320	325	PF01048	0.562
MOD_GlcNHglycan	79	82	PF01048	0.531
MOD_GSK3_1	14	21	PF00069	0.504
MOD_GSK3_1	213	220	PF00069	0.787
MOD_GSK3_1	231	238	PF00069	0.486
MOD_GSK3_1	24	31	PF00069	0.591
MOD_GSK3_1	278	285	PF00069	0.573
MOD_GSK3_1	293	300	PF00069	0.588
MOD_GSK3_1	392	399	PF00069	0.559
MOD_GSK3_1	90	97	PF00069	0.625
MOD_N-GLC_1	386	391	PF02516	0.564
MOD_NEK2_1	117	122	PF00069	0.564
MOD_NEK2_1	18	23	PF00069	0.551
MOD_NEK2_1	24	29	PF00069	0.649
MOD_NEK2_1	393	398	PF00069	0.810
MOD_NEK2_1	76	81	PF00069	0.584
MOD_NEK2_2	199	204	PF00069	0.535
MOD_NEK2_2	36	41	PF00069	0.601
MOD_NEK2_2	94	99	PF00069	0.401
MOD_PIKK_1	393	399	PF00454	0.810
MOD_PK_1	99	105	PF00069	0.493
MOD_PKA_1	279	285	PF00069	0.676
MOD_PKA_1	291	297	PF00069	0.601
MOD_PKA_2	107	113	PF00069	0.568
MOD_PKA_2	213	219	PF00069	0.706
MOD_PKA_2	278	284	PF00069	0.681
MOD_PKA_2	28	34	PF00069	0.534
MOD_PKA_2	291	297	PF00069	0.591
MOD_PKA_2	361	367	PF00069	0.804
MOD_PKA_2	383	389	PF00069	0.610
MOD_PKA_2	45	51	PF00069	0.380
MOD_PKA_2	98	104	PF00069	0.545
MOD_PKB_1	277	285	PF00069	0.706
MOD_Plk_1	217	223	PF00069	0.595
MOD_Plk_1	230	236	PF00069	0.681
MOD_Plk_1	320	326	PF00069	0.563
MOD_Plk_1	386	392	PF00069	0.683
MOD_Plk_2-3	231	237	PF00069	0.530
MOD_Plk_2-3	298	304	PF00069	0.553
MOD_Plk_4	14	20	PF00069	0.526
MOD_Plk_4	186	192	PF00069	0.565
MOD_ProDKin_1	183	189	PF00069	0.726
MOD_ProDKin_1	335	341	PF00069	0.685
MOD_SUMO_for_1	147	150	PF00179	0.571
MOD_SUMO_for_1	356	359	PF00179	0.565
TRG_ENDOCYTIC_2	326	329	PF00928	0.560
TRG_ENDOCYTIC_2	415	418	PF00928	0.520
TRG_ER_diArg_1	165	167	PF00400	0.591
TRG_ER_diArg_1	193	196	PF00400	0.714
TRG_ER_diArg_1	212	215	PF00400	0.732
TRG_ER_diArg_1	274	277	PF00400	0.668
TRG_ER_diArg_1	332	335	PF00400	0.729
TRG_ER_diArg_1	379	382	PF00400	0.823
TRG_NLS_Bipartite_1	192	214	PF00514	0.794
TRG_NLS_MonoCore_2	331	336	PF00514	0.586
TRG_NLS_MonoExtC_3	191	196	PF00514	0.688
TRG_NLS_MonoExtC_3	209	214	PF00514	0.755
TRG_NLS_MonoExtC_3	332	337	PF00514	0.592
TRG_NLS_MonoExtC_3	377	382	PF00514	0.565
TRG_NLS_MonoExtN_4	207	214	PF00514	0.766
TRG_NLS_MonoExtN_4	330	337	PF00514	0.589
TRG_NLS_MonoExtN_4	375	382	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK0	Leptomonas seymouri	31%	100%
A0A3S7X4A5	Leishmania donovani	59%	100%
A4I6M3	Leishmania infantum	59%	100%
E9B1P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q6G4	Leishmania major	59%	96%