Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ78_LEIBR

TriTrypDb:

LbrM.31.1180 , LBRM2903_310019600

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.460
CLV_NRD_NRD_1	400	402	PF00675	0.490
CLV_NRD_NRD_1	63	65	PF00675	0.405
CLV_NRD_NRD_1	704	706	PF00675	0.602
CLV_NRD_NRD_1	756	758	PF00675	0.553
CLV_PCSK_KEX2_1	164	166	PF00082	0.448
CLV_PCSK_KEX2_1	258	260	PF00082	0.387
CLV_PCSK_KEX2_1	342	344	PF00082	0.448
CLV_PCSK_KEX2_1	400	402	PF00082	0.509
CLV_PCSK_KEX2_1	63	65	PF00082	0.405
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.447
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.461
CLV_PCSK_SKI1_1	342	346	PF00082	0.504
CLV_PCSK_SKI1_1	586	590	PF00082	0.676
CLV_PCSK_SKI1_1	716	720	PF00082	0.550
CLV_PCSK_SKI1_1	87	91	PF00082	0.395
CLV_PCSK_SKI1_1	98	102	PF00082	0.375
DEG_APCC_DBOX_1	153	161	PF00400	0.500
DEG_APCC_DBOX_1	749	757	PF00400	0.553
DEG_APCC_DBOX_1	86	94	PF00400	0.387
DEG_SCF_FBW7_1	41	46	PF00400	0.545
DEG_SPOP_SBC_1	485	489	PF00917	0.685
DOC_ANK_TNKS_1	131	138	PF00023	0.293
DOC_CKS1_1	278	283	PF01111	0.574
DOC_CKS1_1	313	318	PF01111	0.536
DOC_CKS1_1	496	501	PF01111	0.757
DOC_CKS1_1	549	554	PF01111	0.739
DOC_CKS1_1	673	678	PF01111	0.606
DOC_CKS1_1	83	88	PF01111	0.475
DOC_CYCLIN_RxL_1	339	347	PF00134	0.574
DOC_MAPK_DCC_7	486	496	PF00069	0.528
DOC_MAPK_gen_1	152	160	PF00069	0.432
DOC_MAPK_MEF2A_6	154	162	PF00069	0.431
DOC_MAPK_MEF2A_6	372	380	PF00069	0.552
DOC_PP2B_LxvP_1	204	207	PF13499	0.514
DOC_PP2B_LxvP_1	381	384	PF13499	0.624
DOC_PP2B_LxvP_1	472	475	PF13499	0.519
DOC_PP4_FxxP_1	380	383	PF00568	0.488
DOC_USP7_MATH_1	421	425	PF00917	0.598
DOC_USP7_MATH_1	484	488	PF00917	0.671
DOC_USP7_MATH_1	538	542	PF00917	0.757
DOC_USP7_MATH_1	568	572	PF00917	0.529
DOC_USP7_MATH_1	601	605	PF00917	0.744
DOC_USP7_MATH_1	608	612	PF00917	0.796
DOC_USP7_MATH_1	627	631	PF00917	0.515
DOC_USP7_UBL2_3	576	580	PF12436	0.760
DOC_USP7_UBL2_3	586	590	PF12436	0.643
DOC_WW_Pin1_4	246	251	PF00397	0.615
DOC_WW_Pin1_4	274	279	PF00397	0.510
DOC_WW_Pin1_4	312	317	PF00397	0.511
DOC_WW_Pin1_4	39	44	PF00397	0.671
DOC_WW_Pin1_4	487	492	PF00397	0.670
DOC_WW_Pin1_4	49	54	PF00397	0.628
DOC_WW_Pin1_4	495	500	PF00397	0.672
DOC_WW_Pin1_4	548	553	PF00397	0.726
DOC_WW_Pin1_4	672	677	PF00397	0.587
DOC_WW_Pin1_4	74	79	PF00397	0.481
DOC_WW_Pin1_4	82	87	PF00397	0.410
LIG_14-3-3_CanoR_1	343	349	PF00244	0.532
LIG_14-3-3_CanoR_1	394	398	PF00244	0.476
LIG_14-3-3_CanoR_1	400	410	PF00244	0.457
LIG_14-3-3_CanoR_1	486	491	PF00244	0.762
LIG_14-3-3_CanoR_1	683	687	PF00244	0.689
LIG_14-3-3_CanoR_1	697	702	PF00244	0.519
LIG_14-3-3_CanoR_1	733	742	PF00244	0.535
LIG_14-3-3_CanoR_1	750	754	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	363	367	PF00533	0.524
LIG_CaM_NSCaTE_8	239	246	PF13499	0.492
LIG_Clathr_ClatBox_1	292	296	PF01394	0.466
LIG_deltaCOP1_diTrp_1	407	410	PF00928	0.540
LIG_Dynein_DLC8_1	171	177	PF01221	0.384
LIG_FHA_1	157	163	PF00498	0.286
LIG_FHA_1	186	192	PF00498	0.373
LIG_FHA_1	203	209	PF00498	0.496
LIG_FHA_1	339	345	PF00498	0.525
LIG_FHA_1	394	400	PF00498	0.394
LIG_FHA_1	40	46	PF00498	0.792
LIG_FHA_1	421	427	PF00498	0.477
LIG_FHA_1	464	470	PF00498	0.388
LIG_FHA_1	5	11	PF00498	0.601
LIG_FHA_1	549	555	PF00498	0.703
LIG_FHA_1	722	728	PF00498	0.592
LIG_FHA_1	77	83	PF00498	0.599
LIG_FHA_2	188	194	PF00498	0.419
LIG_FHA_2	3	9	PF00498	0.624
LIG_FHA_2	305	311	PF00498	0.310
LIG_FHA_2	402	408	PF00498	0.550
LIG_FHA_2	409	415	PF00498	0.547
LIG_LIR_Apic_2	377	383	PF02991	0.528
LIG_LIR_Apic_2	674	680	PF02991	0.610
LIG_LIR_Gen_1	147	155	PF02991	0.456
LIG_LIR_Gen_1	193	203	PF02991	0.382
LIG_LIR_Gen_1	238	247	PF02991	0.430
LIG_LIR_Gen_1	253	262	PF02991	0.511
LIG_LIR_Gen_1	55	65	PF02991	0.560
LIG_LIR_Nem_3	147	151	PF02991	0.420
LIG_LIR_Nem_3	193	198	PF02991	0.383
LIG_LIR_Nem_3	238	242	PF02991	0.390
LIG_LIR_Nem_3	253	257	PF02991	0.523
LIG_LIR_Nem_3	280	285	PF02991	0.454
LIG_LIR_Nem_3	336	340	PF02991	0.550
LIG_LIR_Nem_3	55	60	PF02991	0.562
LIG_MAD2	30	38	PF02301	0.440
LIG_NRBOX	307	313	PF00104	0.455
LIG_PCNA_PIPBox_1	189	198	PF02747	0.272
LIG_PCNA_yPIPBox_3	189	200	PF02747	0.275
LIG_SH2_CRK	102	106	PF00017	0.491
LIG_SH2_CRK	199	203	PF00017	0.378
LIG_SH2_CRK	254	258	PF00017	0.556
LIG_SH2_CRK	57	61	PF00017	0.555
LIG_SH2_PTP2	148	151	PF00017	0.489
LIG_SH2_STAP1	24	28	PF00017	0.509
LIG_SH2_STAP1	340	344	PF00017	0.540
LIG_SH2_STAP1	57	61	PF00017	0.484
LIG_SH2_STAT3	232	235	PF00017	0.468
LIG_SH2_STAT3	726	729	PF00017	0.356
LIG_SH2_STAT5	102	105	PF00017	0.290
LIG_SH2_STAT5	144	147	PF00017	0.442
LIG_SH2_STAT5	148	151	PF00017	0.496
LIG_SH2_STAT5	254	257	PF00017	0.555
LIG_SH2_STAT5	340	343	PF00017	0.574
LIG_SH2_STAT5	726	729	PF00017	0.603
LIG_SH3_1	224	230	PF00018	0.554
LIG_SH3_1	275	281	PF00018	0.548
LIG_SH3_3	224	230	PF00018	0.529
LIG_SH3_3	275	281	PF00018	0.548
LIG_SH3_3	42	48	PF00018	0.751
LIG_SH3_3	643	649	PF00018	0.660
LIG_SH3_3	670	676	PF00018	0.611
LIG_SH3_3	80	86	PF00018	0.532
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.391
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.478
LIG_SUMO_SIM_par_1	238	246	PF11976	0.424
LIG_SUMO_SIM_par_1	267	272	PF11976	0.289
LIG_SUMO_SIM_par_1	291	296	PF11976	0.412
LIG_SUMO_SIM_par_1	465	470	PF11976	0.412
LIG_TYR_ITIM	146	151	PF00017	0.443
LIG_TYR_ITIM	252	257	PF00017	0.473
LIG_UBA3_1	202	210	PF00899	0.298
LIG_UBA3_1	471	476	PF00899	0.560
LIG_UBA3_1	698	706	PF00899	0.616
LIG_WRC_WIRS_1	715	720	PF05994	0.484
MOD_CDK_SPK_2	495	500	PF00069	0.551
MOD_CDK_SPK_2	82	87	PF00069	0.443
MOD_CDK_SPxxK_3	495	502	PF00069	0.551
MOD_CK1_1	127	133	PF00069	0.521
MOD_CK1_1	147	153	PF00069	0.198
MOD_CK1_1	178	184	PF00069	0.508
MOD_CK1_1	2	8	PF00069	0.636
MOD_CK1_1	424	430	PF00069	0.362
MOD_CK1_1	487	493	PF00069	0.699
MOD_CK1_1	672	678	PF00069	0.596
MOD_CK1_1	700	706	PF00069	0.548
MOD_CK1_1	746	752	PF00069	0.588
MOD_CK1_1	76	82	PF00069	0.605
MOD_CK2_1	187	193	PF00069	0.394
MOD_CK2_1	2	8	PF00069	0.652
MOD_CK2_1	214	220	PF00069	0.603
MOD_CK2_1	401	407	PF00069	0.570
MOD_CK2_1	408	414	PF00069	0.516
MOD_CK2_1	627	633	PF00069	0.733
MOD_CK2_1	733	739	PF00069	0.608
MOD_Cter_Amidation	577	580	PF01082	0.791
MOD_GlcNHglycan	1	4	PF01048	0.598
MOD_GlcNHglycan	33	36	PF01048	0.699
MOD_GlcNHglycan	364	367	PF01048	0.438
MOD_GlcNHglycan	390	393	PF01048	0.491
MOD_GlcNHglycan	428	431	PF01048	0.429
MOD_GlcNHglycan	515	518	PF01048	0.667
MOD_GlcNHglycan	536	539	PF01048	0.707
MOD_GlcNHglycan	540	543	PF01048	0.779
MOD_GlcNHglycan	570	573	PF01048	0.559
MOD_GlcNHglycan	635	638	PF01048	0.624
MOD_GSK3_1	124	131	PF00069	0.496
MOD_GSK3_1	168	175	PF00069	0.539
MOD_GSK3_1	242	249	PF00069	0.507
MOD_GSK3_1	37	44	PF00069	0.732
MOD_GSK3_1	420	427	PF00069	0.455
MOD_GSK3_1	485	492	PF00069	0.638
MOD_GSK3_1	498	505	PF00069	0.592
MOD_GSK3_1	534	541	PF00069	0.634
MOD_GSK3_1	697	704	PF00069	0.581
MOD_GSK3_1	73	80	PF00069	0.538
MOD_N-GLC_1	354	359	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	101	106	PF00069	0.483
MOD_NEK2_1	185	190	PF00069	0.425
MOD_NEK2_1	243	248	PF00069	0.491
MOD_NEK2_1	311	316	PF00069	0.531
MOD_NEK2_1	344	349	PF00069	0.539
MOD_NEK2_1	362	367	PF00069	0.300
MOD_NEK2_1	426	431	PF00069	0.407
MOD_NEK2_1	452	457	PF00069	0.494
MOD_NEK2_1	592	597	PF00069	0.781
MOD_NEK2_1	714	719	PF00069	0.442
MOD_NEK2_2	738	743	PF00069	0.608
MOD_PIKK_1	172	178	PF00454	0.521
MOD_PIKK_1	185	191	PF00454	0.450
MOD_PIKK_1	252	258	PF00454	0.554
MOD_PIKK_1	452	458	PF00454	0.509
MOD_PIKK_1	743	749	PF00454	0.597
MOD_PIKK_1	77	83	PF00454	0.546
MOD_PK_1	214	220	PF00069	0.383
MOD_PK_1	502	508	PF00069	0.550
MOD_PKA_1	172	178	PF00069	0.594
MOD_PKA_1	400	406	PF00069	0.524
MOD_PKA_2	11	17	PF00069	0.604
MOD_PKA_2	393	399	PF00069	0.470
MOD_PKA_2	400	406	PF00069	0.455
MOD_PKA_2	485	491	PF00069	0.685
MOD_PKA_2	669	675	PF00069	0.509
MOD_PKA_2	682	688	PF00069	0.576
MOD_PKA_2	749	755	PF00069	0.509
MOD_Plk_1	178	184	PF00069	0.343
MOD_Plk_1	243	249	PF00069	0.543
MOD_Plk_1	295	301	PF00069	0.443
MOD_Plk_1	354	360	PF00069	0.442
MOD_Plk_1	55	61	PF00069	0.546
MOD_Plk_1	593	599	PF00069	0.786
MOD_Plk_1	738	744	PF00069	0.601
MOD_Plk_2-3	669	675	PF00069	0.625
MOD_Plk_4	144	150	PF00069	0.420
MOD_Plk_4	187	193	PF00069	0.379
MOD_Plk_4	317	323	PF00069	0.531
MOD_Plk_4	393	399	PF00069	0.432
MOD_Plk_4	421	427	PF00069	0.449
MOD_Plk_4	463	469	PF00069	0.398
MOD_Plk_4	55	61	PF00069	0.443
MOD_Plk_4	64	70	PF00069	0.402
MOD_Plk_4	721	727	PF00069	0.580
MOD_ProDKin_1	246	252	PF00069	0.618
MOD_ProDKin_1	274	280	PF00069	0.508
MOD_ProDKin_1	312	318	PF00069	0.508
MOD_ProDKin_1	39	45	PF00069	0.674
MOD_ProDKin_1	487	493	PF00069	0.673
MOD_ProDKin_1	49	55	PF00069	0.615
MOD_ProDKin_1	495	501	PF00069	0.671
MOD_ProDKin_1	548	554	PF00069	0.726
MOD_ProDKin_1	672	678	PF00069	0.592
MOD_ProDKin_1	74	80	PF00069	0.480
MOD_ProDKin_1	82	88	PF00069	0.409
MOD_SUMO_for_1	367	370	PF00179	0.490
TRG_DiLeu_BaEn_1	18	23	PF01217	0.537
TRG_DiLeu_BaEn_1	288	293	PF01217	0.494
TRG_DiLeu_BaEn_1	56	61	PF01217	0.322
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.321
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.519
TRG_ENDOCYTIC_2	102	105	PF00928	0.453
TRG_ENDOCYTIC_2	148	151	PF00928	0.450
TRG_ENDOCYTIC_2	199	202	PF00928	0.378
TRG_ENDOCYTIC_2	233	236	PF00928	0.362
TRG_ENDOCYTIC_2	254	257	PF00928	0.555
TRG_ENDOCYTIC_2	57	60	PF00928	0.563
TRG_ER_diArg_1	164	166	PF00400	0.433
TRG_ER_diArg_1	399	401	PF00400	0.493
TRG_ER_diArg_1	63	65	PF00400	0.408
TRG_NES_CRM1_1	289	303	PF08389	0.286
TRG_NLS_MonoExtC_3	575	580	PF00514	0.755
TRG_NLS_MonoExtN_4	702	709	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD12	Leptomonas seymouri	60%	93%
A0A3S5H7P7	Leishmania donovani	76%	98%
A4I6M2	Leishmania infantum	76%	98%
C9ZTI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A527	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B1P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4Q6G5	Leishmania major	78%	100%
V5BCP2	Trypanosoma cruzi	32%	100%
V5BXS1	Trypanosoma cruzi	28%	100%