Putative sodium stibogluconate resistance protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

sodium stibogluconate resistance protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ76_LEIBR

TriTrypDb:

LbrM.31.1160 , LBRM2903_310019000

Length:

262

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.810
CLV_NRD_NRD_1	256	258	PF00675	0.594
CLV_NRD_NRD_1	93	95	PF00675	0.744
CLV_PCSK_KEX2_1	165	167	PF00082	0.787
CLV_PCSK_KEX2_1	180	182	PF00082	0.535
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.787
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.535
CLV_PCSK_SKI1_1	10	14	PF00082	0.824
DEG_SCF_FBW7_1	29	35	PF00400	0.804
DOC_CKS1_1	29	34	PF01111	0.805
DOC_MAPK_gen_1	129	137	PF00069	0.839
DOC_MAPK_MEF2A_6	131	139	PF00069	0.843
DOC_MAPK_MEF2A_6	194	201	PF00069	0.698
DOC_PP1_SILK_1	253	258	PF00149	0.592
DOC_PP2B_LxvP_1	207	210	PF13499	0.671
DOC_PP4_FxxP_1	119	122	PF00568	0.823
DOC_USP7_MATH_1	102	106	PF00917	0.771
DOC_USP7_MATH_1	147	151	PF00917	0.869
DOC_USP7_MATH_1	157	161	PF00917	0.635
DOC_USP7_MATH_1	244	248	PF00917	0.711
DOC_USP7_MATH_1	32	36	PF00917	0.798
DOC_USP7_UBL2_3	172	176	PF12436	0.775
DOC_WW_Pin1_4	28	33	PF00397	0.807
DOC_WW_Pin1_4	61	66	PF00397	0.800
LIG_14-3-3_CanoR_1	182	190	PF00244	0.797
LIG_14-3-3_CanoR_1	47	51	PF00244	0.804
LIG_14-3-3_CanoR_1	68	72	PF00244	0.789
LIG_14-3-3_CanoR_1	94	98	PF00244	0.766
LIG_Actin_WH2_2	78	96	PF00022	0.757
LIG_CSL_BTD_1	29	32	PF09270	0.807
LIG_FHA_1	226	232	PF00498	0.651
LIG_FHA_1	78	84	PF00498	0.770
LIG_FHA_2	110	116	PF00498	0.795
LIG_LIR_Apic_2	117	122	PF02991	0.819
LIG_LIR_Gen_1	211	221	PF02991	0.577
LIG_LIR_Gen_1	246	256	PF02991	0.591
LIG_LIR_Nem_3	211	217	PF02991	0.565
LIG_SH2_STAT5	14	17	PF00017	0.700
LIG_SH2_STAT5	73	76	PF00017	0.789
LIG_SH3_3	132	138	PF00018	0.845
LIG_SH3_3	26	32	PF00018	0.816
LIG_SH3_3	80	86	PF00018	0.757
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.763
LIG_SUMO_SIM_par_1	39	45	PF11976	0.796
LIG_TRAF2_1	114	117	PF00917	0.799
LIG_TRAF2_1	49	52	PF00917	0.806
LIG_UBA3_1	251	258	PF00899	0.701
MOD_CDK_SPxxK_3	61	68	PF00069	0.798
MOD_CK2_1	109	115	PF00069	0.794
MOD_CK2_1	46	52	PF00069	0.801
MOD_GlcNHglycan	158	162	PF01048	0.801
MOD_GlcNHglycan	221	224	PF01048	0.734
MOD_GlcNHglycan	25	28	PF01048	0.827
MOD_GlcNHglycan	34	37	PF01048	0.649
MOD_GSK3_1	147	154	PF00069	0.868
MOD_GSK3_1	188	195	PF00069	0.756
MOD_GSK3_1	2	9	PF00069	0.785
MOD_GSK3_1	28	35	PF00069	0.808
MOD_GSK3_1	42	49	PF00069	0.550
MOD_GSK3_1	50	57	PF00069	0.672
MOD_GSK3_1	67	74	PF00069	0.490
MOD_N-GLC_1	188	193	PF02516	0.765
MOD_NEK2_1	1	6	PF00069	0.801
MOD_NEK2_1	23	28	PF00069	0.822
MOD_NEK2_1	251	256	PF00069	0.573
MOD_NEK2_1	42	47	PF00069	0.461
MOD_NEK2_1	93	98	PF00069	0.755
MOD_OFUCOSY	205	212	PF10250	0.558
MOD_PIKK_1	30	36	PF00454	0.802
MOD_PK_1	131	137	PF00069	0.842
MOD_PKA_2	147	153	PF00069	0.870
MOD_PKA_2	46	52	PF00069	0.801
MOD_PKA_2	67	73	PF00069	0.790
MOD_PKA_2	93	99	PF00069	0.761
MOD_PKB_1	129	137	PF00069	0.839
MOD_Plk_1	192	198	PF00069	0.716
MOD_Plk_4	227	233	PF00069	0.677
MOD_Plk_4	251	257	PF00069	0.690
MOD_ProDKin_1	28	34	PF00069	0.808
MOD_ProDKin_1	61	67	PF00069	0.799
MOD_SUMO_for_1	164	167	PF00179	0.783
TRG_DiLeu_BaEn_1	203	208	PF01217	0.684
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.799
TRG_NLS_Bipartite_1	165	184	PF00514	0.783
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.743