LeishMANIAdb
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Sodium stibogluconate resistance protein like

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein like
Gene product:
sodium stibogluconate resistance protein like
Species:
Leishmania braziliensis
UniProt:
A4HJ75_LEIBR
TriTrypDb:
LbrM.31.1150
Length:
321

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 200 202 PF00675 0.480
CLV_NRD_NRD_1 217 219 PF00675 0.451
CLV_PCSK_KEX2_1 200 202 PF00082 0.480
CLV_PCSK_KEX2_1 217 219 PF00082 0.451
CLV_PCSK_SKI1_1 111 115 PF00082 0.425
CLV_PCSK_SKI1_1 260 264 PF00082 0.438
CLV_PCSK_SKI1_1 52 56 PF00082 0.665
DEG_APCC_DBOX_1 15 23 PF00400 0.432
DOC_CKS1_1 138 143 PF01111 0.504
DOC_CKS1_1 253 258 PF01111 0.456
DOC_CYCLIN_RxL_1 108 117 PF00134 0.424
DOC_MAPK_gen_1 217 227 PF00069 0.460
DOC_MAPK_gen_1 89 96 PF00069 0.417
DOC_MAPK_MEF2A_6 220 229 PF00069 0.453
DOC_PP1_RVXF_1 258 265 PF00149 0.443
DOC_USP7_MATH_1 216 220 PF00917 0.756
DOC_USP7_MATH_1 284 288 PF00917 0.527
DOC_WW_Pin1_4 137 142 PF00397 0.501
DOC_WW_Pin1_4 176 181 PF00397 0.531
DOC_WW_Pin1_4 205 210 PF00397 0.728
DOC_WW_Pin1_4 252 257 PF00397 0.453
LIG_14-3-3_CanoR_1 220 229 PF00244 0.510
LIG_14-3-3_CanoR_1 23 29 PF00244 0.414
LIG_14-3-3_CanoR_1 52 57 PF00244 0.516
LIG_14-3-3_CanoR_1 78 84 PF00244 0.690
LIG_14-3-3_CterR_2 319 321 PF00244 0.487
LIG_Actin_WH2_2 255 273 PF00022 0.460
LIG_eIF4E_1 199 205 PF01652 0.482
LIG_FHA_1 102 108 PF00498 0.406
LIG_FHA_1 138 144 PF00498 0.508
LIG_FHA_1 162 168 PF00498 0.461
LIG_FHA_1 206 212 PF00498 0.492
LIG_FHA_1 243 249 PF00498 0.471
LIG_FHA_1 49 55 PF00498 0.511
LIG_Integrin_RGD_1 293 295 PF01839 0.491
LIG_Integrin_RGD_1 40 42 PF01839 0.478
LIG_LIR_Apic_2 250 256 PF02991 0.442
LIG_LIR_Nem_3 108 113 PF02991 0.601
LIG_PCNA_yPIPBox_3 111 119 PF02747 0.465
LIG_REV1ctd_RIR_1 261 270 PF16727 0.451
LIG_SH2_CRK 110 114 PF00017 0.481
LIG_SH2_CRK 253 257 PF00017 0.455
LIG_SH2_GRB2like 119 122 PF00017 0.483
LIG_SH2_STAT3 157 160 PF00017 0.454
LIG_SH2_STAT3 199 202 PF00017 0.480
LIG_SH2_STAT3 83 86 PF00017 0.427
LIG_SH2_STAT5 119 122 PF00017 0.614
LIG_SH2_STAT5 157 160 PF00017 0.734
LIG_SH2_STAT5 228 231 PF00017 0.718
LIG_SH2_STAT5 83 86 PF00017 0.539
LIG_SH2_STAT5 87 90 PF00017 0.594
LIG_UBA3_1 225 234 PF00899 0.444
LIG_UBA3_1 28 36 PF00899 0.704
MOD_CDK_SPK_2 137 142 PF00069 0.501
MOD_CDK_SPK_2 205 210 PF00069 0.490
MOD_CDK_SPxK_1 252 258 PF00069 0.454
MOD_CDK_SPxxK_3 137 144 PF00069 0.506
MOD_CK1_1 117 123 PF00069 0.711
MOD_CK1_1 169 175 PF00069 0.526
MOD_CK1_1 185 191 PF00069 0.630
MOD_CK1_1 236 242 PF00069 0.440
MOD_CK1_1 45 51 PF00069 0.507
MOD_CK2_1 1 7 PF00069 0.487
MOD_GlcNHglycan 168 171 PF01048 0.484
MOD_GlcNHglycan 184 188 PF01048 0.482
MOD_GlcNHglycan 245 248 PF01048 0.462
MOD_GlcNHglycan 273 276 PF01048 0.609
MOD_GlcNHglycan 3 6 PF01048 0.472
MOD_GSK3_1 101 108 PF00069 0.407
MOD_GSK3_1 162 169 PF00069 0.534
MOD_GSK3_1 176 183 PF00069 0.777
MOD_GSK3_1 18 25 PF00069 0.701
MOD_GSK3_1 216 223 PF00069 0.641
MOD_GSK3_1 280 287 PF00069 0.526
MOD_GSK3_1 42 49 PF00069 0.506
MOD_NEK2_1 114 119 PF00069 0.714
MOD_NEK2_1 132 137 PF00069 0.467
MOD_NEK2_1 161 166 PF00069 0.489
MOD_NEK2_1 193 198 PF00069 0.589
MOD_NEK2_1 233 238 PF00069 0.526
MOD_NEK2_2 18 23 PF00069 0.430
MOD_PIKK_1 236 242 PF00454 0.440
MOD_PKA_2 216 222 PF00069 0.514
MOD_PKA_2 22 28 PF00069 0.412
MOD_PKB_1 218 226 PF00069 0.458
MOD_Plk_2-3 42 48 PF00069 0.506
MOD_Plk_4 102 108 PF00069 0.406
MOD_Plk_4 114 120 PF00069 0.423
MOD_Plk_4 153 159 PF00069 0.462
MOD_Plk_4 162 168 PF00069 0.450
MOD_Plk_4 30 36 PF00069 0.542
MOD_Plk_4 79 85 PF00069 0.670
MOD_ProDKin_1 137 143 PF00069 0.503
MOD_ProDKin_1 176 182 PF00069 0.531
MOD_ProDKin_1 205 211 PF00069 0.728
MOD_ProDKin_1 252 258 PF00069 0.454
MOD_SUMO_rev_2 267 272 PF00179 0.475
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.712
TRG_ENDOCYTIC_2 110 113 PF00928 0.470
TRG_ER_diArg_1 141 144 PF00400 0.518
TRG_ER_diArg_1 199 201 PF00400 0.481
TRG_ER_diArg_1 216 218 PF00400 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
E8NHD2 Leishmania infantum 27% 70%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS