LeishMANIAdb
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Putative sodium stibogluconate resistance protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium stibogluconate resistance protein
Gene product:
sodium stibogluconate resistance protein, putative (fragment)
Species:
Leishmania braziliensis
UniProt:
A4HJ73_LEIBR
TriTrypDb:
LbrM.31.1130 , LBRM2903_310019000
Length:
493

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ73
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ73

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.787
CLV_C14_Caspase3-7 140 144 PF00656 0.694
CLV_C14_Caspase3-7 75 79 PF00656 0.704
CLV_NRD_NRD_1 240 242 PF00675 0.415
CLV_NRD_NRD_1 262 264 PF00675 0.525
CLV_NRD_NRD_1 312 314 PF00675 0.670
CLV_NRD_NRD_1 458 460 PF00675 0.485
CLV_PCSK_KEX2_1 239 241 PF00082 0.444
CLV_PCSK_KEX2_1 262 264 PF00082 0.525
CLV_PCSK_KEX2_1 487 489 PF00082 0.525
CLV_PCSK_PC1ET2_1 239 241 PF00082 0.444
CLV_PCSK_PC1ET2_1 487 489 PF00082 0.525
CLV_PCSK_SKI1_1 241 245 PF00082 0.519
CLV_PCSK_SKI1_1 331 335 PF00082 0.643
CLV_PCSK_SKI1_1 376 380 PF00082 0.533
CLV_PCSK_SKI1_1 459 463 PF00082 0.449
CLV_Separin_Metazoa 456 460 PF03568 0.448
DEG_APCC_DBOX_1 203 211 PF00400 0.322
DEG_APCC_DBOX_1 29 37 PF00400 0.361
DEG_SCF_FBW7_1 395 401 PF00400 0.466
DOC_CKS1_1 395 400 PF01111 0.472
DOC_CYCLIN_RxL_1 238 248 PF00134 0.458
DOC_MAPK_gen_1 239 245 PF00069 0.404
DOC_MAPK_MEF2A_6 156 164 PF00069 0.671
DOC_MAPK_MEF2A_6 450 457 PF00069 0.456
DOC_PP4_FxxP_1 471 474 PF00568 0.524
DOC_USP7_MATH_1 144 148 PF00917 0.550
DOC_USP7_MATH_1 257 261 PF00917 0.633
DOC_USP7_MATH_1 398 402 PF00917 0.716
DOC_USP7_MATH_2 341 347 PF00917 0.739
DOC_WW_Pin1_4 394 399 PF00397 0.755
DOC_WW_Pin1_4 427 432 PF00397 0.797
DOC_WW_Pin1_4 473 478 PF00397 0.521
DOC_WW_Pin1_4 70 75 PF00397 0.585
LIG_14-3-3_CanoR_1 272 277 PF00244 0.678
LIG_14-3-3_CanoR_1 30 38 PF00244 0.623
LIG_14-3-3_CanoR_1 376 382 PF00244 0.516
LIG_14-3-3_CanoR_1 413 417 PF00244 0.664
LIG_14-3-3_CanoR_1 434 438 PF00244 0.647
LIG_AP2alpha_1 50 54 PF02296 0.641
LIG_APCC_ABBAyCdc20_2 450 456 PF00400 0.462
LIG_BIR_III_2 148 152 PF00653 0.539
LIG_BRCT_BRCA1_1 274 278 PF00533 0.679
LIG_CSL_BTD_1 395 398 PF09270 0.755
LIG_eIF4E_1 290 296 PF01652 0.398
LIG_EVH1_2 100 104 PF00568 0.562
LIG_FHA_1 190 196 PF00498 0.554
LIG_FHA_1 211 217 PF00498 0.583
LIG_FHA_1 271 277 PF00498 0.684
LIG_FHA_1 53 59 PF00498 0.667
LIG_FHA_2 30 36 PF00498 0.626
LIG_Integrin_RGD_1 76 78 PF01839 0.592
LIG_LIR_Apic_2 470 474 PF02991 0.524
LIG_LIR_Gen_1 167 177 PF02991 0.385
LIG_LIR_Gen_1 184 193 PF02991 0.600
LIG_LIR_Gen_1 247 257 PF02991 0.614
LIG_LIR_Nem_3 159 164 PF02991 0.638
LIG_LIR_Nem_3 17 23 PF02991 0.653
LIG_LIR_Nem_3 173 178 PF02991 0.378
LIG_LIR_Nem_3 184 188 PF02991 0.440
LIG_LIR_Nem_3 247 253 PF02991 0.599
LIG_LIR_Nem_3 275 280 PF02991 0.381
LIG_LIR_Nem_3 305 309 PF02991 0.608
LIG_MLH1_MIPbox_1 274 278 PF16413 0.405
LIG_Pex14_2 461 465 PF04695 0.446
LIG_Pex14_2 50 54 PF04695 0.641
LIG_SH2_CRK 175 179 PF00017 0.593
LIG_SH2_CRK 20 24 PF00017 0.650
LIG_SH2_CRK 298 302 PF00017 0.492
LIG_SH2_CRK 306 310 PF00017 0.433
LIG_SH2_CRK 319 323 PF00017 0.431
LIG_SH2_GRB2like 319 322 PF00017 0.428
LIG_SH2_SRC 319 322 PF00017 0.428
LIG_SH2_STAP1 319 323 PF00017 0.431
LIG_SH2_STAT3 37 40 PF00017 0.628
LIG_SH2_STAT5 161 164 PF00017 0.356
LIG_SH2_STAT5 185 188 PF00017 0.620
LIG_SH2_STAT5 194 197 PF00017 0.508
LIG_SH2_STAT5 205 208 PF00017 0.279
LIG_SH2_STAT5 250 253 PF00017 0.506
LIG_SH2_STAT5 290 293 PF00017 0.601
LIG_SH2_STAT5 298 301 PF00017 0.475
LIG_SH2_STAT5 344 347 PF00017 0.731
LIG_SH2_STAT5 37 40 PF00017 0.628
LIG_SH2_STAT5 439 442 PF00017 0.824
LIG_SH3_2 474 479 PF14604 0.525
LIG_SH3_3 350 356 PF00018 0.495
LIG_SH3_3 392 398 PF00018 0.772
LIG_SH3_3 471 477 PF00018 0.520
LIG_SUMO_SIM_par_1 377 384 PF11976 0.509
LIG_SUMO_SIM_par_1 405 411 PF11976 0.438
LIG_TRAF2_1 415 418 PF00917 0.584
LIG_TYR_ITIM 18 23 PF00017 0.644
LIG_TYR_ITIM 296 301 PF00017 0.422
LIG_UBA3_1 216 224 PF00899 0.599
MOD_CDC14_SPxK_1 476 479 PF00782 0.527
MOD_CDC14_SPxK_1 73 76 PF00782 0.588
MOD_CDK_SPxK_1 473 479 PF00069 0.525
MOD_CDK_SPxK_1 70 76 PF00069 0.587
MOD_CDK_SPxxK_3 427 434 PF00069 0.797
MOD_CK1_1 3 9 PF00069 0.572
MOD_CK1_1 307 313 PF00069 0.656
MOD_CK1_1 380 386 PF00069 0.589
MOD_CK1_1 444 450 PF00069 0.521
MOD_CK2_1 29 35 PF00069 0.623
MOD_CK2_1 412 418 PF00069 0.597
MOD_GlcNHglycan 101 104 PF01048 0.565
MOD_GlcNHglycan 131 134 PF01048 0.778
MOD_GlcNHglycan 306 309 PF01048 0.375
MOD_GlcNHglycan 357 360 PF01048 0.515
MOD_GlcNHglycan 391 394 PF01048 0.793
MOD_GlcNHglycan 400 403 PF01048 0.560
MOD_GlcNHglycan 62 66 PF01048 0.632
MOD_GSK3_1 206 213 PF00069 0.587
MOD_GSK3_1 244 251 PF00069 0.449
MOD_GSK3_1 252 259 PF00069 0.585
MOD_GSK3_1 266 273 PF00069 0.650
MOD_GSK3_1 363 370 PF00069 0.806
MOD_GSK3_1 394 401 PF00069 0.745
MOD_GSK3_1 408 415 PF00069 0.499
MOD_GSK3_1 416 423 PF00069 0.562
MOD_GSK3_1 433 440 PF00069 0.775
MOD_N-GLC_1 444 449 PF02516 0.519
MOD_N-GLC_2 297 299 PF02516 0.530
MOD_NEK2_1 208 213 PF00069 0.583
MOD_NEK2_1 270 275 PF00069 0.618
MOD_NEK2_1 276 281 PF00069 0.629
MOD_NEK2_1 302 307 PF00069 0.629
MOD_NEK2_1 363 368 PF00069 0.728
MOD_NEK2_1 389 394 PF00069 0.795
MOD_NEK2_1 408 413 PF00069 0.414
MOD_NEK2_1 50 55 PF00069 0.643
MOD_NMyristoyl 1 7 PF02799 0.814
MOD_PIKK_1 210 216 PF00454 0.581
MOD_PIKK_1 396 402 PF00454 0.610
MOD_PK_1 4 10 PF00069 0.836
MOD_PKA_2 29 35 PF00069 0.623
MOD_PKA_2 412 418 PF00069 0.663
MOD_PKA_2 433 439 PF00069 0.648
MOD_Plk_4 181 187 PF00069 0.608
MOD_Plk_4 272 278 PF00069 0.681
MOD_Plk_4 290 296 PF00069 0.309
MOD_Plk_4 297 303 PF00069 0.316
MOD_ProDKin_1 394 400 PF00069 0.751
MOD_ProDKin_1 427 433 PF00069 0.797
MOD_ProDKin_1 473 479 PF00069 0.525
MOD_ProDKin_1 70 76 PF00069 0.587
TRG_DiLeu_BaLyEn_6 173 178 PF01217 0.596
TRG_DiLeu_BaLyEn_6 402 407 PF01217 0.703
TRG_ENDOCYTIC_2 161 164 PF00928 0.451
TRG_ENDOCYTIC_2 174 177 PF00928 0.568
TRG_ENDOCYTIC_2 185 188 PF00928 0.444
TRG_ENDOCYTIC_2 20 23 PF00928 0.647
TRG_ENDOCYTIC_2 205 208 PF00928 0.279
TRG_ENDOCYTIC_2 250 253 PF00928 0.561
TRG_ENDOCYTIC_2 289 292 PF00928 0.609
TRG_ENDOCYTIC_2 298 301 PF00928 0.460
TRG_ENDOCYTIC_2 306 309 PF00928 0.394
TRG_ENDOCYTIC_2 319 322 PF00928 0.428
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.601
TRG_Pf-PMV_PEXEL_1 355 360 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 64% 79%
A0A3Q8ISI8 Leishmania donovani 65% 79%
A0A3S7X4A3 Leishmania donovani 64% 79%
A4HJ70 Leishmania braziliensis 88% 100%
A4HJ71 Leishmania braziliensis 94% 100%
A4I6I2 Leishmania infantum 64% 75%
A4I6L8 Leishmania infantum 64% 79%
E8NHD1 Leishmania infantum 65% 83%
E8NHD2 Leishmania infantum 69% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 79%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 79%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 79%
Q4Q6G7 Leishmania major 66% 100%
Q4Q6G8 Leishmania major 65% 100%
Q4Q6H0 Leishmania major 66% 100%
Q9BHE5 Leishmania major 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS