LeishMANIAdb
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Putative sodium stibogluconate resistance protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium stibogluconate resistance protein
Gene product:
sodium stibogluconate resistance protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HJ71_LEIBR
TriTrypDb:
LbrM.31.1110 , LBRM2903_310019000
Length:
628

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ71

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.774
CLV_C14_Caspase3-7 140 144 PF00656 0.682
CLV_C14_Caspase3-7 75 79 PF00656 0.699
CLV_NRD_NRD_1 240 242 PF00675 0.508
CLV_NRD_NRD_1 262 264 PF00675 0.531
CLV_NRD_NRD_1 312 314 PF00675 0.689
CLV_NRD_NRD_1 459 461 PF00675 0.455
CLV_NRD_NRD_1 547 549 PF00675 0.770
CLV_NRD_NRD_1 584 586 PF00675 0.571
CLV_NRD_NRD_1 622 624 PF00675 0.582
CLV_PCSK_KEX2_1 239 241 PF00082 0.505
CLV_PCSK_KEX2_1 262 264 PF00082 0.531
CLV_PCSK_KEX2_1 531 533 PF00082 0.717
CLV_PCSK_KEX2_1 546 548 PF00082 0.531
CLV_PCSK_PC1ET2_1 239 241 PF00082 0.505
CLV_PCSK_PC1ET2_1 531 533 PF00082 0.739
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.531
CLV_PCSK_SKI1_1 241 245 PF00082 0.648
CLV_PCSK_SKI1_1 331 335 PF00082 0.645
CLV_PCSK_SKI1_1 376 380 PF00082 0.549
DEG_APCC_DBOX_1 203 211 PF00400 0.339
DEG_APCC_DBOX_1 29 37 PF00400 0.366
DEG_SCF_FBW7_1 395 401 PF00400 0.474
DOC_CKS1_1 395 400 PF01111 0.478
DOC_CYCLIN_RxL_1 238 248 PF00134 0.558
DOC_MAPK_gen_1 239 245 PF00069 0.512
DOC_MAPK_gen_1 286 294 PF00069 0.300
DOC_MAPK_gen_1 495 503 PF00069 0.523
DOC_MAPK_MEF2A_6 156 164 PF00069 0.662
DOC_MAPK_MEF2A_6 497 505 PF00069 0.528
DOC_MAPK_MEF2A_6 560 567 PF00069 0.682
DOC_MAPK_RevD_3 572 586 PF00069 0.355
DOC_PP2B_LxvP_1 573 576 PF13499 0.393
DOC_PP4_FxxP_1 485 488 PF00568 0.522
DOC_USP7_MATH_1 144 148 PF00917 0.545
DOC_USP7_MATH_1 257 261 PF00917 0.634
DOC_USP7_MATH_1 398 402 PF00917 0.728
DOC_USP7_MATH_1 468 472 PF00917 0.548
DOC_USP7_MATH_1 513 517 PF00917 0.665
DOC_USP7_MATH_1 523 527 PF00917 0.618
DOC_USP7_MATH_1 610 614 PF00917 0.587
DOC_USP7_MATH_2 341 347 PF00917 0.745
DOC_USP7_UBL2_3 538 542 PF12436 0.489
DOC_WW_Pin1_4 394 399 PF00397 0.752
DOC_WW_Pin1_4 427 432 PF00397 0.743
DOC_WW_Pin1_4 70 75 PF00397 0.582
LIG_14-3-3_CanoR_1 272 277 PF00244 0.681
LIG_14-3-3_CanoR_1 30 38 PF00244 0.617
LIG_14-3-3_CanoR_1 376 382 PF00244 0.532
LIG_14-3-3_CanoR_1 413 417 PF00244 0.605
LIG_14-3-3_CanoR_1 434 438 PF00244 0.555
LIG_14-3-3_CanoR_1 460 464 PF00244 0.469
LIG_14-3-3_CanoR_1 548 556 PF00244 0.642
LIG_Actin_WH2_2 444 462 PF00022 0.707
LIG_AP2alpha_1 50 54 PF02296 0.632
LIG_BIR_III_2 148 152 PF00653 0.538
LIG_BRCT_BRCA1_1 274 278 PF00533 0.665
LIG_CSL_BTD_1 395 398 PF09270 0.744
LIG_eIF4E_1 290 296 PF01652 0.396
LIG_EVH1_2 100 104 PF00568 0.552
LIG_FHA_1 190 196 PF00498 0.568
LIG_FHA_1 211 217 PF00498 0.583
LIG_FHA_1 271 277 PF00498 0.687
LIG_FHA_1 444 450 PF00498 0.545
LIG_FHA_1 53 59 PF00498 0.661
LIG_FHA_2 30 36 PF00498 0.621
LIG_FHA_2 476 482 PF00498 0.752
LIG_Integrin_RGD_1 76 78 PF01839 0.595
LIG_LIR_Apic_2 483 488 PF02991 0.518
LIG_LIR_Gen_1 167 177 PF02991 0.378
LIG_LIR_Gen_1 184 193 PF02991 0.587
LIG_LIR_Gen_1 247 257 PF02991 0.659
LIG_LIR_Gen_1 577 587 PF02991 0.355
LIG_LIR_Gen_1 595 603 PF02991 0.430
LIG_LIR_Gen_1 612 622 PF02991 0.601
LIG_LIR_Nem_3 159 164 PF02991 0.638
LIG_LIR_Nem_3 17 23 PF02991 0.641
LIG_LIR_Nem_3 173 178 PF02991 0.371
LIG_LIR_Nem_3 184 188 PF02991 0.428
LIG_LIR_Nem_3 247 253 PF02991 0.660
LIG_LIR_Nem_3 275 280 PF02991 0.383
LIG_LIR_Nem_3 287 292 PF02991 0.361
LIG_LIR_Nem_3 305 309 PF02991 0.603
LIG_LIR_Nem_3 577 582 PF02991 0.351
LIG_LIR_Nem_3 595 600 PF02991 0.453
LIG_LIR_Nem_3 612 618 PF02991 0.533
LIG_MLH1_MIPbox_1 274 278 PF16413 0.402
LIG_Pex14_2 50 54 PF04695 0.632
LIG_SH2_CRK 175 179 PF00017 0.575
LIG_SH2_CRK 20 24 PF00017 0.638
LIG_SH2_CRK 298 302 PF00017 0.509
LIG_SH2_CRK 306 310 PF00017 0.444
LIG_SH2_CRK 319 323 PF00017 0.426
LIG_SH2_GRB2like 319 322 PF00017 0.426
LIG_SH2_PTP2 597 600 PF00017 0.409
LIG_SH2_SRC 319 322 PF00017 0.426
LIG_SH2_STAP1 319 323 PF00017 0.426
LIG_SH2_STAT3 37 40 PF00017 0.623
LIG_SH2_STAT5 161 164 PF00017 0.367
LIG_SH2_STAT5 185 188 PF00017 0.610
LIG_SH2_STAT5 194 197 PF00017 0.531
LIG_SH2_STAT5 205 208 PF00017 0.302
LIG_SH2_STAT5 250 253 PF00017 0.547
LIG_SH2_STAT5 290 293 PF00017 0.600
LIG_SH2_STAT5 298 301 PF00017 0.488
LIG_SH2_STAT5 344 347 PF00017 0.736
LIG_SH2_STAT5 37 40 PF00017 0.623
LIG_SH2_STAT5 439 442 PF00017 0.691
LIG_SH2_STAT5 597 600 PF00017 0.430
LIG_SH3_3 350 356 PF00018 0.519
LIG_SH3_3 392 398 PF00018 0.766
LIG_SH3_3 446 452 PF00018 0.708
LIG_SH3_3 498 504 PF00018 0.778
LIG_SUMO_SIM_anti_2 445 452 PF11976 0.703
LIG_SUMO_SIM_par_1 377 384 PF11976 0.527
LIG_SUMO_SIM_par_1 405 411 PF11976 0.444
LIG_TRAF2_1 415 418 PF00917 0.537
LIG_TRAF2_1 480 483 PF00917 0.498
LIG_TYR_ITIM 18 23 PF00017 0.631
LIG_TYR_ITIM 296 301 PF00017 0.439
LIG_UBA3_1 216 224 PF00899 0.601
LIG_UBA3_1 578 586 PF00899 0.465
LIG_UBA3_1 617 624 PF00899 0.582
MOD_CDC14_SPxK_1 73 76 PF00782 0.586
MOD_CDK_SPxK_1 70 76 PF00069 0.585
MOD_CDK_SPxxK_3 427 434 PF00069 0.739
MOD_CK1_1 3 9 PF00069 0.570
MOD_CK1_1 307 313 PF00069 0.657
MOD_CK1_1 380 386 PF00069 0.600
MOD_CK1_1 596 602 PF00069 0.445
MOD_CK2_1 29 35 PF00069 0.617
MOD_CK2_1 412 418 PF00069 0.550
MOD_CK2_1 475 481 PF00069 0.725
MOD_GlcNHglycan 101 104 PF01048 0.556
MOD_GlcNHglycan 131 134 PF01048 0.767
MOD_GlcNHglycan 306 309 PF01048 0.377
MOD_GlcNHglycan 357 360 PF01048 0.535
MOD_GlcNHglycan 391 394 PF01048 0.796
MOD_GlcNHglycan 400 403 PF01048 0.580
MOD_GlcNHglycan 524 528 PF01048 0.757
MOD_GlcNHglycan 587 590 PF01048 0.595
MOD_GlcNHglycan 62 66 PF01048 0.651
MOD_GSK3_1 206 213 PF00069 0.588
MOD_GSK3_1 244 251 PF00069 0.553
MOD_GSK3_1 252 259 PF00069 0.596
MOD_GSK3_1 266 273 PF00069 0.681
MOD_GSK3_1 363 370 PF00069 0.808
MOD_GSK3_1 394 401 PF00069 0.744
MOD_GSK3_1 408 415 PF00069 0.462
MOD_GSK3_1 416 423 PF00069 0.535
MOD_GSK3_1 433 440 PF00069 0.658
MOD_GSK3_1 513 520 PF00069 0.575
MOD_GSK3_1 554 561 PF00069 0.728
MOD_GSK3_1 574 581 PF00069 0.298
MOD_N-GLC_1 554 559 PF02516 0.471
MOD_N-GLC_2 297 299 PF02516 0.540
MOD_NEK2_1 208 213 PF00069 0.601
MOD_NEK2_1 270 275 PF00069 0.632
MOD_NEK2_1 276 281 PF00069 0.623
MOD_NEK2_1 282 287 PF00069 0.508
MOD_NEK2_1 302 307 PF00069 0.633
MOD_NEK2_1 363 368 PF00069 0.735
MOD_NEK2_1 389 394 PF00069 0.794
MOD_NEK2_1 408 413 PF00069 0.389
MOD_NEK2_1 459 464 PF00069 0.705
MOD_NEK2_1 50 55 PF00069 0.634
MOD_NEK2_1 578 583 PF00069 0.543
MOD_NMyristoyl 1 7 PF02799 0.808
MOD_PIKK_1 210 216 PF00454 0.581
MOD_PIKK_1 396 402 PF00454 0.623
MOD_PK_1 4 10 PF00069 0.821
MOD_PK_1 497 503 PF00069 0.527
MOD_PKA_1 585 591 PF00069 0.599
MOD_PKA_2 29 35 PF00069 0.617
MOD_PKA_2 412 418 PF00069 0.613
MOD_PKA_2 433 439 PF00069 0.553
MOD_PKA_2 459 465 PF00069 0.462
MOD_PKA_2 513 519 PF00069 0.622
MOD_PKB_1 495 503 PF00069 0.538
MOD_Plk_1 558 564 PF00069 0.705
MOD_Plk_4 181 187 PF00069 0.593
MOD_Plk_4 272 278 PF00069 0.678
MOD_Plk_4 290 296 PF00069 0.311
MOD_Plk_4 574 580 PF00069 0.540
MOD_Plk_4 593 599 PF00069 0.419
MOD_ProDKin_1 394 400 PF00069 0.748
MOD_ProDKin_1 427 433 PF00069 0.743
MOD_ProDKin_1 70 76 PF00069 0.585
MOD_SUMO_for_1 530 533 PF00179 0.473
TRG_DiLeu_BaEn_1 569 574 PF01217 0.361
TRG_DiLeu_BaLyEn_6 173 178 PF01217 0.581
TRG_DiLeu_BaLyEn_6 402 407 PF01217 0.716
TRG_ENDOCYTIC_2 161 164 PF00928 0.458
TRG_ENDOCYTIC_2 174 177 PF00928 0.550
TRG_ENDOCYTIC_2 185 188 PF00928 0.433
TRG_ENDOCYTIC_2 20 23 PF00928 0.636
TRG_ENDOCYTIC_2 205 208 PF00928 0.296
TRG_ENDOCYTIC_2 250 253 PF00928 0.600
TRG_ENDOCYTIC_2 289 292 PF00928 0.603
TRG_ENDOCYTIC_2 298 301 PF00928 0.473
TRG_ENDOCYTIC_2 306 309 PF00928 0.398
TRG_ENDOCYTIC_2 319 322 PF00928 0.426
TRG_ENDOCYTIC_2 597 600 PF00928 0.409
TRG_NLS_Bipartite_1 531 550 PF00514 0.726
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.576
TRG_Pf-PMV_PEXEL_1 355 360 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 624 628 PF00026 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 65% 100%
A0A3Q8ISI8 Leishmania donovani 65% 100%
A0A3S7X4A3 Leishmania donovani 64% 100%
A4HJ70 Leishmania braziliensis 91% 100%
A4HJ73 Leishmania braziliensis 94% 100%
A4HJW7 Leishmania braziliensis 87% 100%
A4I6I2 Leishmania infantum 65% 95%
A4I6L8 Leishmania infantum 66% 100%
E8NHD1 Leishmania infantum 65% 100%
E8NHD2 Leishmania infantum 69% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
Q4Q6G7 Leishmania major 66% 98%
Q4Q6G8 Leishmania major 66% 98%
Q4Q6H0 Leishmania major 66% 98%
Q9BHE5 Leishmania major 66% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS