LeishMANIAdb
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Putative sodium stibogluconate resistance protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium stibogluconate resistance protein
Gene product:
sodium stibogluconate resistance protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HJ70_LEIBR
TriTrypDb:
LbrM.31.1100 , LBRM2903_310019000 *
Length:
628

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ70
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ70

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.731
CLV_C14_Caspase3-7 140 144 PF00656 0.659
CLV_C14_Caspase3-7 75 79 PF00656 0.677
CLV_NRD_NRD_1 240 242 PF00675 0.487
CLV_NRD_NRD_1 262 264 PF00675 0.550
CLV_NRD_NRD_1 311 313 PF00675 0.619
CLV_NRD_NRD_1 316 318 PF00675 0.589
CLV_NRD_NRD_1 459 461 PF00675 0.466
CLV_NRD_NRD_1 547 549 PF00675 0.706
CLV_NRD_NRD_1 584 586 PF00675 0.573
CLV_PCSK_KEX2_1 239 241 PF00082 0.482
CLV_PCSK_KEX2_1 262 264 PF00082 0.550
CLV_PCSK_KEX2_1 316 318 PF00082 0.402
CLV_PCSK_KEX2_1 531 533 PF00082 0.680
CLV_PCSK_KEX2_1 546 548 PF00082 0.512
CLV_PCSK_KEX2_1 624 626 PF00082 0.388
CLV_PCSK_PC1ET2_1 239 241 PF00082 0.482
CLV_PCSK_PC1ET2_1 531 533 PF00082 0.698
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.512
CLV_PCSK_PC1ET2_1 624 626 PF00082 0.388
CLV_PCSK_PC7_1 312 318 PF00082 0.394
CLV_PCSK_SKI1_1 241 245 PF00082 0.681
CLV_PCSK_SKI1_1 376 380 PF00082 0.522
DEG_APCC_DBOX_1 203 211 PF00400 0.370
DEG_APCC_DBOX_1 29 37 PF00400 0.359
DEG_SCF_FBW7_1 395 401 PF00400 0.485
DOC_CKS1_1 395 400 PF01111 0.484
DOC_CYCLIN_RxL_1 238 248 PF00134 0.538
DOC_MAPK_gen_1 239 245 PF00069 0.491
DOC_MAPK_gen_1 495 503 PF00069 0.518
DOC_MAPK_MEF2A_6 156 164 PF00069 0.627
DOC_MAPK_MEF2A_6 497 505 PF00069 0.523
DOC_MAPK_MEF2A_6 560 567 PF00069 0.616
DOC_MAPK_RevD_3 572 586 PF00069 0.347
DOC_PP2B_LxvP_1 573 576 PF13499 0.387
DOC_USP7_MATH_1 144 148 PF00917 0.553
DOC_USP7_MATH_1 257 261 PF00917 0.637
DOC_USP7_MATH_1 398 402 PF00917 0.750
DOC_USP7_MATH_1 468 472 PF00917 0.581
DOC_USP7_MATH_1 513 517 PF00917 0.639
DOC_USP7_MATH_1 523 527 PF00917 0.597
DOC_USP7_MATH_1 610 614 PF00917 0.588
DOC_USP7_MATH_2 341 347 PF00917 0.675
DOC_USP7_UBL2_3 538 542 PF12436 0.482
DOC_WW_Pin1_4 394 399 PF00397 0.703
DOC_WW_Pin1_4 427 432 PF00397 0.723
DOC_WW_Pin1_4 70 75 PF00397 0.579
LIG_14-3-3_CanoR_1 272 277 PF00244 0.629
LIG_14-3-3_CanoR_1 288 292 PF00244 0.322
LIG_14-3-3_CanoR_1 30 38 PF00244 0.567
LIG_14-3-3_CanoR_1 312 319 PF00244 0.517
LIG_14-3-3_CanoR_1 413 417 PF00244 0.627
LIG_14-3-3_CanoR_1 434 438 PF00244 0.559
LIG_14-3-3_CanoR_1 460 464 PF00244 0.479
LIG_Actin_WH2_2 444 462 PF00022 0.671
LIG_AP2alpha_1 50 54 PF02296 0.588
LIG_BIR_III_2 148 152 PF00653 0.530
LIG_BRCT_BRCA1_1 274 278 PF00533 0.603
LIG_CSL_BTD_1 395 398 PF09270 0.759
LIG_EVH1_2 100 104 PF00568 0.558
LIG_FHA_1 190 196 PF00498 0.525
LIG_FHA_1 211 217 PF00498 0.553
LIG_FHA_1 271 277 PF00498 0.642
LIG_FHA_1 53 59 PF00498 0.627
LIG_FHA_2 30 36 PF00498 0.571
LIG_FHA_2 476 482 PF00498 0.704
LIG_Integrin_RGD_1 76 78 PF01839 0.588
LIG_LIR_Gen_1 167 177 PF02991 0.390
LIG_LIR_Gen_1 184 193 PF02991 0.549
LIG_LIR_Gen_1 247 257 PF02991 0.587
LIG_LIR_Gen_1 290 298 PF02991 0.316
LIG_LIR_Gen_1 436 444 PF02991 0.410
LIG_LIR_Gen_1 577 587 PF02991 0.344
LIG_LIR_Gen_1 595 603 PF02991 0.416
LIG_LIR_Gen_1 612 622 PF02991 0.635
LIG_LIR_Nem_3 159 164 PF02991 0.600
LIG_LIR_Nem_3 17 23 PF02991 0.604
LIG_LIR_Nem_3 173 178 PF02991 0.380
LIG_LIR_Nem_3 184 188 PF02991 0.422
LIG_LIR_Nem_3 247 253 PF02991 0.589
LIG_LIR_Nem_3 275 280 PF02991 0.392
LIG_LIR_Nem_3 290 294 PF02991 0.385
LIG_LIR_Nem_3 436 440 PF02991 0.405
LIG_LIR_Nem_3 577 582 PF02991 0.338
LIG_LIR_Nem_3 595 600 PF02991 0.433
LIG_MLH1_MIPbox_1 274 278 PF16413 0.385
LIG_Pex14_2 50 54 PF04695 0.588
LIG_SH2_CRK 175 179 PF00017 0.548
LIG_SH2_CRK 20 24 PF00017 0.601
LIG_SH2_CRK 298 302 PF00017 0.472
LIG_SH2_CRK 437 441 PF00017 0.405
LIG_SH2_GRB2like 439 442 PF00017 0.453
LIG_SH2_PTP2 597 600 PF00017 0.389
LIG_SH2_STAT3 37 40 PF00017 0.574
LIG_SH2_STAT5 161 164 PF00017 0.432
LIG_SH2_STAT5 185 188 PF00017 0.569
LIG_SH2_STAT5 194 197 PF00017 0.446
LIG_SH2_STAT5 205 208 PF00017 0.571
LIG_SH2_STAT5 250 253 PF00017 0.539
LIG_SH2_STAT5 291 294 PF00017 0.559
LIG_SH2_STAT5 298 301 PF00017 0.471
LIG_SH2_STAT5 335 338 PF00017 0.567
LIG_SH2_STAT5 344 347 PF00017 0.702
LIG_SH2_STAT5 37 40 PF00017 0.629
LIG_SH2_STAT5 380 383 PF00017 0.461
LIG_SH2_STAT5 439 442 PF00017 0.652
LIG_SH2_STAT5 597 600 PF00017 0.406
LIG_SH3_3 350 356 PF00018 0.509
LIG_SH3_3 392 398 PF00018 0.710
LIG_SH3_3 446 452 PF00018 0.674
LIG_SH3_3 498 504 PF00018 0.756
LIG_SUMO_SIM_anti_2 446 452 PF11976 0.670
LIG_SUMO_SIM_par_1 405 411 PF11976 0.475
LIG_TRAF2_1 415 418 PF00917 0.569
LIG_TRAF2_1 480 483 PF00917 0.526
LIG_TYR_ITIM 18 23 PF00017 0.595
LIG_TYR_ITIM 296 301 PF00017 0.411
LIG_TYR_ITIM 435 440 PF00017 0.398
LIG_UBA3_1 216 224 PF00899 0.565
LIG_UBA3_1 302 310 PF00899 0.352
LIG_UBA3_1 578 586 PF00899 0.435
LIG_UBA3_1 617 624 PF00899 0.559
MOD_CDC14_SPxK_1 73 76 PF00782 0.582
MOD_CDK_SPxK_1 70 76 PF00069 0.581
MOD_CDK_SPxxK_3 427 434 PF00069 0.684
MOD_CK1_1 3 9 PF00069 0.615
MOD_CK1_1 443 449 PF00069 0.474
MOD_CK1_1 596 602 PF00069 0.420
MOD_CK2_1 29 35 PF00069 0.566
MOD_CK2_1 412 418 PF00069 0.581
MOD_CK2_1 475 481 PF00069 0.705
MOD_GlcNHglycan 101 104 PF01048 0.583
MOD_GlcNHglycan 131 134 PF01048 0.728
MOD_GlcNHglycan 357 360 PF01048 0.561
MOD_GlcNHglycan 391 394 PF01048 0.748
MOD_GlcNHglycan 400 403 PF01048 0.643
MOD_GlcNHglycan 445 448 PF01048 0.511
MOD_GlcNHglycan 524 528 PF01048 0.719
MOD_GlcNHglycan 587 590 PF01048 0.545
MOD_GlcNHglycan 62 66 PF01048 0.631
MOD_GSK3_1 206 213 PF00069 0.587
MOD_GSK3_1 244 251 PF00069 0.539
MOD_GSK3_1 252 259 PF00069 0.526
MOD_GSK3_1 266 273 PF00069 0.712
MOD_GSK3_1 363 370 PF00069 0.777
MOD_GSK3_1 394 401 PF00069 0.747
MOD_GSK3_1 408 415 PF00069 0.512
MOD_GSK3_1 416 423 PF00069 0.562
MOD_GSK3_1 513 520 PF00069 0.572
MOD_GSK3_1 554 561 PF00069 0.657
MOD_GSK3_1 574 581 PF00069 0.455
MOD_N-GLC_1 440 445 PF02516 0.425
MOD_N-GLC_1 554 559 PF02516 0.448
MOD_N-GLC_2 297 299 PF02516 0.502
MOD_NEK2_1 208 213 PF00069 0.556
MOD_NEK2_1 270 275 PF00069 0.482
MOD_NEK2_1 276 281 PF00069 0.546
MOD_NEK2_1 302 307 PF00069 0.582
MOD_NEK2_1 363 368 PF00069 0.733
MOD_NEK2_1 389 394 PF00069 0.714
MOD_NEK2_1 408 413 PF00069 0.450
MOD_NEK2_1 440 445 PF00069 0.470
MOD_NEK2_1 459 464 PF00069 0.687
MOD_NEK2_1 50 55 PF00069 0.590
MOD_NEK2_1 578 583 PF00069 0.501
MOD_NMyristoyl 1 7 PF02799 0.818
MOD_PIKK_1 210 216 PF00454 0.545
MOD_PIKK_1 396 402 PF00454 0.607
MOD_PK_1 4 10 PF00069 0.778
MOD_PK_1 497 503 PF00069 0.520
MOD_PKA_1 585 591 PF00069 0.548
MOD_PKA_2 287 293 PF00069 0.321
MOD_PKA_2 29 35 PF00069 0.566
MOD_PKA_2 311 317 PF00069 0.520
MOD_PKA_2 412 418 PF00069 0.617
MOD_PKA_2 433 439 PF00069 0.577
MOD_PKA_2 459 465 PF00069 0.473
MOD_PKA_2 513 519 PF00069 0.609
MOD_PKB_1 495 503 PF00069 0.531
MOD_Plk_1 440 446 PF00069 0.422
MOD_Plk_1 482 488 PF00069 0.494
MOD_Plk_1 558 564 PF00069 0.624
MOD_Plk_4 181 187 PF00069 0.558
MOD_Plk_4 272 278 PF00069 0.674
MOD_Plk_4 287 293 PF00069 0.339
MOD_Plk_4 331 337 PF00069 0.389
MOD_Plk_4 574 580 PF00069 0.521
MOD_Plk_4 593 599 PF00069 0.391
MOD_Plk_4 616 622 PF00069 0.564
MOD_ProDKin_1 394 400 PF00069 0.703
MOD_ProDKin_1 427 433 PF00069 0.716
MOD_ProDKin_1 70 76 PF00069 0.581
MOD_SUMO_for_1 530 533 PF00179 0.477
TRG_DiLeu_BaEn_1 569 574 PF01217 0.354
TRG_DiLeu_BaLyEn_6 173 178 PF01217 0.553
TRG_DiLeu_BaLyEn_6 402 407 PF01217 0.701
TRG_ENDOCYTIC_2 161 164 PF00928 0.454
TRG_ENDOCYTIC_2 174 177 PF00928 0.530
TRG_ENDOCYTIC_2 185 188 PF00928 0.425
TRG_ENDOCYTIC_2 20 23 PF00928 0.598
TRG_ENDOCYTIC_2 205 208 PF00928 0.561
TRG_ENDOCYTIC_2 250 253 PF00928 0.539
TRG_ENDOCYTIC_2 291 294 PF00928 0.527
TRG_ENDOCYTIC_2 298 301 PF00928 0.440
TRG_ENDOCYTIC_2 437 440 PF00928 0.402
TRG_ENDOCYTIC_2 597 600 PF00928 0.389
TRG_ER_diArg_1 316 318 PF00400 0.402
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.568
TRG_Pf-PMV_PEXEL_1 355 360 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 624 628 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 61% 100%
A0A3Q8ISI8 Leishmania donovani 61% 100%
A0A3S7X4A3 Leishmania donovani 61% 100%
A4HJ71 Leishmania braziliensis 91% 100%
A4HJ73 Leishmania braziliensis 88% 100%
A4HJW7 Leishmania braziliensis 92% 100%
A4I6I2 Leishmania infantum 61% 95%
A4I6L8 Leishmania infantum 61% 100%
E8NHD1 Leishmania infantum 62% 100%
E8NHD2 Leishmania infantum 63% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
Q4Q6G7 Leishmania major 63% 98%
Q4Q6G8 Leishmania major 62% 98%
Q4Q6H0 Leishmania major 63% 98%
Q9BHE5 Leishmania major 62% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS