LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJ65_LEIBR
TriTrypDb:
LbrM.31.1050 , LBRM2903_310019300
Length:
79

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 7
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HJ65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ65

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 49 51 PF00082 0.439
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.526
DOC_MAPK_gen_1 49 56 PF00069 0.650
DOC_MAPK_JIP1_4 50 56 PF00069 0.653
DOC_MAPK_MEF2A_6 23 31 PF00069 0.324
DOC_MAPK_RevD_3 35 50 PF00069 0.381
DOC_PP2B_LxvP_1 54 57 PF13499 0.661
DOC_USP7_MATH_1 13 17 PF00917 0.414
DOC_USP7_MATH_1 19 23 PF00917 0.624
DOC_USP7_MATH_1 64 68 PF00917 0.746
LIG_BIR_II_1 1 5 PF00653 0.684
LIG_FHA_2 61 67 PF00498 0.738
LIG_LIR_Nem_3 24 29 PF02991 0.440
LIG_PDZ_Class_3 74 79 PF00595 0.800
LIG_Pex14_2 26 30 PF04695 0.323
LIG_TRAF2_1 22 25 PF00917 0.537
MOD_CK2_1 19 25 PF00069 0.547
MOD_CK2_1 60 66 PF00069 0.731
MOD_GlcNHglycan 1 4 PF01048 0.496
MOD_GlcNHglycan 66 69 PF01048 0.444
MOD_GSK3_1 56 63 PF00069 0.660
MOD_NEK2_1 33 38 PF00069 0.381
MOD_Plk_4 56 62 PF00069 0.714

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IF91 Leishmania donovani 89% 100%
A0A3S7X498 Leishmania donovani 90% 100%
A4I6L6 Leishmania infantum 88% 100%
A4I6M0 Leishmania infantum 90% 100%
D0A7A1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 74%
E9B1P1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q9BHG9 Leishmania major 90% 100%
V5AXX0 Trypanosoma cruzi 61% 81%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS