Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ62_LEIBR

TriTrypDb:

LbrM.31.1020 , LBRM2903_310017600

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ62

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.235
CLV_C14_Caspase3-7	219	223	PF00656	0.445
CLV_C14_Caspase3-7	394	398	PF00656	0.679
CLV_C14_Caspase3-7	411	415	PF00656	0.630
CLV_C14_Caspase3-7	536	540	PF00656	0.648
CLV_C14_Caspase3-7	78	82	PF00656	0.744
CLV_NRD_NRD_1	199	201	PF00675	0.356
CLV_NRD_NRD_1	242	244	PF00675	0.480
CLV_NRD_NRD_1	464	466	PF00675	0.600
CLV_NRD_NRD_1	468	470	PF00675	0.552
CLV_NRD_NRD_1	504	506	PF00675	0.546
CLV_PCSK_KEX2_1	199	201	PF00082	0.352
CLV_PCSK_KEX2_1	266	268	PF00082	0.253
CLV_PCSK_KEX2_1	468	470	PF00082	0.586
CLV_PCSK_KEX2_1	504	506	PF00082	0.546
CLV_PCSK_KEX2_1	54	56	PF00082	0.396
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.253
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.396
CLV_PCSK_PC7_1	195	201	PF00082	0.343
CLV_PCSK_SKI1_1	456	460	PF00082	0.548
DEG_COP1_1	315	325	PF00400	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.533
DEG_SCF_FBW7_1	428	434	PF00400	0.567
DEG_SCF_TRCP1_1	77	82	PF00400	0.521
DEG_SPOP_SBC_1	314	318	PF00917	0.555
DOC_CKS1_1	428	433	PF01111	0.793
DOC_MAPK_MEF2A_6	339	346	PF00069	0.564
DOC_PP2B_LxvP_1	102	105	PF13499	0.480
DOC_PP2B_LxvP_1	362	365	PF13499	0.630
DOC_PP4_FxxP_1	325	328	PF00568	0.772
DOC_USP7_MATH_1	109	113	PF00917	0.343
DOC_USP7_MATH_1	188	192	PF00917	0.440
DOC_USP7_MATH_1	193	197	PF00917	0.410
DOC_USP7_MATH_1	259	263	PF00917	0.314
DOC_USP7_MATH_1	328	332	PF00917	0.562
DOC_USP7_MATH_1	365	369	PF00917	0.725
DOC_USP7_MATH_1	395	399	PF00917	0.734
DOC_USP7_MATH_1	431	435	PF00917	0.575
DOC_USP7_MATH_1	533	537	PF00917	0.651
DOC_USP7_MATH_1	551	555	PF00917	0.666
DOC_USP7_MATH_1	60	64	PF00917	0.394
DOC_USP7_UBL2_3	232	236	PF12436	0.253
DOC_USP7_UBL2_3	593	597	PF12436	0.571
DOC_USP7_UBL2_3	599	603	PF12436	0.602
DOC_WW_Pin1_4	200	205	PF00397	0.241
DOC_WW_Pin1_4	221	226	PF00397	0.445
DOC_WW_Pin1_4	294	299	PF00397	0.650
DOC_WW_Pin1_4	323	328	PF00397	0.690
DOC_WW_Pin1_4	337	342	PF00397	0.638
DOC_WW_Pin1_4	388	393	PF00397	0.619
DOC_WW_Pin1_4	416	421	PF00397	0.803
DOC_WW_Pin1_4	427	432	PF00397	0.632
DOC_WW_Pin1_4	89	94	PF00397	0.480
LIG_14-3-3_CanoR_1	135	140	PF00244	0.343
LIG_14-3-3_CanoR_1	286	293	PF00244	0.711
LIG_14-3-3_CanoR_1	504	511	PF00244	0.528
LIG_14-3-3_CanoR_1	565	574	PF00244	0.469
LIG_Actin_WH2_2	266	284	PF00022	0.480
LIG_APCC_ABBA_1	250	255	PF00400	0.343
LIG_BIR_III_4	414	418	PF00653	0.590
LIG_FHA_1	118	124	PF00498	0.343
LIG_FHA_1	135	141	PF00498	0.343
LIG_FHA_1	204	210	PF00498	0.338
LIG_FHA_1	338	344	PF00498	0.583
LIG_FHA_1	380	386	PF00498	0.580
LIG_FHA_1	391	397	PF00498	0.510
LIG_FHA_1	439	445	PF00498	0.574
LIG_FHA_1	48	54	PF00498	0.387
LIG_FHA_1	532	538	PF00498	0.561
LIG_FHA_1	90	96	PF00498	0.480
LIG_FHA_2	15	21	PF00498	0.549
LIG_FHA_2	209	215	PF00498	0.272
LIG_LIR_Apic_2	324	328	PF02991	0.739
LIG_LIR_Gen_1	248	258	PF02991	0.341
LIG_LIR_Gen_1	572	581	PF02991	0.499
LIG_LIR_Gen_1	97	108	PF02991	0.288
LIG_LIR_Nem_3	248	253	PF02991	0.341
LIG_LIR_Nem_3	255	261	PF02991	0.345
LIG_LIR_Nem_3	34	40	PF02991	0.402
LIG_LIR_Nem_3	572	577	PF02991	0.501
LIG_LIR_Nem_3	97	103	PF02991	0.353
LIG_PCNA_yPIPBox_3	466	480	PF02747	0.567
LIG_PTB_Apo_2	133	140	PF02174	0.343
LIG_SH2_CRK	100	104	PF00017	0.288
LIG_SH2_CRK	130	134	PF00017	0.253
LIG_SH2_CRK	37	41	PF00017	0.284
LIG_SH2_NCK_1	258	262	PF00017	0.343
LIG_SH2_SRC	258	261	PF00017	0.314
LIG_SH2_STAP1	100	104	PF00017	0.343
LIG_SH2_STAP1	126	130	PF00017	0.343
LIG_SH2_STAT5	35	38	PF00017	0.461
LIG_SH3_3	24	30	PF00018	0.664
LIG_SH3_3	304	310	PF00018	0.748
LIG_SH3_3	513	519	PF00018	0.581
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.343
LIG_SUMO_SIM_par_1	38	44	PF11976	0.375
LIG_TYR_ITIM	256	261	PF00017	0.343
LIG_WRC_WIRS_1	322	327	PF05994	0.546
MOD_CAAXbox	606	609	PF01239	0.591
MOD_CDC14_SPxK_1	224	227	PF00782	0.253
MOD_CDK_SPxK_1	221	227	PF00069	0.253
MOD_CK1_1	148	154	PF00069	0.266
MOD_CK1_1	189	195	PF00069	0.430
MOD_CK1_1	203	209	PF00069	0.248
MOD_CK1_1	217	223	PF00069	0.429
MOD_CK1_1	262	268	PF00069	0.347
MOD_CK1_1	294	300	PF00069	0.526
MOD_CK1_1	315	321	PF00069	0.564
MOD_CK1_1	326	332	PF00069	0.641
MOD_CK1_1	368	374	PF00069	0.767
MOD_CK1_1	408	414	PF00069	0.599
MOD_CK1_1	554	560	PF00069	0.549
MOD_CK1_1	62	68	PF00069	0.681
MOD_CK1_1	70	76	PF00069	0.652
MOD_CK2_1	14	20	PF00069	0.556
MOD_CK2_1	208	214	PF00069	0.272
MOD_CK2_1	388	394	PF00069	0.623
MOD_CK2_1	555	561	PF00069	0.542
MOD_Cter_Amidation	591	594	PF01082	0.461
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.241
MOD_GlcNHglycan	147	150	PF01048	0.241
MOD_GlcNHglycan	195	198	PF01048	0.470
MOD_GlcNHglycan	229	232	PF01048	0.340
MOD_GlcNHglycan	260	264	PF01048	0.343
MOD_GlcNHglycan	328	331	PF01048	0.599
MOD_GlcNHglycan	353	356	PF01048	0.584
MOD_GlcNHglycan	397	400	PF01048	0.736
MOD_GlcNHglycan	406	410	PF01048	0.729
MOD_GlcNHglycan	456	459	PF01048	0.554
MOD_GlcNHglycan	499	502	PF01048	0.698
MOD_GlcNHglycan	516	519	PF01048	0.562
MOD_GlcNHglycan	526	529	PF01048	0.773
MOD_GlcNHglycan	553	556	PF01048	0.577
MOD_GlcNHglycan	69	72	PF01048	0.627
MOD_GlcNHglycan	76	80	PF01048	0.538
MOD_GSK3_1	144	151	PF00069	0.256
MOD_GSK3_1	189	196	PF00069	0.280
MOD_GSK3_1	213	220	PF00069	0.334
MOD_GSK3_1	309	316	PF00069	0.608
MOD_GSK3_1	365	372	PF00069	0.630
MOD_GSK3_1	379	386	PF00069	0.639
MOD_GSK3_1	423	430	PF00069	0.798
MOD_GSK3_1	43	50	PF00069	0.396
MOD_GSK3_1	533	540	PF00069	0.655
MOD_GSK3_1	55	62	PF00069	0.424
MOD_GSK3_1	551	558	PF00069	0.654
MOD_GSK3_1	75	82	PF00069	0.457
MOD_GSK3_1	94	101	PF00069	0.197
MOD_N-GLC_1	135	140	PF02516	0.343
MOD_N-GLC_1	189	194	PF02516	0.243
MOD_N-GLC_1	544	549	PF02516	0.579
MOD_N-GLC_1	79	84	PF02516	0.502
MOD_NEK2_1	134	139	PF00069	0.455
MOD_NEK2_1	144	149	PF00069	0.333
MOD_NEK2_1	170	175	PF00069	0.291
MOD_NEK2_1	303	308	PF00069	0.637
MOD_NEK2_1	379	384	PF00069	0.536
MOD_NEK2_1	75	80	PF00069	0.746
MOD_NEK2_2	109	114	PF00069	0.343
MOD_PIKK_1	328	334	PF00454	0.565
MOD_PIKK_1	423	429	PF00454	0.574
MOD_PIKK_1	565	571	PF00454	0.479
MOD_PIKK_1	60	66	PF00454	0.406
MOD_PK_1	158	164	PF00069	0.333
MOD_PK_1	55	61	PF00069	0.553
MOD_PKA_2	134	140	PF00069	0.253
MOD_PKA_2	198	204	PF00069	0.253
MOD_PKA_2	285	291	PF00069	0.696
MOD_PKA_2	369	375	PF00069	0.557
MOD_PKA_2	503	509	PF00069	0.539
MOD_PKA_2	531	537	PF00069	0.565
MOD_PKA_2	555	561	PF00069	0.769
MOD_Plk_1	135	141	PF00069	0.350
MOD_Plk_1	14	20	PF00069	0.556
MOD_Plk_1	170	176	PF00069	0.299
MOD_Plk_1	189	195	PF00069	0.253
MOD_Plk_1	213	219	PF00069	0.436
MOD_Plk_1	421	427	PF00069	0.684
MOD_Plk_1	43	49	PF00069	0.397
MOD_Plk_2-3	14	20	PF00069	0.556
MOD_Plk_2-3	214	220	PF00069	0.449
MOD_Plk_4	129	135	PF00069	0.352
MOD_Plk_4	171	177	PF00069	0.241
MOD_Plk_4	303	309	PF00069	0.633
MOD_Plk_4	431	437	PF00069	0.572
MOD_Plk_4	48	54	PF00069	0.387
MOD_Plk_4	533	539	PF00069	0.656
MOD_Plk_4	98	104	PF00069	0.323
MOD_ProDKin_1	200	206	PF00069	0.241
MOD_ProDKin_1	221	227	PF00069	0.445
MOD_ProDKin_1	294	300	PF00069	0.648
MOD_ProDKin_1	323	329	PF00069	0.693
MOD_ProDKin_1	337	343	PF00069	0.640
MOD_ProDKin_1	388	394	PF00069	0.619
MOD_ProDKin_1	416	422	PF00069	0.804
MOD_ProDKin_1	427	433	PF00069	0.633
MOD_ProDKin_1	89	95	PF00069	0.480
MOD_SUMO_rev_2	460	467	PF00179	0.721
TRG_DiLeu_BaEn_1	475	480	PF01217	0.459
TRG_ENDOCYTIC_2	100	103	PF00928	0.323
TRG_ENDOCYTIC_2	130	133	PF00928	0.253
TRG_ENDOCYTIC_2	258	261	PF00928	0.343
TRG_ENDOCYTIC_2	37	40	PF00928	0.285
TRG_ER_diArg_1	199	202	PF00400	0.469
TRG_ER_diArg_1	503	505	PF00400	0.567
TRG_ER_diArg_1	548	551	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTB6	Leptomonas seymouri	46%	97%
A0A3Q8IER9	Leishmania donovani	64%	100%
A4I6I0	Leishmania infantum	64%	100%
E9B1N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q6H7	Leishmania major	64%	100%