Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ60_LEIBR

TriTrypDb:

LbrM.31.0990 , LBRM2903_310017200

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4HJ60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.695
CLV_C14_Caspase3-7	455	459	PF00656	0.276
CLV_NRD_NRD_1	168	170	PF00675	0.475
CLV_NRD_NRD_1	256	258	PF00675	0.497
CLV_NRD_NRD_1	296	298	PF00675	0.316
CLV_NRD_NRD_1	335	337	PF00675	0.331
CLV_NRD_NRD_1	393	395	PF00675	0.398
CLV_NRD_NRD_1	465	467	PF00675	0.440
CLV_PCSK_KEX2_1	102	104	PF00082	0.318
CLV_PCSK_KEX2_1	168	170	PF00082	0.490
CLV_PCSK_KEX2_1	256	258	PF00082	0.497
CLV_PCSK_KEX2_1	335	337	PF00082	0.337
CLV_PCSK_KEX2_1	392	394	PF00082	0.390
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.318
CLV_PCSK_PC7_1	331	337	PF00082	0.323
CLV_PCSK_SKI1_1	149	153	PF00082	0.467
CLV_PCSK_SKI1_1	348	352	PF00082	0.424
CLV_PCSK_SKI1_1	372	376	PF00082	0.429
CLV_PCSK_SKI1_1	394	398	PF00082	0.376
CLV_PCSK_SKI1_1	4	8	PF00082	0.413
CLV_PCSK_SKI1_1	467	471	PF00082	0.579
CLV_PCSK_SKI1_1	620	624	PF00082	0.368
CLV_PCSK_SKI1_1	70	74	PF00082	0.398
CLV_PCSK_SKI1_1	95	99	PF00082	0.364
DEG_APCC_DBOX_1	371	379	PF00400	0.560
DEG_Nend_UBRbox_2	1	3	PF02207	0.678
DEG_SPOP_SBC_1	178	182	PF00917	0.619
DOC_CDC14_PxL_1	375	383	PF14671	0.440
DOC_CYCLIN_RxL_1	390	399	PF00134	0.464
DOC_CYCLIN_RxL_1	617	626	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.563
DOC_MAPK_DCC_7	595	603	PF00069	0.303
DOC_MAPK_gen_1	256	264	PF00069	0.621
DOC_MAPK_gen_1	297	305	PF00069	0.564
DOC_MAPK_gen_1	466	472	PF00069	0.190
DOC_MAPK_gen_1	528	536	PF00069	0.349
DOC_MAPK_HePTP_8	617	629	PF00069	0.316
DOC_MAPK_MEF2A_6	595	603	PF00069	0.293
DOC_MAPK_MEF2A_6	620	629	PF00069	0.480
DOC_MAPK_MEF2A_6	84	92	PF00069	0.493
DOC_MAPK_NFAT4_5	595	603	PF00069	0.248
DOC_PP1_RVXF_1	618	625	PF00149	0.284
DOC_PP1_RVXF_1	93	100	PF00149	0.542
DOC_PP2B_LxvP_1	183	186	PF13499	0.610
DOC_PP2B_LxvP_1	215	218	PF13499	0.567
DOC_PP4_FxxP_1	317	320	PF00568	0.634
DOC_PP4_FxxP_1	468	471	PF00568	0.483
DOC_USP7_MATH_1	179	183	PF00917	0.810
DOC_USP7_MATH_1	184	188	PF00917	0.750
DOC_USP7_MATH_1	225	229	PF00917	0.659
DOC_USP7_MATH_1	309	313	PF00917	0.560
DOC_USP7_MATH_1	428	432	PF00917	0.579
DOC_USP7_MATH_1	551	555	PF00917	0.392
DOC_USP7_MATH_1	6	10	PF00917	0.655
DOC_WW_Pin1_4	101	106	PF00397	0.649
DOC_WW_Pin1_4	19	24	PF00397	0.781
DOC_WW_Pin1_4	257	262	PF00397	0.715
DOC_WW_Pin1_4	84	89	PF00397	0.599
LIG_14-3-3_CanoR_1	134	140	PF00244	0.583
LIG_14-3-3_CanoR_1	310	314	PF00244	0.513
LIG_14-3-3_CanoR_1	552	560	PF00244	0.363
LIG_14-3-3_CanoR_1	95	100	PF00244	0.555
LIG_Actin_WH2_2	75	93	PF00022	0.650
LIG_APCC_ABBA_1	621	626	PF00400	0.509
LIG_APCC_ABBAyCdc20_2	620	626	PF00400	0.510
LIG_Clathr_ClatBox_1	536	540	PF01394	0.239
LIG_Clathr_ClatBox_1	622	626	PF01394	0.501
LIG_EH1_1	615	623	PF00400	0.451
LIG_eIF4E_1	113	119	PF01652	0.629
LIG_FHA_1	114	120	PF00498	0.528
LIG_FHA_1	124	130	PF00498	0.552
LIG_FHA_1	417	423	PF00498	0.552
LIG_FHA_1	476	482	PF00498	0.396
LIG_FHA_1	490	496	PF00498	0.543
LIG_FHA_1	519	525	PF00498	0.315
LIG_FHA_1	612	618	PF00498	0.387
LIG_FHA_1	96	102	PF00498	0.610
LIG_FHA_2	134	140	PF00498	0.563
LIG_FHA_2	25	31	PF00498	0.686
LIG_FHA_2	258	264	PF00498	0.775
LIG_FHA_2	453	459	PF00498	0.351
LIG_FHA_2	589	595	PF00498	0.305
LIG_GBD_Chelix_1	436	444	PF00786	0.415
LIG_GBD_Chelix_1	498	506	PF00786	0.372
LIG_LIR_Apic_2	315	320	PF02991	0.617
LIG_LIR_Gen_1	311	320	PF02991	0.544
LIG_LIR_Gen_1	583	593	PF02991	0.338
LIG_LIR_Gen_1	614	624	PF02991	0.397
LIG_LIR_LC3C_4	521	525	PF02991	0.289
LIG_LIR_LC3C_4	614	619	PF02991	0.340
LIG_LIR_Nem_3	138	143	PF02991	0.578
LIG_LIR_Nem_3	193	197	PF02991	0.730
LIG_LIR_Nem_3	311	317	PF02991	0.535
LIG_LIR_Nem_3	500	504	PF02991	0.498
LIG_LIR_Nem_3	53	58	PF02991	0.576
LIG_LIR_Nem_3	583	589	PF02991	0.322
LIG_LIR_Nem_3	610	616	PF02991	0.382
LIG_MAD2	70	78	PF02301	0.551
LIG_NRBOX	439	445	PF00104	0.413
LIG_PCNA_PIPBox_1	349	358	PF02747	0.577
LIG_PCNA_yPIPBox_3	348	356	PF02747	0.594
LIG_Pex14_1	276	280	PF04695	0.539
LIG_Pex14_2	313	317	PF04695	0.590
LIG_Pex14_2	441	445	PF04695	0.416
LIG_Pex14_2	468	472	PF04695	0.330
LIG_PTAP_UEV_1	175	180	PF05743	0.606
LIG_PTB_Apo_2	299	306	PF02174	0.559
LIG_SH2_CRK	115	119	PF00017	0.554
LIG_SH2_CRK	353	357	PF00017	0.612
LIG_SH2_CRK	409	413	PF00017	0.640
LIG_SH2_STAP1	586	590	PF00017	0.361
LIG_SH2_STAP1	613	617	PF00017	0.423
LIG_SH2_STAT3	401	404	PF00017	0.495
LIG_SH2_STAT5	115	118	PF00017	0.564
LIG_SH2_STAT5	135	138	PF00017	0.553
LIG_SH2_STAT5	292	295	PF00017	0.601
LIG_SH2_STAT5	337	340	PF00017	0.533
LIG_SH2_STAT5	423	426	PF00017	0.599
LIG_SH2_STAT5	448	451	PF00017	0.390
LIG_SH2_STAT5	464	467	PF00017	0.305
LIG_SH2_STAT5	501	504	PF00017	0.550
LIG_SH2_STAT5	535	538	PF00017	0.235
LIG_SH2_STAT5	613	616	PF00017	0.471
LIG_SH3_3	106	112	PF00018	0.589
LIG_SH3_3	173	179	PF00018	0.610
LIG_SH3_3	2	8	PF00018	0.647
LIG_SH3_3	55	61	PF00018	0.640
LIG_SH3_3	573	579	PF00018	0.361
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.430
LIG_SUMO_SIM_par_1	472	478	PF11976	0.279
LIG_SUMO_SIM_par_1	535	540	PF11976	0.308
LIG_SUMO_SIM_par_1	598	604	PF11976	0.226
LIG_SUMO_SIM_par_1	605	610	PF11976	0.235
LIG_TRAF2_1	27	30	PF00917	0.693
LIG_TRAF2_1	374	377	PF00917	0.491
LIG_TYR_ITIM	351	356	PF00017	0.439
LIG_TYR_ITSM	612	619	PF00017	0.186
LIG_UBA3_1	421	426	PF00899	0.589
LIG_WRC_WIRS_1	292	297	PF05994	0.549
LIG_WRC_WIRS_1	546	551	PF05994	0.290
MOD_CDK_SPxxK_3	84	91	PF00069	0.580
MOD_CK1_1	120	126	PF00069	0.582
MOD_CK1_1	269	275	PF00069	0.644
MOD_CK1_1	312	318	PF00069	0.543
MOD_CK1_1	321	327	PF00069	0.542
MOD_CK1_1	475	481	PF00069	0.256
MOD_CK1_1	511	517	PF00069	0.245
MOD_CK1_1	584	590	PF00069	0.282
MOD_CK2_1	24	30	PF00069	0.693
MOD_CK2_1	257	263	PF00069	0.747
MOD_CK2_1	588	594	PF00069	0.389
MOD_GlcNHglycan	119	122	PF01048	0.229
MOD_GlcNHglycan	197	200	PF01048	0.480
MOD_GlcNHglycan	225	228	PF01048	0.498
MOD_GlcNHglycan	271	274	PF01048	0.481
MOD_GlcNHglycan	52	55	PF01048	0.533
MOD_GlcNHglycan	603	606	PF01048	0.285
MOD_GSK3_1	113	120	PF00069	0.633
MOD_GSK3_1	174	181	PF00069	0.781
MOD_GSK3_1	24	31	PF00069	0.716
MOD_GSK3_1	308	315	PF00069	0.545
MOD_GSK3_1	50	57	PF00069	0.742
MOD_GSK3_1	541	548	PF00069	0.402
MOD_GSK3_1	580	587	PF00069	0.295
MOD_GSK3_1	6	13	PF00069	0.752
MOD_N-GLC_1	13	18	PF02516	0.541
MOD_N-GLC_1	257	262	PF02516	0.443
MOD_N-GLC_1	581	586	PF02516	0.548
MOD_NEK2_1	223	228	PF00069	0.704
MOD_NEK2_1	283	288	PF00069	0.575
MOD_NEK2_1	296	301	PF00069	0.551
MOD_NEK2_1	338	343	PF00069	0.451
MOD_NEK2_1	416	421	PF00069	0.556
MOD_NEK2_1	422	427	PF00069	0.541
MOD_NEK2_1	472	477	PF00069	0.283
MOD_NEK2_1	571	576	PF00069	0.367
MOD_NEK2_1	588	593	PF00069	0.289
MOD_NEK2_1	601	606	PF00069	0.387
MOD_NEK2_1	73	78	PF00069	0.661
MOD_NEK2_2	309	314	PF00069	0.545
MOD_NEK2_2	354	359	PF00069	0.566
MOD_PIKK_1	236	242	PF00454	0.646
MOD_PIKK_1	339	345	PF00454	0.521
MOD_PIKK_1	588	594	PF00454	0.288
MOD_PKA_2	133	139	PF00069	0.552
MOD_PKA_2	269	275	PF00069	0.595
MOD_PKA_2	296	302	PF00069	0.591
MOD_PKA_2	309	315	PF00069	0.539
MOD_PKA_2	321	327	PF00069	0.532
MOD_PKA_2	527	533	PF00069	0.290
MOD_PKA_2	551	557	PF00069	0.358
MOD_Plk_1	581	587	PF00069	0.420
MOD_Plk_4	125	131	PF00069	0.515
MOD_Plk_4	190	196	PF00069	0.731
MOD_Plk_4	291	297	PF00069	0.620
MOD_Plk_4	309	315	PF00069	0.523
MOD_Plk_4	377	383	PF00069	0.536
MOD_Plk_4	428	434	PF00069	0.478
MOD_Plk_4	460	466	PF00069	0.348
MOD_Plk_4	518	524	PF00069	0.348
MOD_Plk_4	530	536	PF00069	0.362
MOD_Plk_4	545	551	PF00069	0.263
MOD_Plk_4	584	590	PF00069	0.355
MOD_Plk_4	612	618	PF00069	0.372
MOD_ProDKin_1	101	107	PF00069	0.655
MOD_ProDKin_1	19	25	PF00069	0.779
MOD_ProDKin_1	257	263	PF00069	0.714
MOD_ProDKin_1	84	90	PF00069	0.594
MOD_SUMO_rev_2	138	142	PF00179	0.578
MOD_SUMO_rev_2	87	93	PF00179	0.601
TRG_DiLeu_BaEn_1	377	382	PF01217	0.520
TRG_DiLeu_BaEn_1	532	537	PF01217	0.227
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.528
TRG_DiLeu_BaLyEn_6	596	601	PF01217	0.393
TRG_ENDOCYTIC_2	115	118	PF00928	0.540
TRG_ENDOCYTIC_2	292	295	PF00928	0.588
TRG_ENDOCYTIC_2	314	317	PF00928	0.579
TRG_ENDOCYTIC_2	353	356	PF00928	0.569
TRG_ENDOCYTIC_2	448	451	PF00928	0.358
TRG_ENDOCYTIC_2	501	504	PF00928	0.519
TRG_ENDOCYTIC_2	586	589	PF00928	0.387
TRG_ENDOCYTIC_2	616	619	PF00928	0.395
TRG_ER_diArg_1	255	257	PF00400	0.622
TRG_ER_diArg_1	334	336	PF00400	0.521
TRG_ER_diArg_1	392	394	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	38%	100%
A0A0N1HRT9	Leptomonas seymouri	36%	100%
A0A0N1P9A0	Leptomonas seymouri	36%	100%
A0A0N1PBU6	Leptomonas seymouri	33%	100%
A0A1X0P9W4	Trypanosomatidae	35%	100%
A0A3Q8IFF3	Leishmania donovani	49%	98%
A0A3Q8ISH4	Leishmania donovani	55%	100%
A0A3R7KFP4	Trypanosoma rangeli	31%	100%
A0A3S7X483	Leishmania donovani	41%	98%
A0A3S7X888	Leishmania donovani	31%	100%
A4HB26	Leishmania braziliensis	32%	100%
A4HJ59	Leishmania braziliensis	45%	100%
A4I6H4	Leishmania infantum	41%	98%
A4I6H5	Leishmania infantum	55%	100%
A4IA83	Leishmania infantum	31%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q6I2	Leishmania major	55%	99%
Q4Q6I3	Leishmania major	43%	100%
V5B5A9	Trypanosoma cruzi	29%	100%