Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ59_LEIBR

TriTrypDb:

LbrM.31.0980 , LBRM2903_310017100

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HJ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.625
CLV_C14_Caspase3-7	281	285	PF00656	0.688
CLV_C14_Caspase3-7	41	45	PF00656	0.457
CLV_NRD_NRD_1	296	298	PF00675	0.560
CLV_NRD_NRD_1	315	317	PF00675	0.321
CLV_NRD_NRD_1	353	355	PF00675	0.325
CLV_NRD_NRD_1	413	415	PF00675	0.407
CLV_PCSK_KEX2_1	296	298	PF00082	0.565
CLV_PCSK_KEX2_1	315	317	PF00082	0.299
CLV_PCSK_KEX2_1	353	355	PF00082	0.325
CLV_PCSK_KEX2_1	411	413	PF00082	0.396
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.401
CLV_PCSK_PC7_1	349	355	PF00082	0.323
CLV_PCSK_SKI1_1	155	159	PF00082	0.466
CLV_PCSK_SKI1_1	366	370	PF00082	0.269
CLV_PCSK_SKI1_1	390	394	PF00082	0.422
CLV_PCSK_SKI1_1	448	452	PF00082	0.461
CLV_PCSK_SKI1_1	475	479	PF00082	0.386
DEG_APCC_DBOX_1	389	397	PF00400	0.539
DOC_CDC14_PxL_1	393	401	PF14671	0.450
DOC_MAPK_gen_1	315	323	PF00069	0.572
DOC_MAPK_MEF2A_6	80	89	PF00069	0.320
DOC_PP1_RVXF_1	638	644	PF00149	0.305
DOC_PP4_FxxP_1	335	338	PF00568	0.610
DOC_USP7_MATH_1	241	245	PF00917	0.635
DOC_USP7_MATH_1	247	251	PF00917	0.674
DOC_USP7_MATH_1	327	331	PF00917	0.555
DOC_USP7_MATH_1	477	481	PF00917	0.438
DOC_USP7_MATH_1	52	56	PF00917	0.588
DOC_USP7_MATH_1	596	600	PF00917	0.642
DOC_USP7_UBL2_3	444	448	PF12436	0.237
DOC_WW_Pin1_4	157	162	PF00397	0.665
DOC_WW_Pin1_4	184	189	PF00397	0.775
DOC_WW_Pin1_4	200	205	PF00397	0.609
DOC_WW_Pin1_4	24	29	PF00397	0.556
LIG_14-3-3_CanoR_1	137	143	PF00244	0.561
LIG_14-3-3_CanoR_1	226	236	PF00244	0.594
LIG_14-3-3_CanoR_1	328	332	PF00244	0.511
LIG_14-3-3_CanoR_1	98	103	PF00244	0.357
LIG_Actin_WH2_2	78	96	PF00022	0.426
LIG_APCC_ABBA_1	74	79	PF00400	0.311
LIG_BIR_III_4	240	244	PF00653	0.678
LIG_BRCT_BRCA1_1	480	484	PF00533	0.503
LIG_BRCT_BRCA1_1	525	529	PF00533	0.298
LIG_CtBP_PxDLS_1	36	40	PF00389	0.430
LIG_EH1_1	458	466	PF00400	0.201
LIG_eIF4E_1	116	122	PF01652	0.355
LIG_eIF4E_1	633	639	PF01652	0.457
LIG_FHA_1	117	123	PF00498	0.313
LIG_FHA_1	273	279	PF00498	0.711
LIG_FHA_1	435	441	PF00498	0.335
LIG_FHA_1	485	491	PF00498	0.479
LIG_FHA_1	626	632	PF00498	0.380
LIG_FHA_2	137	143	PF00498	0.557
LIG_FHA_2	213	219	PF00498	0.678
LIG_FHA_2	220	226	PF00498	0.714
LIG_FHA_2	251	257	PF00498	0.696
LIG_GBD_Chelix_1	495	503	PF00786	0.218
LIG_LIR_Apic_2	333	338	PF02991	0.595
LIG_LIR_Apic_2	426	430	PF02991	0.415
LIG_LIR_Gen_1	203	212	PF02991	0.610
LIG_LIR_Gen_1	329	339	PF02991	0.536
LIG_LIR_Gen_1	603	613	PF02991	0.524
LIG_LIR_Gen_1	624	633	PF02991	0.305
LIG_LIR_Gen_1	634	642	PF02991	0.299
LIG_LIR_Nem_3	141	146	PF02991	0.555
LIG_LIR_Nem_3	203	209	PF02991	0.774
LIG_LIR_Nem_3	329	335	PF02991	0.528
LIG_LIR_Nem_3	603	609	PF02991	0.505
LIG_LIR_Nem_3	624	629	PF02991	0.357
LIG_LIR_Nem_3	634	638	PF02991	0.326
LIG_NRBOX	542	548	PF00104	0.250
LIG_NRBOX	637	643	PF00104	0.411
LIG_PCNA_PIPBox_1	367	376	PF02747	0.569
LIG_PCNA_yPIPBox_3	366	374	PF02747	0.584
LIG_Pex14_2	331	335	PF04695	0.572
LIG_Pex14_2	455	459	PF04695	0.396
LIG_Pex14_2	482	486	PF04695	0.562
LIG_Pex14_2	529	533	PF04695	0.238
LIG_Pex14_2	635	639	PF04695	0.258
LIG_PTB_Apo_2	317	324	PF02174	0.579
LIG_REV1ctd_RIR_1	431	440	PF16727	0.201
LIG_RPA_C_Fungi	466	478	PF08784	0.274
LIG_SH2_CRK	118	122	PF00017	0.315
LIG_SH2_CRK	182	186	PF00017	0.689
LIG_SH2_CRK	371	375	PF00017	0.485
LIG_SH2_CRK	427	431	PF00017	0.354
LIG_SH2_CRK	606	610	PF00017	0.310
LIG_SH2_CRK	633	637	PF00017	0.271
LIG_SH2_NCK_1	319	323	PF00017	0.341
LIG_SH2_STAP1	182	186	PF00017	0.464
LIG_SH2_STAT5	118	121	PF00017	0.349
LIG_SH2_STAT5	138	141	PF00017	0.482
LIG_SH2_STAT5	147	150	PF00017	0.497
LIG_SH2_STAT5	310	313	PF00017	0.508
LIG_SH2_STAT5	355	358	PF00017	0.407
LIG_SH2_STAT5	441	444	PF00017	0.369
LIG_SH3_3	109	115	PF00018	0.419
LIG_SH3_3	75	81	PF00018	0.406
LIG_SUMO_SIM_anti_2	126	134	PF11976	0.298
LIG_SUMO_SIM_anti_2	628	634	PF11976	0.375
LIG_SxIP_EBH_1	438	448	PF03271	0.296
LIG_TRAF2_1	229	232	PF00917	0.683
LIG_TRAF2_1	3	6	PF00917	0.532
LIG_TRAF2_1	392	395	PF00917	0.367
LIG_TYR_ITIM	369	374	PF00017	0.267
LIG_TYR_ITIM	631	636	PF00017	0.473
LIG_UBA3_1	439	444	PF00899	0.383
LIG_UBA3_1	638	646	PF00899	0.415
LIG_WRC_WIRS_1	310	315	PF05994	0.434
LIG_WRC_WIRS_1	479	484	PF05994	0.482
LIG_WRC_WIRS_1	632	637	PF05994	0.271
MOD_CDK_SPK_2	184	189	PF00069	0.468
MOD_CDK_SPK_2	24	29	PF00069	0.528
MOD_CK1_1	13	19	PF00069	0.746
MOD_CK1_1	250	256	PF00069	0.454
MOD_CK1_1	27	33	PF00069	0.553
MOD_CK1_1	272	278	PF00069	0.753
MOD_CK1_1	330	336	PF00069	0.402
MOD_CK1_1	469	475	PF00069	0.474
MOD_CK2_1	212	218	PF00069	0.604
MOD_CK2_1	226	232	PF00069	0.707
MOD_CK2_1	250	256	PF00069	0.628
MOD_CK2_1	35	41	PF00069	0.620
MOD_GlcNHglycan	15	18	PF01048	0.806
MOD_GlcNHglycan	271	274	PF01048	0.669
MOD_GlcNHglycan	284	287	PF01048	0.607
MOD_GlcNHglycan	468	471	PF01048	0.233
MOD_GlcNHglycan	525	528	PF01048	0.398
MOD_GlcNHglycan	573	576	PF01048	0.330
MOD_GSK3_1	13	20	PF00069	0.663
MOD_GSK3_1	151	158	PF00069	0.567
MOD_GSK3_1	180	187	PF00069	0.614
MOD_GSK3_1	226	233	PF00069	0.598
MOD_GSK3_1	326	333	PF00069	0.386
MOD_GSK3_1	465	472	PF00069	0.414
MOD_GSK3_1	596	603	PF00069	0.389
MOD_GSK3_1	604	611	PF00069	0.335
MOD_GSK3_1	621	628	PF00069	0.359
MOD_N-GLC_1	269	274	PF02516	0.559
MOD_N-GLC_1	580	585	PF02516	0.389
MOD_N-GLC_2	167	169	PF02516	0.431
MOD_NEK2_1	12	17	PF00069	0.689
MOD_NEK2_1	301	306	PF00069	0.564
MOD_NEK2_1	356	361	PF00069	0.296
MOD_NEK2_1	434	439	PF00069	0.333
MOD_NEK2_1	440	445	PF00069	0.333
MOD_NEK2_1	466	471	PF00069	0.340
MOD_NEK2_1	478	483	PF00069	0.434
MOD_NEK2_1	621	626	PF00069	0.387
MOD_NEK2_2	247	252	PF00069	0.470
MOD_NEK2_2	327	332	PF00069	0.401
MOD_NEK2_2	372	377	PF00069	0.452
MOD_PIKK_1	195	201	PF00454	0.680
MOD_PIKK_1	219	225	PF00454	0.710
MOD_PIKK_1	27	33	PF00454	0.674
MOD_PIKK_1	357	363	PF00454	0.371
MOD_PIKK_1	580	586	PF00454	0.338
MOD_PIKK_1	608	614	PF00454	0.360
MOD_PKA_2	13	19	PF00069	0.614
MOD_PKA_2	136	142	PF00069	0.415
MOD_PKA_2	327	333	PF00069	0.401
MOD_PKA_2	339	345	PF00069	0.369
MOD_Plk_1	126	132	PF00069	0.281
MOD_Plk_1	230	236	PF00069	0.499
MOD_Plk_1	52	58	PF00069	0.553
MOD_Plk_2-3	35	41	PF00069	0.537
MOD_Plk_4	128	134	PF00069	0.297
MOD_Plk_4	180	186	PF00069	0.461
MOD_Plk_4	309	315	PF00069	0.510
MOD_Plk_4	327	333	PF00069	0.389
MOD_Plk_4	395	401	PF00069	0.272
MOD_Plk_4	478	484	PF00069	0.396
MOD_Plk_4	506	512	PF00069	0.472
MOD_Plk_4	604	610	PF00069	0.429
MOD_Plk_4	631	637	PF00069	0.344
MOD_ProDKin_1	157	163	PF00069	0.578
MOD_ProDKin_1	184	190	PF00069	0.737
MOD_ProDKin_1	200	206	PF00069	0.502
MOD_ProDKin_1	24	30	PF00069	0.708
TRG_DiLeu_BaEn_1	395	400	PF01217	0.377
TRG_DiLeu_BaEn_1	66	71	PF01217	0.350
TRG_DiLeu_BaEn_4	231	237	PF01217	0.471
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.287
TRG_ENDOCYTIC_2	118	121	PF00928	0.332
TRG_ENDOCYTIC_2	182	185	PF00928	0.689
TRG_ENDOCYTIC_2	310	313	PF00928	0.532
TRG_ENDOCYTIC_2	332	335	PF00928	0.433
TRG_ENDOCYTIC_2	371	374	PF00928	0.425
TRG_ENDOCYTIC_2	606	609	PF00928	0.436
TRG_ENDOCYTIC_2	633	636	PF00928	0.449
TRG_ER_diArg_1	295	297	PF00400	0.688
TRG_ER_diArg_1	314	316	PF00400	0.350
TRG_ER_diArg_1	352	354	PF00400	0.381
TRG_ER_diArg_1	412	414	PF00400	0.442
TRG_NES_CRM1_1	65	79	PF08389	0.423
TRG_NES_CRM1_1	92	106	PF08389	0.281
TRG_NLS_MonoCore_2	410	415	PF00514	0.345
TRG_NLS_MonoExtN_4	408	415	PF00514	0.402
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	37%	100%
A0A0N1HRT9	Leptomonas seymouri	37%	100%
A0A0N1P9A0	Leptomonas seymouri	34%	100%
A0A0N1PBU6	Leptomonas seymouri	32%	100%
A0A1X0P9W4	Trypanosomatidae	32%	100%
A0A3Q8IFF3	Leishmania donovani	45%	100%
A0A3Q8ISH4	Leishmania donovani	41%	100%
A0A3S7X483	Leishmania donovani	48%	100%
A0A3S7X888	Leishmania donovani	30%	100%
A4HB26	Leishmania braziliensis	29%	97%
A4HJ60	Leishmania braziliensis	45%	100%
A4I6H4	Leishmania infantum	48%	100%
A4I6H5	Leishmania infantum	41%	100%
A4IA83	Leishmania infantum	29%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q6I2	Leishmania major	41%	98%
Q4Q6I3	Leishmania major	47%	100%