Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ58_LEIBR

TriTrypDb:

LbrM.31.0970 , LBRM2903_310017000

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ58

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CKS1_1	145	150	PF01111	0.410
DOC_CKS1_1	199	204	PF01111	0.572
DOC_MAPK_gen_1	19	29	PF00069	0.278
DOC_MAPK_MEF2A_6	22	31	PF00069	0.278
DOC_PIKK_1	76	84	PF02985	0.314
DOC_PP2B_LxvP_1	176	179	PF13499	0.594
DOC_PP4_FxxP_1	199	202	PF00568	0.484
DOC_USP7_UBL2_3	30	34	PF12436	0.354
DOC_WW_Pin1_4	144	149	PF00397	0.414
DOC_WW_Pin1_4	157	162	PF00397	0.434
DOC_WW_Pin1_4	198	203	PF00397	0.577
DOC_WW_Pin1_4	222	227	PF00397	0.607
DOC_WW_Pin1_4	244	249	PF00397	0.504
DOC_WW_Pin1_4	251	256	PF00397	0.496
LIG_14-3-3_CanoR_1	135	141	PF00244	0.470
LIG_EVH1_2	155	159	PF00568	0.390
LIG_FHA_1	101	107	PF00498	0.349
LIG_FHA_1	66	72	PF00498	0.243
LIG_FHA_1	94	100	PF00498	0.353
LIG_LIR_Apic_2	150	156	PF02991	0.417
LIG_LIR_Apic_2	197	202	PF02991	0.491
LIG_LIR_Gen_1	102	112	PF02991	0.419
LIG_LIR_Gen_1	24	31	PF02991	0.360
LIG_LIR_Nem_3	102	107	PF02991	0.349
LIG_LIR_Nem_3	24	29	PF02991	0.360
LIG_Pex14_1	54	58	PF04695	0.330
LIG_PTB_Apo_2	52	59	PF02174	0.278
LIG_SH2_CRK	153	157	PF00017	0.413
LIG_SH2_CRK	184	188	PF00017	0.479
LIG_SH2_CRK	221	225	PF00017	0.682
LIG_SH2_CRK	231	235	PF00017	0.634
LIG_SH2_CRK	252	256	PF00017	0.566
LIG_SH2_CRK	266	270	PF00017	0.541
LIG_SH2_PTP2	26	29	PF00017	0.322
LIG_SH2_STAP1	88	92	PF00017	0.455
LIG_SH2_STAT5	198	201	PF00017	0.610
LIG_SH2_STAT5	26	29	PF00017	0.327
LIG_SH3_1	184	190	PF00018	0.480
LIG_SH3_1	221	227	PF00018	0.578
LIG_SH3_1	231	237	PF00018	0.577
LIG_SH3_1	252	258	PF00018	0.480
LIG_SH3_2	172	177	PF14604	0.484
LIG_SH3_2	255	260	PF14604	0.535
LIG_SH3_3	169	175	PF00018	0.585
LIG_SH3_3	17	23	PF00018	0.329
LIG_SH3_3	184	190	PF00018	0.590
LIG_SH3_3	199	205	PF00018	0.584
LIG_SH3_3	211	217	PF00018	0.602
LIG_SH3_3	221	227	PF00018	0.679
LIG_SH3_3	231	237	PF00018	0.591
LIG_SH3_3	240	246	PF00018	0.760
LIG_SH3_3	252	258	PF00018	0.515
LIG_SH3_CIN85_PxpxPR_1	255	260	PF14604	0.466
LIG_SUMO_SIM_anti_2	102	110	PF11976	0.297
LIG_SUMO_SIM_par_1	102	110	PF11976	0.482
LIG_TRAF2_1	139	142	PF00917	0.477
LIG_WW_1	216	219	PF00397	0.482
LIG_WW_3	257	261	PF00397	0.466
MOD_CK2_1	110	116	PF00069	0.462
MOD_CK2_1	136	142	PF00069	0.436
MOD_GSK3_1	107	114	PF00069	0.467
MOD_GSK3_1	143	150	PF00069	0.496
MOD_GSK3_1	194	201	PF00069	0.498
MOD_N-GLC_1	143	148	PF02516	0.407
MOD_N-GLC_1	157	162	PF02516	0.429
MOD_NEK2_1	107	112	PF00069	0.635
MOD_NEK2_2	46	51	PF00069	0.320
MOD_PIKK_1	147	153	PF00454	0.388
MOD_PIKK_1	34	40	PF00454	0.324
MOD_PIKK_1	65	71	PF00454	0.285
MOD_PKA_1	34	40	PF00069	0.270
MOD_Plk_1	46	52	PF00069	0.474
MOD_Plk_1	65	71	PF00069	0.235
MOD_Plk_4	100	106	PF00069	0.305
MOD_Plk_4	194	200	PF00069	0.508
MOD_Plk_4	46	52	PF00069	0.220
MOD_ProDKin_1	144	150	PF00069	0.415
MOD_ProDKin_1	157	163	PF00069	0.443
MOD_ProDKin_1	198	204	PF00069	0.577
MOD_ProDKin_1	222	228	PF00069	0.532
MOD_ProDKin_1	244	250	PF00069	0.507
MOD_ProDKin_1	251	257	PF00069	0.491
TRG_ENDOCYTIC_2	26	29	PF00928	0.322
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M8	Leptomonas seymouri	64%	98%
A0A3Q8IFD2	Leishmania donovani	37%	96%
A0A3S7X485	Leishmania donovani	72%	94%
A0A3S7X4C0	Leishmania donovani	52%	100%
A4HJ46	Leishmania braziliensis	36%	96%
A4HJ57	Leishmania braziliensis	53%	99%
A4I6G2	Leishmania infantum	37%	96%
A4I6H2	Leishmania infantum	52%	100%
A4I6H3	Leishmania infantum	72%	94%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q9BHE7	Leishmania major	49%	100%
Q9BHE8	Leishmania major	70%	100%
Q9BHF8	Leishmania major	40%	100%