Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ57_LEIBR

TriTrypDb:

LbrM.31.0960 , LBRM2903_310016900

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ57

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.230
CLV_NRD_NRD_1	97	99	PF00675	0.219
CLV_PCSK_KEX2_1	97	99	PF00082	0.219
CLV_PCSK_SKI1_1	98	102	PF00082	0.234
DOC_MAPK_gen_1	97	107	PF00069	0.239
DOC_MAPK_HePTP_8	95	107	PF00069	0.218
DOC_MAPK_MEF2A_6	98	107	PF00069	0.234
DOC_PIKK_1	76	84	PF02985	0.310
DOC_USP7_MATH_1	130	134	PF00917	0.547
DOC_USP7_MATH_1	46	50	PF00917	0.263
DOC_USP7_UBL2_3	36	40	PF12436	0.313
DOC_WW_Pin1_4	188	193	PF00397	0.621
LIG_14-3-3_CanoR_1	34	41	PF00244	0.254
LIG_14-3-3_CanoR_1	89	93	PF00244	0.237
LIG_FHA_1	94	100	PF00498	0.463
LIG_FHA_2	147	153	PF00498	0.520
LIG_LIR_Gen_1	102	112	PF02991	0.521
LIG_LIR_Gen_1	166	174	PF02991	0.551
LIG_LIR_Gen_1	24	31	PF02991	0.355
LIG_LIR_Nem_3	102	107	PF02991	0.344
LIG_LIR_Nem_3	166	170	PF02991	0.549
LIG_LIR_Nem_3	24	29	PF02991	0.355
LIG_PCNA_yPIPBox_3	78	89	PF02747	0.284
LIG_SH2_CRK	212	216	PF00017	0.542
LIG_SH2_CRK	233	237	PF00017	0.595
LIG_SH2_NCK_1	65	69	PF00017	0.216
LIG_SH2_PTP2	26	29	PF00017	0.318
LIG_SH2_SRC	200	203	PF00017	0.519
LIG_SH2_SRC	231	234	PF00017	0.490
LIG_SH2_STAT3	211	214	PF00017	0.630
LIG_SH2_STAT5	143	146	PF00017	0.493
LIG_SH2_STAT5	200	203	PF00017	0.715
LIG_SH2_STAT5	231	234	PF00017	0.559
LIG_SH2_STAT5	26	29	PF00017	0.323
LIG_SH3_1	200	206	PF00018	0.659
LIG_SH3_3	19	25	PF00018	0.299
LIG_SH3_3	196	202	PF00018	0.639
LIG_SH3_3	223	229	PF00018	0.702
LIG_SUMO_SIM_par_1	120	125	PF11976	0.538
LIG_TRAF2_1	139	142	PF00917	0.564
MOD_CK2_1	110	116	PF00069	0.562
MOD_CK2_1	136	142	PF00069	0.564
MOD_CK2_1	146	152	PF00069	0.571
MOD_GlcNHglycan	113	116	PF01048	0.449
MOD_GlcNHglycan	162	165	PF01048	0.546
MOD_GlcNHglycan	66	69	PF01048	0.216
MOD_GSK3_1	107	114	PF00069	0.517
MOD_GSK3_1	132	139	PF00069	0.533
MOD_GSK3_1	153	160	PF00069	0.551
MOD_GSK3_1	166	173	PF00069	0.508
MOD_NEK2_1	107	112	PF00069	0.574
MOD_PIKK_1	14	20	PF00454	0.216
MOD_PIKK_1	34	40	PF00454	0.318
MOD_PKA_1	34	40	PF00069	0.267
MOD_PKA_2	88	94	PF00069	0.218
MOD_Plk_1	170	176	PF00069	0.503
MOD_Plk_2-3	166	172	PF00069	0.511
MOD_Plk_4	132	138	PF00069	0.589
MOD_ProDKin_1	188	194	PF00069	0.616
MOD_SUMO_rev_2	152	161	PF00179	0.516
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.523
TRG_ENDOCYTIC_2	212	215	PF00928	0.546
TRG_ENDOCYTIC_2	26	29	PF00928	0.320
TRG_ER_diArg_1	97	99	PF00400	0.218

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D0	Leptomonas seymouri	66%	82%
A0A3Q8IFD2	Leishmania donovani	40%	100%
A0A3S7X485	Leishmania donovani	50%	83%
A0A3S7X4C0	Leishmania donovani	67%	97%
A4HJ46	Leishmania braziliensis	37%	98%
A4HJ58	Leishmania braziliensis	53%	88%
A4I6G2	Leishmania infantum	40%	100%
A4I6H2	Leishmania infantum	67%	97%
A4I6H3	Leishmania infantum	49%	83%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	84%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	87%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q9BHE7	Leishmania major	63%	100%
Q9BHE8	Leishmania major	52%	100%
Q9BHF8	Leishmania major	41%	100%