BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ56_LEIBR

TriTrypDb:

LbrM.31.0950 , LBRM2903_310016800

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.432
CLV_C14_Caspase3-7	243	247	PF00656	0.364
CLV_MEL_PAP_1	284	290	PF00089	0.533
CLV_NRD_NRD_1	278	280	PF00675	0.566
CLV_NRD_NRD_1	354	356	PF00675	0.527
CLV_PCSK_KEX2_1	354	356	PF00082	0.527
CLV_PCSK_SKI1_1	111	115	PF00082	0.472
CLV_PCSK_SKI1_1	117	121	PF00082	0.400
CLV_PCSK_SKI1_1	124	128	PF00082	0.344
CLV_PCSK_SKI1_1	174	178	PF00082	0.343
CLV_PCSK_SKI1_1	32	36	PF00082	0.347
CLV_PCSK_SKI1_1	421	425	PF00082	0.490
CLV_Separin_Metazoa	74	78	PF03568	0.278
DOC_CKS1_1	59	64	PF01111	0.324
DOC_MAPK_gen_1	122	130	PF00069	0.308
DOC_MAPK_gen_1	279	286	PF00069	0.536
DOC_MAPK_gen_1	354	361	PF00069	0.518
DOC_MAPK_gen_1	77	84	PF00069	0.296
DOC_MAPK_JIP1_4	280	286	PF00069	0.535
DOC_MAPK_MEF2A_6	279	288	PF00069	0.536
DOC_PP4_FxxP_1	278	281	PF00568	0.534
DOC_PP4_FxxP_1	59	62	PF00568	0.322
DOC_PP4_FxxP_1	7	10	PF00568	0.429
DOC_USP7_MATH_1	115	119	PF00917	0.392
DOC_USP7_MATH_1	138	142	PF00917	0.442
DOC_USP7_MATH_1	22	26	PF00917	0.380
DOC_USP7_MATH_1	265	269	PF00917	0.663
DOC_USP7_MATH_1	274	278	PF00917	0.768
DOC_USP7_MATH_1	294	298	PF00917	0.596
DOC_USP7_MATH_1	304	308	PF00917	0.615
DOC_USP7_MATH_1	341	345	PF00917	0.532
DOC_USP7_MATH_1	357	361	PF00917	0.494
DOC_USP7_MATH_1	53	57	PF00917	0.408
DOC_USP7_UBL2_3	103	107	PF12436	0.453
DOC_WW_Pin1_4	261	266	PF00397	0.673
DOC_WW_Pin1_4	286	291	PF00397	0.613
DOC_WW_Pin1_4	297	302	PF00397	0.680
DOC_WW_Pin1_4	309	314	PF00397	0.540
DOC_WW_Pin1_4	334	339	PF00397	0.516
DOC_WW_Pin1_4	58	63	PF00397	0.342
LIG_14-3-3_CanoR_1	101	107	PF00244	0.331
LIG_14-3-3_CanoR_1	157	162	PF00244	0.336
LIG_14-3-3_CanoR_1	315	320	PF00244	0.598
LIG_14-3-3_CanoR_1	387	397	PF00244	0.546
LIG_Actin_WH2_2	88	105	PF00022	0.428
LIG_AP2alpha_1	171	175	PF02296	0.397
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	274	278	PF00533	0.565
LIG_BRCT_BRCA1_1	47	51	PF00533	0.392
LIG_BRCT_BRCA1_1	55	59	PF00533	0.419
LIG_BRCT_BRCA1_2	274	280	PF00533	0.535
LIG_Clathr_ClatBox_1	96	100	PF01394	0.292
LIG_DLG_GKlike_1	157	164	PF00625	0.330
LIG_eIF4E_1	123	129	PF01652	0.312
LIG_FHA_1	200	206	PF00498	0.406
LIG_FHA_1	306	312	PF00498	0.594
LIG_FHA_1	335	341	PF00498	0.649
LIG_FHA_1	401	407	PF00498	0.462
LIG_FHA_1	59	65	PF00498	0.323
LIG_FHA_2	207	213	PF00498	0.446
LIG_FHA_2	40	46	PF00498	0.400
LIG_FHA_2	414	420	PF00498	0.458
LIG_FHA_2	422	428	PF00498	0.530
LIG_Integrin_isoDGR_2	259	261	PF01839	0.535
LIG_LIR_Apic_2	275	281	PF02991	0.536
LIG_LIR_Apic_2	56	62	PF02991	0.333
LIG_LIR_Apic_2	6	10	PF02991	0.446
LIG_LIR_Gen_1	172	182	PF02991	0.475
LIG_LIR_Gen_1	48	59	PF02991	0.434
LIG_LIR_Nem_3	118	123	PF02991	0.409
LIG_LIR_Nem_3	172	178	PF02991	0.407
LIG_LIR_Nem_3	363	369	PF02991	0.562
LIG_LIR_Nem_3	48	54	PF02991	0.428
LIG_Pex14_2	171	175	PF04695	0.420
LIG_SH2_CRK	87	91	PF00017	0.344
LIG_SH2_SRC	67	70	PF00017	0.372
LIG_SH2_STAP1	402	406	PF00017	0.464
LIG_SH2_STAT3	249	252	PF00017	0.422
LIG_SH2_STAT5	193	196	PF00017	0.436
LIG_SH2_STAT5	402	405	PF00017	0.471
LIG_SH2_STAT5	67	70	PF00017	0.382
LIG_SH3_3	298	304	PF00018	0.660
LIG_SH3_3	375	381	PF00018	0.501
LIG_SH3_3	394	400	PF00018	0.759
LIG_SH3_3	425	431	PF00018	0.546
LIG_SH3_3	92	98	PF00018	0.380
LIG_TRAF2_1	214	217	PF00917	0.453
LIG_TRAF2_2	10	15	PF00917	0.380
LIG_TRFH_1	254	258	PF08558	0.615
LIG_UBA3_1	33	38	PF00899	0.400
LIG_WRC_WIRS_1	23	28	PF05994	0.376
LIG_WRC_WIRS_1	382	387	PF05994	0.564
LIG_WW_1	380	383	PF00397	0.553
MOD_CDC14_SPxK_1	312	315	PF00782	0.560
MOD_CDK_SPK_2	261	266	PF00069	0.540
MOD_CDK_SPxK_1	309	315	PF00069	0.565
MOD_CDK_SPxxK_3	58	65	PF00069	0.329
MOD_CK1_1	149	155	PF00069	0.548
MOD_CK1_1	160	166	PF00069	0.418
MOD_CK1_1	248	254	PF00069	0.508
MOD_CK1_1	25	31	PF00069	0.321
MOD_CK1_1	297	303	PF00069	0.546
MOD_CK1_1	307	313	PF00069	0.517
MOD_CK1_1	325	331	PF00069	0.539
MOD_CK1_1	391	397	PF00069	0.571
MOD_CK1_1	58	64	PF00069	0.371
MOD_CK2_1	102	108	PF00069	0.587
MOD_CK2_1	133	139	PF00069	0.336
MOD_CK2_1	164	170	PF00069	0.410
MOD_CK2_1	177	183	PF00069	0.317
MOD_CK2_1	211	217	PF00069	0.434
MOD_CK2_1	39	45	PF00069	0.394
MOD_CK2_1	413	419	PF00069	0.453
MOD_CK2_1	421	427	PF00069	0.525
MOD_CK2_1	57	63	PF00069	0.542
MOD_GlcNHglycan	116	120	PF01048	0.416
MOD_GlcNHglycan	231	234	PF01048	0.411
MOD_GlcNHglycan	373	376	PF01048	0.501
MOD_GlcNHglycan	394	397	PF01048	0.587
MOD_GSK3_1	102	109	PF00069	0.300
MOD_GSK3_1	160	167	PF00069	0.380
MOD_GSK3_1	261	268	PF00069	0.751
MOD_GSK3_1	286	293	PF00069	0.716
MOD_GSK3_1	305	312	PF00069	0.787
MOD_GSK3_1	321	328	PF00069	0.553
MOD_GSK3_1	330	337	PF00069	0.550
MOD_GSK3_1	367	374	PF00069	0.520
MOD_GSK3_1	388	395	PF00069	0.566
MOD_GSK3_1	419	426	PF00069	0.506
MOD_GSK3_1	53	60	PF00069	0.414
MOD_N-GLC_1	157	162	PF02516	0.386
MOD_N-GLC_1	261	266	PF02516	0.540
MOD_N-GLC_1	290	295	PF02516	0.555
MOD_N-GLC_1	406	411	PF02516	0.433
MOD_NEK2_1	102	107	PF00069	0.390
MOD_NEK2_1	144	149	PF00069	0.465
MOD_NEK2_1	164	169	PF00069	0.319
MOD_NEK2_1	245	250	PF00069	0.378
MOD_NEK2_1	305	310	PF00069	0.562
MOD_NEK2_1	322	327	PF00069	0.593
MOD_NEK2_1	406	411	PF00069	0.433
MOD_NEK2_1	57	62	PF00069	0.412
MOD_NEK2_2	274	279	PF00069	0.534
MOD_PIKK_1	248	254	PF00454	0.548
MOD_PIKK_1	367	373	PF00454	0.560
MOD_PIKK_1	388	394	PF00454	0.515
MOD_PK_1	315	321	PF00069	0.539
MOD_PKA_2	229	235	PF00069	0.434
MOD_PKA_2	265	271	PF00069	0.585
MOD_PKA_2	314	320	PF00069	0.538
MOD_Plk_1	115	121	PF00069	0.564
MOD_Plk_1	133	139	PF00069	0.312
MOD_Plk_1	157	163	PF00069	0.354
MOD_Plk_1	245	251	PF00069	0.439
MOD_Plk_1	357	363	PF00069	0.512
MOD_Plk_1	406	412	PF00069	0.425
MOD_Plk_4	174	180	PF00069	0.513
MOD_Plk_4	200	206	PF00069	0.405
MOD_Plk_4	406	412	PF00069	0.434
MOD_ProDKin_1	261	267	PF00069	0.675
MOD_ProDKin_1	286	292	PF00069	0.615
MOD_ProDKin_1	297	303	PF00069	0.679
MOD_ProDKin_1	309	315	PF00069	0.544
MOD_ProDKin_1	334	340	PF00069	0.517
MOD_ProDKin_1	58	64	PF00069	0.340
MOD_SUMO_for_1	113	116	PF00179	0.403
MOD_SUMO_rev_2	167	176	PF00179	0.307
MOD_SUMO_rev_2	413	423	PF00179	0.436
TRG_DiLeu_BaEn_1	348	353	PF01217	0.521
TRG_DiLeu_BaEn_4	216	222	PF01217	0.432
TRG_ENDOCYTIC_2	193	196	PF00928	0.436
TRG_ENDOCYTIC_2	87	90	PF00928	0.372
TRG_ER_diArg_1	353	355	PF00400	0.530
TRG_NLS_MonoExtN_4	122	128	PF00514	0.382
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S1	Leptomonas seymouri	58%	95%
A0A3Q8IG21	Leishmania donovani	66%	100%
A0A3Q8IIE7	Leishmania donovani	66%	100%
A4H6C6	Leishmania braziliensis	21%	100%
A4I6H9	Leishmania infantum	66%	100%
E9AHL0	Leishmania infantum	68%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q6H8	Leishmania major	64%	100%
Q4Q6I6	Leishmania major	69%	100%
Q4QI82	Leishmania major	24%	100%