Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ54_LEIBR

TriTrypDb:

LbrM.31.0930 , LBRM2903_310016600

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ54

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009306	protein secretion	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0030254	protein secretion by the type III secretion system	4	10
GO:0032940	secretion by cell	3	10
GO:0033036	macromolecule localization	2	10
GO:0035592	establishment of protein localization to extracellular region	4	10
GO:0045184	establishment of protein localization	3	10
GO:0046903	secretion	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071692	protein localization to extracellular region	5	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071806	protein transmembrane transport	3	10
GO:0140352	export from cell	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.497
CLV_NRD_NRD_1	14	16	PF00675	0.511
CLV_NRD_NRD_1	34	36	PF00675	0.260
CLV_NRD_NRD_1	81	83	PF00675	0.611
CLV_PCSK_KEX2_1	34	36	PF00082	0.409
CLV_PCSK_KEX2_1	81	83	PF00082	0.611
CLV_PCSK_SKI1_1	15	19	PF00082	0.423
CLV_PCSK_SKI1_1	198	202	PF00082	0.342
CLV_PCSK_SKI1_1	4	8	PF00082	0.450
DEG_APCC_DBOX_1	21	29	PF00400	0.427
DEG_APCC_DBOX_1	239	247	PF00400	0.479
DEG_Nend_UBRbox_2	1	3	PF02207	0.526
DEG_SPOP_SBC_1	272	276	PF00917	0.542
DOC_MAPK_gen_1	15	21	PF00069	0.479
DOC_MAPK_gen_1	240	248	PF00069	0.479
DOC_MAPK_MEF2A_6	189	196	PF00069	0.542
DOC_USP7_MATH_1	113	117	PF00917	0.463
DOC_USP7_MATH_1	148	152	PF00917	0.595
DOC_USP7_MATH_1	179	183	PF00917	0.445
DOC_USP7_MATH_1	77	81	PF00917	0.709
DOC_USP7_MATH_1	87	91	PF00917	0.688
LIG_14-3-3_CanoR_1	159	167	PF00244	0.624
LIG_14-3-3_CanoR_1	280	287	PF00244	0.420
LIG_14-3-3_CanoR_1	300	305	PF00244	0.545
LIG_14-3-3_CanoR_1	35	41	PF00244	0.433
LIG_APCC_ABBA_1	192	197	PF00400	0.398
LIG_APCC_ABBA_1	291	296	PF00400	0.519
LIG_BRCT_BRCA1_1	192	196	PF00533	0.504
LIG_BRCT_BRCA1_2	192	198	PF00533	0.540
LIG_CaM_IQ_9	114	130	PF13499	0.399
LIG_eIF4E_1	224	230	PF01652	0.479
LIG_FHA_1	199	205	PF00498	0.461
LIG_FHA_1	218	224	PF00498	0.461
LIG_FHA_1	272	278	PF00498	0.504
LIG_FHA_1	288	294	PF00498	0.470
LIG_FHA_1	83	89	PF00498	0.721
LIG_FHA_2	105	111	PF00498	0.811
LIG_FHA_2	204	210	PF00498	0.542
LIG_Integrin_RGD_1	22	24	PF01839	0.462
LIG_Integrin_RGD_TGFB_3	22	28	PF01839	0.431
LIG_LIR_Apic_2	39	43	PF02991	0.478
LIG_LIR_Gen_1	207	218	PF02991	0.521
LIG_LIR_Nem_3	207	213	PF02991	0.521
LIG_MLH1_MIPbox_1	192	196	PF16413	0.398
LIG_NRBOX	242	248	PF00104	0.420
LIG_PTAP_UEV_1	88	93	PF05743	0.539
LIG_SH2_CRK	226	230	PF00017	0.461
LIG_SH2_NCK_1	216	220	PF00017	0.542
LIG_SH2_SRC	216	219	PF00017	0.498
LIG_SH2_SRC	224	227	PF00017	0.456
LIG_SH2_STAP1	226	230	PF00017	0.461
LIG_SH2_STAP1	244	248	PF00017	0.461
LIG_SH2_STAT3	102	105	PF00017	0.741
LIG_SH2_STAT5	195	198	PF00017	0.507
LIG_SH2_STAT5	224	227	PF00017	0.463
LIG_SH2_STAT5	36	39	PF00017	0.400
LIG_SH3_3	86	92	PF00018	0.713
LIG_SH3_3	98	104	PF00018	0.634
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.421
LIG_SUMO_SIM_par_1	269	276	PF11976	0.462
LIG_TRAF2_1	103	106	PF00917	0.540
LIG_TRAF2_1	116	119	PF00917	0.425
MOD_CK1_1	228	234	PF00069	0.540
MOD_CK2_1	113	119	PF00069	0.615
MOD_Cter_Amidation	13	16	PF01082	0.513
MOD_GlcNHglycan	151	154	PF01048	0.629
MOD_GlcNHglycan	282	285	PF01048	0.218
MOD_GlcNHglycan	49	52	PF01048	0.490
MOD_GlcNHglycan	89	92	PF01048	0.667
MOD_GSK3_1	208	215	PF00069	0.469
MOD_GSK3_1	224	231	PF00069	0.479
MOD_GSK3_1	262	269	PF00069	0.458
MOD_N-GLC_1	149	154	PF02516	0.553
MOD_N-GLC_1	198	203	PF02516	0.261
MOD_NEK2_1	190	195	PF00069	0.489
MOD_NEK2_1	248	253	PF00069	0.479
MOD_NEK2_1	266	271	PF00069	0.414
MOD_NEK2_1	273	278	PF00069	0.458
MOD_NEK2_1	287	292	PF00069	0.469
MOD_NEK2_1	294	299	PF00069	0.474
MOD_PIKK_1	114	120	PF00454	0.576
MOD_PIKK_1	184	190	PF00454	0.539
MOD_PKA_2	114	120	PF00069	0.616
MOD_Plk_1	198	204	PF00069	0.461
MOD_Plk_1	208	214	PF00069	0.461
MOD_Plk_4	190	196	PF00069	0.464
MOD_Plk_4	225	231	PF00069	0.496
MOD_Plk_4	248	254	PF00069	0.479
MOD_Plk_4	266	272	PF00069	0.479
MOD_Plk_4	294	300	PF00069	0.552
TRG_DiLeu_BaEn_1	44	49	PF01217	0.538
TRG_ENDOCYTIC_2	226	229	PF00928	0.461
TRG_ENDOCYTIC_2	244	247	PF00928	0.461
TRG_ER_diArg_1	33	35	PF00400	0.420
TRG_ER_diArg_1	81	83	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT22	Leptomonas seymouri	54%	93%
A0A0S4IPP0	Bodo saltans	30%	67%
A0A3S7X487	Leishmania donovani	74%	98%
A4I6G8	Leishmania infantum	74%	98%
D0A443	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	85%
E9B1M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	94%
Q9BHG3	Leishmania major	73%	100%
V5BJ53	Trypanosoma cruzi	46%	88%