LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MFS general substrate transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS general substrate transporter
Gene product:
major facilitator superfamily, putative
Species:
Leishmania braziliensis
UniProt:
A4HJ52_LEIBR
TriTrypDb:
LbrM.31.0910 , LBRM2903_310016300 , LBRM2903_310016400 *
Length:
976

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HJ52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ52

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 5
GO:0022857 transmembrane transporter activity 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.676
CLV_C14_Caspase3-7 131 135 PF00656 0.746
CLV_C14_Caspase3-7 427 431 PF00656 0.715
CLV_C14_Caspase3-7 506 510 PF00656 0.817
CLV_C14_Caspase3-7 8 12 PF00656 0.647
CLV_C14_Caspase3-7 955 959 PF00656 0.595
CLV_NRD_NRD_1 127 129 PF00675 0.552
CLV_NRD_NRD_1 151 153 PF00675 0.445
CLV_NRD_NRD_1 345 347 PF00675 0.315
CLV_NRD_NRD_1 370 372 PF00675 0.351
CLV_NRD_NRD_1 41 43 PF00675 0.637
CLV_NRD_NRD_1 624 626 PF00675 0.507
CLV_NRD_NRD_1 89 91 PF00675 0.450
CLV_NRD_NRD_1 898 900 PF00675 0.681
CLV_NRD_NRD_1 924 926 PF00675 0.415
CLV_NRD_NRD_1 937 939 PF00675 0.379
CLV_PCSK_FUR_1 943 947 PF00082 0.369
CLV_PCSK_KEX2_1 151 153 PF00082 0.445
CLV_PCSK_KEX2_1 26 28 PF00082 0.494
CLV_PCSK_KEX2_1 345 347 PF00082 0.315
CLV_PCSK_KEX2_1 369 371 PF00082 0.366
CLV_PCSK_KEX2_1 624 626 PF00082 0.507
CLV_PCSK_KEX2_1 898 900 PF00082 0.681
CLV_PCSK_KEX2_1 91 93 PF00082 0.455
CLV_PCSK_KEX2_1 924 926 PF00082 0.415
CLV_PCSK_KEX2_1 937 939 PF00082 0.379
CLV_PCSK_KEX2_1 945 947 PF00082 0.447
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.494
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.366
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.458
CLV_PCSK_PC1ET2_1 945 947 PF00082 0.370
CLV_PCSK_PC7_1 22 28 PF00082 0.438
CLV_PCSK_PC7_1 341 347 PF00082 0.306
CLV_PCSK_SKI1_1 154 158 PF00082 0.262
CLV_PCSK_SKI1_1 189 193 PF00082 0.657
CLV_PCSK_SKI1_1 303 307 PF00082 0.552
CLV_PCSK_SKI1_1 345 349 PF00082 0.508
CLV_PCSK_SKI1_1 544 548 PF00082 0.464
CLV_PCSK_SKI1_1 775 779 PF00082 0.512
CLV_PCSK_SKI1_1 945 949 PF00082 0.465
CLV_Separin_Metazoa 570 574 PF03568 0.668
DEG_Nend_Nbox_1 1 3 PF02207 0.657
DEG_SCF_SKP2-CKS1_1 397 404 PF00560 0.489
DOC_ANK_TNKS_1 405 412 PF00023 0.418
DOC_CYCLIN_yCln2_LP_2 825 831 PF00134 0.249
DOC_MAPK_gen_1 151 157 PF00069 0.617
DOC_MAPK_gen_1 26 33 PF00069 0.614
DOC_MAPK_gen_1 369 377 PF00069 0.618
DOC_MAPK_gen_1 789 797 PF00069 0.701
DOC_MAPK_MEF2A_6 26 33 PF00069 0.614
DOC_MAPK_MEF2A_6 370 379 PF00069 0.618
DOC_MAPK_MEF2A_6 524 532 PF00069 0.850
DOC_MAPK_MEF2A_6 544 552 PF00069 0.612
DOC_MAPK_MEF2A_6 573 580 PF00069 0.716
DOC_MAPK_MEF2A_6 588 595 PF00069 0.817
DOC_MAPK_MEF2A_6 903 911 PF00069 0.357
DOC_MAPK_NFAT4_5 573 581 PF00069 0.668
DOC_PP1_RVXF_1 152 158 PF00149 0.504
DOC_PP1_RVXF_1 28 34 PF00149 0.800
DOC_PP2B_LxvP_1 422 425 PF13499 0.512
DOC_PP2B_LxvP_1 576 579 PF13499 0.860
DOC_PP2B_LxvP_1 72 75 PF13499 0.818
DOC_PP2B_LxvP_1 825 828 PF13499 0.249
DOC_PP4_FxxP_1 204 207 PF00568 0.352
DOC_SPAK_OSR1_1 152 156 PF12202 0.618
DOC_USP7_MATH_1 222 226 PF00917 0.512
DOC_USP7_MATH_1 25 29 PF00917 0.629
DOC_USP7_MATH_1 425 429 PF00917 0.647
DOC_USP7_MATH_1 511 515 PF00917 0.666
DOC_USP7_MATH_1 526 530 PF00917 0.653
DOC_USP7_MATH_1 645 649 PF00917 0.672
DOC_USP7_MATH_1 764 768 PF00917 0.355
DOC_USP7_MATH_1 803 807 PF00917 0.352
DOC_USP7_MATH_1 886 890 PF00917 0.327
DOC_USP7_MATH_1 912 916 PF00917 0.352
DOC_WW_Pin1_4 17 22 PF00397 0.776
DOC_WW_Pin1_4 345 350 PF00397 0.712
DOC_WW_Pin1_4 398 403 PF00397 0.489
DOC_WW_Pin1_4 472 477 PF00397 0.635
DOC_WW_Pin1_4 507 512 PF00397 0.649
DOC_WW_Pin1_4 558 563 PF00397 0.720
DOC_WW_Pin1_4 610 615 PF00397 0.663
DOC_WW_Pin1_4 665 670 PF00397 0.831
DOC_WW_Pin1_4 74 79 PF00397 0.806
DOC_WW_Pin1_4 884 889 PF00397 0.508
DOC_WW_Pin1_4 91 96 PF00397 0.673
LIG_14-3-3_CanoR_1 118 127 PF00244 0.700
LIG_14-3-3_CanoR_1 30 34 PF00244 0.794
LIG_14-3-3_CanoR_1 361 368 PF00244 0.551
LIG_14-3-3_CanoR_1 45 54 PF00244 0.634
LIG_14-3-3_CanoR_1 588 594 PF00244 0.850
LIG_14-3-3_CanoR_1 681 685 PF00244 0.774
LIG_Actin_WH2_2 393 408 PF00022 0.594
LIG_AP2alpha_1 306 310 PF02296 0.441
LIG_BIR_III_4 11 15 PF00653 0.660
LIG_BRCT_BRCA1_1 612 616 PF00533 0.661
LIG_BRCT_BRCA1_1 831 835 PF00533 0.392
LIG_BRCT_BRCA1_1 840 844 PF00533 0.484
LIG_deltaCOP1_diTrp_1 720 725 PF00928 0.352
LIG_EH1_1 371 379 PF00400 0.427
LIG_eIF4E_1 718 724 PF01652 0.504
LIG_FHA_1 108 114 PF00498 0.857
LIG_FHA_1 166 172 PF00498 0.352
LIG_FHA_1 282 288 PF00498 0.618
LIG_FHA_1 388 394 PF00498 0.512
LIG_FHA_1 597 603 PF00498 0.667
LIG_FHA_1 649 655 PF00498 0.828
LIG_FHA_1 693 699 PF00498 0.685
LIG_FHA_1 708 714 PF00498 0.555
LIG_FHA_1 726 732 PF00498 0.352
LIG_FHA_1 792 798 PF00498 0.588
LIG_FHA_1 841 847 PF00498 0.352
LIG_FHA_2 102 108 PF00498 0.725
LIG_FHA_2 120 126 PF00498 0.714
LIG_FHA_2 129 135 PF00498 0.777
LIG_FHA_2 346 352 PF00498 0.624
LIG_FHA_2 582 588 PF00498 0.769
LIG_FHA_2 6 12 PF00498 0.800
LIG_FHA_2 709 715 PF00498 0.548
LIG_FHA_2 847 853 PF00498 0.570
LIG_IRF3_LxIS_1 160 165 PF10401 0.512
LIG_LIR_Apic_2 213 217 PF02991 0.535
LIG_LIR_Apic_2 686 691 PF02991 0.617
LIG_LIR_Apic_2 701 706 PF02991 0.600
LIG_LIR_Gen_1 296 306 PF02991 0.352
LIG_LIR_Gen_1 308 318 PF02991 0.303
LIG_LIR_Gen_1 657 665 PF02991 0.740
LIG_LIR_Gen_1 715 726 PF02991 0.502
LIG_LIR_Nem_3 173 178 PF02991 0.352
LIG_LIR_Nem_3 205 211 PF02991 0.253
LIG_LIR_Nem_3 289 293 PF02991 0.352
LIG_LIR_Nem_3 296 301 PF02991 0.352
LIG_LIR_Nem_3 308 313 PF02991 0.345
LIG_LIR_Nem_3 646 652 PF02991 0.705
LIG_LIR_Nem_3 657 661 PF02991 0.710
LIG_LIR_Nem_3 715 721 PF02991 0.544
LIG_LIR_Nem_3 832 838 PF02991 0.371
LIG_LIR_Nem_3 841 847 PF02991 0.484
LIG_MLH1_MIPbox_1 831 835 PF16413 0.244
LIG_NRBOX 229 235 PF00104 0.352
LIG_Pex14_1 722 726 PF04695 0.352
LIG_Pex14_1 875 879 PF04695 0.494
LIG_Pex14_2 153 157 PF04695 0.504
LIG_Pex14_2 204 208 PF04695 0.352
LIG_Pex14_2 235 239 PF04695 0.352
LIG_Pex14_2 298 302 PF04695 0.352
LIG_Pex14_2 306 310 PF04695 0.357
LIG_REV1ctd_RIR_1 303 311 PF16727 0.350
LIG_SH2_CRK 658 662 PF00017 0.818
LIG_SH2_CRK 688 692 PF00017 0.732
LIG_SH2_CRK 726 730 PF00017 0.512
LIG_SH2_CRK 926 930 PF00017 0.594
LIG_SH2_GRB2like 688 691 PF00017 0.734
LIG_SH2_PTP2 703 706 PF00017 0.671
LIG_SH2_STAP1 262 266 PF00017 0.352
LIG_SH2_STAP1 54 58 PF00017 0.786
LIG_SH2_STAP1 781 785 PF00017 0.551
LIG_SH2_STAP1 882 886 PF00017 0.475
LIG_SH2_STAP1 926 930 PF00017 0.666
LIG_SH2_STAT3 362 365 PF00017 0.667
LIG_SH2_STAT5 195 198 PF00017 0.512
LIG_SH2_STAT5 331 334 PF00017 0.517
LIG_SH2_STAT5 337 340 PF00017 0.531
LIG_SH2_STAT5 372 375 PF00017 0.352
LIG_SH2_STAT5 385 388 PF00017 0.341
LIG_SH2_STAT5 395 398 PF00017 0.455
LIG_SH2_STAT5 703 706 PF00017 0.671
LIG_SH2_STAT5 718 721 PF00017 0.466
LIG_SH2_STAT5 726 729 PF00017 0.359
LIG_SH2_STAT5 760 763 PF00017 0.512
LIG_SH2_STAT5 829 832 PF00017 0.430
LIG_SH2_STAT5 845 848 PF00017 0.388
LIG_SH2_STAT5 863 866 PF00017 0.352
LIG_SH2_STAT5 879 882 PF00017 0.317
LIG_SH2_STAT5 893 896 PF00017 0.445
LIG_SH2_STAT5 908 911 PF00017 0.249
LIG_SH2_STAT5 920 923 PF00017 0.402
LIG_SH3_2 508 513 PF14604 0.649
LIG_SH3_3 505 511 PF00018 0.707
LIG_SH3_3 519 525 PF00018 0.632
LIG_SH3_3 547 553 PF00018 0.849
LIG_SH3_3 559 565 PF00018 0.723
LIG_SH3_3 590 596 PF00018 0.735
LIG_SH3_3 72 78 PF00018 0.813
LIG_SH3_3 792 798 PF00018 0.507
LIG_SH3_3 936 942 PF00018 0.752
LIG_SUMO_SIM_par_1 160 168 PF11976 0.352
LIG_SUMO_SIM_par_1 219 225 PF11976 0.352
LIG_SUMO_SIM_par_1 793 799 PF11976 0.614
LIG_TRAF2_1 445 448 PF00917 0.754
LIG_TYR_ITIM 716 721 PF00017 0.547
LIG_UBA3_1 84 91 PF00899 0.649
LIG_WRC_WIRS_1 287 292 PF05994 0.352
MOD_CDC14_SPxK_1 510 513 PF00782 0.653
MOD_CDK_SPK_2 17 22 PF00069 0.658
MOD_CDK_SPK_2 558 563 PF00069 0.673
MOD_CDK_SPxK_1 398 404 PF00069 0.488
MOD_CDK_SPxK_1 472 478 PF00069 0.640
MOD_CDK_SPxK_1 507 513 PF00069 0.652
MOD_CK1_1 163 169 PF00069 0.512
MOD_CK1_1 197 203 PF00069 0.512
MOD_CK1_1 472 478 PF00069 0.640
MOD_CK1_1 558 564 PF00069 0.703
MOD_CK1_1 57 63 PF00069 0.691
MOD_CK1_1 609 615 PF00069 0.833
MOD_CK1_1 648 654 PF00069 0.743
MOD_CK1_1 670 676 PF00069 0.823
MOD_CK1_1 686 692 PF00069 0.541
MOD_CK1_1 767 773 PF00069 0.237
MOD_CK1_1 887 893 PF00069 0.523
MOD_CK1_1 915 921 PF00069 0.352
MOD_CK1_1 97 103 PF00069 0.742
MOD_CK2_1 345 351 PF00069 0.629
MOD_CK2_1 494 500 PF00069 0.654
MOD_CK2_1 581 587 PF00069 0.770
MOD_CK2_1 640 646 PF00069 0.805
MOD_CK2_1 670 676 PF00069 0.635
MOD_CK2_1 708 714 PF00069 0.547
MOD_CK2_1 99 105 PF00069 0.792
MOD_CMANNOS 875 878 PF00535 0.512
MOD_GlcNHglycan 136 139 PF01048 0.405
MOD_GlcNHglycan 196 199 PF01048 0.512
MOD_GlcNHglycan 543 547 PF01048 0.506
MOD_GlcNHglycan 557 560 PF01048 0.629
MOD_GlcNHglycan 669 672 PF01048 0.538
MOD_GlcNHglycan 766 769 PF01048 0.244
MOD_GlcNHglycan 831 834 PF01048 0.392
MOD_GlcNHglycan 840 843 PF01048 0.484
MOD_GlcNHglycan 950 953 PF01048 0.443
MOD_GSK3_1 160 167 PF00069 0.512
MOD_GSK3_1 25 32 PF00069 0.719
MOD_GSK3_1 477 484 PF00069 0.684
MOD_GSK3_1 507 514 PF00069 0.652
MOD_GSK3_1 54 61 PF00069 0.799
MOD_GSK3_1 606 613 PF00069 0.761
MOD_GSK3_1 623 630 PF00069 0.731
MOD_GSK3_1 657 664 PF00069 0.661
MOD_GSK3_1 680 687 PF00069 0.649
MOD_GSK3_1 708 715 PF00069 0.551
MOD_GSK3_1 836 843 PF00069 0.352
MOD_GSK3_1 911 918 PF00069 0.352
MOD_GSK3_1 94 101 PF00069 0.706
MOD_N-GLC_1 118 123 PF02516 0.454
MOD_N-GLC_1 38 43 PF02516 0.543
MOD_N-GLC_1 46 51 PF02516 0.572
MOD_N-GLC_1 472 477 PF02516 0.465
MOD_NEK2_1 162 167 PF00069 0.357
MOD_NEK2_1 235 240 PF00069 0.384
MOD_NEK2_1 286 291 PF00069 0.352
MOD_NEK2_1 29 34 PF00069 0.797
MOD_NEK2_1 293 298 PF00069 0.352
MOD_NEK2_1 318 323 PF00069 0.383
MOD_NEK2_1 38 43 PF00069 0.732
MOD_NEK2_1 384 389 PF00069 0.450
MOD_NEK2_1 572 577 PF00069 0.861
MOD_NEK2_1 623 628 PF00069 0.690
MOD_NEK2_1 661 666 PF00069 0.692
MOD_NEK2_1 680 685 PF00069 0.735
MOD_NEK2_1 712 717 PF00069 0.553
MOD_NEK2_1 724 729 PF00069 0.352
MOD_NEK2_1 736 741 PF00069 0.397
MOD_NEK2_1 911 916 PF00069 0.411
MOD_NEK2_1 948 953 PF00069 0.562
MOD_NEK2_2 170 175 PF00069 0.352
MOD_NEK2_2 25 30 PF00069 0.792
MOD_NEK2_2 589 594 PF00069 0.851
MOD_NEK2_2 645 650 PF00069 0.643
MOD_PIKK_1 129 135 PF00454 0.606
MOD_PIKK_1 165 171 PF00454 0.352
MOD_PIKK_1 361 367 PF00454 0.552
MOD_PIKK_1 48 54 PF00454 0.797
MOD_PKA_1 128 134 PF00069 0.730
MOD_PKA_1 624 630 PF00069 0.666
MOD_PKA_1 924 930 PF00069 0.670
MOD_PKA_2 117 123 PF00069 0.718
MOD_PKA_2 29 35 PF00069 0.799
MOD_PKA_2 572 578 PF00069 0.760
MOD_PKA_2 623 629 PF00069 0.695
MOD_PKA_2 680 686 PF00069 0.794
MOD_PKA_2 924 930 PF00069 0.670
MOD_PKB_1 359 367 PF00069 0.553
MOD_PKB_1 789 797 PF00069 0.701
MOD_Plk_1 511 517 PF00069 0.663
MOD_Plk_1 54 60 PF00069 0.796
MOD_Plk_1 542 548 PF00069 0.672
MOD_Plk_1 645 651 PF00069 0.723
MOD_Plk_2-3 430 436 PF00069 0.736
MOD_Plk_2-3 714 720 PF00069 0.541
MOD_Plk_2-3 99 105 PF00069 0.712
MOD_Plk_4 170 176 PF00069 0.485
MOD_Plk_4 189 195 PF00069 0.195
MOD_Plk_4 222 228 PF00069 0.512
MOD_Plk_4 243 249 PF00069 0.465
MOD_Plk_4 293 299 PF00069 0.352
MOD_Plk_4 54 60 PF00069 0.796
MOD_Plk_4 589 595 PF00069 0.660
MOD_Plk_4 645 651 PF00069 0.639
MOD_Plk_4 692 698 PF00069 0.653
MOD_Plk_4 708 714 PF00069 0.545
MOD_Plk_4 791 797 PF00069 0.558
MOD_Plk_4 80 86 PF00069 0.690
MOD_Plk_4 840 846 PF00069 0.515
MOD_Plk_4 916 922 PF00069 0.459
MOD_ProDKin_1 17 23 PF00069 0.774
MOD_ProDKin_1 345 351 PF00069 0.712
MOD_ProDKin_1 398 404 PF00069 0.488
MOD_ProDKin_1 472 478 PF00069 0.640
MOD_ProDKin_1 507 513 PF00069 0.650
MOD_ProDKin_1 558 564 PF00069 0.721
MOD_ProDKin_1 610 616 PF00069 0.662
MOD_ProDKin_1 665 671 PF00069 0.830
MOD_ProDKin_1 74 80 PF00069 0.802
MOD_ProDKin_1 884 890 PF00069 0.511
MOD_ProDKin_1 91 97 PF00069 0.674
MOD_SUMO_for_1 445 448 PF00179 0.754
MOD_SUMO_rev_2 20 28 PF00179 0.679
MOD_SUMO_rev_2 436 445 PF00179 0.558
TRG_DiLeu_BaEn_1 447 452 PF01217 0.593
TRG_DiLeu_BaEn_1 543 548 PF01217 0.650
TRG_DiLeu_BaEn_3 447 453 PF01217 0.560
TRG_ENDOCYTIC_2 212 215 PF00928 0.539
TRG_ENDOCYTIC_2 254 257 PF00928 0.357
TRG_ENDOCYTIC_2 372 375 PF00928 0.438
TRG_ENDOCYTIC_2 385 388 PF00928 0.269
TRG_ENDOCYTIC_2 658 661 PF00928 0.816
TRG_ENDOCYTIC_2 718 721 PF00928 0.539
TRG_ENDOCYTIC_2 726 729 PF00928 0.352
TRG_ENDOCYTIC_2 752 755 PF00928 0.478
TRG_ENDOCYTIC_2 760 763 PF00928 0.380
TRG_ENDOCYTIC_2 908 911 PF00928 0.352
TRG_ENDOCYTIC_2 926 929 PF00928 0.554
TRG_ER_diArg_1 150 152 PF00400 0.654
TRG_ER_diArg_1 345 347 PF00400 0.647
TRG_ER_diArg_1 358 361 PF00400 0.480
TRG_ER_diArg_1 370 372 PF00400 0.551
TRG_ER_diArg_1 458 461 PF00400 0.753
TRG_ER_diArg_1 623 625 PF00400 0.677
TRG_ER_diArg_1 788 791 PF00400 0.516
TRG_ER_diArg_1 924 926 PF00400 0.608
TRG_ER_diArg_1 937 939 PF00400 0.582
TRG_NLS_Bipartite_1 26 46 PF00514 0.630
TRG_NLS_Bipartite_1 945 965 PF00514 0.587
TRG_NLS_MonoExtN_4 368 373 PF00514 0.560

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NZT1 Trypanosomatidae 38% 100%
A0A3Q8IG09 Leishmania donovani 74% 100%
A4I6G6 Leishmania infantum 74% 100%
E9B1M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q4Q6J1 Leishmania major 73% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS