LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania braziliensis
UniProt:
A4HJ51_LEIBR
TriTrypDb:
LbrM.31.0900 , LBRM2903_310016300 *
Length:
623

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HJ51
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ51

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 153 157 PF00656 0.827
CLV_C14_Caspase3-7 602 606 PF00656 0.776
CLV_C14_Caspase3-7 74 78 PF00656 0.704
CLV_NRD_NRD_1 17 19 PF00675 0.399
CLV_NRD_NRD_1 271 273 PF00675 0.642
CLV_NRD_NRD_1 545 547 PF00675 0.665
CLV_NRD_NRD_1 571 573 PF00675 0.414
CLV_NRD_NRD_1 584 586 PF00675 0.396
CLV_PCSK_FUR_1 590 594 PF00082 0.538
CLV_PCSK_KEX2_1 16 18 PF00082 0.391
CLV_PCSK_KEX2_1 271 273 PF00082 0.642
CLV_PCSK_KEX2_1 545 547 PF00082 0.665
CLV_PCSK_KEX2_1 571 573 PF00082 0.414
CLV_PCSK_KEX2_1 584 586 PF00082 0.396
CLV_PCSK_KEX2_1 592 594 PF00082 0.457
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.391
CLV_PCSK_PC1ET2_1 592 594 PF00082 0.540
CLV_PCSK_SKI1_1 191 195 PF00082 0.561
CLV_PCSK_SKI1_1 422 426 PF00082 0.500
CLV_PCSK_SKI1_1 592 596 PF00082 0.474
CLV_Separin_Metazoa 217 221 PF03568 0.843
DEG_Nend_UBRbox_1 1 3 PF02207 0.679
DEG_SCF_SKP2-CKS1_1 44 51 PF00560 0.480
DOC_ANK_TNKS_1 52 59 PF00023 0.500
DOC_CYCLIN_yCln2_LP_2 472 478 PF00134 0.359
DOC_MAPK_gen_1 16 24 PF00069 0.600
DOC_MAPK_gen_1 436 444 PF00069 0.683
DOC_MAPK_MEF2A_6 17 26 PF00069 0.519
DOC_MAPK_MEF2A_6 171 179 PF00069 0.834
DOC_MAPK_MEF2A_6 220 227 PF00069 0.836
DOC_MAPK_MEF2A_6 235 242 PF00069 0.628
DOC_MAPK_MEF2A_6 550 558 PF00069 0.386
DOC_MAPK_NFAT4_5 220 228 PF00069 0.835
DOC_PP2B_LxvP_1 223 226 PF13499 0.835
DOC_PP2B_LxvP_1 472 475 PF13499 0.361
DOC_PP2B_LxvP_1 69 72 PF13499 0.500
DOC_USP7_MATH_1 158 162 PF00917 0.833
DOC_USP7_MATH_1 173 177 PF00917 0.608
DOC_USP7_MATH_1 292 296 PF00917 0.814
DOC_USP7_MATH_1 411 415 PF00917 0.395
DOC_USP7_MATH_1 450 454 PF00917 0.383
DOC_USP7_MATH_1 533 537 PF00917 0.498
DOC_USP7_MATH_1 559 563 PF00917 0.383
DOC_USP7_MATH_1 72 76 PF00917 0.650
DOC_WW_Pin1_4 119 124 PF00397 0.800
DOC_WW_Pin1_4 154 159 PF00397 0.741
DOC_WW_Pin1_4 205 210 PF00397 0.851
DOC_WW_Pin1_4 257 262 PF00397 0.829
DOC_WW_Pin1_4 312 317 PF00397 0.816
DOC_WW_Pin1_4 45 50 PF00397 0.479
DOC_WW_Pin1_4 531 536 PF00397 0.489
LIG_14-3-3_CanoR_1 235 241 PF00244 0.812
LIG_14-3-3_CanoR_1 328 332 PF00244 0.797
LIG_14-3-3_CanoR_1 8 15 PF00244 0.618
LIG_Actin_WH2_2 40 55 PF00022 0.599
LIG_BRCT_BRCA1_1 259 263 PF00533 0.825
LIG_BRCT_BRCA1_1 478 482 PF00533 0.500
LIG_BRCT_BRCA1_1 487 491 PF00533 0.342
LIG_deltaCOP1_diTrp_1 367 372 PF00928 0.383
LIG_EH1_1 18 26 PF00400 0.600
LIG_eIF4E_1 365 371 PF01652 0.516
LIG_FHA_1 244 250 PF00498 0.796
LIG_FHA_1 296 302 PF00498 0.797
LIG_FHA_1 340 346 PF00498 0.702
LIG_FHA_1 35 41 PF00498 0.500
LIG_FHA_1 355 361 PF00498 0.586
LIG_FHA_1 373 379 PF00498 0.383
LIG_FHA_1 439 445 PF00498 0.654
LIG_FHA_1 488 494 PF00498 0.383
LIG_FHA_2 229 235 PF00498 0.820
LIG_FHA_2 275 281 PF00498 0.846
LIG_FHA_2 356 362 PF00498 0.581
LIG_FHA_2 494 500 PF00498 0.577
LIG_LIR_Apic_2 333 338 PF02991 0.652
LIG_LIR_Apic_2 348 353 PF02991 0.631
LIG_LIR_Gen_1 304 312 PF02991 0.793
LIG_LIR_Gen_1 362 373 PF02991 0.516
LIG_LIR_Nem_3 293 299 PF02991 0.806
LIG_LIR_Nem_3 304 308 PF02991 0.645
LIG_LIR_Nem_3 362 368 PF02991 0.560
LIG_LIR_Nem_3 479 485 PF02991 0.500
LIG_LIR_Nem_3 488 494 PF02991 0.342
LIG_MLH1_MIPbox_1 478 482 PF16413 0.500
LIG_Pex14_1 369 373 PF04695 0.383
LIG_Pex14_1 522 526 PF04695 0.500
LIG_SH2_CRK 305 309 PF00017 0.786
LIG_SH2_CRK 335 339 PF00017 0.737
LIG_SH2_CRK 373 377 PF00017 0.500
LIG_SH2_CRK 573 577 PF00017 0.602
LIG_SH2_GRB2like 335 338 PF00017 0.738
LIG_SH2_PTP2 350 353 PF00017 0.670
LIG_SH2_STAP1 428 432 PF00017 0.573
LIG_SH2_STAP1 529 533 PF00017 0.462
LIG_SH2_STAP1 573 577 PF00017 0.652
LIG_SH2_STAT3 9 12 PF00017 0.636
LIG_SH2_STAT5 19 22 PF00017 0.525
LIG_SH2_STAT5 32 35 PF00017 0.293
LIG_SH2_STAT5 350 353 PF00017 0.670
LIG_SH2_STAT5 365 368 PF00017 0.471
LIG_SH2_STAT5 373 376 PF00017 0.383
LIG_SH2_STAT5 407 410 PF00017 0.500
LIG_SH2_STAT5 42 45 PF00017 0.397
LIG_SH2_STAT5 476 479 PF00017 0.447
LIG_SH2_STAT5 492 495 PF00017 0.383
LIG_SH2_STAT5 510 513 PF00017 0.383
LIG_SH2_STAT5 526 529 PF00017 0.278
LIG_SH2_STAT5 540 543 PF00017 0.446
LIG_SH2_STAT5 555 558 PF00017 0.266
LIG_SH2_STAT5 567 570 PF00017 0.436
LIG_SH3_2 155 160 PF14604 0.826
LIG_SH3_3 152 158 PF00018 0.827
LIG_SH3_3 166 172 PF00018 0.624
LIG_SH3_3 194 200 PF00018 0.834
LIG_SH3_3 206 212 PF00018 0.750
LIG_SH3_3 237 243 PF00018 0.815
LIG_SH3_3 439 445 PF00018 0.596
LIG_SH3_3 583 589 PF00018 0.737
LIG_SUMO_SIM_par_1 440 446 PF11976 0.668
LIG_TRAF2_1 92 95 PF00917 0.716
LIG_TYR_ITIM 363 368 PF00017 0.563
MOD_CDC14_SPxK_1 157 160 PF00782 0.829
MOD_CDK_SPK_2 205 210 PF00069 0.851
MOD_CDK_SPxK_1 119 125 PF00069 0.805
MOD_CDK_SPxK_1 154 160 PF00069 0.826
MOD_CDK_SPxK_1 45 51 PF00069 0.479
MOD_CK1_1 119 125 PF00069 0.805
MOD_CK1_1 205 211 PF00069 0.852
MOD_CK1_1 256 262 PF00069 0.828
MOD_CK1_1 295 301 PF00069 0.800
MOD_CK1_1 317 323 PF00069 0.807
MOD_CK1_1 333 339 PF00069 0.534
MOD_CK1_1 414 420 PF00069 0.386
MOD_CK1_1 534 540 PF00069 0.507
MOD_CK1_1 562 568 PF00069 0.383
MOD_CK2_1 141 147 PF00069 0.788
MOD_CK2_1 228 234 PF00069 0.813
MOD_CK2_1 287 293 PF00069 0.832
MOD_CK2_1 317 323 PF00069 0.807
MOD_CK2_1 355 361 PF00069 0.586
MOD_CMANNOS 522 525 PF00535 0.500
MOD_GlcNHglycan 190 194 PF01048 0.631
MOD_GlcNHglycan 204 207 PF01048 0.475
MOD_GlcNHglycan 413 416 PF01048 0.500
MOD_GlcNHglycan 478 481 PF01048 0.500
MOD_GlcNHglycan 487 490 PF01048 0.342
MOD_GlcNHglycan 597 600 PF01048 0.546
MOD_GSK3_1 124 131 PF00069 0.776
MOD_GSK3_1 154 161 PF00069 0.743
MOD_GSK3_1 253 260 PF00069 0.777
MOD_GSK3_1 270 277 PF00069 0.671
MOD_GSK3_1 304 311 PF00069 0.789
MOD_GSK3_1 327 334 PF00069 0.701
MOD_GSK3_1 355 362 PF00069 0.581
MOD_GSK3_1 483 490 PF00069 0.383
MOD_GSK3_1 558 565 PF00069 0.383
MOD_N-GLC_1 119 124 PF02516 0.600
MOD_NEK2_1 219 224 PF00069 0.838
MOD_NEK2_1 270 275 PF00069 0.842
MOD_NEK2_1 308 313 PF00069 0.804
MOD_NEK2_1 31 36 PF00069 0.468
MOD_NEK2_1 327 332 PF00069 0.561
MOD_NEK2_1 359 364 PF00069 0.575
MOD_NEK2_1 371 376 PF00069 0.383
MOD_NEK2_1 383 388 PF00069 0.383
MOD_NEK2_1 558 563 PF00069 0.429
MOD_NEK2_1 595 600 PF00069 0.740
MOD_NEK2_2 236 241 PF00069 0.808
MOD_NEK2_2 292 297 PF00069 0.813
MOD_PIKK_1 8 14 PF00454 0.626
MOD_PKA_1 271 277 PF00069 0.844
MOD_PKA_1 571 577 PF00069 0.656
MOD_PKA_2 219 225 PF00069 0.799
MOD_PKA_2 270 276 PF00069 0.761
MOD_PKA_2 327 333 PF00069 0.787
MOD_PKA_2 571 577 PF00069 0.656
MOD_PKB_1 436 444 PF00069 0.683
MOD_PKB_1 6 14 PF00069 0.630
MOD_Plk_1 158 164 PF00069 0.835
MOD_Plk_1 189 195 PF00069 0.829
MOD_Plk_1 292 298 PF00069 0.810
MOD_Plk_2-3 361 367 PF00069 0.567
MOD_Plk_2-3 77 83 PF00069 0.722
MOD_Plk_4 236 242 PF00069 0.813
MOD_Plk_4 292 298 PF00069 0.810
MOD_Plk_4 339 345 PF00069 0.712
MOD_Plk_4 355 361 PF00069 0.491
MOD_Plk_4 438 444 PF00069 0.641
MOD_Plk_4 487 493 PF00069 0.491
MOD_Plk_4 563 569 PF00069 0.460
MOD_ProDKin_1 119 125 PF00069 0.805
MOD_ProDKin_1 154 160 PF00069 0.743
MOD_ProDKin_1 205 211 PF00069 0.852
MOD_ProDKin_1 257 263 PF00069 0.828
MOD_ProDKin_1 312 318 PF00069 0.814
MOD_ProDKin_1 45 51 PF00069 0.479
MOD_ProDKin_1 531 537 PF00069 0.491
MOD_SUMO_for_1 92 95 PF00179 0.716
MOD_SUMO_rev_2 83 92 PF00179 0.728
TRG_DiLeu_BaEn_1 190 195 PF01217 0.831
TRG_DiLeu_BaEn_1 94 99 PF01217 0.716
TRG_DiLeu_BaEn_3 94 100 PF01217 0.714
TRG_ENDOCYTIC_2 19 22 PF00928 0.562
TRG_ENDOCYTIC_2 305 308 PF00928 0.781
TRG_ENDOCYTIC_2 32 35 PF00928 0.293
TRG_ENDOCYTIC_2 365 368 PF00928 0.554
TRG_ENDOCYTIC_2 373 376 PF00928 0.383
TRG_ENDOCYTIC_2 399 402 PF00928 0.457
TRG_ENDOCYTIC_2 407 410 PF00928 0.360
TRG_ENDOCYTIC_2 555 558 PF00928 0.383
TRG_ENDOCYTIC_2 573 576 PF00928 0.569
TRG_ER_diArg_1 17 19 PF00400 0.620
TRG_ER_diArg_1 270 272 PF00400 0.841
TRG_ER_diArg_1 435 438 PF00400 0.684
TRG_ER_diArg_1 5 8 PF00400 0.645
TRG_ER_diArg_1 571 573 PF00400 0.610
TRG_ER_diArg_1 584 586 PF00400 0.599
TRG_NLS_Bipartite_1 592 612 PF00514 0.764
TRG_NLS_MonoExtN_4 15 20 PF00514 0.600

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NZT1 Trypanosomatidae 32% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS