Nodulin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ50_LEIBR

TriTrypDb:

LbrM.31.0890 , LBRM2903_310016200

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HJ50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.295
CLV_PCSK_KEX2_1	11	13	PF00082	0.281
CLV_PCSK_SKI1_1	14	18	PF00082	0.233
CLV_PCSK_SKI1_1	163	167	PF00082	0.509
CLV_PCSK_SKI1_1	236	240	PF00082	0.702
CLV_PCSK_SKI1_1	49	53	PF00082	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SCF_FBW7_1	195	201	PF00400	0.593
DOC_CKS1_1	195	200	PF01111	0.581
DOC_CKS1_1	227	232	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.216
DOC_MAPK_gen_1	11	17	PF00069	0.402
DOC_MAPK_MEF2A_6	236	245	PF00069	0.202
DOC_PP1_RVXF_1	12	18	PF00149	0.416
DOC_PP4_FxxP_1	64	67	PF00568	0.223
DOC_SPAK_OSR1_1	12	16	PF12202	0.402
DOC_USP7_MATH_1	198	202	PF00917	0.585
DOC_USP7_MATH_1	203	207	PF00917	0.577
DOC_USP7_MATH_1	82	86	PF00917	0.243
DOC_USP7_MATH_2	203	209	PF00917	0.580
DOC_WW_Pin1_4	194	199	PF00397	0.693
DOC_WW_Pin1_4	226	231	PF00397	0.511
DOC_WW_Pin1_4	237	242	PF00397	0.290
LIG_14-3-3_CanoR_1	236	241	PF00244	0.361
LIG_AP2alpha_1	166	170	PF02296	0.298
LIG_BRCT_BRCA1_1	220	224	PF00533	0.243
LIG_BRCT_BRCA1_1	230	234	PF00533	0.336
LIG_FHA_1	142	148	PF00498	0.492
LIG_FHA_1	26	32	PF00498	0.257
LIG_FHA_2	188	194	PF00498	0.617
LIG_IRF3_LxIS_1	20	25	PF10401	0.243
LIG_LIR_Apic_2	73	77	PF02991	0.478
LIG_LIR_Gen_1	156	166	PF02991	0.335
LIG_LIR_Gen_1	168	178	PF02991	0.176
LIG_LIR_Gen_1	221	232	PF02991	0.245
LIG_LIR_Nem_3	149	153	PF02991	0.223
LIG_LIR_Nem_3	156	161	PF02991	0.253
LIG_LIR_Nem_3	168	173	PF02991	0.445
LIG_LIR_Nem_3	221	227	PF02991	0.243
LIG_LIR_Nem_3	231	237	PF02991	0.331
LIG_LIR_Nem_3	33	38	PF02991	0.301
LIG_LIR_Nem_3	65	71	PF02991	0.246
LIG_MAD2	236	244	PF02301	0.216
LIG_NRBOX	89	95	PF00104	0.243
LIG_PDZ_Class_1	254	259	PF00595	0.597
LIG_Pex14_2	13	17	PF04695	0.479
LIG_Pex14_2	158	162	PF04695	0.243
LIG_Pex14_2	166	170	PF04695	0.271
LIG_Pex14_2	247	251	PF04695	0.243
LIG_Pex14_2	64	68	PF04695	0.243
LIG_Pex14_2	95	99	PF04695	0.243
LIG_REV1ctd_RIR_1	163	171	PF16727	0.300
LIG_SH2_STAP1	122	126	PF00017	0.243
LIG_SH2_STAT5	55	58	PF00017	0.444
LIG_SH3_3	197	203	PF00018	0.586
LIG_SH3_3	227	233	PF00018	0.538
LIG_SH3_3	238	244	PF00018	0.246
LIG_SUMO_SIM_par_1	20	28	PF11976	0.243
LIG_SUMO_SIM_par_1	79	85	PF11976	0.314
LIG_TRFH_1	226	230	PF08558	0.463
LIG_TYR_ITIM	254	259	PF00017	0.457
LIG_WRC_WIRS_1	147	152	PF05994	0.243
MOD_CK1_1	23	29	PF00069	0.255
MOD_CK1_1	57	63	PF00069	0.241
MOD_CK2_1	187	193	PF00069	0.393
MOD_CK2_1	199	205	PF00069	0.620
MOD_GlcNHglycan	56	59	PF01048	0.243
MOD_GSK3_1	194	201	PF00069	0.662
MOD_GSK3_1	20	27	PF00069	0.243
MOD_GSK3_1	203	210	PF00069	0.547
MOD_GSK3_1	214	221	PF00069	0.369
MOD_GSK3_1	228	235	PF00069	0.355
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	146	151	PF00069	0.243
MOD_NEK2_1	153	158	PF00069	0.210
MOD_NEK2_1	178	183	PF00069	0.429
MOD_NEK2_1	207	212	PF00069	0.583
MOD_NEK2_1	22	27	PF00069	0.243
MOD_NEK2_1	254	259	PF00069	0.457
MOD_NEK2_1	95	100	PF00069	0.314
MOD_NEK2_2	30	35	PF00069	0.330
MOD_PIKK_1	25	31	PF00454	0.444
MOD_Plk_4	103	109	PF00069	0.288
MOD_Plk_4	153	159	PF00069	0.278
MOD_Plk_4	30	36	PF00069	0.332
MOD_Plk_4	49	55	PF00069	0.155
MOD_Plk_4	82	88	PF00069	0.226
MOD_ProDKin_1	194	200	PF00069	0.695
MOD_ProDKin_1	226	232	PF00069	0.512
MOD_ProDKin_1	237	243	PF00069	0.290
TRG_ENDOCYTIC_2	114	117	PF00928	0.271
TRG_ENDOCYTIC_2	256	259	PF00928	0.576
TRG_ENDOCYTIC_2	72	75	PF00928	0.489
TRG_ER_diArg_1	10	12	PF00400	0.502
TRG_PTS1	256	259	PF00515	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NK77	Trypanosomatidae	29%	94%