Velvet domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ47_LEIBR

TriTrypDb:

LbrM.31.0860 , LBRM2903_310015900

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.577
CLV_NRD_NRD_1	55	57	PF00675	0.504
CLV_PCSK_KEX2_1	55	57	PF00082	0.504
CLV_PCSK_SKI1_1	276	280	PF00082	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.559
DOC_CKS1_1	114	119	PF01111	0.646
DOC_CKS1_1	135	140	PF01111	0.649
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.553
DOC_MAPK_DCC_7	414	423	PF00069	0.541
DOC_MAPK_gen_1	303	311	PF00069	0.433
DOC_MAPK_MEF2A_6	299	306	PF00069	0.467
DOC_MAPK_MEF2A_6	414	423	PF00069	0.541
DOC_MAPK_NFAT4_5	299	307	PF00069	0.431
DOC_PP2B_LxvP_1	194	197	PF13499	0.518
DOC_PP2B_LxvP_1	379	382	PF13499	0.548
DOC_PP4_FxxP_1	102	105	PF00568	0.421
DOC_PP4_FxxP_1	135	138	PF00568	0.694
DOC_PP4_MxPP_1	423	426	PF00568	0.682
DOC_SPAK_OSR1_1	101	105	PF12202	0.458
DOC_USP7_MATH_1	145	149	PF00917	0.546
DOC_USP7_MATH_1	178	182	PF00917	0.767
DOC_USP7_MATH_1	200	204	PF00917	0.611
DOC_USP7_MATH_1	208	212	PF00917	0.618
DOC_USP7_MATH_1	360	364	PF00917	0.481
DOC_WW_Pin1_4	113	118	PF00397	0.654
DOC_WW_Pin1_4	119	124	PF00397	0.687
DOC_WW_Pin1_4	134	139	PF00397	0.548
DOC_WW_Pin1_4	185	190	PF00397	0.639
DOC_WW_Pin1_4	196	201	PF00397	0.566
DOC_WW_Pin1_4	224	229	PF00397	0.535
DOC_WW_Pin1_4	239	244	PF00397	0.378
DOC_WW_Pin1_4	316	321	PF00397	0.609
DOC_WW_Pin1_4	354	359	PF00397	0.573
DOC_WW_Pin1_4	446	451	PF00397	0.708
DOC_WW_Pin1_4	473	478	PF00397	0.539
LIG_14-3-3_CanoR_1	218	224	PF00244	0.586
LIG_14-3-3_CanoR_1	299	303	PF00244	0.433
LIG_14-3-3_CanoR_1	55	64	PF00244	0.500
LIG_14-3-3_CanoR_1	72	79	PF00244	0.636
LIG_Actin_WH2_2	189	204	PF00022	0.521
LIG_BIR_III_4	10	14	PF00653	0.610
LIG_BRCT_BRCA1_1	179	183	PF00533	0.678
LIG_CSL_BTD_1	317	320	PF09270	0.599
LIG_deltaCOP1_diTrp_1	91	102	PF00928	0.426
LIG_EVH1_2	189	193	PF00568	0.502
LIG_FHA_1	196	202	PF00498	0.640
LIG_FHA_1	251	257	PF00498	0.430
LIG_FHA_1	55	61	PF00498	0.467
LIG_FHA_2	83	89	PF00498	0.568
LIG_LIR_Apic_2	137	142	PF02991	0.616
LIG_LIR_Apic_2	186	190	PF02991	0.549
LIG_LIR_Apic_2	253	257	PF02991	0.396
LIG_LIR_Apic_2	337	343	PF02991	0.584
LIG_LIR_Apic_2	476	481	PF02991	0.556
LIG_LIR_Gen_1	14	24	PF02991	0.390
LIG_LIR_Gen_1	192	201	PF02991	0.593
LIG_LIR_Gen_1	417	427	PF02991	0.536
LIG_LIR_Gen_1	42	52	PF02991	0.402
LIG_LIR_Gen_1	58	69	PF02991	0.530
LIG_LIR_Gen_1	93	104	PF02991	0.402
LIG_LIR_Nem_3	14	19	PF02991	0.392
LIG_LIR_Nem_3	192	196	PF02991	0.586
LIG_LIR_Nem_3	229	234	PF02991	0.489
LIG_LIR_Nem_3	367	372	PF02991	0.482
LIG_LIR_Nem_3	42	48	PF02991	0.418
LIG_LIR_Nem_3	473	478	PF02991	0.690
LIG_LIR_Nem_3	58	64	PF02991	0.530
LIG_LIR_Nem_3	98	103	PF02991	0.479
LIG_LYPXL_yS_3	231	234	PF13949	0.527
LIG_MYND_1	106	110	PF01753	0.467
LIG_NRBOX	375	381	PF00104	0.539
LIG_NRP_CendR_1	483	484	PF00754	0.611
LIG_Pex14_1	96	100	PF04695	0.470
LIG_PTB_Apo_2	94	101	PF02174	0.471
LIG_SH2_CRK	139	143	PF00017	0.689
LIG_SH2_CRK	187	191	PF00017	0.502
LIG_SH2_CRK	254	258	PF00017	0.423
LIG_SH2_CRK	478	482	PF00017	0.680
LIG_SH2_NCK_1	139	143	PF00017	0.538
LIG_SH2_NCK_1	187	191	PF00017	0.502
LIG_SH2_NCK_1	359	363	PF00017	0.511
LIG_SH2_PTP2	16	19	PF00017	0.415
LIG_SH2_PTP2	45	48	PF00017	0.393
LIG_SH2_SRC	16	19	PF00017	0.415
LIG_SH2_STAP1	252	256	PF00017	0.421
LIG_SH2_STAT5	139	142	PF00017	0.687
LIG_SH2_STAT5	16	19	PF00017	0.415
LIG_SH2_STAT5	252	255	PF00017	0.425
LIG_SH2_STAT5	45	48	PF00017	0.393
LIG_SH3_1	139	145	PF00018	0.538
LIG_SH3_2	197	202	PF14604	0.532
LIG_SH3_3	100	106	PF00018	0.453
LIG_SH3_3	107	113	PF00018	0.569
LIG_SH3_3	114	120	PF00018	0.618
LIG_SH3_3	135	141	PF00018	0.667
LIG_SH3_3	194	200	PF00018	0.678
LIG_SH3_3	202	208	PF00018	0.532
LIG_SH3_3	412	418	PF00018	0.664
LIG_SH3_3	437	443	PF00018	0.695
LIG_SH3_3	447	453	PF00018	0.661
LIG_SH3_3	471	477	PF00018	0.645
LIG_SUMO_SIM_anti_2	275	282	PF11976	0.552
LIG_SUMO_SIM_par_1	275	282	PF11976	0.552
LIG_TRAF2_1	85	88	PF00917	0.600
MOD_CDC14_SPxK_1	199	202	PF00782	0.537
MOD_CDK_SPxK_1	196	202	PF00069	0.530
MOD_CK1_1	122	128	PF00069	0.752
MOD_CK1_1	146	152	PF00069	0.576
MOD_CK1_1	217	223	PF00069	0.605
MOD_CK1_1	467	473	PF00069	0.680
MOD_CK1_1	65	71	PF00069	0.566
MOD_CK2_1	65	71	PF00069	0.549
MOD_CK2_1	82	88	PF00069	0.531
MOD_GlcNHglycan	124	127	PF01048	0.717
MOD_GlcNHglycan	145	148	PF01048	0.616
MOD_GlcNHglycan	169	172	PF01048	0.548
MOD_GlcNHglycan	179	183	PF01048	0.611
MOD_GlcNHglycan	202	205	PF01048	0.699
MOD_GlcNHglycan	210	213	PF01048	0.648
MOD_GlcNHglycan	336	339	PF01048	0.662
MOD_GlcNHglycan	344	347	PF01048	0.604
MOD_GlcNHglycan	354	357	PF01048	0.488
MOD_GlcNHglycan	36	39	PF01048	0.481
MOD_GlcNHglycan	389	392	PF01048	0.593
MOD_GlcNHglycan	403	406	PF01048	0.628
MOD_GlcNHglycan	446	449	PF01048	0.658
MOD_GlcNHglycan	64	67	PF01048	0.582
MOD_GlcNHglycan	82	85	PF01048	0.775
MOD_GSK3_1	185	192	PF00069	0.577
MOD_GSK3_1	196	203	PF00069	0.618
MOD_GSK3_1	213	220	PF00069	0.586
MOD_GSK3_1	226	233	PF00069	0.495
MOD_GSK3_1	238	245	PF00069	0.643
MOD_GSK3_1	360	367	PF00069	0.500
MOD_GSK3_1	383	390	PF00069	0.543
MOD_GSK3_1	461	468	PF00069	0.611
MOD_GSK3_1	55	62	PF00069	0.480
MOD_N-GLC_1	214	219	PF02516	0.595
MOD_N-GLC_1	332	337	PF02516	0.517
MOD_NEK2_1	167	172	PF00069	0.534
MOD_NEK2_1	183	188	PF00069	0.533
MOD_NEK2_1	238	243	PF00069	0.443
MOD_NEK2_1	334	339	PF00069	0.514
MOD_NEK2_1	383	388	PF00069	0.501
MOD_NEK2_1	401	406	PF00069	0.653
MOD_NEK2_1	60	65	PF00069	0.555
MOD_NEK2_2	360	365	PF00069	0.485
MOD_PIKK_1	128	134	PF00454	0.550
MOD_PIKK_1	467	473	PF00454	0.724
MOD_PKA_1	55	61	PF00069	0.539
MOD_PKA_2	217	223	PF00069	0.719
MOD_PKA_2	298	304	PF00069	0.430
MOD_PKA_2	54	60	PF00069	0.456
MOD_PKA_2	71	77	PF00069	0.644
MOD_Plk_1	265	271	PF00069	0.443
MOD_Plk_1	461	467	PF00069	0.671
MOD_Plk_2-3	266	272	PF00069	0.428
MOD_Plk_4	189	195	PF00069	0.565
MOD_Plk_4	284	290	PF00069	0.536
MOD_Plk_4	360	366	PF00069	0.496
MOD_Plk_4	419	425	PF00069	0.688
MOD_Plk_4	470	476	PF00069	0.636
MOD_ProDKin_1	113	119	PF00069	0.653
MOD_ProDKin_1	134	140	PF00069	0.586
MOD_ProDKin_1	185	191	PF00069	0.638
MOD_ProDKin_1	196	202	PF00069	0.570
MOD_ProDKin_1	224	230	PF00069	0.527
MOD_ProDKin_1	239	245	PF00069	0.377
MOD_ProDKin_1	316	322	PF00069	0.616
MOD_ProDKin_1	354	360	PF00069	0.570
MOD_ProDKin_1	446	452	PF00069	0.707
MOD_ProDKin_1	473	479	PF00069	0.539
TRG_DiLeu_BaEn_1	275	280	PF01217	0.541
TRG_DiLeu_BaEn_2	97	103	PF01217	0.436
TRG_ENDOCYTIC_2	16	19	PF00928	0.376
TRG_ENDOCYTIC_2	231	234	PF00928	0.527
TRG_ENDOCYTIC_2	45	48	PF00928	0.543
TRG_ER_diArg_1	302	305	PF00400	0.430
TRG_ER_diArg_1	54	56	PF00400	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K0	Leptomonas seymouri	42%	100%
A0A3Q8ISG1	Leishmania donovani	68%	100%
A4I6G3	Leishmania infantum	69%	100%
E9B1M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q6J4	Leishmania major	70%	100%