C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ46_LEIBR

TriTrypDb:

LbrM.31.0850 , LBRM2903_310015800

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJ46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.396
CLV_PCSK_KEX2_1	12	14	PF00082	0.242
CLV_PCSK_KEX2_1	142	144	PF00082	0.519
CLV_PCSK_KEX2_1	34	36	PF00082	0.273
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.519
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.269
CLV_PCSK_PC7_1	138	144	PF00082	0.514
CLV_PCSK_SKI1_1	130	134	PF00082	0.455
DOC_MAPK_gen_1	104	113	PF00069	0.439
DOC_MAPK_MEF2A_6	106	115	PF00069	0.430
DOC_SPAK_OSR1_1	54	58	PF12202	0.331
DOC_USP7_UBL2_3	92	96	PF12436	0.331
DOC_WW_Pin1_4	179	184	PF00397	0.603
LIG_14-3-3_CanoR_1	130	140	PF00244	0.443
LIG_14-3-3_CanoR_1	28	32	PF00244	0.242
LIG_AP2alpha_2	24	26	PF02296	0.331
LIG_Clathr_ClatBox_1	115	119	PF01394	0.418
LIG_CSL_BTD_1	149	152	PF09270	0.488
LIG_CtBP_PxDLS_1	126	130	PF00389	0.412
LIG_deltaCOP1_diTrp_1	48	55	PF00928	0.284
LIG_FHA_1	131	137	PF00498	0.501
LIG_FHA_1	171	177	PF00498	0.556
LIG_FHA_1	36	42	PF00498	0.400
LIG_FHA_1	82	88	PF00498	0.404
LIG_FHA_1	89	95	PF00498	0.444
LIG_FHA_2	105	111	PF00498	0.424
LIG_FHA_2	28	34	PF00498	0.230
LIG_FHA_2	72	78	PF00498	0.331
LIG_LIR_Gen_1	24	31	PF02991	0.471
LIG_LIR_Gen_1	97	103	PF02991	0.344
LIG_LIR_Nem_3	119	123	PF02991	0.453
LIG_LIR_Nem_3	24	29	PF02991	0.471
LIG_LIR_Nem_3	97	102	PF02991	0.447
LIG_PCNA_yPIPBox_3	72	83	PF02747	0.314
LIG_Pex14_1	49	53	PF04695	0.363
LIG_SH2_CRK	204	208	PF00017	0.475
LIG_SH2_CRK	239	243	PF00017	0.660
LIG_SH2_CRK	251	255	PF00017	0.686
LIG_SH2_NCK_1	204	208	PF00017	0.475
LIG_SH2_NCK_1	251	255	PF00017	0.565
LIG_SH2_PTP2	197	200	PF00017	0.526
LIG_SH2_STAP1	83	87	PF00017	0.372
LIG_SH2_STAT3	188	191	PF00017	0.597
LIG_SH2_STAT3	238	241	PF00017	0.720
LIG_SH2_STAT3	250	253	PF00017	0.607
LIG_SH2_STAT3	259	262	PF00017	0.509
LIG_SH2_STAT3	36	39	PF00017	0.331
LIG_SH2_STAT5	178	181	PF00017	0.542
LIG_SH2_STAT5	188	191	PF00017	0.598
LIG_SH2_STAT5	197	200	PF00017	0.564
LIG_SH2_STAT5	83	86	PF00017	0.285
LIG_SH3_1	213	219	PF00018	0.628
LIG_SH3_3	157	163	PF00018	0.663
LIG_SH3_3	186	192	PF00018	0.567
LIG_SH3_3	195	201	PF00018	0.584
LIG_SH3_3	213	219	PF00018	0.660
LIG_SH3_3	224	230	PF00018	0.575
LIG_SH3_3	239	245	PF00018	0.672
LIG_SUMO_SIM_par_1	114	119	PF11976	0.544
LIG_TRFH_1	226	230	PF08558	0.479
LIG_TYR_ITIM	195	200	PF00017	0.520
LIG_TYR_ITIM	223	228	PF00017	0.494
MOD_CK2_1	104	110	PF00069	0.587
MOD_CK2_1	27	33	PF00069	0.230
MOD_GlcNHglycan	155	158	PF01048	0.535
MOD_N-GLC_1	49	54	PF02516	0.246
MOD_NEK2_1	102	107	PF00069	0.604
MOD_NEK2_2	49	54	PF00069	0.373
MOD_PIKK_1	104	110	PF00454	0.434
MOD_PIKK_1	163	169	PF00454	0.560
MOD_PIKK_1	170	176	PF00454	0.555
MOD_PIKK_1	35	41	PF00454	0.331
MOD_PKA_2	27	33	PF00069	0.230
MOD_Plk_1	4	10	PF00069	0.331
MOD_Plk_1	49	55	PF00069	0.303
MOD_ProDKin_1	179	185	PF00069	0.603
MOD_SUMO_for_1	124	127	PF00179	0.482
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.432
TRG_ENDOCYTIC_2	197	200	PF00928	0.510
TRG_ENDOCYTIC_2	225	228	PF00928	0.497
TRG_ENDOCYTIC_2	239	242	PF00928	0.571
TRG_ENDOCYTIC_2	82	85	PF00928	0.361
TRG_ER_diArg_1	12	14	PF00400	0.230
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFD2	Leishmania donovani	66%	95%
A0A3S7X4C0	Leishmania donovani	38%	100%
A4HJ57	Leishmania braziliensis	37%	100%
A4HJ58	Leishmania braziliensis	36%	98%
A4I6G2	Leishmania infantum	65%	95%
A4I6H2	Leishmania infantum	39%	100%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	95%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	97%
Q9BHE7	Leishmania major	37%	97%
Q9BHF8	Leishmania major	68%	96%