Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ41_LEIBR

TriTrypDb:

LbrM.31.0790 , LBRM2903_310015000 , LBRM2903_310015100

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.571
CLV_C14_Caspase3-7	303	307	PF00656	0.693
CLV_C14_Caspase3-7	502	506	PF00656	0.492
CLV_C14_Caspase3-7	787	791	PF00656	0.666
CLV_NRD_NRD_1	100	102	PF00675	0.578
CLV_NRD_NRD_1	154	156	PF00675	0.673
CLV_NRD_NRD_1	214	216	PF00675	0.601
CLV_NRD_NRD_1	622	624	PF00675	0.544
CLV_NRD_NRD_1	735	737	PF00675	0.667
CLV_PCSK_FUR_1	645	649	PF00082	0.810
CLV_PCSK_KEX2_1	147	149	PF00082	0.634
CLV_PCSK_KEX2_1	154	156	PF00082	0.613
CLV_PCSK_KEX2_1	214	216	PF00082	0.622
CLV_PCSK_KEX2_1	622	624	PF00082	0.541
CLV_PCSK_KEX2_1	635	637	PF00082	0.525
CLV_PCSK_KEX2_1	647	649	PF00082	0.795
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.657
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.615
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.516
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.775
CLV_PCSK_PC7_1	643	649	PF00082	0.536
CLV_PCSK_SKI1_1	221	225	PF00082	0.580
CLV_PCSK_SKI1_1	256	260	PF00082	0.701
CLV_PCSK_SKI1_1	749	753	PF00082	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.804
DEG_SCF_FBW7_2	725	732	PF00400	0.687
DEG_SPOP_SBC_1	206	210	PF00917	0.714
DEG_SPOP_SBC_1	404	408	PF00917	0.573
DOC_ANK_TNKS_1	450	457	PF00023	0.405
DOC_CYCLIN_RxL_1	235	245	PF00134	0.616
DOC_MAPK_FxFP_2	81	84	PF00069	0.680
DOC_MAPK_gen_1	357	365	PF00069	0.624
DOC_MAPK_MEF2A_6	11	19	PF00069	0.361
DOC_MAPK_MEF2A_6	485	494	PF00069	0.466
DOC_MAPK_RevD_3	723	737	PF00069	0.712
DOC_PP1_RVXF_1	186	193	PF00149	0.420
DOC_PP1_RVXF_1	236	243	PF00149	0.515
DOC_PP4_FxxP_1	259	262	PF00568	0.617
DOC_PP4_FxxP_1	443	446	PF00568	0.501
DOC_PP4_FxxP_1	81	84	PF00568	0.680
DOC_SPAK_OSR1_1	238	242	PF12202	0.591
DOC_USP7_MATH_1	157	161	PF00917	0.707
DOC_USP7_MATH_1	206	210	PF00917	0.738
DOC_USP7_MATH_1	262	266	PF00917	0.638
DOC_USP7_MATH_1	379	383	PF00917	0.577
DOC_USP7_MATH_1	387	391	PF00917	0.531
DOC_USP7_MATH_1	404	408	PF00917	0.737
DOC_USP7_MATH_1	512	516	PF00917	0.576
DOC_USP7_MATH_1	532	536	PF00917	0.578
DOC_USP7_MATH_1	560	564	PF00917	0.620
DOC_USP7_MATH_1	576	580	PF00917	0.771
DOC_USP7_MATH_1	710	714	PF00917	0.497
DOC_USP7_UBL2_3	152	156	PF12436	0.675
DOC_USP7_UBL2_3	411	415	PF12436	0.806
DOC_WW_Pin1_4	102	107	PF00397	0.690
DOC_WW_Pin1_4	265	270	PF00397	0.687
DOC_WW_Pin1_4	351	356	PF00397	0.473
DOC_WW_Pin1_4	43	48	PF00397	0.635
DOC_WW_Pin1_4	725	730	PF00397	0.693
DOC_WW_Pin1_4	781	786	PF00397	0.667
DOC_WW_Pin1_4	795	800	PF00397	0.607
LIG_14-3-3_CanoR_1	118	125	PF00244	0.512
LIG_14-3-3_CanoR_1	148	152	PF00244	0.580
LIG_14-3-3_CanoR_1	215	221	PF00244	0.457
LIG_14-3-3_CanoR_1	277	283	PF00244	0.616
LIG_14-3-3_CanoR_1	362	366	PF00244	0.617
LIG_14-3-3_CanoR_1	380	385	PF00244	0.512
LIG_14-3-3_CanoR_1	389	393	PF00244	0.496
LIG_14-3-3_CanoR_1	536	542	PF00244	0.449
LIG_14-3-3_CanoR_1	690	695	PF00244	0.607
LIG_14-3-3_CanoR_1	711	715	PF00244	0.488
LIG_14-3-3_CanoR_1	79	84	PF00244	0.632
LIG_APCC_ABBA_1	428	433	PF00400	0.314
LIG_APCC_ABBA_1	727	732	PF00400	0.687
LIG_BIR_III_2	568	572	PF00653	0.538
LIG_BIR_III_2	573	577	PF00653	0.517
LIG_BIR_III_4	2	6	PF00653	0.688
LIG_BRCT_BRCA1_1	712	716	PF00533	0.512
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.653
LIG_FHA_1	133	139	PF00498	0.576
LIG_FHA_1	341	347	PF00498	0.577
LIG_FHA_1	416	422	PF00498	0.589
LIG_FHA_1	512	518	PF00498	0.345
LIG_FHA_1	536	542	PF00498	0.585
LIG_FHA_1	8	14	PF00498	0.589
LIG_FHA_2	138	144	PF00498	0.597
LIG_FHA_2	298	304	PF00498	0.774
LIG_FHA_2	345	351	PF00498	0.612
LIG_FHA_2	362	368	PF00498	0.563
LIG_FHA_2	565	571	PF00498	0.787
LIG_FHA_2	661	667	PF00498	0.774
LIG_FHA_2	785	791	PF00498	0.614
LIG_IRF3_LxIS_1	133	139	PF10401	0.468
LIG_LIR_Gen_1	18	28	PF02991	0.591
LIG_LIR_Gen_1	317	328	PF02991	0.689
LIG_LIR_Gen_1	514	523	PF02991	0.397
LIG_LIR_Gen_1	525	533	PF02991	0.416
LIG_LIR_Gen_1	552	560	PF02991	0.605
LIG_LIR_Gen_1	713	723	PF02991	0.579
LIG_LIR_Gen_1	728	738	PF02991	0.501
LIG_LIR_Gen_1	743	751	PF02991	0.479
LIG_LIR_Gen_1	801	810	PF02991	0.642
LIG_LIR_Nem_3	18	24	PF02991	0.591
LIG_LIR_Nem_3	219	223	PF02991	0.681
LIG_LIR_Nem_3	27	33	PF02991	0.544
LIG_LIR_Nem_3	317	323	PF02991	0.679
LIG_LIR_Nem_3	514	519	PF02991	0.432
LIG_LIR_Nem_3	525	531	PF02991	0.340
LIG_LIR_Nem_3	552	556	PF02991	0.680
LIG_LIR_Nem_3	612	618	PF02991	0.600
LIG_LIR_Nem_3	713	719	PF02991	0.567
LIG_LIR_Nem_3	728	733	PF02991	0.518
LIG_LIR_Nem_3	743	748	PF02991	0.469
LIG_LIR_Nem_3	75	81	PF02991	0.569
LIG_LIR_Nem_3	801	806	PF02991	0.573
LIG_Pex14_1	744	748	PF04695	0.512
LIG_Pex14_2	520	524	PF04695	0.327
LIG_Rb_LxCxE_1	67	85	PF01857	0.370
LIG_Rb_pABgroove_1	808	816	PF01858	0.458
LIG_SH2_CRK	134	138	PF00017	0.438
LIG_SH2_CRK	320	324	PF00017	0.676
LIG_SH2_CRK	37	41	PF00017	0.594
LIG_SH2_CRK	615	619	PF00017	0.568
LIG_SH2_CRK	625	629	PF00017	0.373
LIG_SH2_GRB2like	37	40	PF00017	0.626
LIG_SH2_NCK_1	320	324	PF00017	0.676
LIG_SH2_NCK_1	625	629	PF00017	0.489
LIG_SH2_PTP2	21	24	PF00017	0.627
LIG_SH2_SRC	21	24	PF00017	0.586
LIG_SH2_SRC	37	40	PF00017	0.585
LIG_SH2_STAP1	134	138	PF00017	0.438
LIG_SH2_STAP1	436	440	PF00017	0.455
LIG_SH2_STAT5	134	137	PF00017	0.341
LIG_SH2_STAT5	21	24	PF00017	0.543
LIG_SH2_STAT5	227	230	PF00017	0.522
LIG_SH2_STAT5	275	278	PF00017	0.504
LIG_SH2_STAT5	516	519	PF00017	0.393
LIG_SH2_STAT5	594	597	PF00017	0.517
LIG_SH3_1	651	657	PF00018	0.537
LIG_SH3_2	654	659	PF14604	0.539
LIG_SH3_3	19	25	PF00018	0.623
LIG_SH3_3	225	231	PF00018	0.595
LIG_SH3_3	323	329	PF00018	0.537
LIG_SH3_3	526	532	PF00018	0.431
LIG_SH3_3	544	550	PF00018	0.405
LIG_SH3_3	553	559	PF00018	0.716
LIG_SH3_3	651	657	PF00018	0.537
LIG_SH3_3	81	87	PF00018	0.623
LIG_SUMO_SIM_par_1	134	140	PF11976	0.565
LIG_SxIP_EBH_1	715	724	PF03271	0.611
LIG_TRAF2_1	119	122	PF00917	0.509
LIG_TYR_ITIM	19	24	PF00017	0.591
LIG_TYR_ITIM	318	323	PF00017	0.688
LIG_TYR_ITSM	512	519	PF00017	0.338
LIG_WRC_WIRS_1	800	805	PF05994	0.638
MOD_CDC14_SPxK_1	354	357	PF00782	0.462
MOD_CDK_SPxK_1	351	357	PF00069	0.438
MOD_CDK_SPxxK_3	45	52	PF00069	0.508
MOD_CK1_1	265	271	PF00069	0.675
MOD_CK1_1	305	311	PF00069	0.728
MOD_CK1_1	407	413	PF00069	0.754
MOD_CK1_1	48	54	PF00069	0.770
MOD_CK1_1	506	512	PF00069	0.721
MOD_CK1_1	515	521	PF00069	0.481
MOD_CK1_1	535	541	PF00069	0.594
MOD_CK1_1	579	585	PF00069	0.589
MOD_CK1_1	626	632	PF00069	0.543
MOD_CK1_1	717	723	PF00069	0.551
MOD_CK1_1	773	779	PF00069	0.692
MOD_CK1_1	781	787	PF00069	0.723
MOD_CK1_1	82	88	PF00069	0.622
MOD_CK2_1	116	122	PF00069	0.741
MOD_CK2_1	297	303	PF00069	0.745
MOD_CK2_1	344	350	PF00069	0.526
MOD_CK2_1	361	367	PF00069	0.561
MOD_CK2_1	564	570	PF00069	0.802
MOD_CK2_1	660	666	PF00069	0.695
MOD_CK2_1	795	801	PF00069	0.547
MOD_CMANNOS	449	452	PF00535	0.670
MOD_Cter_Amidation	99	102	PF01082	0.494
MOD_GlcNHglycan	159	163	PF01048	0.702
MOD_GlcNHglycan	228	231	PF01048	0.645
MOD_GlcNHglycan	244	247	PF01048	0.515
MOD_GlcNHglycan	278	281	PF01048	0.372
MOD_GlcNHglycan	306	310	PF01048	0.731
MOD_GlcNHglycan	385	388	PF01048	0.533
MOD_GlcNHglycan	394	397	PF01048	0.543
MOD_GlcNHglycan	407	410	PF01048	0.725
MOD_GlcNHglycan	486	489	PF01048	0.433
MOD_GlcNHglycan	505	508	PF01048	0.619
MOD_GlcNHglycan	510	513	PF01048	0.691
MOD_GlcNHglycan	59	62	PF01048	0.653
MOD_GlcNHglycan	628	631	PF01048	0.492
MOD_GlcNHglycan	756	759	PF01048	0.700
MOD_GlcNHglycan	772	775	PF01048	0.430
MOD_GlcNHglycan	780	783	PF01048	0.545
MOD_GSK3_1	112	119	PF00069	0.693
MOD_GSK3_1	132	139	PF00069	0.516
MOD_GSK3_1	242	249	PF00069	0.521
MOD_GSK3_1	340	347	PF00069	0.640
MOD_GSK3_1	379	386	PF00069	0.522
MOD_GSK3_1	388	395	PF00069	0.500
MOD_GSK3_1	403	410	PF00069	0.712
MOD_GSK3_1	411	418	PF00069	0.770
MOD_GSK3_1	462	469	PF00069	0.744
MOD_GSK3_1	508	515	PF00069	0.652
MOD_GSK3_1	531	538	PF00069	0.590
MOD_GSK3_1	560	567	PF00069	0.686
MOD_GSK3_1	576	583	PF00069	0.663
MOD_GSK3_1	675	682	PF00069	0.779
MOD_GSK3_1	710	717	PF00069	0.516
MOD_GSK3_1	781	788	PF00069	0.635
MOD_GSK3_1	795	802	PF00069	0.628
MOD_N-GLC_1	462	467	PF02516	0.498
MOD_N-GLC_1	475	480	PF02516	0.336
MOD_N-GLC_1	542	547	PF02516	0.446
MOD_N-GLC_1	659	664	PF02516	0.828
MOD_N-GLC_1	668	673	PF02516	0.645
MOD_N-GLC_2	699	701	PF02516	0.457
MOD_NEK2_1	112	117	PF00069	0.667
MOD_NEK2_1	136	141	PF00069	0.494
MOD_NEK2_1	314	319	PF00069	0.580
MOD_NEK2_1	366	371	PF00069	0.454
MOD_NEK2_1	484	489	PF00069	0.529
MOD_NEK2_1	595	600	PF00069	0.418
MOD_NEK2_2	537	542	PF00069	0.537
MOD_PIKK_1	117	123	PF00454	0.509
MOD_PIKK_1	372	378	PF00454	0.637
MOD_PIKK_1	595	601	PF00454	0.447
MOD_PIKK_1	773	779	PF00454	0.457
MOD_PK_1	623	629	PF00069	0.317
MOD_PKA_1	147	153	PF00069	0.536
MOD_PKA_1	411	417	PF00069	0.796
MOD_PKA_2	117	123	PF00069	0.771
MOD_PKA_2	147	153	PF00069	0.577
MOD_PKA_2	157	163	PF00069	0.645
MOD_PKA_2	276	282	PF00069	0.506
MOD_PKA_2	297	303	PF00069	0.690
MOD_PKA_2	361	367	PF00069	0.612
MOD_PKA_2	379	385	PF00069	0.546
MOD_PKA_2	388	394	PF00069	0.532
MOD_PKA_2	484	490	PF00069	0.485
MOD_PKA_2	535	541	PF00069	0.566
MOD_PKA_2	689	695	PF00069	0.628
MOD_PKA_2	710	716	PF00069	0.495
MOD_PKB_1	688	696	PF00069	0.658
MOD_PKB_1	77	85	PF00069	0.684
MOD_Plk_1	366	372	PF00069	0.487
MOD_Plk_1	436	442	PF00069	0.537
MOD_Plk_1	475	481	PF00069	0.369
MOD_Plk_1	542	548	PF00069	0.356
MOD_Plk_1	668	674	PF00069	0.554
MOD_Plk_1	678	684	PF00069	0.497
MOD_Plk_2-3	470	476	PF00069	0.470
MOD_Plk_4	132	138	PF00069	0.622
MOD_Plk_4	361	367	PF00069	0.559
MOD_Plk_4	380	386	PF00069	0.590
MOD_Plk_4	388	394	PF00069	0.626
MOD_Plk_4	444	450	PF00069	0.451
MOD_Plk_4	512	518	PF00069	0.540
MOD_Plk_4	524	530	PF00069	0.432
MOD_Plk_4	543	549	PF00069	0.385
MOD_Plk_4	581	587	PF00069	0.645
MOD_Plk_4	623	629	PF00069	0.445
MOD_Plk_4	679	685	PF00069	0.793
MOD_Plk_4	740	746	PF00069	0.651
MOD_Plk_4	808	814	PF00069	0.680
MOD_ProDKin_1	102	108	PF00069	0.678
MOD_ProDKin_1	265	271	PF00069	0.687
MOD_ProDKin_1	351	357	PF00069	0.475
MOD_ProDKin_1	43	49	PF00069	0.638
MOD_ProDKin_1	725	731	PF00069	0.690
MOD_ProDKin_1	781	787	PF00069	0.663
MOD_ProDKin_1	795	801	PF00069	0.608
MOD_SUMO_for_1	174	177	PF00179	0.698
MOD_SUMO_rev_2	181	190	PF00179	0.662
MOD_SUMO_rev_2	251	258	PF00179	0.703
MOD_SUMO_rev_2	48	56	PF00179	0.491
TRG_DiLeu_BaEn_1	679	684	PF01217	0.526
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.678
TRG_DiLeu_BaLyEn_6	790	795	PF01217	0.614
TRG_ENDOCYTIC_2	134	137	PF00928	0.443
TRG_ENDOCYTIC_2	21	24	PF00928	0.586
TRG_ENDOCYTIC_2	320	323	PF00928	0.682
TRG_ENDOCYTIC_2	37	40	PF00928	0.363
TRG_ENDOCYTIC_2	516	519	PF00928	0.393
TRG_ENDOCYTIC_2	615	618	PF00928	0.520
TRG_ENDOCYTIC_2	625	628	PF00928	0.416
TRG_ER_diArg_1	214	216	PF00400	0.495
TRG_ER_diArg_1	482	485	PF00400	0.520
TRG_ER_diArg_1	622	624	PF00400	0.541
TRG_NLS_Bipartite_1	622	639	PF00514	0.356
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T0	Leptomonas seymouri	46%	99%
A0A1X0NK18	Trypanosomatidae	27%	100%
A0A3R7NKJ0	Trypanosoma rangeli	26%	100%
A0A3S7X461	Leishmania donovani	74%	100%
A4I6F6	Leishmania infantum	74%	100%
C9ZN74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B1L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q6K1	Leishmania major	73%	100%