LeishMANIAdb
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Ribosomal_L7Ae domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal_L7Ae domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJ40_LEIBR
TriTrypDb:
LbrM.31.0780 , LBRM2903_310014900 *
Length:
567

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1
GO:0005840 ribosome 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HJ40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ40

Function

Biological processes
Term Name Level Count
GO:0001514 selenocysteine incorporation 7 1
GO:0006414 translational elongation 5 1
GO:0006417 regulation of translation 6 1
GO:0006451 translational readthrough 6 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0003729 mRNA binding 5 11
GO:0005488 binding 1 11
GO:0035368 selenocysteine insertion sequence binding 6 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003730 mRNA 3'-UTR binding 6 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0044877 protein-containing complex binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 253 257 PF00656 0.716
CLV_NRD_NRD_1 105 107 PF00675 0.382
CLV_NRD_NRD_1 162 164 PF00675 0.663
CLV_NRD_NRD_1 194 196 PF00675 0.511
CLV_NRD_NRD_1 214 216 PF00675 0.456
CLV_NRD_NRD_1 26 28 PF00675 0.544
CLV_NRD_NRD_1 381 383 PF00675 0.336
CLV_NRD_NRD_1 459 461 PF00675 0.534
CLV_PCSK_FUR_1 212 216 PF00082 0.522
CLV_PCSK_KEX2_1 105 107 PF00082 0.473
CLV_PCSK_KEX2_1 194 196 PF00082 0.495
CLV_PCSK_KEX2_1 203 205 PF00082 0.458
CLV_PCSK_KEX2_1 214 216 PF00082 0.372
CLV_PCSK_KEX2_1 24 26 PF00082 0.658
CLV_PCSK_KEX2_1 98 100 PF00082 0.479
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.466
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.658
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.504
CLV_PCSK_SKI1_1 106 110 PF00082 0.388
CLV_PCSK_SKI1_1 343 347 PF00082 0.526
CLV_PCSK_SKI1_1 404 408 PF00082 0.505
CLV_PCSK_SKI1_1 412 416 PF00082 0.454
CLV_PCSK_SKI1_1 453 457 PF00082 0.654
CLV_PCSK_SKI1_1 461 465 PF00082 0.556
CLV_PCSK_SKI1_1 535 539 PF00082 0.454
CLV_PCSK_SKI1_1 546 550 PF00082 0.403
DEG_APCC_DBOX_1 105 113 PF00400 0.399
DEG_APCC_DBOX_1 409 417 PF00400 0.391
DEG_APCC_DBOX_1 534 542 PF00400 0.398
DEG_SPOP_SBC_1 36 40 PF00917 0.584
DEG_SPOP_SBC_1 447 451 PF00917 0.440
DOC_CKS1_1 112 117 PF01111 0.441
DOC_CKS1_1 84 89 PF01111 0.505
DOC_CYCLIN_yCln2_LP_2 318 324 PF00134 0.374
DOC_MAPK_gen_1 105 111 PF00069 0.457
DOC_MAPK_gen_1 203 213 PF00069 0.475
DOC_MAPK_gen_1 382 389 PF00069 0.404
DOC_MAPK_gen_1 390 399 PF00069 0.348
DOC_MAPK_gen_1 404 413 PF00069 0.473
DOC_MAPK_gen_1 519 528 PF00069 0.480
DOC_MAPK_gen_1 93 103 PF00069 0.490
DOC_MAPK_MEF2A_6 407 415 PF00069 0.465
DOC_PP2B_LxvP_1 430 433 PF13499 0.465
DOC_PP4_FxxP_1 266 269 PF00568 0.550
DOC_USP7_MATH_1 190 194 PF00917 0.412
DOC_USP7_MATH_1 221 225 PF00917 0.435
DOC_USP7_MATH_1 230 234 PF00917 0.620
DOC_USP7_MATH_1 262 266 PF00917 0.479
DOC_USP7_MATH_1 324 328 PF00917 0.537
DOC_USP7_MATH_1 344 348 PF00917 0.525
DOC_USP7_MATH_1 437 441 PF00917 0.685
DOC_USP7_MATH_1 448 452 PF00917 0.591
DOC_USP7_MATH_1 518 522 PF00917 0.517
DOC_USP7_MATH_2 14 20 PF00917 0.504
DOC_USP7_UBL2_3 24 28 PF12436 0.762
DOC_USP7_UBL2_3 457 461 PF12436 0.632
DOC_USP7_UBL2_3 73 77 PF12436 0.484
DOC_WW_Pin1_4 111 116 PF00397 0.435
DOC_WW_Pin1_4 130 135 PF00397 0.627
DOC_WW_Pin1_4 258 263 PF00397 0.535
DOC_WW_Pin1_4 328 333 PF00397 0.654
DOC_WW_Pin1_4 83 88 PF00397 0.624
LIG_14-3-3_CanoR_1 175 181 PF00244 0.375
LIG_14-3-3_CanoR_1 220 226 PF00244 0.453
LIG_14-3-3_CanoR_1 509 515 PF00244 0.535
LIG_BRCT_BRCA1_1 346 350 PF00533 0.489
LIG_CaM_IQ_9 396 412 PF13499 0.469
LIG_EVH1_1 430 434 PF00568 0.463
LIG_FHA_1 160 166 PF00498 0.536
LIG_FHA_1 354 360 PF00498 0.310
LIG_FHA_1 551 557 PF00498 0.516
LIG_FHA_2 315 321 PF00498 0.588
LIG_FHA_2 416 422 PF00498 0.409
LIG_FHA_2 464 470 PF00498 0.399
LIG_FHA_2 552 558 PF00498 0.464
LIG_Integrin_RGD_1 227 229 PF01839 0.370
LIG_LIR_Apic_2 265 269 PF02991 0.558
LIG_LIR_Apic_2 442 448 PF02991 0.466
LIG_LIR_Gen_1 182 191 PF02991 0.410
LIG_LIR_Gen_1 365 375 PF02991 0.323
LIG_LIR_Nem_3 182 187 PF02991 0.384
LIG_LIR_Nem_3 261 266 PF02991 0.512
LIG_LIR_Nem_3 270 275 PF02991 0.469
LIG_LIR_Nem_3 288 294 PF02991 0.346
LIG_LIR_Nem_3 320 325 PF02991 0.481
LIG_LIR_Nem_3 365 371 PF02991 0.337
LIG_LYPXL_yS_3 291 294 PF13949 0.464
LIG_NRBOX 221 227 PF00104 0.357
LIG_PCNA_yPIPBox_3 301 315 PF02747 0.381
LIG_Pex14_1 107 111 PF04695 0.390
LIG_SH2_CRK 322 326 PF00017 0.464
LIG_SH2_STAP1 514 518 PF00017 0.339
LIG_SH2_STAP1 544 548 PF00017 0.326
LIG_SH2_STAP1 552 556 PF00017 0.361
LIG_SH2_STAT3 375 378 PF00017 0.343
LIG_SH2_STAT5 354 357 PF00017 0.324
LIG_SH2_STAT5 395 398 PF00017 0.416
LIG_SH2_STAT5 547 550 PF00017 0.485
LIG_SH2_STAT5 552 555 PF00017 0.473
LIG_SH3_3 323 329 PF00018 0.569
LIG_SH3_3 428 434 PF00018 0.636
LIG_SH3_3 81 87 PF00018 0.466
LIG_SUMO_SIM_par_1 412 419 PF11976 0.412
LIG_TRFH_1 46 50 PF08558 0.480
LIG_UBA3_1 370 376 PF00899 0.452
LIG_WRC_WIRS_1 263 268 PF05994 0.632
MOD_CDC14_SPxK_1 261 264 PF00782 0.441
MOD_CDK_SPxK_1 258 264 PF00069 0.448
MOD_CK1_1 133 139 PF00069 0.628
MOD_CK1_1 169 175 PF00069 0.418
MOD_CK1_1 179 185 PF00069 0.442
MOD_CK1_1 32 38 PF00069 0.614
MOD_CK1_1 327 333 PF00069 0.608
MOD_CK1_1 435 441 PF00069 0.591
MOD_CK1_1 449 455 PF00069 0.555
MOD_CK1_1 493 499 PF00069 0.564
MOD_CK1_1 505 511 PF00069 0.417
MOD_CK2_1 138 144 PF00069 0.724
MOD_CK2_1 415 421 PF00069 0.352
MOD_CK2_1 463 469 PF00069 0.414
MOD_CK2_1 551 557 PF00069 0.455
MOD_Cter_Amidation 75 78 PF01082 0.508
MOD_GlcNHglycan 280 283 PF01048 0.499
MOD_GlcNHglycan 326 329 PF01048 0.426
MOD_GlcNHglycan 334 337 PF01048 0.636
MOD_GlcNHglycan 34 37 PF01048 0.693
MOD_GlcNHglycan 427 430 PF01048 0.689
MOD_GlcNHglycan 441 444 PF01048 0.589
MOD_GlcNHglycan 492 495 PF01048 0.551
MOD_GSK3_1 135 142 PF00069 0.674
MOD_GSK3_1 169 176 PF00069 0.425
MOD_GSK3_1 231 238 PF00069 0.628
MOD_GSK3_1 258 265 PF00069 0.596
MOD_GSK3_1 31 38 PF00069 0.782
MOD_GSK3_1 324 331 PF00069 0.671
MOD_GSK3_1 332 339 PF00069 0.568
MOD_GSK3_1 353 360 PF00069 0.357
MOD_GSK3_1 435 442 PF00069 0.699
MOD_GSK3_1 546 553 PF00069 0.385
MOD_NEK2_1 237 242 PF00069 0.558
MOD_NEK2_1 245 250 PF00069 0.630
MOD_NEK2_1 338 343 PF00069 0.626
MOD_NEK2_1 345 350 PF00069 0.477
MOD_NEK2_1 366 371 PF00069 0.367
MOD_NEK2_1 502 507 PF00069 0.481
MOD_NEK2_1 556 561 PF00069 0.495
MOD_NEK2_2 262 267 PF00069 0.451
MOD_NEK2_2 463 468 PF00069 0.514
MOD_PIKK_1 166 172 PF00454 0.551
MOD_PIKK_1 231 237 PF00454 0.592
MOD_PIKK_1 338 344 PF00454 0.542
MOD_PIKK_1 37 43 PF00454 0.711
MOD_PIKK_1 432 438 PF00454 0.421
MOD_PKA_2 166 172 PF00069 0.402
MOD_PKA_2 231 237 PF00069 0.641
MOD_PKA_2 314 320 PF00069 0.438
MOD_PKA_2 485 491 PF00069 0.679
MOD_PKA_2 510 516 PF00069 0.534
MOD_PKA_2 58 64 PF00069 0.645
MOD_PKA_2 92 98 PF00069 0.549
MOD_Plk_1 173 179 PF00069 0.556
MOD_Plk_1 296 302 PF00069 0.393
MOD_Plk_1 423 429 PF00069 0.430
MOD_Plk_1 556 562 PF00069 0.448
MOD_Plk_2-3 314 320 PF00069 0.511
MOD_Plk_4 179 185 PF00069 0.431
MOD_Plk_4 221 227 PF00069 0.357
MOD_Plk_4 268 274 PF00069 0.521
MOD_Plk_4 345 351 PF00069 0.538
MOD_ProDKin_1 111 117 PF00069 0.437
MOD_ProDKin_1 130 136 PF00069 0.626
MOD_ProDKin_1 258 264 PF00069 0.532
MOD_ProDKin_1 328 334 PF00069 0.659
MOD_ProDKin_1 83 89 PF00069 0.620
TRG_DiLeu_BaEn_1 469 474 PF01217 0.405
TRG_ENDOCYTIC_2 184 187 PF00928 0.382
TRG_ENDOCYTIC_2 263 266 PF00928 0.513
TRG_ENDOCYTIC_2 291 294 PF00928 0.585
TRG_ENDOCYTIC_2 322 325 PF00928 0.470
TRG_ER_diArg_1 105 107 PF00400 0.498
TRG_ER_diArg_1 194 196 PF00400 0.499
TRG_ER_diArg_1 211 214 PF00400 0.474
TRG_ER_diArg_1 25 27 PF00400 0.514
TRG_ER_diArg_1 392 395 PF00400 0.410
TRG_ER_diArg_1 410 413 PF00400 0.401
TRG_ER_diArg_1 509 512 PF00400 0.404
TRG_ER_diArg_1 91 94 PF00400 0.622
TRG_NLS_MonoCore_2 22 27 PF00514 0.515
TRG_NLS_MonoExtC_3 22 27 PF00514 0.515
TRG_NLS_MonoExtC_3 381 386 PF00514 0.422
TRG_NLS_MonoExtN_4 23 28 PF00514 0.511
TRG_NLS_MonoExtN_4 457 464 PF00514 0.512
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.501
TRG_Pf-PMV_PEXEL_1 546 550 PF00026 0.260

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMN8 Leptomonas seymouri 50% 100%
A0A1X0NJ63 Trypanosomatidae 30% 89%
A0A3R7LBH7 Trypanosoma rangeli 31% 100%
A0A3S7X464 Leishmania donovani 68% 100%
A4I6F5 Leishmania infantum 69% 100%
C9ZN70 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9B1L2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
Q9BHF1 Leishmania major 70% 99%
V5BDV6 Trypanosoma cruzi 29% 95%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS