Putative C-5 sterol desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-5 sterol desaturase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ38_LEIBR

TriTrypDb:

LbrM.31.0760 , LBRM2903_310014700

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HJ38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ38

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	121	125	PF00082	0.358
CLV_PCSK_SKI1_1	87	91	PF00082	0.363
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.537
DOC_MAPK_gen_1	62	69	PF00069	0.383
DOC_MAPK_gen_1	78	85	PF00069	0.301
DOC_MAPK_MEF2A_6	121	130	PF00069	0.501
DOC_MAPK_MEF2A_6	62	69	PF00069	0.257
DOC_MAPK_MEF2A_6	78	85	PF00069	0.301
DOC_MAPK_NFAT4_5	121	129	PF00069	0.537
DOC_PP1_RVXF_1	119	126	PF00149	0.501
DOC_PP1_RVXF_1	247	253	PF00149	0.562
DOC_PP2B_LxvP_1	124	127	PF13499	0.444
DOC_PP2B_LxvP_1	230	233	PF13499	0.537
DOC_USP7_MATH_1	10	14	PF00917	0.611
DOC_USP7_MATH_2	179	185	PF00917	0.351
DOC_USP7_UBL2_3	70	74	PF12436	0.421
DOC_WW_Pin1_4	163	168	PF00397	0.276
LIG_14-3-3_CanoR_1	102	109	PF00244	0.610
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BRCT_BRCA1_1	109	113	PF00533	0.594
LIG_CSL_BTD_1	124	127	PF09270	0.344
LIG_deltaCOP1_diTrp_1	260	266	PF00928	0.486
LIG_FHA_1	207	213	PF00498	0.363
LIG_FHA_2	224	230	PF00498	0.476
LIG_FHA_2	74	80	PF00498	0.310
LIG_GBD_Chelix_1	191	199	PF00786	0.551
LIG_LIR_Gen_1	12	23	PF02991	0.694
LIG_LIR_Gen_1	138	148	PF02991	0.344
LIG_LIR_Gen_1	184	195	PF02991	0.282
LIG_LIR_Nem_3	122	128	PF02991	0.365
LIG_LIR_Nem_3	138	144	PF02991	0.315
LIG_LIR_Nem_3	184	190	PF02991	0.315
LIG_LIR_Nem_3	260	266	PF02991	0.473
LIG_LIR_Nem_3	35	41	PF02991	0.330
LIG_LIR_Nem_3	79	85	PF02991	0.276
LIG_LYPXL_S_1	153	157	PF13949	0.396
LIG_LYPXL_yS_3	154	157	PF13949	0.196
LIG_Pex14_1	150	154	PF04695	0.276
LIG_Pex14_1	259	263	PF04695	0.476
LIG_Pex14_2	140	144	PF04695	0.316
LIG_Rb_pABgroove_1	131	139	PF01858	0.472
LIG_SH2_CRK	49	53	PF00017	0.393
LIG_SH2_STAP1	137	141	PF00017	0.335
LIG_SH2_STAP1	15	19	PF00017	0.624
LIG_SH2_STAT5	141	144	PF00017	0.315
LIG_SH2_STAT5	182	185	PF00017	0.276
LIG_SH2_STAT5	187	190	PF00017	0.276
LIG_SH2_STAT5	194	197	PF00017	0.276
LIG_SH2_STAT5	234	237	PF00017	0.489
LIG_SH2_STAT5	255	258	PF00017	0.468
LIG_SH2_STAT5	82	85	PF00017	0.358
LIG_SH3_3	125	131	PF00018	0.413
LIG_SH3_3	149	155	PF00018	0.204
LIG_SH3_3	49	55	PF00018	0.404
LIG_SH3_4	70	77	PF00018	0.417
LIG_SUMO_SIM_par_1	17	22	PF11976	0.512
LIG_WRC_WIRS_1	263	268	PF05994	0.526
LIG_WW_1	151	154	PF00397	0.301
MOD_CDC14_SPxK_1	166	169	PF00782	0.337
MOD_CDK_SPxK_1	163	169	PF00069	0.276
MOD_CK1_1	107	113	PF00069	0.573
MOD_CK1_1	273	279	PF00069	0.707
MOD_CK1_1	4	10	PF00069	0.589
MOD_GlcNHglycan	183	186	PF01048	0.551
MOD_GlcNHglycan	274	278	PF01048	0.495
MOD_GSK3_1	219	226	PF00069	0.383
MOD_N-GLC_1	223	228	PF02516	0.276
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	139	144	PF00069	0.339
MOD_NEK2_1	223	228	PF00069	0.454
MOD_NEK2_2	10	15	PF00069	0.508
MOD_PKA_2	101	107	PF00069	0.522
MOD_Plk_1	104	110	PF00069	0.577
MOD_Plk_1	223	229	PF00069	0.475
MOD_Plk_2-3	73	79	PF00069	0.430
MOD_Plk_4	10	16	PF00069	0.675
MOD_Plk_4	139	145	PF00069	0.330
MOD_ProDKin_1	163	169	PF00069	0.276
TRG_DiLeu_BaEn_1	186	191	PF01217	0.317
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.230
TRG_ENDOCYTIC_2	137	140	PF00928	0.323
TRG_ENDOCYTIC_2	141	144	PF00928	0.315
TRG_ENDOCYTIC_2	15	18	PF00928	0.692
TRG_ENDOCYTIC_2	154	157	PF00928	0.266
TRG_ENDOCYTIC_2	187	190	PF00928	0.276
TRG_ENDOCYTIC_2	255	258	PF00928	0.468
TRG_ENDOCYTIC_2	49	52	PF00928	0.338
TRG_ENDOCYTIC_2	82	85	PF00928	0.359
TRG_ER_diLys_1	281	284	PF00400	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA25	Leptomonas seymouri	81%	100%
A0A0S4KFW2	Bodo saltans	57%	96%
A0A1X0NKZ9	Trypanosomatidae	57%	100%
A0A3Q8IJV0	Leishmania donovani	84%	100%
A0A3R7P157	Trypanosoma rangeli	62%	100%
A4I6F3	Leishmania infantum	84%	100%
C9ZN68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9B1L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q9BHE9	Leishmania major	85%	100%
V5DER6	Trypanosoma cruzi	63%	100%