Mevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mevalonate kinase

Gene product:

mevalonate kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ34_LEIBR

TriTrypDb:

LbrM.31.0720 , LBRM2903_310014100

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HJ34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ34

PDB structure(s): 2hfs_A , 2hfs_B , 2hfu_A , 2hfu_B

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006629	lipid metabolic process	3	11
GO:0006637	acyl-CoA metabolic process	4	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006694	steroid biosynthetic process	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008202	steroid metabolic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009240	isopentenyl diphosphate biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009987	cellular process	1	11
GO:0016125	sterol metabolic process	4	11
GO:0016126	sterol biosynthetic process	5	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0035383	thioester metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046490	isopentenyl diphosphate metabolic process	5	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004496	mevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.419
CLV_C14_Caspase3-7	297	301	PF00656	0.504
CLV_NRD_NRD_1	168	170	PF00675	0.371
CLV_NRD_NRD_1	205	207	PF00675	0.297
CLV_NRD_NRD_1	253	255	PF00675	0.292
CLV_PCSK_KEX2_1	168	170	PF00082	0.371
CLV_PCSK_KEX2_1	71	73	PF00082	0.396
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.425
CLV_PCSK_SKI1_1	18	22	PF00082	0.275
CLV_PCSK_SKI1_1	206	210	PF00082	0.345
CLV_PCSK_SKI1_1	231	235	PF00082	0.285
CLV_PCSK_SKI1_1	3	7	PF00082	0.492
CLV_PCSK_SKI1_1	304	308	PF00082	0.320
DOC_MAPK_gen_1	76	83	PF00069	0.386
DOC_MAPK_MEF2A_6	285	292	PF00069	0.419
DOC_PP1_RVXF_1	16	23	PF00149	0.282
DOC_PP1_RVXF_1	175	182	PF00149	0.457
DOC_USP7_MATH_1	111	115	PF00917	0.419
DOC_USP7_MATH_1	200	204	PF00917	0.282
DOC_USP7_MATH_1	4	8	PF00917	0.521
DOC_USP7_UBL2_3	173	177	PF12436	0.428
DOC_USP7_UBL2_3	314	318	PF12436	0.266
DOC_USP7_UBL2_3	8	12	PF12436	0.493
DOC_WW_Pin1_4	147	152	PF00397	0.419
DOC_WW_Pin1_4	46	51	PF00397	0.360
LIG_14-3-3_CanoR_1	121	129	PF00244	0.450
LIG_APCC_ABBA_1	19	24	PF00400	0.270
LIG_APCC_ABBAyCdc20_2	18	24	PF00400	0.272
LIG_BRCT_BRCA1_1	177	181	PF00533	0.228
LIG_eIF4E_1	16	22	PF01652	0.357
LIG_FHA_1	196	202	PF00498	0.405
LIG_FHA_1	222	228	PF00498	0.482
LIG_FHA_1	47	53	PF00498	0.330
LIG_LIR_Gen_1	214	223	PF02991	0.369
LIG_LIR_Nem_3	160	164	PF02991	0.437
LIG_LIR_Nem_3	214	219	PF02991	0.368
LIG_LIR_Nem_3	221	226	PF02991	0.407
LIG_LIR_Nem_3	24	29	PF02991	0.231
LIG_Pex14_2	22	26	PF04695	0.288
LIG_SH2_CRK	16	20	PF00017	0.363
LIG_SH2_CRK	273	277	PF00017	0.513
LIG_SH2_STAP1	223	227	PF00017	0.446
LIG_SH2_STAT3	319	322	PF00017	0.423
LIG_SH2_STAT3	67	70	PF00017	0.514
LIG_SH2_STAT5	186	189	PF00017	0.312
LIG_SH2_STAT5	223	226	PF00017	0.461
LIG_SH2_STAT5	319	322	PF00017	0.379
LIG_SH2_STAT5	41	44	PF00017	0.296
LIG_SH2_STAT5	67	70	PF00017	0.401
LIG_SH3_3	317	323	PF00018	0.223
LIG_SH3_3	47	53	PF00018	0.447
LIG_SH3_3	59	65	PF00018	0.302
LIG_SH3_3	99	105	PF00018	0.321
LIG_SUMO_SIM_par_1	186	192	PF11976	0.346
LIG_TYR_ITIM	14	19	PF00017	0.366
MOD_CK1_1	171	177	PF00069	0.298
MOD_CK1_1	7	13	PF00069	0.459
MOD_CK2_1	256	262	PF00069	0.419
MOD_GlcNHglycan	106	109	PF01048	0.195
MOD_GlcNHglycan	111	114	PF01048	0.219
MOD_GlcNHglycan	138	141	PF01048	0.227
MOD_GlcNHglycan	151	154	PF01048	0.217
MOD_GlcNHglycan	170	173	PF01048	0.485
MOD_GlcNHglycan	280	283	PF01048	0.219
MOD_GlcNHglycan	323	326	PF01048	0.520
MOD_GSK3_1	117	124	PF00069	0.461
MOD_GSK3_1	171	178	PF00069	0.375
MOD_GSK3_1	192	199	PF00069	0.308
MOD_GSK3_1	221	228	PF00069	0.517
MOD_GSK3_1	262	269	PF00069	0.533
MOD_N-GLC_1	129	134	PF02516	0.251
MOD_N-GLC_1	136	141	PF02516	0.212
MOD_N-GLC_1	221	226	PF02516	0.386
MOD_NEK2_1	280	285	PF00069	0.419
MOD_OFUCOSY	253	260	PF10250	0.247
MOD_PIKK_1	225	231	PF00454	0.396
MOD_PIKK_1	66	72	PF00454	0.335
MOD_PKA_1	168	174	PF00069	0.397
MOD_PKA_2	168	174	PF00069	0.330
MOD_Plk_1	136	142	PF00069	0.432
MOD_Plk_1	221	227	PF00069	0.379
MOD_Plk_4	171	177	PF00069	0.342
MOD_Plk_4	262	268	PF00069	0.507
MOD_ProDKin_1	147	153	PF00069	0.419
MOD_ProDKin_1	46	52	PF00069	0.365
MOD_SUMO_for_1	306	309	PF00179	0.378
MOD_SUMO_rev_2	309	316	PF00179	0.453
TRG_ENDOCYTIC_2	16	19	PF00928	0.363
TRG_ENDOCYTIC_2	186	189	PF00928	0.312
TRG_ENDOCYTIC_2	223	226	PF00928	0.401
TRG_ENDOCYTIC_2	273	276	PF00928	0.513
TRG_ER_diArg_1	167	169	PF00400	0.342
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE67	Leptomonas seymouri	80%	100%
A0A0S4KH54	Bodo saltans	62%	98%
A0A1D8PEL1	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	76%
A0A1X0NJ39	Trypanosomatidae	63%	100%
A0A3R7M8L1	Trypanosoma rangeli	61%	100%
A0A3S7X459	Leishmania donovani	87%	100%
A4I6L2	Leishmania infantum	87%	100%
B6YST1	Thermococcus onnurineus (strain NA1)	32%	99%
C5A7L8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	34%	99%
C6A3T5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	33%	99%
C9ZN67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B1K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	93%
O27995	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O58107	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	94%
O59291	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	98%
P07277	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	74%
P17256	Rattus norvegicus	26%	83%
P46086	Arabidopsis thaliana	27%	87%
Q03426	Homo sapiens	26%	83%
Q09780	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	81%
Q4Q6K7	Leishmania major	86%	100%
Q50559	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
Q58487	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q5E9T8	Bos taurus	27%	83%
Q5JEK8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	94%
Q5JJC6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	35%	98%
Q86AG7	Dictyostelium discoideum	23%	84%
Q8U0F3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	99%
Q980D2	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	27%	100%
Q9HHB6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	26%	93%
Q9R008	Mus musculus	26%	83%
Q9V187	Pyrococcus abyssi (strain GE5 / Orsay)	32%	98%
Q9Y946	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%