Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJ31_LEIBR

TriTrypDb:

LbrM.31.0690 , LBRM2903_310013800

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.776
CLV_MEL_PAP_1	14	20	PF00089	0.560
CLV_NRD_NRD_1	396	398	PF00675	0.595
CLV_NRD_NRD_1	465	467	PF00675	0.778
CLV_NRD_NRD_1	636	638	PF00675	0.686
CLV_NRD_NRD_1	84	86	PF00675	0.576
CLV_PCSK_FUR_1	634	638	PF00082	0.732
CLV_PCSK_KEX2_1	16	18	PF00082	0.568
CLV_PCSK_KEX2_1	396	398	PF00082	0.595
CLV_PCSK_KEX2_1	465	467	PF00082	0.778
CLV_PCSK_KEX2_1	636	638	PF00082	0.728
CLV_PCSK_KEX2_1	84	86	PF00082	0.576
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.568
CLV_PCSK_SKI1_1	170	174	PF00082	0.587
CLV_PCSK_SKI1_1	188	192	PF00082	0.673
CLV_PCSK_SKI1_1	239	243	PF00082	0.580
CLV_PCSK_SKI1_1	278	282	PF00082	0.701
CLV_PCSK_SKI1_1	330	334	PF00082	0.828
CLV_PCSK_SKI1_1	477	481	PF00082	0.663
DEG_APCC_DBOX_1	531	539	PF00400	0.789
DEG_Nend_UBRbox_3	1	3	PF02207	0.736
DEG_SCF_FBW7_1	351	357	PF00400	0.555
DEG_SPOP_SBC_1	354	358	PF00917	0.592
DEG_SPOP_SBC_1	484	488	PF00917	0.755
DOC_CDC14_PxL_1	22	30	PF14671	0.545
DOC_CKS1_1	351	356	PF01111	0.553
DOC_CKS1_1	658	663	PF01111	0.561
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.811
DOC_CYCLIN_yCln2_LP_2	500	506	PF00134	0.553
DOC_MAPK_gen_1	16	22	PF00069	0.557
DOC_MAPK_MEF2A_6	649	658	PF00069	0.792
DOC_PP4_FxxP_1	432	435	PF00568	0.538
DOC_PP4_MxPP_1	1	4	PF00568	0.711
DOC_SPAK_OSR1_1	17	21	PF12202	0.554
DOC_SPAK_OSR1_1	469	473	PF12202	0.562
DOC_USP7_MATH_1	186	190	PF00917	0.786
DOC_USP7_MATH_1	241	245	PF00917	0.624
DOC_USP7_MATH_1	332	336	PF00917	0.677
DOC_USP7_MATH_1	354	358	PF00917	0.559
DOC_USP7_MATH_1	400	404	PF00917	0.769
DOC_USP7_MATH_1	437	441	PF00917	0.542
DOC_USP7_UBL2_3	376	380	PF12436	0.572
DOC_WW_Pin1_4	146	151	PF00397	0.647
DOC_WW_Pin1_4	239	244	PF00397	0.580
DOC_WW_Pin1_4	26	31	PF00397	0.659
DOC_WW_Pin1_4	269	274	PF00397	0.830
DOC_WW_Pin1_4	293	298	PF00397	0.650
DOC_WW_Pin1_4	312	317	PF00397	0.510
DOC_WW_Pin1_4	35	40	PF00397	0.787
DOC_WW_Pin1_4	350	355	PF00397	0.550
DOC_WW_Pin1_4	396	401	PF00397	0.647
DOC_WW_Pin1_4	435	440	PF00397	0.578
DOC_WW_Pin1_4	45	50	PF00397	0.594
DOC_WW_Pin1_4	452	457	PF00397	0.749
DOC_WW_Pin1_4	472	477	PF00397	0.478
DOC_WW_Pin1_4	494	499	PF00397	0.756
DOC_WW_Pin1_4	507	512	PF00397	0.584
DOC_WW_Pin1_4	513	518	PF00397	0.597
DOC_WW_Pin1_4	530	535	PF00397	0.723
DOC_WW_Pin1_4	567	572	PF00397	0.724
DOC_WW_Pin1_4	597	602	PF00397	0.583
DOC_WW_Pin1_4	644	649	PF00397	0.532
DOC_WW_Pin1_4	657	662	PF00397	0.526
LIG_14-3-3_CanoR_1	10	15	PF00244	0.571
LIG_14-3-3_CanoR_1	17	21	PF00244	0.547
LIG_14-3-3_CanoR_1	258	264	PF00244	0.574
LIG_14-3-3_CanoR_1	285	294	PF00244	0.666
LIG_14-3-3_CanoR_1	406	412	PF00244	0.608
LIG_14-3-3_CanoR_1	460	464	PF00244	0.717
LIG_14-3-3_CanoR_1	465	472	PF00244	0.751
LIG_14-3-3_CanoR_1	636	640	PF00244	0.676
LIG_BIR_III_2	621	625	PF00653	0.587
LIG_BRCT_BRCA1_1	428	432	PF00533	0.800
LIG_BRCT_BRCA1_1	466	470	PF00533	0.568
LIG_CSL_BTD_1	92	95	PF09270	0.797
LIG_CtBP_PxDLS_1	260	264	PF00389	0.611
LIG_FHA_1	114	120	PF00498	0.813
LIG_FHA_1	167	173	PF00498	0.557
LIG_FHA_1	197	203	PF00498	0.548
LIG_FHA_1	205	211	PF00498	0.533
LIG_FHA_1	212	218	PF00498	0.518
LIG_FHA_1	249	255	PF00498	0.614
LIG_FHA_1	289	295	PF00498	0.759
LIG_FHA_1	341	347	PF00498	0.606
LIG_FHA_1	489	495	PF00498	0.553
LIG_FHA_1	570	576	PF00498	0.558
LIG_FHA_1	63	69	PF00498	0.823
LIG_FHA_1	9	15	PF00498	0.803
LIG_FHA_2	112	118	PF00498	0.617
LIG_FHA_2	217	223	PF00498	0.744
LIG_FHA_2	262	268	PF00498	0.585
LIG_LIR_Apic_2	429	435	PF02991	0.545
LIG_LIR_Gen_1	179	190	PF02991	0.583
LIG_LIR_Gen_1	343	351	PF02991	0.551
LIG_LIR_Nem_3	179	185	PF02991	0.572
LIG_LIR_Nem_3	244	249	PF02991	0.700
LIG_LIR_Nem_3	343	347	PF02991	0.806
LIG_LIR_Nem_3	410	414	PF02991	0.539
LIG_LIR_Nem_3	87	92	PF02991	0.553
LIG_MYND_1	26	30	PF01753	0.546
LIG_Pex14_2	89	93	PF04695	0.555
LIG_SH2_CRK	496	500	PF00017	0.549
LIG_SH2_CRK	515	519	PF00017	0.520
LIG_SH2_NCK_1	515	519	PF00017	0.582
LIG_SH2_PTP2	411	414	PF00017	0.526
LIG_SH2_STAP1	182	186	PF00017	0.531
LIG_SH2_STAT5	182	185	PF00017	0.537
LIG_SH2_STAT5	411	414	PF00017	0.526
LIG_SH3_1	515	521	PF00018	0.603
LIG_SH3_3	1	7	PF00018	0.757
LIG_SH3_3	144	150	PF00018	0.688
LIG_SH3_3	195	201	PF00018	0.548
LIG_SH3_3	291	297	PF00018	0.829
LIG_SH3_3	343	349	PF00018	0.604
LIG_SH3_3	399	405	PF00018	0.723
LIG_SH3_3	450	456	PF00018	0.562
LIG_SH3_3	492	498	PF00018	0.793
LIG_SH3_3	500	506	PF00018	0.674
LIG_SH3_3	515	521	PF00018	0.603
LIG_SH3_3	528	534	PF00018	0.759
LIG_SH3_3	598	604	PF00018	0.575
LIG_SH3_3	613	619	PF00018	0.598
LIG_SH3_3	65	71	PF00018	0.669
LIG_SUMO_SIM_anti_2	442	447	PF11976	0.722
LIG_SUMO_SIM_par_1	193	199	PF11976	0.642
LIG_SUMO_SIM_par_1	250	255	PF11976	0.599
LIG_SUMO_SIM_par_1	259	264	PF11976	0.556
LIG_SUMO_SIM_par_1	497	502	PF11976	0.667
LIG_SUMO_SIM_par_1	570	577	PF11976	0.539
LIG_TRAF2_1	159	162	PF00917	0.838
LIG_TRAF2_1	447	450	PF00917	0.828
LIG_TRAF2_1	74	77	PF00917	0.579
LIG_TRFH_1	597	601	PF08558	0.582
LIG_TYR_ITIM	494	499	PF00017	0.541
LIG_WRC_WIRS_1	182	187	PF05994	0.601
LIG_WRC_WIRS_1	341	346	PF05994	0.803
MOD_CDC14_SPxK_1	457	460	PF00782	0.585
MOD_CDC14_SPxK_1	48	51	PF00782	0.839
MOD_CDK_SPK_2	472	477	PF00069	0.794
MOD_CDK_SPK_2	644	649	PF00069	0.532
MOD_CDK_SPxK_1	45	51	PF00069	0.848
MOD_CDK_SPxK_1	454	460	PF00069	0.577
MOD_CDK_SPxxK_3	146	153	PF00069	0.649
MOD_CK1_1	120	126	PF00069	0.834
MOD_CK1_1	138	144	PF00069	0.552
MOD_CK1_1	178	184	PF00069	0.538
MOD_CK1_1	203	209	PF00069	0.738
MOD_CK1_1	269	275	PF00069	0.831
MOD_CK1_1	284	290	PF00069	0.630
MOD_CK1_1	293	299	PF00069	0.569
MOD_CK1_1	315	321	PF00069	0.721
MOD_CK1_1	325	331	PF00069	0.768
MOD_CK1_1	352	358	PF00069	0.786
MOD_CK1_1	359	365	PF00069	0.677
MOD_CK1_1	45	51	PF00069	0.796
MOD_CK1_1	475	481	PF00069	0.743
MOD_CK1_1	483	489	PF00069	0.637
MOD_CK1_1	507	513	PF00069	0.586
MOD_CK1_1	54	60	PF00069	0.738
MOD_CK1_1	546	552	PF00069	0.726
MOD_CK1_1	602	608	PF00069	0.817
MOD_CK1_1	62	68	PF00069	0.820
MOD_CK1_1	657	663	PF00069	0.651
MOD_CK2_1	111	117	PF00069	0.732
MOD_CK2_1	216	222	PF00069	0.739
MOD_CK2_1	261	267	PF00069	0.584
MOD_CK2_1	444	450	PF00069	0.824
MOD_CK2_1	530	536	PF00069	0.653
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.580
MOD_GlcNHglycan	202	205	PF01048	0.572
MOD_GlcNHglycan	238	242	PF01048	0.837
MOD_GlcNHglycan	243	246	PF01048	0.740
MOD_GlcNHglycan	35	38	PF01048	0.670
MOD_GlcNHglycan	376	379	PF01048	0.804
MOD_GlcNHglycan	429	432	PF01048	0.644
MOD_GlcNHglycan	439	442	PF01048	0.672
MOD_GlcNHglycan	446	449	PF01048	0.590
MOD_GlcNHglycan	477	480	PF01048	0.641
MOD_GlcNHglycan	482	485	PF01048	0.683
MOD_GlcNHglycan	491	494	PF01048	0.750
MOD_GlcNHglycan	506	509	PF01048	0.572
MOD_GlcNHglycan	53	57	PF01048	0.498
MOD_GlcNHglycan	607	611	PF01048	0.708
MOD_GlcNHglycan	62	65	PF01048	0.769
MOD_GlcNHglycan	666	669	PF01048	0.691
MOD_GlcNHglycan	86	89	PF01048	0.559
MOD_GSK3_1	109	116	PF00069	0.813
MOD_GSK3_1	166	173	PF00069	0.732
MOD_GSK3_1	196	203	PF00069	0.644
MOD_GSK3_1	233	240	PF00069	0.755
MOD_GSK3_1	248	255	PF00069	0.566
MOD_GSK3_1	268	275	PF00069	0.814
MOD_GSK3_1	276	283	PF00069	0.746
MOD_GSK3_1	284	291	PF00069	0.685
MOD_GSK3_1	315	322	PF00069	0.731
MOD_GSK3_1	349	356	PF00069	0.776
MOD_GSK3_1	35	42	PF00069	0.761
MOD_GSK3_1	392	399	PF00069	0.646
MOD_GSK3_1	413	420	PF00069	0.642
MOD_GSK3_1	422	429	PF00069	0.652
MOD_GSK3_1	435	442	PF00069	0.580
MOD_GSK3_1	461	468	PF00069	0.750
MOD_GSK3_1	471	478	PF00069	0.572
MOD_GSK3_1	479	486	PF00069	0.544
MOD_GSK3_1	51	58	PF00069	0.574
MOD_GSK3_1	548	555	PF00069	0.760
MOD_GSK3_1	565	572	PF00069	0.499
MOD_GSK3_1	59	66	PF00069	0.664
MOD_GSK3_1	602	609	PF00069	0.602
MOD_GSK3_1	660	667	PF00069	0.810
MOD_GSK3_1	84	91	PF00069	0.700
MOD_N-GLC_1	281	286	PF02516	0.592
MOD_N-GLC_1	380	385	PF02516	0.612
MOD_N-GLC_1	391	396	PF02516	0.710
MOD_N-GLC_1	400	405	PF02516	0.698
MOD_N-GLC_1	470	475	PF02516	0.812
MOD_N-GLC_1	484	489	PF02516	0.556
MOD_N-GLC_1	8	13	PF02516	0.679
MOD_NEK2_1	237	242	PF00069	0.740
MOD_NEK2_1	252	257	PF00069	0.813
MOD_NEK2_1	261	266	PF00069	0.652
MOD_NEK2_1	276	281	PF00069	0.546
MOD_NEK2_1	292	297	PF00069	0.587
MOD_NEK2_1	33	38	PF00069	0.599
MOD_NEK2_1	360	365	PF00069	0.602
MOD_NEK2_1	422	427	PF00069	0.727
MOD_NEK2_1	459	464	PF00069	0.581
MOD_NEK2_1	470	475	PF00069	0.516
MOD_NEK2_1	480	485	PF00069	0.661
MOD_NEK2_1	548	553	PF00069	0.671
MOD_NEK2_1	583	588	PF00069	0.823
MOD_NEK2_1	59	64	PF00069	0.758
MOD_PIKK_1	323	329	PF00454	0.688
MOD_PIKK_1	381	387	PF00454	0.575
MOD_PIKK_1	42	48	PF00454	0.858
MOD_PK_1	16	22	PF00069	0.571
MOD_PKA_1	16	22	PF00069	0.557
MOD_PKA_1	465	471	PF00069	0.771
MOD_PKA_1	84	90	PF00069	0.566
MOD_PKA_2	120	126	PF00069	0.834
MOD_PKA_2	16	22	PF00069	0.761
MOD_PKA_2	284	290	PF00069	0.673
MOD_PKA_2	422	428	PF00069	0.546
MOD_PKA_2	459	465	PF00069	0.757
MOD_PKA_2	635	641	PF00069	0.674
MOD_PKA_2	84	90	PF00069	0.565
MOD_PKA_2	9	15	PF00069	0.744
MOD_Plk_1	178	184	PF00069	0.538
MOD_Plk_1	196	202	PF00069	0.481
MOD_Plk_1	484	490	PF00069	0.763
MOD_Plk_1	549	555	PF00069	0.568
MOD_Plk_4	10	16	PF00069	0.823
MOD_Plk_4	135	141	PF00069	0.553
MOD_Plk_4	28	34	PF00069	0.525
MOD_Plk_4	407	413	PF00069	0.546
MOD_Plk_4	417	423	PF00069	0.508
MOD_Plk_4	543	549	PF00069	0.740
MOD_Plk_4	55	61	PF00069	0.817
MOD_Plk_4	560	566	PF00069	0.599
MOD_Plk_4	63	69	PF00069	0.823
MOD_ProDKin_1	146	152	PF00069	0.645
MOD_ProDKin_1	239	245	PF00069	0.578
MOD_ProDKin_1	26	32	PF00069	0.663
MOD_ProDKin_1	269	275	PF00069	0.832
MOD_ProDKin_1	293	299	PF00069	0.651
MOD_ProDKin_1	312	318	PF00069	0.512
MOD_ProDKin_1	35	41	PF00069	0.783
MOD_ProDKin_1	350	356	PF00069	0.552
MOD_ProDKin_1	396	402	PF00069	0.645
MOD_ProDKin_1	435	441	PF00069	0.579
MOD_ProDKin_1	45	51	PF00069	0.594
MOD_ProDKin_1	452	458	PF00069	0.749
MOD_ProDKin_1	472	478	PF00069	0.481
MOD_ProDKin_1	494	500	PF00069	0.758
MOD_ProDKin_1	507	513	PF00069	0.586
MOD_ProDKin_1	530	536	PF00069	0.794
MOD_ProDKin_1	567	573	PF00069	0.724
MOD_ProDKin_1	597	603	PF00069	0.582
MOD_ProDKin_1	644	650	PF00069	0.530
MOD_ProDKin_1	657	663	PF00069	0.527
TRG_DiLeu_BaEn_1	128	133	PF01217	0.560
TRG_DiLeu_BaEn_4	128	134	PF01217	0.562
TRG_DiLeu_BaEn_4	162	168	PF01217	0.820
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.553
TRG_ENDOCYTIC_2	182	185	PF00928	0.553
TRG_ENDOCYTIC_2	411	414	PF00928	0.526
TRG_ENDOCYTIC_2	496	499	PF00928	0.548
TRG_ER_diArg_1	396	398	PF00400	0.595
TRG_ER_diArg_1	524	527	PF00400	0.814
TRG_ER_diArg_1	83	85	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ISE9	Leishmania donovani	59%	100%
A4I6L0	Leishmania infantum	59%	99%
E9B1K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4Q6L0	Leishmania major	60%	100%