tRNA:m(4)X modification enzyme TRM13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCCH zinc finger in TRM13 protein/U11-48K-like CHHC zinc finger/Methyltransferase TRM13, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ30_LEIBR

TriTrypDb:

LbrM.31.0680 , LBRM2903_310013700

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ30

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0030488	tRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008171	O-methyltransferase activity	5	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008175	tRNA methyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0062105	RNA 2'-O-methyltransferase activity	5	11
GO:0106050	tRNA 2'-O-methyltransferase activity	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.486
CLV_NRD_NRD_1	109	111	PF00675	0.588
CLV_NRD_NRD_1	121	123	PF00675	0.573
CLV_NRD_NRD_1	128	130	PF00675	0.488
CLV_NRD_NRD_1	178	180	PF00675	0.266
CLV_NRD_NRD_1	498	500	PF00675	0.251
CLV_NRD_NRD_1	63	65	PF00675	0.498
CLV_NRD_NRD_1	656	658	PF00675	0.298
CLV_NRD_NRD_1	660	662	PF00675	0.298
CLV_NRD_NRD_1	676	678	PF00675	0.150
CLV_PCSK_FUR_1	126	130	PF00082	0.502
CLV_PCSK_KEX2_1	109	111	PF00082	0.583
CLV_PCSK_KEX2_1	120	122	PF00082	0.570
CLV_PCSK_KEX2_1	128	130	PF00082	0.488
CLV_PCSK_KEX2_1	498	500	PF00082	0.242
CLV_PCSK_KEX2_1	63	65	PF00082	0.498
CLV_PCSK_KEX2_1	656	658	PF00082	0.252
CLV_PCSK_KEX2_1	664	666	PF00082	0.228
CLV_PCSK_KEX2_1	676	678	PF00082	0.150
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.508
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.247
CLV_PCSK_SKI1_1	121	125	PF00082	0.599
CLV_PCSK_SKI1_1	132	136	PF00082	0.484
CLV_PCSK_SKI1_1	215	219	PF00082	0.615
CLV_PCSK_SKI1_1	250	254	PF00082	0.291
CLV_PCSK_SKI1_1	259	263	PF00082	0.422
CLV_PCSK_SKI1_1	285	289	PF00082	0.552
CLV_PCSK_SKI1_1	526	530	PF00082	0.296
CLV_PCSK_SKI1_1	690	694	PF00082	0.255
DEG_APCC_DBOX_1	485	493	PF00400	0.501
DEG_APCC_DBOX_1	525	533	PF00400	0.576
DEG_APCC_DBOX_1	602	610	PF00400	0.455
DEG_APCC_DBOX_1	63	71	PF00400	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.434
DEG_SCF_FBW7_1	346	351	PF00400	0.497
DEG_SCF_FBW7_2	342	349	PF00400	0.507
DOC_CKS1_1	465	470	PF01111	0.461
DOC_CYCLIN_yCln2_LP_2	74	77	PF00134	0.422
DOC_MAPK_FxFP_2	41	44	PF00069	0.420
DOC_MAPK_gen_1	128	137	PF00069	0.521
DOC_MAPK_gen_1	504	512	PF00069	0.457
DOC_MAPK_gen_1	661	672	PF00069	0.465
DOC_MAPK_gen_1	676	683	PF00069	0.428
DOC_MAPK_MEF2A_6	128	137	PF00069	0.523
DOC_MAPK_MEF2A_6	418	425	PF00069	0.380
DOC_MAPK_MEF2A_6	486	494	PF00069	0.504
DOC_MAPK_MEF2A_6	665	674	PF00069	0.536
DOC_PP1_RVXF_1	430	436	PF00149	0.384
DOC_PP1_RVXF_1	669	675	PF00149	0.536
DOC_PP2B_LxvP_1	622	625	PF13499	0.475
DOC_PP2B_LxvP_1	74	77	PF13499	0.422
DOC_PP4_FxxP_1	137	140	PF00568	0.522
DOC_PP4_FxxP_1	41	44	PF00568	0.420
DOC_PP4_FxxP_1	86	89	PF00568	0.444
DOC_PP4_FxxP_1	95	98	PF00568	0.450
DOC_PP4_MxPP_1	609	612	PF00568	0.384
DOC_USP7_MATH_1	151	155	PF00917	0.777
DOC_USP7_MATH_1	205	209	PF00917	0.699
DOC_USP7_MATH_1	236	240	PF00917	0.500
DOC_USP7_MATH_1	26	30	PF00917	0.524
DOC_USP7_MATH_1	471	475	PF00917	0.496
DOC_USP7_MATH_1	534	538	PF00917	0.492
DOC_USP7_MATH_1	625	629	PF00917	0.532
DOC_USP7_MATH_1	638	642	PF00917	0.411
DOC_USP7_MATH_1	77	81	PF00917	0.476
DOC_USP7_MATH_1	98	102	PF00917	0.541
DOC_USP7_MATH_2	348	354	PF00917	0.489
DOC_USP7_UBL2_3	120	124	PF12436	0.511
DOC_WW_Pin1_4	155	160	PF00397	0.699
DOC_WW_Pin1_4	203	208	PF00397	0.674
DOC_WW_Pin1_4	342	347	PF00397	0.754
DOC_WW_Pin1_4	461	466	PF00397	0.582
DOC_WW_Pin1_4	99	104	PF00397	0.567
LIG_14-3-3_CanoR_1	182	190	PF00244	0.475
LIG_14-3-3_CanoR_1	259	268	PF00244	0.527
LIG_14-3-3_CanoR_1	295	303	PF00244	0.393
LIG_14-3-3_CanoR_1	379	388	PF00244	0.416
LIG_14-3-3_CanoR_1	398	406	PF00244	0.680
LIG_14-3-3_CanoR_1	504	512	PF00244	0.482
LIG_14-3-3_CanoR_1	526	536	PF00244	0.496
LIG_14-3-3_CanoR_1	656	660	PF00244	0.406
LIG_14-3-3_CanoR_1	99	103	PF00244	0.473
LIG_Actin_WH2_2	245	261	PF00022	0.498
LIG_APCC_ABBAyCdc20_2	403	409	PF00400	0.306
LIG_BRCT_BRCA1_1	45	49	PF00533	0.428
LIG_Clathr_ClatBox_1	489	493	PF01394	0.473
LIG_CSL_BTD_1	137	140	PF09270	0.473
LIG_FHA_1	195	201	PF00498	0.476
LIG_FHA_1	260	266	PF00498	0.485
LIG_FHA_1	389	395	PF00498	0.680
LIG_FHA_1	438	444	PF00498	0.538
LIG_FHA_1	687	693	PF00498	0.530
LIG_FHA_2	145	151	PF00498	0.613
LIG_FHA_2	295	301	PF00498	0.475
LIG_FHA_2	345	351	PF00498	0.767
LIG_FHA_2	453	459	PF00498	0.384
LIG_FHA_2	628	634	PF00498	0.534
LIG_FHA_2	686	692	PF00498	0.498
LIG_HP1_1	488	492	PF01393	0.536
LIG_Integrin_RGD_1	228	230	PF01839	0.543
LIG_LIR_Apic_2	38	44	PF02991	0.426
LIG_LIR_Apic_2	94	98	PF02991	0.474
LIG_LIR_Gen_1	38	47	PF02991	0.426
LIG_LIR_Gen_1	409	416	PF02991	0.403
LIG_LIR_Gen_1	474	484	PF02991	0.384
LIG_LIR_Gen_1	556	565	PF02991	0.444
LIG_LIR_Gen_1	628	639	PF02991	0.452
LIG_LIR_Nem_3	169	175	PF02991	0.369
LIG_LIR_Nem_3	38	42	PF02991	0.432
LIG_LIR_Nem_3	409	414	PF02991	0.403
LIG_LIR_Nem_3	474	480	PF02991	0.454
LIG_LIR_Nem_3	556	561	PF02991	0.457
LIG_LIR_Nem_3	633	639	PF02991	0.459
LIG_Pex14_2	39	43	PF04695	0.434
LIG_Pex14_2	45	49	PF04695	0.417
LIG_PTAP_UEV_1	467	472	PF05743	0.401
LIG_SH2_NCK_1	355	359	PF00017	0.473
LIG_SH2_STAP1	244	248	PF00017	0.442
LIG_SH2_STAP1	317	321	PF00017	0.406
LIG_SH2_STAT3	260	263	PF00017	0.324
LIG_SH2_STAT5	176	179	PF00017	0.444
LIG_SH2_STAT5	194	197	PF00017	0.442
LIG_SH2_STAT5	260	263	PF00017	0.510
LIG_SH2_STAT5	267	270	PF00017	0.473
LIG_SH2_STAT5	296	299	PF00017	0.457
LIG_SH2_STAT5	680	683	PF00017	0.471
LIG_SH2_STAT5	687	690	PF00017	0.450
LIG_SH3_3	110	116	PF00018	0.531
LIG_SH3_3	158	164	PF00018	0.736
LIG_SH3_3	230	236	PF00018	0.304
LIG_SH3_3	462	468	PF00018	0.576
LIG_SH3_3	586	592	PF00018	0.519
LIG_SH3_3	70	76	PF00018	0.443
LIG_SH3_3	86	92	PF00018	0.446
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.511
LIG_SUMO_SIM_par_1	487	493	PF11976	0.444
LIG_SUMO_SIM_par_1	53	60	PF11976	0.448
LIG_SUMO_SIM_par_1	578	585	PF11976	0.554
LIG_SUMO_SIM_par_1	592	598	PF11976	0.527
LIG_TRAF2_1	347	350	PF00917	0.645
LIG_TRAF2_2	164	169	PF00917	0.377
MOD_CDK_SPK_2	155	160	PF00069	0.513
MOD_CK1_1	102	108	PF00069	0.565
MOD_CK1_1	219	225	PF00069	0.626
MOD_CK1_1	239	245	PF00069	0.350
MOD_CK1_1	438	444	PF00069	0.419
MOD_CK1_1	464	470	PF00069	0.558
MOD_CK1_1	48	54	PF00069	0.497
MOD_CK1_1	57	63	PF00069	0.546
MOD_CK1_1	575	581	PF00069	0.467
MOD_CK1_1	641	647	PF00069	0.448
MOD_CK2_1	144	150	PF00069	0.715
MOD_CK2_1	243	249	PF00069	0.546
MOD_CK2_1	344	350	PF00069	0.731
MOD_CK2_1	439	445	PF00069	0.552
MOD_CK2_1	627	633	PF00069	0.467
MOD_Cter_Amidation	659	662	PF01082	0.296
MOD_GlcNHglycan	153	156	PF01048	0.711
MOD_GlcNHglycan	207	210	PF01048	0.595
MOD_GlcNHglycan	212	215	PF01048	0.521
MOD_GlcNHglycan	338	341	PF01048	0.671
MOD_GlcNHglycan	356	359	PF01048	0.707
MOD_GlcNHglycan	468	471	PF01048	0.283
MOD_GlcNHglycan	50	53	PF01048	0.431
MOD_GlcNHglycan	536	539	PF01048	0.333
MOD_GSK3_1	140	147	PF00069	0.758
MOD_GSK3_1	151	158	PF00069	0.615
MOD_GSK3_1	171	178	PF00069	0.518
MOD_GSK3_1	215	222	PF00069	0.752
MOD_GSK3_1	239	246	PF00069	0.494
MOD_GSK3_1	290	297	PF00069	0.580
MOD_GSK3_1	344	351	PF00069	0.664
MOD_GSK3_1	43	50	PF00069	0.522
MOD_GSK3_1	435	442	PF00069	0.458
MOD_GSK3_1	460	467	PF00069	0.559
MOD_GSK3_1	625	632	PF00069	0.495
MOD_GSK3_1	686	693	PF00069	0.535
MOD_GSK3_1	98	105	PF00069	0.494
MOD_N-GLC_1	239	244	PF02516	0.242
MOD_N-GLC_2	171	173	PF02516	0.244
MOD_N-GLC_2	696	698	PF02516	0.255
MOD_NEK2_1	142	147	PF00069	0.638
MOD_NEK2_1	183	188	PF00069	0.474
MOD_NEK2_1	280	285	PF00069	0.586
MOD_NEK2_1	354	359	PF00069	0.705
MOD_NEK2_1	435	440	PF00069	0.401
MOD_NEK2_1	45	50	PF00069	0.489
MOD_NEK2_1	572	577	PF00069	0.455
MOD_NEK2_2	471	476	PF00069	0.384
MOD_OFUCOSY	569	576	PF10250	0.273
MOD_PIKK_1	162	168	PF00454	0.659
MOD_PIKK_1	183	189	PF00454	0.384
MOD_PIKK_1	259	265	PF00454	0.424
MOD_PIKK_1	290	296	PF00454	0.603
MOD_PIKK_1	364	370	PF00454	0.536
MOD_PIKK_1	398	404	PF00454	0.622
MOD_PIKK_1	452	458	PF00454	0.453
MOD_PIKK_1	582	588	PF00454	0.515
MOD_PK_1	299	305	PF00069	0.307
MOD_PKA_2	294	300	PF00069	0.419
MOD_PKA_2	397	403	PF00069	0.584
MOD_PKA_2	505	511	PF00069	0.438
MOD_PKA_2	655	661	PF00069	0.477
MOD_PKA_2	98	104	PF00069	0.469
MOD_Plk_1	239	245	PF00069	0.442
MOD_Plk_1	299	305	PF00069	0.307
MOD_Plk_4	171	177	PF00069	0.536
MOD_Plk_4	189	195	PF00069	0.432
MOD_Plk_4	239	245	PF00069	0.442
MOD_Plk_4	350	356	PF00069	0.483
MOD_Plk_4	390	396	PF00069	0.590
MOD_ProDKin_1	155	161	PF00069	0.695
MOD_ProDKin_1	203	209	PF00069	0.677
MOD_ProDKin_1	342	348	PF00069	0.752
MOD_ProDKin_1	461	467	PF00069	0.582
MOD_ProDKin_1	99	105	PF00069	0.566
MOD_SUMO_rev_2	269	274	PF00179	0.377
TRG_DiLeu_BaEn_1	579	584	PF01217	0.384
TRG_DiLeu_BaEn_1	695	700	PF01217	0.384
TRG_ENDOCYTIC_2	680	683	PF00928	0.536
TRG_ER_diArg_1	121	123	PF00400	0.582
TRG_ER_diArg_1	126	129	PF00400	0.548
TRG_ER_diArg_1	497	499	PF00400	0.442
TRG_ER_diArg_1	514	517	PF00400	0.464
TRG_ER_diArg_1	675	677	PF00400	0.568
TRG_NLS_Bipartite_1	109	124	PF00514	0.496
TRG_NLS_MonoExtC_3	119	124	PF00514	0.509
TRG_NLS_MonoExtC_3	660	665	PF00514	0.496
TRG_NLS_MonoExtN_4	117	124	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP0	Leptomonas seymouri	56%	100%
A0A1X0NKZ4	Trypanosomatidae	37%	100%
A0A3Q8IFC1	Leishmania donovani	77%	100%
A0A3R7N0X9	Trypanosoma rangeli	41%	100%
A4I6K9	Leishmania infantum	77%	100%
C9ZN61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q6L1	Leishmania major	75%	100%
V5BII3	Trypanosoma cruzi	41%	100%