J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJ29_LEIBR

TriTrypDb:

LbrM.31.0670 , LBRM2903_310013600

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HJ29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.614
CLV_NRD_NRD_1	225	227	PF00675	0.431
CLV_NRD_NRD_1	293	295	PF00675	0.285
CLV_NRD_NRD_1	298	300	PF00675	0.263
CLV_NRD_NRD_1	397	399	PF00675	0.313
CLV_NRD_NRD_1	486	488	PF00675	0.418
CLV_PCSK_KEX2_1	396	398	PF00082	0.298
CLV_PCSK_KEX2_1	457	459	PF00082	0.417
CLV_PCSK_KEX2_1	486	488	PF00082	0.450
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.430
CLV_PCSK_SKI1_1	108	112	PF00082	0.383
CLV_PCSK_SKI1_1	12	16	PF00082	0.391
CLV_PCSK_SKI1_1	299	303	PF00082	0.306
CLV_PCSK_SKI1_1	358	362	PF00082	0.433
CLV_PCSK_SKI1_1	382	386	PF00082	0.341
CLV_PCSK_SKI1_1	400	404	PF00082	0.370
CLV_PCSK_SKI1_1	486	490	PF00082	0.464
CLV_PCSK_SKI1_1	520	524	PF00082	0.318
DEG_APCC_DBOX_1	519	527	PF00400	0.607
DEG_COP1_1	343	352	PF00400	0.705
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CKS1_1	427	432	PF01111	0.451
DOC_CYCLIN_RxL_1	355	364	PF00134	0.479
DOC_CYCLIN_RxL_1	397	410	PF00134	0.536
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.609
DOC_MAPK_gen_1	396	406	PF00069	0.431
DOC_MAPK_gen_1	536	545	PF00069	0.543
DOC_PP1_RVXF_1	380	386	PF00149	0.579
DOC_PP1_RVXF_1	518	525	PF00149	0.584
DOC_USP7_MATH_1	247	251	PF00917	0.760
DOC_USP7_MATH_1	310	314	PF00917	0.510
DOC_USP7_MATH_1	584	588	PF00917	0.719
DOC_USP7_MATH_1	59	63	PF00917	0.693
DOC_USP7_MATH_1	76	80	PF00917	0.588
DOC_USP7_UBL2_3	227	231	PF12436	0.654
DOC_WW_Pin1_4	254	259	PF00397	0.774
DOC_WW_Pin1_4	286	291	PF00397	0.463
DOC_WW_Pin1_4	426	431	PF00397	0.451
DOC_WW_Pin1_4	49	54	PF00397	0.672
DOC_WW_Pin1_4	526	531	PF00397	0.632
DOC_WW_Pin1_4	589	594	PF00397	0.710
DOC_WW_Pin1_4	71	76	PF00397	0.743
DOC_WW_Pin1_4	89	94	PF00397	0.706
LIG_14-3-3_CanoR_1	119	127	PF00244	0.393
LIG_Actin_WH2_2	386	402	PF00022	0.547
LIG_APCC_ABBA_1	302	307	PF00400	0.467
LIG_BRCT_BRCA1_1	91	95	PF00533	0.652
LIG_Clathr_ClatBox_1	521	525	PF01394	0.597
LIG_DCNL_PONY_1	1	4	PF03556	0.445
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.430
LIG_deltaCOP1_diTrp_1	192	202	PF00928	0.577
LIG_deltaCOP1_diTrp_1	461	467	PF00928	0.634
LIG_FHA_1	266	272	PF00498	0.615
LIG_FHA_2	215	221	PF00498	0.599
LIG_FHA_2	287	293	PF00498	0.484
LIG_FHA_2	362	368	PF00498	0.499
LIG_GBD_Chelix_1	401	409	PF00786	0.348
LIG_LIR_Gen_1	15	25	PF02991	0.471
LIG_LIR_Gen_1	200	208	PF02991	0.563
LIG_LIR_Gen_1	316	326	PF02991	0.467
LIG_LIR_Gen_1	92	103	PF02991	0.698
LIG_LIR_Nem_3	15	21	PF02991	0.465
LIG_LIR_Nem_3	163	168	PF02991	0.382
LIG_LIR_Nem_3	200	205	PF02991	0.554
LIG_LIR_Nem_3	210	214	PF02991	0.621
LIG_LIR_Nem_3	316	322	PF02991	0.467
LIG_LIR_Nem_3	339	344	PF02991	0.626
LIG_LIR_Nem_3	9	14	PF02991	0.216
LIG_LIR_Nem_3	92	98	PF02991	0.687
LIG_Pex14_2	375	379	PF04695	0.597
LIG_REV1ctd_RIR_1	21	31	PF16727	0.561
LIG_SH2_CRK	168	172	PF00017	0.400
LIG_SH2_CRK	279	283	PF00017	0.484
LIG_SH2_CRK	326	330	PF00017	0.508
LIG_SH2_NCK_1	229	233	PF00017	0.617
LIG_SH2_STAP1	297	301	PF00017	0.540
LIG_SH2_STAP1	464	468	PF00017	0.660
LIG_SH2_STAT5	297	300	PF00017	0.538
LIG_SH2_STAT5	438	441	PF00017	0.543
LIG_SH3_3	202	208	PF00018	0.587
LIG_SH3_3	236	242	PF00018	0.732
LIG_SH3_3	424	430	PF00018	0.463
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.617
LIG_TRAF2_1	547	550	PF00917	0.629
MOD_CDC14_SPxK_1	52	55	PF00782	0.736
MOD_CDK_SPxK_1	49	55	PF00069	0.751
MOD_CDK_SPxxK_3	526	533	PF00069	0.629
MOD_CK1_1	183	189	PF00069	0.652
MOD_CK1_1	237	243	PF00069	0.655
MOD_CK1_1	313	319	PF00069	0.555
MOD_CK1_1	462	468	PF00069	0.573
MOD_CK1_1	470	476	PF00069	0.618
MOD_CK1_1	557	563	PF00069	0.640
MOD_CK1_1	587	593	PF00069	0.647
MOD_CK2_1	186	192	PF00069	0.649
MOD_CK2_1	194	200	PF00069	0.623
MOD_CK2_1	286	292	PF00069	0.475
MOD_CK2_1	35	41	PF00069	0.804
MOD_CK2_1	361	367	PF00069	0.494
MOD_CK2_1	411	417	PF00069	0.614
MOD_GlcNHglycan	182	185	PF01048	0.459
MOD_GlcNHglycan	249	252	PF01048	0.579
MOD_GlcNHglycan	37	40	PF01048	0.580
MOD_GlcNHglycan	413	416	PF01048	0.415
MOD_GlcNHglycan	417	420	PF01048	0.428
MOD_GlcNHglycan	469	472	PF01048	0.425
MOD_GlcNHglycan	80	83	PF01048	0.575
MOD_GSK3_1	176	183	PF00069	0.616
MOD_GSK3_1	2	9	PF00069	0.312
MOD_GSK3_1	237	244	PF00069	0.710
MOD_GSK3_1	327	334	PF00069	0.544
MOD_GSK3_1	411	418	PF00069	0.620
MOD_GSK3_1	459	466	PF00069	0.548
MOD_GSK3_1	560	567	PF00069	0.605
MOD_GSK3_1	583	590	PF00069	0.744
MOD_GSK3_1	60	67	PF00069	0.654
MOD_GSK3_1	97	104	PF00069	0.605
MOD_N-GLC_1	313	318	PF02516	0.345
MOD_N-GLC_1	587	592	PF02516	0.486
MOD_NEK2_1	101	106	PF00069	0.639
MOD_NEK2_1	118	123	PF00069	0.510
MOD_NEK2_1	2	7	PF00069	0.465
MOD_NEK2_1	361	366	PF00069	0.509
MOD_NEK2_1	469	474	PF00069	0.528
MOD_NEK2_1	524	529	PF00069	0.563
MOD_PIKK_1	577	583	PF00454	0.774
MOD_PKA_2	118	124	PF00069	0.393
MOD_PKA_2	237	243	PF00069	0.761
MOD_PKA_2	41	47	PF00069	0.680
MOD_PKA_2	557	563	PF00069	0.607
MOD_Plk_1	313	319	PF00069	0.523
MOD_Plk_1	331	337	PF00069	0.441
MOD_Plk_1	524	530	PF00069	0.541
MOD_Plk_1	541	547	PF00069	0.536
MOD_Plk_1	96	102	PF00069	0.686
MOD_Plk_4	241	247	PF00069	0.797
MOD_Plk_4	361	367	PF00069	0.512
MOD_Plk_4	404	410	PF00069	0.494
MOD_Plk_4	434	440	PF00069	0.549
MOD_Plk_4	459	465	PF00069	0.596
MOD_Plk_4	470	476	PF00069	0.654
MOD_Plk_4	541	547	PF00069	0.577
MOD_Plk_4	97	103	PF00069	0.630
MOD_ProDKin_1	254	260	PF00069	0.773
MOD_ProDKin_1	286	292	PF00069	0.463
MOD_ProDKin_1	426	432	PF00069	0.450
MOD_ProDKin_1	49	55	PF00069	0.673
MOD_ProDKin_1	526	532	PF00069	0.633
MOD_ProDKin_1	589	595	PF00069	0.711
MOD_ProDKin_1	71	77	PF00069	0.733
MOD_ProDKin_1	89	95	PF00069	0.702
TRG_ENDOCYTIC_2	168	171	PF00928	0.400
TRG_ENDOCYTIC_2	278	281	PF00928	0.467
TRG_ENDOCYTIC_2	326	329	PF00928	0.501
TRG_ENDOCYTIC_2	341	344	PF00928	0.561
TRG_ER_diArg_1	396	398	PF00400	0.512
TRG_NES_CRM1_1	367	380	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU7	Leptomonas seymouri	60%	98%
A0A0S4JJ62	Bodo saltans	30%	100%
A0A1X0NJF9	Trypanosomatidae	43%	100%
A0A1X0NZV2	Trypanosomatidae	42%	100%
A0A3S7X455	Leishmania donovani	79%	99%
A0A422NZZ9	Trypanosoma rangeli	40%	100%
A4I6K8	Leishmania infantum	80%	99%
C9ZN58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZWY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B1K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q6L2	Leishmania major	79%	99%
V5BN17	Trypanosoma cruzi	39%	100%