Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJ28_LEIBR

TriTrypDb:

LbrM.31.0660 , LBRM2903_310013500

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJ28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJ28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	486	490	PF00656	0.602
CLV_C14_Caspase3-7	92	96	PF00656	0.637
CLV_NRD_NRD_1	104	106	PF00675	0.576
CLV_NRD_NRD_1	233	235	PF00675	0.663
CLV_NRD_NRD_1	265	267	PF00675	0.548
CLV_NRD_NRD_1	63	65	PF00675	0.619
CLV_PCSK_KEX2_1	104	106	PF00082	0.573
CLV_PCSK_KEX2_1	233	235	PF00082	0.772
CLV_PCSK_KEX2_1	265	267	PF00082	0.548
CLV_PCSK_KEX2_1	433	435	PF00082	0.569
CLV_PCSK_KEX2_1	540	542	PF00082	0.495
CLV_PCSK_KEX2_1	566	568	PF00082	0.523
CLV_PCSK_KEX2_1	578	580	PF00082	0.672
CLV_PCSK_KEX2_1	63	65	PF00082	0.619
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.564
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.469
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.478
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.546
CLV_PCSK_PC7_1	229	235	PF00082	0.635
CLV_PCSK_SKI1_1	11	15	PF00082	0.546
CLV_PCSK_SKI1_1	205	209	PF00082	0.623
CLV_PCSK_SKI1_1	265	269	PF00082	0.576
CLV_PCSK_SKI1_1	325	329	PF00082	0.562
CLV_PCSK_SKI1_1	512	516	PF00082	0.577
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DEG_SCF_FBW7_1	422	428	PF00400	0.531
DEG_SPOP_SBC_1	78	82	PF00917	0.563
DOC_CKS1_1	28	33	PF01111	0.545
DOC_CKS1_1	422	427	PF01111	0.532
DOC_MAPK_gen_1	104	110	PF00069	0.529
DOC_MAPK_gen_1	519	526	PF00069	0.604
DOC_MAPK_gen_1	540	547	PF00069	0.459
DOC_MAPK_MEF2A_6	540	547	PF00069	0.528
DOC_USP7_MATH_1	169	173	PF00917	0.629
DOC_USP7_MATH_1	189	193	PF00917	0.640
DOC_USP7_MATH_1	259	263	PF00917	0.615
DOC_USP7_MATH_1	41	45	PF00917	0.793
DOC_USP7_MATH_1	414	418	PF00917	0.794
DOC_USP7_MATH_1	499	503	PF00917	0.731
DOC_USP7_MATH_1	571	575	PF00917	0.600
DOC_USP7_MATH_1	590	594	PF00917	0.575
DOC_USP7_MATH_1	97	101	PF00917	0.630
DOC_WW_Pin1_4	211	216	PF00397	0.742
DOC_WW_Pin1_4	267	272	PF00397	0.692
DOC_WW_Pin1_4	27	32	PF00397	0.666
DOC_WW_Pin1_4	421	426	PF00397	0.534
DOC_WW_Pin1_4	501	506	PF00397	0.773
DOC_WW_Pin1_4	585	590	PF00397	0.599
LIG_14-3-3_CanoR_1	104	109	PF00244	0.672
LIG_14-3-3_CanoR_1	193	202	PF00244	0.635
LIG_14-3-3_CanoR_1	233	242	PF00244	0.593
LIG_14-3-3_CanoR_1	265	271	PF00244	0.571
LIG_14-3-3_CanoR_1	272	279	PF00244	0.520
LIG_14-3-3_CanoR_1	370	378	PF00244	0.653
LIG_14-3-3_CanoR_1	521	527	PF00244	0.436
LIG_14-3-3_CanoR_1	79	86	PF00244	0.563
LIG_APCC_ABBA_1	140	145	PF00400	0.435
LIG_BRCT_BRCA1_1	106	110	PF00533	0.614
LIG_BRCT_BRCA1_2	106	112	PF00533	0.688
LIG_FHA_1	284	290	PF00498	0.465
LIG_FHA_1	530	536	PF00498	0.402
LIG_FHA_1	595	601	PF00498	0.539
LIG_FHA_1	615	621	PF00498	0.623
LIG_FHA_1	630	636	PF00498	0.503
LIG_FHA_1	88	94	PF00498	0.556
LIG_FHA_2	220	226	PF00498	0.617
LIG_FHA_2	426	432	PF00498	0.543
LIG_FHA_2	554	560	PF00498	0.382
LIG_LIR_Apic_2	255	259	PF02991	0.550
LIG_LIR_Gen_1	137	143	PF02991	0.504
LIG_LIR_Nem_3	137	141	PF02991	0.497
LIG_LIR_Nem_3	241	245	PF02991	0.545
LIG_PCNA_PIPBox_1	621	630	PF02747	0.507
LIG_SH2_CRK	256	260	PF00017	0.577
LIG_SH2_STAT5	357	360	PF00017	0.549
LIG_SH2_STAT5	554	557	PF00017	0.486
LIG_SH3_3	25	31	PF00018	0.577
LIG_SH3_3	384	390	PF00018	0.538
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.504
LIG_SUMO_SIM_par_1	542	548	PF11976	0.522
LIG_SxIP_EBH_1	116	125	PF03271	0.532
LIG_TRAF2_1	344	347	PF00917	0.590
LIG_TRFH_1	328	332	PF08558	0.635
LIG_UBA3_1	139	146	PF00899	0.434
LIG_WW_3	412	416	PF00397	0.542
LIG_WW_3	76	80	PF00397	0.547
MOD_CDK_SPK_2	267	272	PF00069	0.692
MOD_CDK_SPK_2	421	426	PF00069	0.534
MOD_CK1_1	111	117	PF00069	0.693
MOD_CK1_1	196	202	PF00069	0.695
MOD_CK1_1	211	217	PF00069	0.690
MOD_CK1_1	232	238	PF00069	0.573
MOD_CK1_1	278	284	PF00069	0.521
MOD_CK1_1	313	319	PF00069	0.579
MOD_CK1_1	366	372	PF00069	0.741
MOD_CK1_1	421	427	PF00069	0.779
MOD_CK1_1	435	441	PF00069	0.665
MOD_CK1_1	468	474	PF00069	0.579
MOD_CK1_1	570	576	PF00069	0.579
MOD_CK1_1	584	590	PF00069	0.740
MOD_CK1_1	594	600	PF00069	0.567
MOD_CK1_1	609	615	PF00069	0.533
MOD_CK1_1	70	76	PF00069	0.588
MOD_CK2_1	219	225	PF00069	0.622
MOD_CK2_1	23	29	PF00069	0.788
MOD_CK2_1	553	559	PF00069	0.377
MOD_GlcNHglycan	148	151	PF01048	0.604
MOD_GlcNHglycan	18	21	PF01048	0.686
MOD_GlcNHglycan	210	213	PF01048	0.542
MOD_GlcNHglycan	236	239	PF01048	0.642
MOD_GlcNHglycan	282	285	PF01048	0.611
MOD_GlcNHglycan	287	292	PF01048	0.588
MOD_GlcNHglycan	345	351	PF01048	0.500
MOD_GlcNHglycan	392	395	PF01048	0.682
MOD_GlcNHglycan	409	412	PF01048	0.767
MOD_GlcNHglycan	416	419	PF01048	0.568
MOD_GlcNHglycan	43	46	PF01048	0.684
MOD_GlcNHglycan	450	453	PF01048	0.680
MOD_GlcNHglycan	501	504	PF01048	0.635
MOD_GlcNHglycan	508	512	PF01048	0.646
MOD_GlcNHglycan	569	572	PF01048	0.661
MOD_GlcNHglycan	573	576	PF01048	0.692
MOD_GlcNHglycan	582	586	PF01048	0.725
MOD_GlcNHglycan	642	645	PF01048	0.700
MOD_GlcNHglycan	69	72	PF01048	0.648
MOD_GlcNHglycan	81	84	PF01048	0.677
MOD_GlcNHglycan	95	98	PF01048	0.655
MOD_GlcNHglycan	99	102	PF01048	0.619
MOD_GSK3_1	104	111	PF00069	0.648
MOD_GSK3_1	114	121	PF00069	0.541
MOD_GSK3_1	189	196	PF00069	0.608
MOD_GSK3_1	219	226	PF00069	0.601
MOD_GSK3_1	229	236	PF00069	0.561
MOD_GSK3_1	23	30	PF00069	0.641
MOD_GSK3_1	267	274	PF00069	0.747
MOD_GSK3_1	283	290	PF00069	0.466
MOD_GSK3_1	313	320	PF00069	0.579
MOD_GSK3_1	374	381	PF00069	0.622
MOD_GSK3_1	414	421	PF00069	0.748
MOD_GSK3_1	43	50	PF00069	0.765
MOD_GSK3_1	497	504	PF00069	0.669
MOD_GSK3_1	515	522	PF00069	0.577
MOD_GSK3_1	55	62	PF00069	0.703
MOD_GSK3_1	567	574	PF00069	0.653
MOD_GSK3_1	580	587	PF00069	0.768
MOD_GSK3_1	590	597	PF00069	0.621
MOD_GSK3_1	85	92	PF00069	0.733
MOD_GSK3_1	93	100	PF00069	0.754
MOD_N-GLC_1	118	123	PF02516	0.537
MOD_N-GLC_1	313	318	PF02516	0.621
MOD_N-GLC_1	36	41	PF02516	0.559
MOD_N-GLC_1	399	404	PF02516	0.709
MOD_N-GLC_1	459	464	PF02516	0.601
MOD_N-GLC_1	522	527	PF02516	0.445
MOD_N-GLC_1	630	635	PF02516	0.618
MOD_NEK2_1	223	228	PF00069	0.530
MOD_NEK2_1	317	322	PF00069	0.493
MOD_NEK2_1	36	41	PF00069	0.559
MOD_NEK2_1	363	368	PF00069	0.552
MOD_NEK2_1	399	404	PF00069	0.636
MOD_NEK2_1	507	512	PF00069	0.509
MOD_NEK2_1	515	520	PF00069	0.475
MOD_NEK2_1	93	98	PF00069	0.702
MOD_PIKK_1	114	120	PF00454	0.699
MOD_PIKK_1	196	202	PF00454	0.571
MOD_PIKK_1	332	338	PF00454	0.645
MOD_PIKK_1	399	405	PF00454	0.704
MOD_PK_1	104	110	PF00069	0.529
MOD_PK_1	459	465	PF00069	0.506
MOD_PKA_1	104	110	PF00069	0.529
MOD_PKA_1	233	239	PF00069	0.660
MOD_PKA_1	432	438	PF00069	0.556
MOD_PKA_2	103	109	PF00069	0.656
MOD_PKA_2	232	238	PF00069	0.487
MOD_PKA_2	271	277	PF00069	0.611
MOD_PKA_2	369	375	PF00069	0.493
MOD_PKA_2	414	420	PF00069	0.752
MOD_PKA_2	448	454	PF00069	0.534
MOD_PKA_2	604	610	PF00069	0.657
MOD_PKA_2	78	84	PF00069	0.638
MOD_Plk_1	118	124	PF00069	0.663
MOD_Plk_1	22	28	PF00069	0.560
MOD_Plk_1	287	293	PF00069	0.541
MOD_Plk_1	313	319	PF00069	0.630
MOD_Plk_1	374	380	PF00069	0.585
MOD_Plk_1	459	465	PF00069	0.567
MOD_Plk_1	483	489	PF00069	0.634
MOD_Plk_1	522	528	PF00069	0.667
MOD_Plk_2-3	23	29	PF00069	0.567
MOD_Plk_2-3	483	489	PF00069	0.740
MOD_Plk_2-3	89	95	PF00069	0.566
MOD_Plk_4	111	117	PF00069	0.621
MOD_Plk_4	219	225	PF00069	0.546
MOD_Plk_4	313	319	PF00069	0.473
MOD_Plk_4	348	354	PF00069	0.644
MOD_Plk_4	459	465	PF00069	0.506
MOD_Plk_4	591	597	PF00069	0.560
MOD_ProDKin_1	211	217	PF00069	0.737
MOD_ProDKin_1	267	273	PF00069	0.692
MOD_ProDKin_1	27	33	PF00069	0.665
MOD_ProDKin_1	421	427	PF00069	0.533
MOD_ProDKin_1	501	507	PF00069	0.771
MOD_ProDKin_1	585	591	PF00069	0.597
MOD_SUMO_rev_2	468	474	PF00179	0.573
MOD_SUMO_rev_2	88	93	PF00179	0.656
TRG_DiLeu_BaEn_2	287	293	PF01217	0.530
TRG_ER_diArg_1	103	105	PF00400	0.571
TRG_NLS_MonoExtN_4	563	569	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	434	439	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA33	Leptomonas seymouri	45%	100%
A0A3S7X488	Leishmania donovani	63%	100%
A4I6K7	Leishmania infantum	63%	100%
E9B1K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q6L3	Leishmania major	61%	100%